• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.697-702
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• 2016

Background: The Asia-Pacific Breast Initiatives (APBI) I and II registries were established to collect safety data for patients with early stage breast cancer receiving adjuvant docetaxel-based regimens in the Asia-Pacific region. Materials and Methods: Data from the two registries were combined to perform a safety analysis. Participants in the registry were women with early stage operable breast cancer with an intermediate or high risk of recurrence. These women received adjuvant chemotherapy that included docetaxel between 2006 and 2011. Adverse events (AEs) were recorded and analyzed. Results: Data were collected from 3,224 patients from 13 countries. The mean dose intensity of docetaxel was 24.1, 22.7, $25.1mg/m^2/week$ among patients receiving docetaxel-based monotherapy, combination therapy and sequential therapy, respectively. Granulocyte colony-stimulating factor (G-CSF) was given with docetaxel to 41.8% of women and 20.6% of women receiving prophylactic antibiotics. Adverse events were reported in 86% of patients (anthracycline-containing regimens vs. non-anthracycline regimens; 87% vs. 80%). The most common adverse events were alopecia, nausea, neutropenia, vomiting, and myalgia. Adverse events NCI CTCAE ${\geq}$Grade 3 were reported in 45.4% of patients. Serious adverse events were reported in 13% of patients, of which 2.5% led to study discontinuation. Forty-six deaths (1.4%) were reported, with no significant difference between regimens. Conclusions: The safety parameters of adjuvant docetaxel therapy used to treat sequential Asian women were comparable to those reported in clinical trials evaluating the role of adjuvant docetaxel. No unusual adverse events linked to Asia-Pacific region patients were observed.

• Journal of the East Asian Society of Dietary Life
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• v.12 no.4
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• pp.280-288
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• 2002

The purpose of this study is finding a solution to increase the consumption of Korean cookies by investigating and analyzing the actual consumption patterns, suggestions fur improvement and preferences for Korean cookies. The data fer this study was collected from 358 housewives living in Daegu province. Results show that 77.4% of housewives in this locale eat Korean cookies on a special day such as memorial service day of ancestors, festive day or party. The frequency of having Korean cookies were significantly different due to the income (p<.05): the higher the income, the more often people had Korean cookies. They usually purchase Korean cookies on the market rather than making them by themselves. The percentile of housewives who have never made Korean cookies before was up to 51.7% Only the housewives over fifty had some experience making the Korean cookies. The number of people who teamed the method fur making Korean cookies from their family elders increased according to their age. The reasons why they buy Korean cookies on the market are as follows: the most frequent answer (45.5%) was the price. 34.5% of the responder리s did not know how to make them. 32.1% replied that the process is too complex and troublesome. The most frequent requests for the market was expanding the diversity and improving the quality. In response to why they want the Korean cookies to be inherited. 68.8% of respondents answered that it is traditional culture. 4.01% of respondents replied that `ssalyeatgangung' is their favorite Korean cookie. 3.90% of them like 'sanja' the best and 3.91% of the housewives preferred yakwa to other Korean cookies. This study shows that the most preferred Korean cookies are yeatganjung, yakwa and sanja

• Journal of architectural history
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• v.21 no.6
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• pp.7-18
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• 2012

This study was aimed at analyzing the location and topology of the 'Gungmyo(宮廟)' and in Hanyang Doseong(漢陽都城) during 18th and 19th century. Based on the changes of royal processions(行幸) which had been done between the Gungmyo and the Palace, the Gungmyo can be a barometer of cognition where the city center was. Hanyang Doseong was the the capital of Joseon(朝鮮) which had established by king Taejo(太祖). The city had been organized with Gyeongbok-gung(景福宮) as the center. However, after the Imjin War(1592), Gyeongbok-gung was destroyed and urban space was reorganized with Changduk-gung(昌德宮) which reconstructed first. As most kings in late Joseon dynasty had mainly stayed in Changduk-gung, lots of Gungmyos where a memorial service for king's relatives had been held were established in and around the palace and the frequency of visiting the Gungmyo varied by political purpose. Therefore, the location of the Gungmyo and the rounte of parade were important to impress on the center of urban space. In 18th century, lots of King's procession had been done with Changduk-gung as departure point. The king used to start from Donwha-mun(敦化門), and the routes included main street around Changduk-gung. It shows that the urban center focused on the east of the city. On the other hand, when the king lived in Kyeonghee-gung(慶熙宮), a secondary palace in late Joseon dynasty, the parade started from Hungwha-mun(興化門) and the urban center was expended to the west. Since Gyeongbok-gung had reconstructed in 1865, recognition scheme of urban space had changed from Changduk-gung to Gyeongbok-gung as the center. When the Gungmyo relocated western side of Gyeongbok-gung, spatial proximity of the palace and relation with facilities around downtown fed into changing the route of king's parade.

• Journal of Hospice and Palliative Care
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• v.20 no.4
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• pp.242-252
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• 2017

Purpose: Given the emergence of a new profession called a palliative care aide, this study aims to develop the scope of its practice using the Delphi consensus method. Methods: This study was participated by a panel of experts comprising 36 members who were involved in either hospice palliative care practice or making relevant policies. Through a four-step Delphi study, the feasibility of the duty, task and task element was examined. Among the results, items that scored over 4.0 out of 5.0 were selected. Results: The analysis of the Delphi study suggested four job duties, 15 tasks and 46 task elements to be included in the practice scope for palliative care aides. Conclusion: This study defined the scope of practice for palliative care aides, which is expected to prevent any conflict or confusion regarding their job and to promote the quality of their service.

• Molecules and Cells
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• v.39 no.12
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• pp.877-887
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• 2016

Tazarotene-induced gene 1 (TIG1) is a retinoic acid-inducible protein that is considered a putative tumor suppressor. The expression of TIG1 is decreased in malignant prostate carcinoma or poorly differentiated colorectal adenocarcinoma, but TIG1 is present in benign or well-differentiated tumors. Ectopic TIG1 expression led to suppression of growth in cancer cells. However, the function of TIG1 in cell differentiation is still unknown. Using a yeast two-hybrid system, we found that transmembrane protein 192 (TMEM192) interacted with TIG1. We also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins, including Beclin-1 and LC-3B. The silencing of TMEM192 reduced the TIG1-mediated upregulation of autophagic activity. Furthermore, silencing of either TIG1 or TMEM192 led to alleviation of the upregulation of autophagy induced by all-trans retinoic acid. Our results demonstrate that the expression of TIG1 leads to cell autophagy through TMEM192. Our study also suggests that TIG1 and TMEM192 play an important role in the all-trans retinoic acid-mediated upregulation of autophagic activity.

• Molecules and Cells
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• v.41 no.6
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• pp.562-574
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• 2018

The tazarotene-induced gene 1 (TIG1) protein is a retinoidinducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression. TIG1 interacted with DNAJC8 in the cytosol, and this interaction completely blocked DNAJC8-mediated PKM2 translocation and inhibited glucose uptake. Furthermore, increased glycose uptake was observed in cells in which TIG1 was silenced. In conclusion, TIG1 acts as a pivotal repressor of DNAJC8 to enhance glucose uptake by partially regulating PKM2 translocation.

• Journal of the Korean Society of Physical Medicine
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• v.5 no.2
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• pp.151-164
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• 2010

Purpose : The purpose of this study was to investigate curriculums of physical therapy department in order to provide the basic data for developing educational standard. Methods : We identified the curriculums of physical therapy department in the world from January to may 2010 by internet, e-mail, fax and telephone. We compared the credits, education semesters, the names of departments, the numbers of departments for physical therapy education in all countries of the world and suggested some alternative for improvement. Results : The mean credits of 25 senior colleges were 140 and the mean credits of 22 Junior colleges were 136.6 in south Korea. The mean educational semesters and the mean credits were 9 semesters, 175.8credits of 1,363 universities in 73countries in the world. Of the 1,289 universities in the world, South Korea was ranked the fifth in the number of existing physical therapy education institutions with the number of 72. The name of department were comprised of physical therapy(1,289, 94.6%) and compound name(75, 5.4%) Conclusion : We suggest that the KAPT gradually rearranges senior college(4years), 170 creditS and consider time of community services and forms commission on accreditation in physical therapy education for developing educational standard. Also, we suggest to change the name of department into compound name because the student can have a chance to studies various subjects and get a chance to more occupations. We hope that the results of study can be helpful in order to rearrange the curriculum and the KAPT encourages the universities about following the educational standard.

• Korean Journal of Heritage: History & Science
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• v.37
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• pp.213-242
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• 2004

"China", "Guang-Xi(廣西)", "Dong-Shan(東山)", a marriage of "Yao-zu(瑤族)" divide mainly into a distinguished family form, but are by a marriage of a traditional general form (a woman getting married) and "Zhaoxu-Hun(招婿婚)", a marriage of "Liangtou-che(兩頭扯)". These two marriage format that mentioned the back is a marriage format to often appear in other Chinese minority race region while being a custom peculiar to "Yao-zu(瑤族)" marriage method. "Zhaoxu-Hun(招婿婚)" provides labor force as a workman while living with a man sinks with "son-in-law" to a woman house, and doing, and it is to carry out a lot of duty as a husband too. "A Liangtou-che(兩頭扯)" marriage is more characteristic, but lives while going around a bilateral family while man and woman each stay in an own house. There are inheritance of property rights to own family, too and obeys anger of he direction family bilateral where if lays a child even if stands up and holds a memorial service. At the same time that these marriages are performed between the same "Yao-zu(瑤族)" near a track, and solution does a distribution problem between a labor problem and the families which were unstable through a mutual marriage for the purpose a compunction "Yao-zu(瑤族)" social network construction into intimacy anger. A general idea is covered he base with in order the porcelain which is a weak race prevent that it is assimilated by external aggression because "Yo-zu(瑤族)" has always received aggression of "a Han-zu(漢族)" too historically, and to keep an ethnic pure blood.

• Journal of Korean Society of Archives and Records Management
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• v.22 no.3
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• pp.151-156
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• 2022

The Kim Dae-jung Library is Asia's first presidential library and is a private presidential archive with over 250,000 historical materials. It mainly collects records related to the life of former President Kim Dae-jung, modern and contemporary history, and democratization, While most of the private presidential archives in Korea are operated by memorial foundations, the Kim Dae-jung Library is unique in that a higher education institution operates it. Accordingly, it aims to take an educational role in history and democracy based on records, providing free research space for researchers, and supporting research through records. This report introduces examples of the Kim Dae-jung Library's representative archival information service, an affiliated institution of educational institutions and private presidential archives, and presents the future tasks of the presidential archives.

• Journal of Korean Society of Archives and Records Management
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• v.23 no.3
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• pp.137-163
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• 2023

In 2020, the digitization of the previously partially researched "6.25 War military records" was completed and transitioned to public access, allowing anyone to utilize the digitized materials. Following concerns regarding the effective utilization of these records and the creation of historical value, this study analyzed issues found in the specific region of Hamyang in Gyeongsangnam-do based on the management status and utilization information of the National Archives of Korea, War Memorial of Korea, and Army Records and Information Management System that primarily managed the records. Furthermore, it proposes developing the metadata elements to address the issues, constructing a digital archive, enhancing the interconnectedness of war records, providing educational and exhibition services, and offering various forms of research materials.