• 대한임상독성학회지
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• 제11권1호
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• pp.28-30
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• 2013

A 66-year-old male with chronic alcoholism presented with tremor, gait disturbance, memory impairment, insomnia, decreased appetite, and confusion. The patient had been taking lithium daily for treatment of bipolar disorder. Brain CT showed no specific abnormality, and serum lithium and ammonia levels were 3.63 mEq/L (therapeutic range, 0.6~1.2 mEq/L) and $85{\mu}g/dL$ (reference range: $19{\sim}54{\mu}g/dL$), respectively. Therefore, the initial differential diagnosis included chronic lithium intoxication, hepatic encephalopathy, Wernicke encephalopathy, or alcohol withdrawal syndrome. Even with the provision of adequate hydration, the patient's neurologic status did not show improvement, so that lactulose enema, thiamine replacement, and continuous venovenous hemodiafiltration (CVVHDF) were started on the third admission day. By the fifth admission day he had made a rapid neurologic recovery, and was discharged on the 20th admission day. Therefore, CVVHDF might be a treatment for patients with chronic lithium intoxication, because, even if serum lithium concentration is normal, lithium concentration in the brain may be different from that of the serum.

• 융합신호처리학회논문지
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• 제10권3호
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• pp.170-175
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• 2009

본 논문은 PDA 디바이스에서 개인정보를 보호하기 위한 자동화자확인 시스템을 제안한다. 최근 M-커머스와 같은 모바일 환경을 위한 PDA의 용량이 확장되고 사용이 증가되고 있다. 그러나 너무 많은 계산량 때문에 PDA 디바이스에서 자동화자확인의 실질적인 응용은 여전히 많은 어려움이 존재한다. 본 논문에서는 이러한 문제점을 해결하기 위해서 음성발성 동안 스펙트럼 차감법과 음성 검출과 같은 전처리를 수행함으로써 계산량을 줄일 수 있는 방법을 적용하였다. 또한 빠른 처리 결과를 얻기 위한 은닉마코프모델의 최적 상태 정합과 시퀀스 확률비 테스트를 적용하였다. 전체적인 시스템은 PDA디바이스의 제한된 메모리와 낮은 CPU 속도에 적합하도록 간결하게 구현하였다.

• 전자공학회논문지CI
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• 제49권2호
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• pp.53-60
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• 2012

최근접 이웃 분류에서 입력 데이터의 클래스는 선택된 근접 학습 데이터들 중에서 가장 빈번한 클래스로 예측된다. 최근접분류 학습은 학습 단계가 없으나, 준비된 데이터가 모두 예측 분류에 참여하여 일반화 성능이 학습 데이터의 질에 의존된다. 그러므로 학습 데이터가 많아지면 높은 기억 장치 용량과 예측 분류 시 높은 계산 시간이 요구된다. 본 논문에서는 분리 경계면에 위치한 학습 데이터들로 구성된 새로운 학습 데이터를 생성시켜 분류 예측을 수행하는 프로토타입 선택 알고리즘을 제안한다. 제안하는 알고리즘에서는 분리 경계 영역에 위치한 데이터를 Tomek links와 거리를 이용하여 선별하며, 이미 선택된 데이터와 클래스와 거리 관계 분석을 이용하여 프로토타입 집합에 추가 여부를 결정한다. 실험에서 선택된 프로토타입의 수는 원래 학습 데이터에 비해 적은 수의 데이터 집합이 되어 최근접 분류의 적용 시 기억장소의 축소와 빠른 예측 시간을 제공할수 있다.

• 수면정신생리
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• 제8권2호
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• pp.138-143
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• 2001

Sleepiness is associated with many different conditions and, as a neglected topic, it can be the cause of serious psychological and social disadvantages. In the aspect of learning, additional problems may arise from poor progress in school caused by the effect of sleepiness on concentration, memory, and other cognitive functions. Narcolepsy is by no means the most common cause of excessive sleepiness. Nonetheless, it is not a rarity, especially in young people. The non-specific nature of early features of narcolepsy, combined with very limited awareness that the condition can start in various ways, leads to many misinterpretations. Misinterpretation of narcolepsy symptoms is not confined to the medical profession. Teachers may well be critical of a student with narcolepsy because of their perception of narcolepsy symptoms as laziness, poor motivation, or difficult behavior and dull learning ability. Inappropriate reactions by parents, teachers, and peers, based on misinterpretation of narcolepsy symptoms or the patient's reactions to them, make a difficult situation worse. Especially in Korea, where schooling is focused on college entrance examinations, the problem is very serious and intensified by inappropriate or delayed diagnosis and treatment. Therefore, psychiatrists should be aware that narcolepsy in young adolescents is not rare and that they need to be familiar with its clinical features in both its classic and less obvious forms. Narcolepsy should be suspected if a adolescent's excessive sleepiness can not be explained in other ways. Therefore, we report on two patients who portray the tendency of dull learning ability and are mistaken as idle students. We diagnosed narcolepsy through polysomnography and multiple sleep latency testing. We treated the students with methylphenidate and pemolin. The students showed improvement in learning ability and were able to adapt better to school.

• 정보처리학회논문지C
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• 제10C권7호
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• pp.879-884
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• 2003

일반적으로 웹 기반 시스템의 성능을 높이기 위하여 웹 캐시를 사용하며, 대체 기법은 웹 캐시의 성능에 큰 영향을 미친다. 웹 캐시를 위한 대체 기법은 메모리 영역의 대체 기법과는 다르게, 대체되는 단위가 웹 객체이다. 또한 웹 객체는 사용자 참조 특성의 편차가 매우 크다. 따라서 웹 캐시론 위한 대체 기법은 이러한 웹 객체의 특성을 충분히 반영할 수 있어야한다. 하지만 기존의 기법에서는 이러한 특성을 충분히 반영하고 있지 못하다. 본 연구의 주된 관점은 참조특성 분석, 객체적중률의 향상, 응답시간의 개선이다. 이를 위해 로그분석을 이용하여 웹 객체의 참조특성을 분석하고, 이 참조특성의 분석 결과를 기반으로 분할된 웹 캐시 대체 기법을 제안하고 실험하였다. 실험 결과에서는, 제안 기법이 기존의 기법에 대해 객체 적중률과 응답속도의 성능이 개선되었음을 확인할 수 있다.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제51권5호
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• pp.185-190
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• 2002

Capacitor material utilized in the downsizing passive devices and dynamic random access memory(DRAM) requires the physical and electrical properties at given area such as capacitor thickness reduction, relative dielectric constant increase, low leakage current and thermal stability. Common capacitor materials, $SiO_2$, $Si_3N_4$, $SiO_2$/$Si_3N_4$,TaN and et al., used until recently have reached their physical limits in their application to several hundred angstrom scale capacitor. $Ta_2O_{5}$ is known to be a good alternative to the existing materials for the capacitor application because of its high dielectric constant (25 ~35), low leakage current and high breakdown strength. Despite the numerous investigations of $Ta_2O_{5}$ material, there have little been established the clear understanding of the annealing effect on capacitance characteristic and conduction mechanism, design and fabrication for $Ta_2O_{5}$ film capacitor. This study presents the structure-property relationship of reactive-sputtered $Ta_2O_{5}$ MIM capacitor structure processed by annealing in a vacuum. X-ray diffraction patterns skewed the existence of amorphous phase in as-deposited condition and the formation of preferentially oriented-$Ta_2O_{5}$ in 670, $700^{\circ}C$ annealing. On 670, $700^{\circ}C$ annealing under the vacuum, the leakage current decrease and the enhanced temperature-capacitance characteristic stability. and the leakage current behavior is stable irrespective of applied electric field. The results states that keeping $Ta_2O_{5}$ annealed at vacuum gives rise to improvement of electrical characteristics in the capacitor by reducing oxygen-vacancy and the broken bond between Ta and O.

• 약학회지
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• 제51권6호
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• pp.463-468
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• 2007

Chong Myung Tang is consisted of three medicinal herbs (Acori Graminei Rhizoma, Polygalae Radix and Hoelen cum Radix). It has been used as a medicine for the purpose of learning and memory improvement. In this paper, Chong Myung Tang was screened the biological activities for Alzheimer's disease. The extract (70% ethanol) of Acari Graminei Rhizoma (1 mg/ml) showed that acetylcholinesterase (AChE) and amyloid beta ($A{\beta}$) peptide aggregation inhibitory potency are 43.1% and 76.5%, respectively. The extract of Polygalae Radix showed inhibitory activity against $A{\beta}_{1-42}$ peptide aggregation (51.5%). To predict the drug-likeness, oral absorption ability; blood-brain barrier (BBB) penetraion rate, mutagenecity and carcinogenicity; in silico screening was performed against 16 compounds in the three medicinal herbs. According to the results, all compounds have appropriate chemical structures as medicines. The six compounds in Acori Graminei Rhizoma and the five compounds in Hoelen cum Radix showed excellent oral absorption rate and BBB penetration rate. The four compounds in Polygalae Radix showed excellent oral absorption rate, but their BBB penetration was presented low rate. And, the extract of Hoelen cum Radix didn't show AChE and $A{\beta}_{1-42}$ peptide aggregation inhibitory activities in vitro. Therefore, their activity in brain may be other mechanism. According to all of the results, in silico prediction technology is convenient and effective to determine biological active compounds in medicinal herbs.

• Nuclear Engineering and Technology
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• 제52권10호
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• pp.2162-2172
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• 2020

Due to its computational efficiency and geometrical flexibility, the Method of Characteristics (MOC) has been widely used for light water reactor lattice physics analysis. Usually acceleration methods are necessary for MOC to achieve acceptable convergence on practical reactor physics problems. Among them, Coarse Mesh Finite Difference (CMFD) is very popular and can drastically reduce the number of transport iterations. In OpenMOC, CMFD acceleration was implemented but had the limitation of supporting only a uniform CMFD mesh, which would often lead to splitting MOC source regions, thus creating an unnecessary increase in computation and memory use. In this study, CMFD acceleration with a non-uniform Cartesian mesh is implemented into OpenMOC. We also propose a quadratic fit based CMFD prolongation method in the axial direction to further improve the acceleration when multiple MOC source regions are contained in one CMFD coarse mesh. Numerical results are presented to demonstrate the improvement of the CMFD acceleration capability in OpenMOC in terms of both efficiency and stability.

• 대한예방한의학회지
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• 제14권3호
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• pp.63-75
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• 2010

Vascular dementia(VaD) is currently considered to be the second most common type of dementia. VaD is not a single diagnostic entity, but a heterogeneous syndrome which encompasses several clinicopathological forms of dementia resulting from cerebrovascular diseases. A common form of VaD is subcortical VaD which is characterized by lacunar infarcts and deep white matter changes, leading to a progressive decline in memory and cognitive function. The neuropsychological and cognitive profiles of subcortical VaD have been reported relatively homogeneous. At present, subcortical vascular dementia is regarded as the most important subtype of VaD with getting the attention of vascular dementia. The aims of this study are to discuss the concept of subcortical VaD and its importance focusing on diagnosis, prevention and treatment with a case report.

• 한국정보통신학회논문지
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• 제17권8호
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• pp.1851-1856
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• 2013

XML은 SOAP(Simple Object Access Protocol)와 REST(Representational State Transfer) 같은 웹서비스들을 위해 널리 사용되며 데이터를 표현하기 위한 사실상의 표준이다. DOM(Document Object Model)을 사용하는 XML 파서는 DOM 트리로 생성하여 메모리에 저장하는 전처리가 요구되기 때문에, 제한적 자원을 갖는 임베디드 시스템들은 일반적으로 전처리를 요구하지 않는 스트리밍 XML 파서를 채택하여 사용하고 있다. 본 논문에서는 FPGA(Field Programmable Gate Array)에서 적응적 병렬 검색을 사용하는 스트리밍 XML 파서를 위한 새로운 구조를 제안한다. 제안된 APSearch(Adaptive Parallel Search) 파서는 이전 연구들과 비교하여 소프트웨어의 오버헤드를 상당 수 감소시켰으며 XML 파싱을 위한 처리 시간이 약 2.55배와 2.96배 향상되었다. 따라서, 제안된 APSearch 파서는 XML 파싱을 가속화하기 위한 시스템들에 적합한 구조이다.