• 대한한방소아과학회지
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• 제31권4호
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• pp.49-60
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• 2017

Objectives The purpose of this study is to report the effectiveness of Korean medicine on treating autism spectrum disorder (ASD) in childhood. Methods We treated an 8-years-old patient who was diagnosed with autism (grade II) with herbal medicine, acupuncture and electric moxibustion. Every 11 months, Korean-Childhood Autism Rating Scale (K-CARS) was used to assess the patient's symptom progression. Results After 21 months of Korean medicine treatment, the child's overall health was improved. Moreover, language ability, emotional control, memory and cognitive abilities got better, as well as anxiety, agitation, and aggressive behavior related to ASD were also decreased. K-CARS score at the initial stage of the treatment was 39.5 points, which can be considered as severe autism. After 11 months of the treatment, the K-CARS score was 34.5 points which is mild-moderate autism. Conclusions Korean medicine treatment can be effective in improving symptoms of ASD. However, further studies are needed to demonstrate the treatment benefits to ASD.

• 노인정신의학
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• 제18권2호
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• pp.86-91
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• 2014

Objective : The aims of this study were to investigate the prevalence of co-morbid depression and related factors of depression in mild cognitive impairment (MCI) patients. Methods : Nine hundred and six MCI individuals were included in this study. Depression was defined as major and minor depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Depression-related demographic and clinical factors were also explored through multivariate logistic regression analysis. Results : In MCI patients, the prevalence of depression as defined according to the DSM-IV diagnostic criteria was 1.8% for major depressive disorder, 11.4% for minor depressive disorder, and overall 13.2% for both. Multivariate logistic regression showed that increased prevalence of overall depression was associated with female gender and non-amnestic subtype of MCI. Conclusion : Our findings based on a large number of MCI subjects who visited memory clinic indicated that more than ten percent of MCI patients have comorbid depression. In addition, female and non-amnestic subtype of MCI patients seems to be more vulnerable to depression.

• 수면정신생리
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• 제5권2호
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• pp.194-201
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• 1998

목적 : 저자들은 강박장애 환자의 대뇌기능을 알아보기 위해 신경심리검사 바테리를 이용하여 정상대조군과 비교하였다. 방법 : 강박장애군(12명)과 연령 및 교육을 짝짓기한 정상대조군(17명)에게 신경심리검사 바테리를 시행하였다. 결과 : K-WAIS 검사상 전체지능은 강박장애군 115.2(${\pm}9.9$), 정상대조군 111.8(${\pm}8.4$)로 양군간에 유의한 차이가 없었다. 그러나 언어성 지능의 경우 강박장애 환자군($118.0{\pm}10.6$)이 정상대조군($110.3{\pm}9.4$)보다 유의하게 높았으나(P=0.049), 동작성 지능은 강박장애군($108.4{\pm}11.7$)이 정상대조군($114.4{\pm}11.2$)보다 낮은 경향을 보였다. 양군간의 소검사 항목점수를 비교하면 tactual performance test의 전체시간에서 강박장애군(15.26분)이 정상대조군(9.56분) 보다 유의하게 길었으며(P=0.028), 양손 수행에서도 강박장애군(0.16)의 수행이 정상대조군(0.38) 보다 유의하게 떨어졌다(P=0.047). 전체적인 Halsted Reitan 손상지수도 강박장애군($3.17{\pm}2.1$)이 정상대조군($1.31{\pm}1.8$) 보다 유의하게 높았다(P=0.019). 웨슬러 기억검사의 시각회상에서도 강박장애군($12.3{\pm}1.6$)이 정상대조군($13.4{\pm}0.9$)에 비해 기능이 유의하게 떨어졌다. 결론 : 강박장애 환자는 정상대조군에 비해 공간구조 인지기능의 장애, 과잉된 언어 및 집중력을 보이고 있고, 이는 강박장애 환자의 언어기능과 공간구조 인식기능의 불균형이 강박장애 환자의 정신병리와연관 될 수 있음을 시사한다. 향후 강박장애 환자에서 신경 심리 검사상 보이는 이상소견이 강박장애의 특정적인 소견인가, 치료경과에 따라 선경 심리검사상의 이상소견이 영향을 받는가에 대한 연구가 이어져야할 것으로 생각된다.

• 생물정신의학
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• 제13권2호
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• pp.117-120
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• 2006

Localized amnesia is characterized by a failure to recall events that occurred during a circumscribed period of time. Localized amnesia is the most common type of dissociative amnesia. It is assumed that this is a disorder of memory retrieval. Recent neuroimaing studies reported that posterior cingulate cortex may play a important role in memory(autobiographical) retrieval. The authors reported a case of localized amnesia with mass on left posterior cingulate cortex.

• 약학회지
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• 제55권6호
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• pp.473-477
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• 2011

Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.

• 생물정신의학
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• 제17권4호
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• pp.194-202
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• 2010

Alzheimer's disease(AD) is the most common neurodegenerative disorder and constitutes about two thirds of dementia. Despite a lot of effort to find drugs for AD worldwide, an efficient medicine that can cure AD has not come yet, which is due to the complicated pathogenic pathways and progressively degenerative properties of AD. In its early clinical phase, it is important to find the subtle alterations in synapses responsible for memory because symptoms of AD patients characteristically start with pure impairment of memory. Attempts to find the target synaptic proteins and their pathogenic pathways will be the most powerful alternative strategy for developing AD medicine. Here we review recent progress in deciphering the role of target synaptic proteins related to AD in hippocampal glutamatergic synapses.

• 구강회복응용과학지
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• 제23권2호
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• pp.179-186
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• 2007

The decrease of masticatory function caused by tooth loss leads to a decrease of cerebral blood flow volume resulting in impairment of cognitive function and learning memory disorder. However, the reduced mastication-mediated morphological alteration in the central nervous system (CNS) responsible for senile deficit of cognition, learning and memory has not been well documented. In this study, the effect of the loss of the molar teeth (molarless condition) on the hippocampal expression of glial fibrillary acidic protein (GFAP) protein was studied by immunohistochemical techniques. The results were as follows : 1. The molarless mice showed a lower density of pyramidal cells in the cornu ammonis 1 (CA1) and dentate gyrus (DG) region of the hippocampus than control mice. 2. Immunohistochemical analysis showed that the molarless condition enhanced the time-dependent increase in the cell density and hypertrophy of GFAP immunoreactivity in the CA1 region of the hippocampus. The molarless condition enhanced an time-dependent decrease in the number of neurons in the hippocampal formation and the time-dependent increase in the number and hypertrophy of GFAP-labeled cells in the same region. The data suggest a possible link between reduced mastication and histological changes in hippocampal formation that may be one risk factor for senile impairment of cognitive function and spatial learning memory.

• 대한불안의학회지
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• 제6권2호
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• pp.102-108
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• 2010

Objective : Although studies have explored responses to fear had been assessed using various psychophysiological methods, results have been inconsistent. The present study examined psychophysiological responses in healthy subjects after viewing fear stimuli in a video clip for set up future fear related psychophysiological studies. Methods : We monitored three psychophysiological variables (electroencephalography, skin temperature, and heart rate variability) in adults who watched either a control stimulus movie clip or a fear-inducing movie clip. Results : In 16 healthy adults, theta activity decreased significantly after the fear stimulus as compared to the normal stimulus. However the participants showed no differences in heart rate variability or skin temperature between the fear and normal control stimulus situations. Conclusion : In the limbic area, theta activity corresponds with information processing, integration into previous memories and long-term potentiation. In this study, we suggest decreased theta activity represents amygdalo-hippocampal activity, associated with fear, short-term memory, and memory extinction in the healthy adults. Further studies are needed to evaluate the interaction of fear, memory, and the pathophysiology of anxiety disorder in patient with anxiety disorders.

• 수면정신생리
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• 제10권2호
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• pp.88-92
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• 2003

Sleep-disordered breathing (SDB), including snoring, sleep apnea and upper airway resistance syndrome are common problems in children. The pathophysiological mechanism of SDB in children is unclear but may include hypoxemia and changes in sleep architecture. Children with SDB show reduced neurocognitive function, and memory and attentional capacity. Furthermore, these children show increased problematic behaviour and reduced school performance. Whether early recognition and treatment of SDB in children may improve neurocognitive function and school performance remains to be fully evaluated in the future.

• 생약학회지
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• 제45권1호
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• pp.48-54
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• 2014

Alzheimer's disease is progressive neurodegenerative disorder by the loss of memory and learning abilities. Codonopsis lanceolata (C. lanceolata) is traditional medicinal plant used for the treatment of inflammatory diseases. The aim of study was to evaluate the effect of steamed C. lanceolata on scopolamine-induced memory impairment in the Morris water maze test and passive avoidance test. In addition, this study investigated the neuroprotective effects of steamed C. lanceolata on glutamate-induced cell death in HT22 cells using MTT assay. The results showed that steamed C. lanceolata (500 mg/kg body weight, p.o.) reversed spatial memory impairment by scopolamine in Morris water maze test and passive avoidance test. Steamed C. lanceolata attenuated memory impairment by scopolamine compared with common C. lanceolata. In addition, administration of steamed C. lanceolata significantly also reduced cell death. We suggest that steaming process more improve cognitive enhancing and neuroprotective effect of C. lanceolata than common C. lanceolata.