• Journal of Ginseng Research
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• 제37권4호
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• pp.425-434
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• 2013

UV irradiation is the main factor contributing to skin damages that are associated with an excessive production of matrix-degrading metalloproteinase (MMP)-1 and a deficient expression of collagens. To date, red ginseng has been revealed to possess many biomedical effects, such as anti-aging, anti-oxidation, and anti-inflammatory. In this study, we prepared the Korean Red Ginseng extracts treated with enzyme (KRGE) and investigated the effects of dietary KRGE on the formation of wrinkles generated by UVB irradiation in hairless mice. It was found that KRGE inhibited the UVB-induced formation of wrinkles, epidermal thickness, and skin dryness in hairless mice. Further results also showed that KRGE attenuated UVB-induced MMP-${\beta}$1 level, while accelerated procollagen type I, transforming growth factor-${\beta}$1 secretion. Interestingly, the expression of profilaggrin and filaggrin in both the epidermis and dermis were decreased due to UVB exposure and reversed by KRGE. The KRGE 0.06% was prior to KRGE 0.24%. In view of these results, which indicated that KRGE protected skin from UVB-induced photodamages, which may not only mediated by regulating of MMP-1 and procollagen type I, but also by increasing the production of profilaggrin and filaggrin. In conclusion, our results suggest that KRGE may be a promising agent for the treatment of skin photodamages. The challenge of KRGE will be expected as cosmeceuticals and nutraceuticals in order to intervene in aging-related degenerative skin changes.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2012년도 심포지엄 및 춘계학술발표회
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• pp.223-224
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• 2012

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2012년도 심포지엄 및 춘계학술발표회
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• pp.137-138
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• 2012

• 대한한약학회:학술대회논문집
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• 대한한약학회 2007년도 Autumn Conference
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• pp.129-144
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• 2007

In order for stable demand-supply and regularity of distribution, "The regulations for management of demand-supply and distribution of medicinal herbs" were established on 1995. Therefore, the medicinal herbs of good quality have been controled to be distributed in the market. However, to be wide of the purpose, the standardized sound distribution system was caused due to the governmental control on demand-supply to protect domestic farmers who produce the material for medicinal herbs, which results in the over distribution of non-standardized or illegally imported medicinal herbs. In addition, because of the distribution of faulty or poor medicinal herbs, there are chances of affecting bad effects on public health. The standardized medicinal herbs cover 514 different kinds in total, of which 69 products are specified to be standardized in the oriental medicine product companies. Also, in order to protect farmers who produce the materials for medicinal herbs, the amount of imported materials are regulated in normal times. The 14 different materials for medicinal herbs, which are allowed to be imported to a certain amount only when the shortage of goods or sudden rise of prices is to happen, are frequently introduced into domestic market as food not as medical usage, and the origin of those illegally changes to home cropped one for the distribution in the market. In addition, the system of distribution are to be disordered and the condition for the distribution of medicinal herbs of good quality can not be made since they illegally changes the usage of the materials for medicinal herbs from their original one and can not be regulated by the domestic laws.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2005년도 춘계 학술발표대회
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• pp.159-159
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• 2005

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2005년도 춘계 학술발표대회
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• pp.17-25
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• 2005

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2005년도 춘계 학술발표대회
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• pp.105-105
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• 2005

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2005년도 International Symposium & conference of the Plant Resources Society of Korea
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• pp.183-183
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• 2005

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.467-469
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• 2021

The dendritic molecule has focused on the target material for photodynamic therapy, and used as the energy harvesting molecule for the application of medicinal field. Those molecules have also researched on the molecule design for the preparation of new dendritic material on PDD and PDT. In this presentation, new dendritic molecules are introduced on the development of DPPZ dendritic molecule for PDT and the efficient synthetic process.

• 대한한의학방제학회지
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• 제21권2호
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• pp.72-80
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• 2013

Objectives : Ontology is a good tool to represent the knowledge and has developed for Traditional Korean Medicine(TKM) in Korea Institute of Oriental Medicine. There are a lot of TKM terms, which have a complex meaning, especially major indication terms of medicinal treatment and terms of symptom and disease. These complex meaning terms result in the low linkage between major indication terms of medicinal treatment and terms of symptom and disease in TKM ontology. We studied to enhance the percentage of the linkage among those data in TKM ontology. Methods : We disassembled major indication terms of medicinal treatment into minimum meaning units and then linked them to enhance the percentage of the linkage among medicinal material, formula and disease ontology based on Traditional Korean Medicine. To retain objectivity, several experts of Korean Medicine used a web-based tool that supports users in refining terms and disassembling them into the minimum meaning efficiently. Results : The outcome shows that the percentage of the linkage among medicinal material, formula and disease ontology increased. By linking disassembled major indication terms to symptoms and diseases, the amount of information for medicinal materials and formulas also increased quantitatively in comparison with given formula for diseases in disease ontology. Conclusions : By this study, disassembled data increases the percentage of linkage between diseases and medicinal treatments. And the applicability of TKM ontology is also increased.