• Parasites, Hosts and Diseases
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• v.47 no.3
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• pp.227-233
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• 2009

Local malaria transmission in the United Arab Emirates (UAE) came to an end in 1997. Nevertheless, UAE has been subjected to substantial importation of malaria cases from abroad, concerning both UAE nationals and immigrants from malarious countries with a total number of 2,119 cases in 2007. To evaluate a new DNA extraction technique using nested PCR, blood samples were collected from 132 individuals who presented to Infectious Diseases Department in Rashid Hospital, Dubai, and Central Department of Malaria Control with fever and persistent headache. Giemsa-stained blood films and ELISA test for malaria antibodies were carried out for detection of Plasmodium infection. Plasmodium infections were identified with the genus-specific primer set and species differentiation using nested PCR. A rapid procedure for diagnosis of malaria infections directly from dried blood spots using for the first time DNA extract from FTA Elute cards was evaluated in contrast to extraction techniques using FTA classic cards and rapid boiling technique. Our new simple technique for DNA extraction using FTA Elute cards was very sensitive giving a sensitivity of 100% compared to 94% using FTA classic cards and 62% in the rapid boiling technique. No complex preparation of blood samples was required prior to the amplification. The production cost of DNA isolation in our PCR assay was much less incomparable to that of other DNA extraction protocols. The nested PCR detected plasmodial infection and could differentiate P. falciparum from P. vivax, and also detected the mixed infection.

• Journal of Oriental Neuropsychiatry
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• v.11 no.2
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• pp.189-200
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• 2000

Object : The purpose of this study is assistant to medical treatment for patient, who suffers from headache, by classifing etiologies of headache and investigating using meridian and acupuncture point.Method : By considering through the oriental literature, we investigated etiologies and frequency of using meridian and acupuncture point on headache.Result:1. The Oriental etiologies of headache is classified in 'wind(風)', 'hot and feverish(熱)', 'humidity(濕)', 'cold(寒)', 'defidiency of qi(氣處)', 'deficiency of blood(血虛)', 'extravasated blood(瘀血)', 'asthenia of kidney(賢處)', 'anger by depression(鬱怒)', 'Damhwa(痰火)'2. The frequently used meridians on headache are followings : the 1st is Choksoyang-Tam-Kyong(足少陽膽經), the 2nd Choktaeyang-Pabggwabg-Kyong(足太陽膀胱經), the 3rd Tok-maek(督脈), and the 4th Chokyangmyong Wi-Kyong(足陽明胃經).3. The frequently used acupuncture points on headache are followings : the 1st is paek'oe(百會), the 2nd Hapkok(合谷) and the 3rd P'ungji(風池).Conclusion:1. The books about treatment of headache by using acupuncture are The Yellow Emperor's Classic on internal Medicine(黃帝內經) and Gab-UI-Kyoung(甲乙經) and so on.2. In The Yellow Emperor's Classic on Internal Medicine(黃帝內經), they mainly used treatment by following the stream of meridian on headache.3. After Gab-U1-Kyoung(甲乙經), they suggested specialized acupunctre point.4. Three Yang meridians(三陽經) that has many acupuncture point located on head area, are related to medical treatment on headache.

• Journal of Acupuncture Research
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• v.25 no.5
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• pp.1-16
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• 2008

Backgrounds : There have not been so many studies about the correlation of logical background between acupuncture and herbal medicine. Objectives : This study was aimed to find out the logical relationship between acupuncture points of Wushijiuyu(五十九兪) and Fangfengtongshengsan(防風通聖散) for the treatment of fever disease. Methods : I investigated the background of rationale of Wushijiuyu(五十九兪) and Fangfengtongshengsan(防風通聖散) through survey of classical text include Yellow Emperor's Classic of Medicine(.帝.經內經, Hwang Di Nei Jing), Liujing(類經), Zhenjiujiayijing(鍼灸甲乙經) and Huangdisuwenxuanmingfanglun(黃帝素問宣明方論). Results & Conclusions : The words "Wushijiuyu(五十九兪) and Wushijiuci(五十九刺)" are founded in the Yellow Emperor's Classic of Medicine(黃帝內經) are either prescription of the acupuncture points for the treatment of fever disease. However, acupuncture points of two methods are not same. According to Liujing(類經), Wushijiuyu(五十九兪) have used acupuncture points located in head, upper and lower extremities, trunk, and back. However Wushijiuci(五十九刺) just select acupuncture points of head and extremities without those of trunk and back. Acupuncture points located in yang meridian(45points) and Dumai(督脈, 5points) are significantly used more than those of yin meridian(8 points) and Renmai(任脈, 2points) in Wushijiuyu(五十九兪) and Wushijiuci(五十九刺). The distribution of acupuncture points used Wushijiuyu(五十九兪) have closer correlation with Fangfengtongshengsan(防風通聖散) than Wushijiuci(五十九刺) in the prescription.

• Journal of Genetic Medicine
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• v.19 no.2
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• pp.85-93
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• 2022

Purpose: Cornelia de Lange syndrome (CdLS) is a rare genetically heterogeneous disorder caused by genetic variants of the cohesin complex. However, the diverse genetic etiologies and their phenotypic correlations in Korean patients with CdLS are still largely unknown. Hence, this study aimed to clarify the clinical characteristics and genetic background of Korean patients with CdLS. Materials and Methods: The medical records of 15 unrelated patients (3 males and 12 females) genetically confirmed to have CdLS were retrospectively reviewed. All individuals were diagnosed with CdLS using target gene analysis, whole-exome sequencing, and/or chromosomal microarray analysis. The clinical score (CS) was calculated to assess disease severity. Results: The median age at diagnosis was 1.7 (range, 0.0-11.8) years, and median follow-up duration was 3.8 (range, 0.4-11.7) years. Eight (53.3%) patients showed classic phenotypes of CdLS, two (13.3%) showed non-classic phenotypes, and five (33.3%) had other phenotypes sharing limited signs of CdLS. Fifteen causative variants were identified: NIPBL in five (33.3%, including 3 males), SMC1A in three (20.0%), SMC3 in three (20.0%), and HDAC8 in four (26.7%) patients. The CS was significantly higher in the NIPBL group than in the non-NIPBL group (14.2±1.3 vs. 8.7±2.9, P<0.001). Conclusion: We identified the clinical and genetic heterogeneity of CdLS in Korean patients. Patients with variants of NIPBL had a more distinctive phenotype than those carrying variants of other cohesin complex genes (SMC1A, SMC3, and HDAC8). However, further studies are warranted to understand the pathogenesis of CdLS as a cohesinopathy and its genotype-phenotype correlations.

• The Journal of Internal Korean Medicine
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• v.31 no.4
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• pp.792-812
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• 2010

In the 18th century, Xu Lingtai (徐靈胎) and Yoshimasu Todo (吉益東洞) were famous doctors advocating ancient medicine, though they lived in different countries, China and Japan. We compared their major books, analyzed their academic thoughts and then took conclusions as below. 1. The first, for instance "Classified Prescriptions of Treatise on Cold Damage Diseases, 傷寒論類方" and "Classified Assemblage of Prescriptions, 類聚方". Based on essential thought that a prescription and a syndrome should correspond, these books arranged and classified the Zhang Zhongjing (張仲景)'s texts."Classified Prescriptions of Treatise on Cold Damage Diseases", based on the thought that principles, methods, formulas and medicinals (理法方藥) were integrated in prescriptions, tried to find out the implicit treatment rules in prescriptions and syndromes through analyzing "Treatise on Cold Damage Diseases, 傷寒論". On the other hand, because Classified Assemblage of Prescriptions focused on the syndromes of ancient prescriptions (古方), it classified and collected the related texts of Treatise on Cold Damage Diseases and "Synopsis of Prescriptions of the Golden Chamber, 금궤요략", and then suggested only simple instructions on how to prescribe medicine. So in this book, the trend of experience was clear. 2. The second, there is "100 Kinds Records from Shennong's Classic of Materia Medica, 神農本草經百種錄" and "Description work of herbal pharmacology comprised of excerpts from Shanhanlun and medical experiences, 藥徵". Though both of these books are professional oriental pharmacology publications that advocate reactionism, there were remarkable differences in writing style between them. "Description work of herbal pharmacology comprised of excerpts from Shanhanlun and medical experiences" was based on "Treat on Cold Damage Diseases" and "Synopsis of Prescriptions of the Golden Chamber", just explained the effects of medications and discussed 'matter of course (所當然)', but not discussed 'the reason why (所以然)'. In explaining style of syndromes, it confirmed through research, and emphasized the inductive method. On the other hand, "100 Kinds Records from Shennong's Classic of Materia Medica based on "Shennong's Classic of Materia Medica, 神農本草經", explained the nature of medications and discussed 'the reason why (所以然)'. In explaining style of syndromes, it annotated and explained, and emphasized the process of reasoning. 3. The third, there is "Discuss the Headwaters of Medicine, 醫學源流論" and Severance of Medical evils, 醫斷". Aiming the then medical theories fallen in confused state, these books brought order out of chaos, clarified the categories of medical research, and emphasized the scientific method that could put theories into practice and verify them. The difference is that "Severance of Medical Evils" researched only macroscopic viewable clinical phenomena, and even denied the existence of names of diseases and etiological causes. Thus, it emphasized the accumulation of experiences, laid emphasis on "watching and realizing (目認)", and "understand and taking in (解悟)". Discuss the Headwaters of Medicine extremely emphasized the research of 'something not occuring (未然)', that is to say, induced notions of a disease from observing clinical phenomena, furthermore based on these, predicted the 'something not occuring (未然)' and emphasized researching 'the reason why (所以然)'. As regards how they deal with the traditional theories and post-Zhang Zhongjing's medicines, "Severance of Medical evils" took completely denying attitudes. In case of "Discuss the Headwaters of Medicine", it could be used reasonably through specific situation and detailed analysis. Collectively speaking, there were some differences between medical theories of Xu Lingtai and Yoshimasu Todo. Actually, these differences were whether he tried to research the essence of disease, whether he tried to consider it rationally, and how he treated various opinions occurring in the theories of traditional medicine and clinical experience.

• The Journal of Korean Medical History
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• v.20 no.1
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• pp.165-205
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• 2007

This dissertation aims at studying how 'the 28 Lunar Mansions' was applied to the Oriental medicine(韓醫學) and was set up as one of the most important theories of Oriental medicine. This study especially examines how 'the 28 Lunar Mansions' has influenced Oriental medicine focusing on the exploration of "The Huang Di Nei Jing, the Inner Classic of the Yellow Emperor ${\ll}$黃帝內經${\gg}$" and "Lei Jing ${\ll}$類經${\gg}$". Through that examination, there came some findings as follow.

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.61-64
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• 2005

The purpose of this paper is to take a closer look at an area having shorted emergence facilities and to determine optional candidate sites instead of vulnerable area by using GIS spatial analysis. Newly determined new candidate is performed by concerning spatial efficiency and spatial equity for a public service. It was determined through using the analyzing of the physical accessibility measure, the Location-Allocation, sort of classic model in spatial statistics and general network analysis. The area of this research has been used in administrative boundary of Young-Dong in Gangneung including 13 emergency, medical hospitals, 46 fire-stations and sub-fire stations. In general terms, what all this show is that the way we are approached for geographical view from using GIS spatial analyzing technique of determined location and allocation problem by the social, economical, political factor and simple administrative discrimination at the meantime. At the same time, with problem occurred in the space it is possible to make an Effective proposal or means, policy, decision for new candidate location-allocation suggesting optimum model.

• The Journal of Korean Medical History
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• v.21 no.1
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• pp.13-28
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• 2008

The concept of health has existed through the history of mankind; the recognition and adaptation of such concept has transformed over time with the development of culture throughout the age of humans. These concept wasn't absent in the content East Asian Medicines, which is represented by Huangdi's Internal Classic. However, due to imperialism and colonial polocies in the past, biomedical concepts of health has been accepted with force. The concept of "health" in pathological medicines of biomedicine refers to the of anatomical and biological completeness of the body system. In East Asia, Korean especially, a number of concepts regarding these subjects has been informed by Japanese physicians, such as Hukujawa Yukichi. Understanding the idea of body in the angle of philosophy, history, and medicine in the cultural area of East Asia is necessary.

• The Journal of Korean Medical History
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• v.17 no.1
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• pp.83-104
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• 2004

BiaoYouFu(標幽賦) is a classic of accupuncuret&moxibustion, written by a famous accupuncurist& moxibustionist DouHanQing, and it is published in DouHanQing's ZhenQingZhiNan, BiaoYouFu is an accupuncuret&moxibustion GeFu(歌賦-a type of song) that simply expressed the profound and abstract parts of the theory and practice of acupuncture&moxibustion in GeFu forms, and allowed people studying to understand the details of acupuncture&moxibustion readily, and also help doctors to memorize easily. The author wrote annotations for abstruse parts and pronunciations for the original text to help in reading the original text with ease. The most important point is that it was translated according to our country's unique rhythm of folk song, the $3{\cdot}4$, $4{\cdot}4beat$, to make it easily readable, so that it could be studied repeatedly and understood deeply.

• The Korean Journal of Pain
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• v.4 no.1
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• pp.37-41
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• 1991

Celiac Plexus neurolysis (C. P. N) has been commonly used to treat malignant pain of the abdominal area that is intractable. It relieves the pain effectively instead of using massive systemic narcotic analgesics. C. P. N. with modified transaortic technique was performed under C-T guidance, in which a single needle was advanced from a left posterior paramedian approach through the aorta in order to inject anesthetic agents directly into the celiac plexus. There was marked pain relief without any hemorrhagic and neurological or other complications. We found this modified transaortic method of C. P. N. to be very effective, safe and easy to perform compared with the classic two needle technique.