• Clinical and Experimental Reproductive Medicine
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• 제22권2호
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• pp.203-210
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• 1995

Many oocytes fail to fertilize and cleave in vitro and many embryos transferred back to uterus fail to implant or maintain implantation. Chromosomal abnormalities in the male and female gametes may contribute to this loss. The higher incidence of meiotic chromosomal abnormalities bas been found in oocytes than in sperm. The wide range of incidence of chromosomal abnormalities in unfertilized oocytes has been reported in human IVF program (26-63%). However, factors affecting chromosomal abnormalities are not well understood. The present study has been conducted to investigate effects of the method for ovarian hyperstimulation, women's age, and the number of oocytes retrieved per patients on the incidence of numerical chromosomal abnormalities. Five hundred eighty four unfertilized metaphase II oocytes were subjected to chromosomal analysis. Included unfertilized oocytes were from 220 patients (mean $age=32.7{\pm}3.0$) and three hundred thirty oocytes were legible for analysis. Two hundred fourty five oocytes out of 330 (73.3%) were normal, while 38 (11.5%) were hyperploidy, 35 (10.6%) were hypoploidy, and 12 (3.6%) were diploidy. Significant difference in chromosomal abnormalities was not found between two patient groups stimulated by follicular stimulating hormone/human menopausal gonadotrophin (FSH/HMG) (25.9%) and gonadotrophin-releasing hormone agonist/follicular stimulating hormone/human menopausal gonadotrophin (GnRHa/FSH/HMG) (28%). There was a tendency of increasing chromosomal abnormalities in unfertilized oocytes from older patients (<30 yrs: 20.3%, 30-34yrs: 26.9%, >34 yrs: 35.3%). The number of oocytes retrieved per patient had no effect the incidence of chromosomal abnormalities (1-5: 31. 4%, 6-10: 29.8%, 11-15: 28.6%, > 15: 16.5%). These results from the present study suggest that the chromosomal abnormalities observed in the unfertilized oocytes has not affected by the stimulation methods, patient's age, and the number of oocytes retrieved per patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1007-1010
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• 2015

Background: The clinical significance of bilateral breast cancer is unclear and its influence on prognosis is controversial. Materials and Methods: Between 2005 and 2009 we identified 110 cases of bilateral breast cancer (BBC) ; 49 patients had synchronous (duration between the occurrence of carcinoma in both breasts was less than 12 months) and 61 had metachronous (duration was more than one year with no ipsilateral local recurrence). We compared the patient characteristics including age, menopausal status, clinical stage, tumor size, histological classification, lymph node status, and hormone receptor and Her-2 status. We also compared the treatment given and overall and disease free survival (DFS) of both groups. Results: Synchronous cases tend to present more aggressively than metachronous cases and age at first presentation adversely affects survival. The 5 year overall survival was 78.7% for metachronous and 60% for synchronous. Patients with positive hormonal status had better five year disease free survival in metachronous compared to synchronous cases, at 76% and 63%, respectively. Age at first presentation >45years had better DFS (65%) compared to those with age ${\leq}45$ years (52%) at 5 years follow up. Conclusions: Patients with synchronous breast cancer may have worse prognosis. Young age and hormone receptor negative were risk factors in our study. Close follow up and early detection of contralateral breast cancer is mandatory.

• 대한한의학회지
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• 제25권4호
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• pp.43-50
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• 2004

Objective : Obesity is associated with degenerative arthropathy giving stress on joints. It also amplifies loads of weight bearing joints by changing the gravity line of the body. Our aim is to investigate the correlation between obesity and lumbar lordosis in obese pre-menopausal Korean females. The hypothesis was tested that there is a correlation between obesity and lumbar lordosis. Methods : A cross-sectional evaluation of 44 Females (baseline age 30.77 ± 6.46) with BMI 31.53 ± 3.82 (kg/㎡) was done. Body composition was measured using bio-impedance analysis (BIA), and anthropometry was done by the same observer. A lateral whole spine X-ray was taken in standing position to measure the lumbar lordotic angle (LLA), Ferguson angle (FA) and lumbar gravity line (LGL). A Pearson correlation was used to measure the correlation between obesity and lumbar lordosis (SPSS 10.0 for windows). Results : Body mass index (BMI kg/㎡) had a negative relationship with LLA((equation omitted)=-0.469), FA((equation omitted) =-0.347) and LGL((equation omitted)=-0.389). Body fat rate had a negative relationship with LLA only(γ=-0.385). Waist circumference had a negative relationship with LLA((equation omitted)=-0.345) and LGL((equation omitted)=-0.346). WH ratio had no relationship with lumbar lordosis. Conclusion : These data show that obesity is related to mechanical structures, such as lumbar lordosis. BMI was the most useful index, which reflects a change of mechanical structure of lumbar, more than other variables in this study.

• 한국보건간호학회지
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• 제4권2호
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• pp.15-23
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• 1990

This study was carried out to explore the illness-related activities of the menopaused women. To achieve such a purpose, sixty-six cases of the middle aged women were sampled the naturally and the artificially menopaused group respectively from 1st, Aug. to 31th, Aug. in 1988. For the collection of data, 1, 140 women aged between 45-54 were selected through stratified sampling techniques in urban and rural area. Among them the final subjects for analysis were restricted to only those who had experienced menopause naturally or artificially. And then, after control for age and education analysis was performed. The data was analysed by use of frequency, percentage, $X^2-test,$ t-test, Pearson correlation coefficiency and stop-wise multiple regression. The obtained results were as follows. I. As for the se1f-perception on menopausal symptoms, it was revealed than Korean women, neithe in naturally and artificially, accepted the change of menstruation itself as serious. This shows us that middle-aged women had positively receptive attitudes that the change of menstruation is follwed by amenorrhea. 2. The artificially menopaused group scored more than the naturally one: (I) on the self-control activities such as self-assessment, lay-consultation, fever check, pulse check and observation of vagina discharge, (2) on the self-decision activities such as hospital and pharmacy utilization, (3) on the self maintenance activities such as walking, aerobic, weight check, skin care, skin protect, calori control diet control, milk intake, vegetable intake, cold water drinking before meal, parasol use and BP check The above results lead us that the self care practices of the menopaused women revealed' coping wit I menopausal symptoms at the first level in community and must be developed by the adequate nursin intervention.

• 한방비만학회지
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• 제8권1호
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• pp.81-88
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• 2008

Objectives To investigate the relationship between Heart Rate Variability and menopause among obese middle-aged women in Korea. Subjects and Methods Forty middle-aged women (age 49.05 $\pm$ 2.64 years) with BMI > $23kg/m^2$ were recruited by local advertisement. Blood profiles of estrogen, FSH, LH, glucose, total cholesterol, HDL-cholesterol, and triglyceride were measured. Autonomic Nervous System (ANS) was estimated by short-term spectral analysis of heart rate variability (HRV). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were accessed using Computerized Tomography (CT), Bioimpedance Analysis (BIA), and anthropometry. To scrutinize the influence of ANS on obesity-related factors, we divided the subjects into pre- and post-menopausal women. Results The total cholesterol, FSH and LH were significantly higher in post-menopausal obese women group. The estradiol and standard deviation of all normal R-R intervals (SDNN), high-frequency components (HF) of the HRV were significantly lower in postmenopausal obese women group (P<0.05). Adipose tissue distribution and blood profiles were not significantly different between two groups. Conclusion Menopause induced a decrease in SDNN and HF values and increase in total cholesterol level in obese women although the VAT itself was not related with ANS in obese women.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.387-393
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• 2016

Background: CYP1A1 is a candidate gene for low-penetrance breast cancer susceptibility, as it plays an important role in the metabolism of carcinogens and estrogens. Purpose: The objective of this study was to assess the association between M2 (A2455G, Ile462Val) and M4 (C2453A, Thr461Asn) polymorphisms in CYP1A1 and breast cancer risk among Jordanian women and in subgroups stratified by menopausal status and smoking history. Materials and Methods: Blood samples were collected from 112 breast cancer female patients and 115 age-matched controls who underwent breast cancer screening with imaging and showed negative results (BI-RADS I or BI-RADS II). Genotyping was performed using the PCR-RFLP technique. Results: No statistically significant overall association was found between breast cancer risk and CYP1A1 M2 genotypes (p= 0.55; OR = 0.77; 95% CI= 0.32 - 1.83) nor with the M4 polymorphism (p= 0.95; OR= 0.95; 95% CI= 0.51 - 1.88). Analysis of subgroups defined by menopausal status or smoking history also revealed no association with these polymorphisms. Furthermore, the four identified haplotypes (AC; AA; GC and GA) were equally distributed among cases and controls, and haplotype analysis showed a strong linkage disequilibrium of both studied loci in either cases or controls (D'=1). Conclusions: Based on the study results, CYP1A1 M2 and M4 polymorphisms do not seem to play a major role in breast cancer risk among Jordanian females.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2945-2948
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• 2013

Background: Mouse mammary tumor virus (MMTV) is the major cause of mammary tumors in mice. There is limited controversial evidence about the probable etiologic role of MMTV- like virus in human breast cancer. Materials and Methods: A total of 40 Formalin fixed paraffin embedded samples with diagnosis of breast cancer were collected in a period of 3 years from cancer institute of Iran. We selected both pre-menopausal and post-menopausal patients with different histologic grades and different ethnic groups. We evaluated presence of MMTV-like virus env gene through real time PCR method. Results: Forty patients (20 pre and 20 postmenopausal women) were evaluated with the mean age of 49.67. The average tumor size was 39 mm. None of the studied samples were positive for MMTV-like virus env gene target sequences. Conclusions: We found no evidence on the potential role of MMTV-like virus in the carcinogenicity of breast cancer among Iranian women.

• 한방비만학회지
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• 제4권1호
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• pp.23-31
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• 2004

Background: Obesity is associated with menstrual disorder. Especially, upper-body obesity affects on female reproductive function. Objectives: The goals were to investigate relation between fat distribution and menstrual disorder in obese pre-menopausal Korean females. The hypothesis were tested that there is a relation between upper body obesity and menstrual disorder. Design: A cross-sectional evaluation of 66 Females (baseline age $32.15{\pm}7,32)$ with body mass index $31.22{\pm}4.05\;kg/m^2$. Body composition was measured using bioimpedence analysis (BIA) and anthropometry was done by same observer. VAS and Multidimensional verval rating scale(MVRS) were checked for menstrual pain. Dual-Energy X-ray Absorptiometry (DXA) was measured for evaluating body fat distribution. Menstrual disorder and body fat distribution were compared using statistical methods. Results: TLFR and WH ratio was higher in menstrual cyclic disorder group than controls. There was negative relationship between VAS and TLFR. Conclusions: The data shows that disorder of menstrual cycle was associated with upper body obesity. WH ratio could be one of the factor of menstrual disorder. VAS was correlated with lower body obesity. Further studies for role of upper body fat distribution on female reproductive function and relationship between menstrual pain and fat distribution thought to be needed.

• 생명과학회지
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• 제20권7호
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• pp.1100-1106
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• 2010

본 연구는 체지방률이 35% 이상인 폐경기 비만중년여성 26명을 대상으로 하타요가 운동이 체조성과 렙틴 및 대사증후군관련인자에 미치는 영향과 렙틴에 영향을 미치는 대사증후군인자들을 규명하기 위하여 하타요가 운동을 16주간 실시한 후 운동전과 후의 체조성, 렙틴 및 대사증후군인자를 측정하여 비교분석하였다. 본 연구의 결과 운동 후에 하타요가집단에서 체중, 체지방률, 체질량지수, 허리둘레, 허리엉덩이둘레비 및 내장지방면적이 유의하게 감소하였고, 골격근량(SMM)은 증가하였다. 고밀도지단백 콜레스테롤(HDL-C)은 유의하게 증가하였고, 렙틴, 총콜레스테롤(TC), 중성지방(TG), 저밀도지단백 콜레스테롤(LDL-C), 인슐린, 글루코스 및 인슐린저항성지수(HOMA-IR)는 유의하게 감소하였으며, 하타요가집단의 렙틴에 영향을 미치는 대사증후군인자는 HDL-C로 나타났다. 이상과 같이 하타요가운동으로 체지방의 감량이 렙틴저항성을 개선하여 렙틴의 감소와 대사증후군인자의 개선으로 생활습관병을 예방하는 데 효과가 있을 것으로 사료된다.

• Journal of Preventive Medicine and Public Health
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• 제33권2호
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• pp.199-207
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• 2000

농촌지역 성인들에서 고혈압 발생과 관련이 있는 위험요인을 조사하기 위하여 1996년 경상북도 청송군의 20세이상 성인 3,573명을 대상으로 면담조사와 신체검사를 실시하였다. 연구대상 코호트는 고혈압이 없는 2,580명으로 하였는데, 1년 후 1,781명(69.0%)의 추적조사가 완료되었다. 조사한 독립변수들은 일반적 특성(연령, 성, 교육수준, 경제적상태, 결혼상태), 고혈압 가족력, 식이, 술, 담배, 커피, 스트레스, 그리고 여성에서 경구용 피임약, 폐경상태가 추가되었다. 그리고, 키, 몸무게, 허리둘레, 엉덩이둘레, 초기혈압, 혈청 총 콜레스테롤이었다. 다중 로지스틱 회귀분석 결과, 남자에서는 연령의 비교위험도가 1.50(95% 신뢰구간; 1.15-1.96), 고혈압 가족력이 2.11(95% 신뢰구간; 1.04-4.26), 허리-엉덩이 둘레비가 2.09(95% 신뢰구간; 1.15-3.79), 초기 수축기 혈압은 120mmHg 미만을 기준으로 하였을 때 130-139mmHg가 3.34(95% 신뢰구간; 1.47-7.60)로 경계형이상 고혈압의 발생과 유의한 관련이 있는 위험요인이었다. 여자에서는 연령의 비교 위험도가 1.06(95% 신뢰 구간; 1.03-1.09), 추적 기간동안 새로이 폐경을 경험한 경우는 3.32(95% 신뢰구간; 1.01-10.87), 초기 수축기 혈압은 120mmHg미만을 기준으로 하였을 때 120-129mmHg가 2.00(95% 신뢰구간; 1.02-3.90), 130-139mmHg가 2.64(95% 신뢰구간; 1.34-5.20), 그리고 초기 이완기 혈압은 80mmHg미만을 기준으로 하였을 때 85-89mmHg가 4.09(95% 신뢰구간; 1.86-8.96)로 유의한 관련이 있는 위험요인이었다. 결론적으로 경 계형 이상 고혈압 발생과 관련된 위험요인으로는 남자에서는 연령, 고혈압 가족력, 허리-엉덩이 둘레비 그리고 높은 정상 혈압이었다. 여자에서는 연령, 폐경이 새롭게 일어난 경우 그리고 높은 정상 혈압이었다.