• Biomedical Science Letters
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• v.17 no.3
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• pp.197-202
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• 2011

Mitosis count is one of the most helpful morphologic features for distinguishing pulmonary typical carcinoid (TC) from atypical carcinoid (AC). However, identifying areas of highest mitotic activity is tedious and time-consuming, and mitosis count may vary substantially among pathologists. Anti-phosphohistone H3 (PHH3) is an antibody that specifically detects histone H3 only when phosphorylated at serine 10 or serine 28, an event that is concurrent with mitotic chromatin condensation and not observed during apoptosis. In this study, immunohistochemical staining for PHH3 was performed to determine whether PHH3 was a reliable and objective mitosis-specific marker for pulmonary carcinoid tumors. Seventeen cases of surgically resected pulmonary carcinoid tumors (12 TCs and 5 ACs) were obtained and classified according to the 2004 World Health Organization classification. Mitotic counts determined by PHH3 correlated to ones determined by hematoxylin and eosin (H&E) staining; however, PHH3 mitotic counts (mean mitotic counts: 1 in TCs and 3.2 in ACs) were slightly higher than H&E mitotic counts (mean mitotic counts: 0.25 in TCs and 1.8 in ACs). The mitotic counts determined by experienced observer were more correlated to those determined by inexperienced observer with the PHH3-based method (R=0.968, P<0.001) rather than H&E staining (R=0.658, P<0.001). These results suggest that the PHH3 mitotic counting method was more sensitive and simple for detecting mitoses compared to traditional H&E staining. Therefore, PHH3 immunohistochemistry may contribute to more accurate and reproducible diagnosis of pulmonary carcinoid tumors and may be a valuable aid for administrating appropriate clinical treatment.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.643-646
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• 2016

Background: Depression is the most common psychological reactions in women with breast cancer. This study aimed at investigating the amount of depression and its role in predicting the quality of life of women suffering from breast cancer. Materials and Methods: The present descriptive study in volved a correlation method with 98 women living in Kermanshah-Iran with breast cancer. According to the access to the patients and the condition of conducting the research, they were chosen by available sampling. Life quality inventory (World Health Organization, 1989) and depression inventory (Beck et al., 2000) were used to gather the data. Moreover, to analyze the relationships among the variables correlation analysis with Pearson method, as well as multiple regression with the enter method and frequency analysis were applied. Results: The findings revealed that not only is depression high, but also there is a negative significant relationship between depression and the quality of life, with predictive potential. Conclusions: The finding of a relationship between depression and the quality of life points to the need for addressing psychological problems of the affected individuals more appropriately. It is suggested that we consider psychological and educational services for patients in treatment planning to make people aware of different psychological aspects of their disease and ways of struggling and overcoming the problems.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.557-562
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• 2016

Background: Lung cancer is one of the most common cancers in the world and a major cause of death from cancer. One of the important indicators to compare the prevalence and incidence of the disease is a change in the trend. The aim of this study was to investigate the changes in the incidence of lung cancer in Iran. Materials and Methods: This study was conducted based on existing data obtained from a national registry of cancer cases and the Disease Management Center of Ministry of Health in Iran. All cases registered in the country were included during 2003-2008. Incidence rates were reported based on the direct method and standard population of World Health Organization. The study also examined the morphology of common lung cancers. Trends in incidence underwent joinpoint regression analysis. Results: Based on the results of this study, 14,403 cases of lung cancer have been recorded of which 10,582 cases were in men and 3,821 in women. Highest incidence rates were observed in the 80-84 age group. Considerable variation across provinces was evident. In females squamous cell carcinoma (SCC) demonstrated a reduction from 24% to 16% of lesions over the period of study, while adenocarcinoma rose from 21% to 29%. In males a similar reduction in SCC was apparent (42% to 29%, again with increase in AC (13 % to 18%). Conclusions: The results show that the increase in the incidence of lung cancer the trend is that more men than women and in men and may be caused by changes in smoking pattern. The incidence of lung cancer in the North West and West provinces was higher than in other regions.

• Journal of Korean Neurosurgical Society
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• v.55 no.1
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• pp.43-47
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• 2014

Patients with neurofibromatosis 1 (NF1) are predisposed to develop central nervous system tumors, due to the loss of neurofibromin, an inactivator of proto-oncogene Ras. However, to our knowledge, only three cases of ependymomas with NF1 have been reported in the literature. The authors present a case of NF1 patient with a spinal cord ependymoma. She was referred for about half a year history of increasing numbness that progressed from her fingers to her entire body above the bellybutton. Magnetic resonance imaging revealed a relative-demarcated, heterogeneously enhanced mass lesion accompanied by perifocal edema in C5-7 level, a left-sided T11 spinous process heterogeneously enhanced mass in soft tissue, intervertebral disk hernia in L2-5 level, and widespread punctum enhancing lesion in her scalp and in T11-L5 level. The patient underwent C5-7 laminectomies and total excision of the tumor under operative microscope, and intraoperative ultrasonography and physiological monitoring were used during the surgery. Histopathologically, her tumor was found to be a ependymoma without malignant features (grade II in the World Health Organization classification). Therefore, no adjuvant therapy was applied. Following the operation, the patient showed an uneventful clinical recovery with no evidence of tumor recurrence after one year of follow-up.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.11
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• pp.4623-4628
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• 2015

Breast cancer still remains as the most frequent cancer with second mortality rate in women worldwide. There are no validated biomarkers for detection of the disease in early stages with effective power in diagnosis and therapeutic approaches. Cancer/testis antigens are recently promising tumor antigens and suitable candidates for targeted therapies and generating cancer vaccines. We conducted the present study to analyze transcript changes of two cancer/testis antigens, OIP5 and TAF7L, in breast tumors and cell lines in comparison with normal breast tissues by quantitative real time RT-PCR for the first time. Significant over-expression of OIP5 was observed in breast tumors and three out of six cell lines including MDA-MB-468, T47D and SKBR3. Not significant expression of TAF7L was evident in breast tumors but significant increase was noted in three out of six cell lines including MDA-MB-231, BT474 and T47D. OIP5 has ssignificant role in chromatin organization and cell cycle control during cell cycle exit and normal chromosome segregation during mitosis and TAF7L is a component of the transcription factor IID, which is involved in transcription initiation of most protein coding genes. TAF7Lis located at X chromosome and belongs to the CT-X gene family of cancer/testis antigens which contains about 50% of CT antigens, including those which have been used in cancer immunotherapy.

• Korea Journal of Hospital Management
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• v.23 no.2
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• pp.54-66
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• 2018

Purpose: This study was to figure out relationships of perceived Technology Readiness Index(TRI), usefulness, acceptance intension, and the recognition of substitute employment of medical personnel on the artificial intelligence (AI) and internet of things (IoT) among main technologies. Methodology: To achieve the purpose, this study utilized structured survey tools to conduct a questionnaire survey of nursing, administrative and medical technology professionals at six university hospitals in Korea metropolitan area. A PLS(Partial Least Square) Path analysis was utilized To analyze the material. Findings: In the relation with the technology readiness and perceived usefulness, it had a positive influence to the perceived usefulness when the optimism and innovativeness were higher and the discomfort was lower. In the relation with the technology readiness and acceptance intension, it showed a positive influence when the innovativeness was higher and the discomfort was lower. In the relation with the perceived usefulness and acceptance intension, it had a positive influence to the acceptance intension when the perceived usefulness was higher. In the relation with the acceptance intension and the recognition of substitute employment, it showed a positive influence to the recognition of substitute employment when the acceptance intension was higher. Practical Implications: Judging based on the above study results and reference reviews, it confirmed that it is necessary to prepare in the level of hospital organization in the $4^{th}$ Industrial Revolution. They should increase the efficiency of human resources through the technological factors or changes of employment types for the additional demands of human resources to handle increasing medical demands or induce to secure necessary abilities which are changing at the right time by performing the $4^{th}$ Industrial Revolution related re-training continuously to develop the value of existing human resources.

• The Korean Journal of Emergency Medical Services
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• v.10 no.2
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• pp.43-52
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• 2006

Purpose: The purpose of this study was to investigate the relationship between motivator, hygiene factor and organizational commitment of fire officials. Method: The subjects of this study were 228 fire officials in Kongju and Choengju province. Data were collected using self-reporting questionnaire during the period from 1st to 25th of February 2006. Collected data were analyzed using SPSS 12.0 program. Real number, percentage, mean and standard deviation were calculated, and t-test, ANOVA, Pearson correlation coefficient were carried out. Result: The findings of this study as follows: The motivator according to job characteristics was statistically significant differences in certificate(F=3.29, p= .002), aptitude(F=15.49, p= .000). The hygiene factors according to job characteristics was statistically significant differences in certificate(F=2.59 p= .01), aptitude(F=6.72, p= .000). The organizational commitment according to general characteristics were statistically significant differences in age(F= 2.625, p= .036), religion(F=3.869, p= .005). The organizational commitment according to job characteristics were statistically significant differences in experience(F=3.746, p= .001), aptitude(F=13.743, p= .000), wish of practice change(F=8.907, p= .000). The commitment was found to be in significant positive correlations with motivator(r= .436, p= .000) and hygiene factors(r= .336, p= .000). Conclusion: From the results, we recommend that the organization management program develops for increasing motivator in fire officials be used.

• Convergence Security Journal
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• v.19 no.5
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• pp.25-36
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• 2019

With the development of information and communication technology, hospitals that electronically process and manage medical information of patients are increasing. However, if medical information is processed electronically, there is still room for infringing personal information of the patient or medical staff. Accordingly, in 2017, the International Organization for Standardization (ISO) published ISO TS 25237 Health Information - Pseudonymization[1]. In this paper, we examine the re - identification process based on ISO TS 25237, the procedure and the problems of our proposed method. In addition, we propose a new processing scheme that adds a re-identification procedure to our secure differential privacy method [2] by keeping a mapping table between de-identified data sets and original data as ciphertext. The proposed method has proved to satisfy the requirements of ISO TS 25237 trust service providers except for some policy matters.

• The Korean Journal of Emergency Medical Services
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• v.6 no.1
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• pp.169-184
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• 2002

The purpose of this study was to find out the 119 rescue and first aid's satisfaction level for their occupations, understand the influential factors of the satisfaction level and also analyze the level of each working districts. Therefore to provide basic information of policy decisions to increase the satisfaction level. Date were collected from 400 national the 119 rescue and first aids by questionnaire and using the tools, which has developed by Slavitt, from August 2 to September 30, 2002. The data were analyzed by percentage, mean t-test and ANOVA. Divided 39 items into 7 provinces to find out the satisfaction level of each province, follow as the influential factors of the satisfaction level. 1. The most of the 119 rescue and first aids were satisfying about their occupations as they got 3.02 marks out of 5, which is the full mark. 2. As the results after analyzed the relation ship between the satisfaction level and the general characteristics of analyzed the relation ship between the satisfaction level and the general characteristics of the 119 rescue and first aids, there were not statistically significant differences of sex distinction, age, scholarship, not married and has or have married, grade and qualification. There were statistically significant differences follow as working period, applying motive, moving, seeking a job, working place, an adviser, work overtime and compensation follow as work overtime. 3. It appeared that all the 119 rescue and first aids were satisfying enough about duty itself but were dissatisfying about working condition. As the results; job itself got 4.00, reciprocal action got 3.74, business demand got 3.28, autonomy got 3.06, organization demand got 2.96, pay got 2.43 and working condition got 1.72, each out of 5 full marks. As you see the results, most of the 119 rescue and first aids are satisfying about a job itself but they are dissatisfying about their working condition. Therefore we should formulate a plan that can increase the satisfaction level by improving duty system for 24 working hours per week.

• The Korean Journal of Emergency Medical Services
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• v.9 no.1
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• pp.43-53
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• 2005

The purpose of this study was to survey a perception of frequency & importance level of job performance, from 249 paramedics who were working at fire station. The job related activities of 4 duties, 18 tasks and 145 task elements were checked by 4 rating scale. The data were analyzed using a SPSS program for descriptive statistics. The results of the study were as follows ; 1. Some of the most frequent tasks were medical tx, managing people & organization, trauma care, pt assessment, general coping skill 2. Some of the most frequent task elements were preparation of written reports, operation of pt lifting supplies, transportation of patients on stretchers, administration of cervical collar and utilization of scoop stretcher. 3. Some of the highest level of importance in task were resuscitation of circulation, surgical tx, safety & infection control, environmental emergency care, trauma care. 4. Some of the highest level of importance in task elements were administration of cervical collar, adult CPR, infant CPR, child CPR, and AED. 5. The highest level of task elements in perception of frequency & importance were administration of cervical collar, infection control after pt care, utilization of long back board, disinfection of ambulance after ride a long, care of chest pain pt, care of unconscious pt, tx of asthma. 6. A difference between frequent & importance score were due to lack of supplies(41%), structural problems(30%) and medical control system(16%), lack of skills(10%), Suggestion; 1. This paper would be more reliable and confirm through wilder range of survey. 2. It would be necessary of more depth survey through dacom study from paramedic. 3. Development of field oriented protocol & curriculum that based on task elements which have high score of both frequency & importance level is required.