• Title/Summary/Keyword: Medical classic

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The association of leptin with severity of non-alcoholic fatty liver disease: A population-based study

  • Rotundo, Laura;Persaud, Alana;Feurdean, Mirela;Ahlawat, Sushil;Kim, Hyun-seok
    • Clinical and Molecular Hepatology
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    • v.24 no.4
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    • pp.392-401
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    • 2018
  • Background/Aims: Leptin is associated with metabolic disorders, which predispose one to non-alcoholic fatty liver disease (NAFLD). The role of leptin in NAFLD pathogenesis is not fully understood. We aim to investigate the association between serum leptin level and severity of NAFLD using U.S. nationally representative data. Methods: Data were obtained from the United States Third National Health and Nutrition Examination Survey. NAFLD was defined by ultrasound detection and severity of hepatic steatosis in the absence of other liver diseases. The severity of hepatic fibrosis was determined by NAFLD fibrosis score (NFS). We used multivariate survey-weighted generalized logistic regression to evaluate the association between leptin level and the degree of NAFLD. We also performed subgroup analyses by body mass index (lean vs. classic NAFLD). Results: Among 4,571 people, 1,610 (35%) had NAFLD. By ultrasound findings, there were 621 people with mild, 664 with moderate, and 325 with severe steatosis. There were 885 people with low NFS (<-1.455, no significant fibrosis), 596 with intermediate NFS, and 129 with high NFS (>0.676, advanced fibrosis). Leptin levels for normal, mild, moderate and severe steatosis were $10.7{\pm}0.3ng/mL$, $12.1{\pm}0.7ng/mL$, $15.6{\pm}0.8ng/mL$, $16{\pm}1.0ng/mL$, respectively (trend P-value<0.001). Leptin levels for low, intermediate, and high NFS were $11.8{\pm}0.5ng/mL$, $15.6{\pm}0.8ng/mL$, $28.5{\pm}3.5ng/mL$, respectively (trend P-value<0.001). This association remained significant even after adjusting for known demographic and metabolic risk factors. In the subgroup analysis, this association was only prominent in classic NAFLD, but not in lean NAFLD. Conclusions: Serum leptin level is associated with the severity of NAFLD, especially in classic NAFLD patients.

Classic Floating Elbow in Adults: A Case Series

  • Cho, Chul-Hyun;Min, Kyung-Keun
    • Clinics in Shoulder and Elbow
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    • v.18 no.1
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    • pp.8-12
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    • 2015
  • Background: The aim of this study was to assess demographics, clinical outcomes, and complications of classic floating elbow in adults. Methods: Six patients with ipsilateral diaphyseal fractures of the humerus, radius, and ulna were reviewed retrospectively. All patients were treated operatively and available for follow-up at a minimum of 1 year after surgery. The average age of the patients was 45.2 years (22-64 years) and the average follow-up period was 37.0 months (14-103 months). They were evaluated with postoperative outcome measures, including a visual analog scale (VAS) for pain, Mayo elbow performance score (MEPS), and American Shoulder and Elbow Surgeons (ASES) shoulder score. Residual complications were also evaluated. Results: Five patients (83.3%) had open fracture, and 4 patients (66.7%) presented with associated nerve injury. All fractures were united within postoperative 4 months, except 1 delayed union. The average VAS pain score, MEPS, and ASES shoulder score at the final follow-up examination was 2.5, 79.8, and 67.5 respectively. Three patients including 2 cases of joint stiffness with incomplete recovery from nerve injury and 1 case of complex regional pain syndrome had poor clinical outcome. Conclusions: Although the classic floating elbow is rare, these injuries potentially have associated problems such as open fracture or nerve injury. The presence of residual neurological symptoms predispose to poorer clinical outcomes.

Study on Medical Records In ${\ulcorner}$the Historical Records of the Three Kingdoms${\lrcorner}$ ("삼국사기(三國史記)"에 기록된 의약내용(醫藥內容) 분석)

  • Shin, Soon-Shik;Choi, Hwan-Soo
    • Journal of The Association for Neo Medicine
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    • v.2 no.1
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    • pp.35-54
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    • 1997
  • We tried to observe the features of ancient medical practice by analysing the records related to medicine in the book, ${\ulcorner}$the Historical Records of the Three Kingdom${\lrcorner}$ of which content includes the features of medicine in mythology, plague, delivery of twins, drugs, medical system, shamanism, constitutional medicine, psychiatry, forensic medicine, deformity, a spa, medical phrase, health and welfare work, religion, death. physiological anatomy, Taoist medicine, acupuncture, the occult af of transformation and etc. Our initial concern was about where to draw line as of medical field and we defined medicine in more broad meaning. The book ${\ulcorner}$the Historical Records of the Three Kingdoms${\lrcorner}$ describes the world of mythology by way of medicine which is not clearly a conventional one. There appears records of birth of multiple offsprings 7 times in which cases are of triplets or more. Delivering multiple offsprings were rare phenomenon though such fertility was highly admired. This shows one aspect of ancient country having more population meant more power of the nation. Of those medical records conveyed in that book includes stories of childbirth such as giving birth to a son after praying, giving birth to Kim Yoo-shin after 20 months after mother's dream of conception, and a song longing for getting a laudable child. Plagues were prevalent throughout winter to spring season and one can observe various symptoms of plagues in the record. Of these epidemic diseases, cold type might have been more common than the heat one. Appearance of epidemic diseases frequently coincided with that of natural disasters that this suggests a linkage between plague and underlying doctrine on five elements' motion and six kinds of natural factors. There exists only a few names of diseases such as epidemic disease, wind disease, and syndrome characterized by dyspnea. Otherwise there appeared only afflictions that were not specified therefore it remains cluless to keep track of certain diseases of prevalence. Since this ${\ulcorner}$Historical Records of the Three Kingdoms'${\lrcorner}$ wasn't any sort of medical book, words and terms used were not technical kind and most were the ones used generally among lay people. Therefore any mechanisms of the diseases were hardly mentioned. Some of medicinal substances such as Calculus Bovis, Radix Ginseng, Gaboderma Luciderm, magnetitum were also in use in those days. 53 kinds of dietary supplies appears in the records and some of these might have been used as medicinal purpose. Records concerning dicipline of one's body includes activities such as hunting, archery, horseback riding etc. In Shilla dynasty there were positions such as professor of medicine, Naekongbong(內供奉), Kongbong's doctor(供奉醫師), Kongbong's diviner(供奉卜師). As an educational facility, medical school was built at the first year of King Hyoso's reign and it's curricula included various subjects as ${\ulcorner}$Shin Nong's Herbal classic${\lrcorner}$, ${\ulcorner}$Kabeul classic of acupuncture and moxbustion${\lrcorner}$, ${\ulcorner}$The Plain Questions of the Yellow Emperor's Classic of Internal Medicine${\lrcorner}$, ${\ulcorner}$Classic of Acupuncturer${\lrcorner}$, ${\ulcorner}$The Pulse Classic${\lrcorner}$, ${\ulcorner}$Classic of Channels and Acupuncture Points${\lrcorner}$ and ${\ulcorner}$Difficult Classic${\lrcorner}$. There were 2 medical professors who were in charge of education. To establish pharmacopoeia, 2 Shaji(舍知), 6 Sha(史), 2 Jongshaji(從舍知) were appointed. In Baekje dynasty, Department of Herb was maintained. Doing praying for the sake of health, doing phrenology also can be extended to medical arena. Those who survived over 100 years of age appear 3 times in the record, while 98 appears once. The earliest psychiatrist Nokjin differentiated symptoms to apply either therapies using acupuncture and drug or psychotherapy. There appears a case of rape, a case of burying alive with the dead, 8 cases of suicide that can characterize a prototype of forensic medicine. Deformity-related records include phrases as follow: 'there seems protrudent bone behind the head', 'a body which has two heads, two trunks, four arms.', 'a body equipped with two heads' In those times spa can be said to be used as a place for he리ing, convalescence, and relaxation seeing the records describing a person pretended illness and went to spa to enjoy with his friends. Priest doctors and millitary surgeons were in charge of the medical sevice in the period of the Three Kingdoms by the record written by Mookhoja(墨胡子) and Hoonkyeom(訓謙). Poor diet and regimen makes people more vulnerable to diseases. So there existed charity services for those poor people who couldn't live with one's own capacity such as single parents, orphans, the aged people no one to take care and those who are ill. The cause of affliction was frequently coined with human relation. There appeared the phenomenon of releasing prisoners and allowing people to become priests at the time of king's suffering. Besides, as a healing procedure, sutra-chanting was peformed. There appears 10 cases of death related records which varies from death by drowning, or by freezing, death from animals, death from war, death from wightloss and killing oneself at the moment of spouse's death and etc. There also exist certain records which suggest the knowledge of physiology and anatomy in those times. Since the taoist books such as ${\ulcorner}$Book of the Way and Its Power(老子道德經)${\lrcorner}$ were introduced in the period of Three Kingdoms, it can be considered that medicine was also influenced by taoism. Records of higher level of acupuncture, records which links the medicine and occult art of transformation existed. Although limited, we could figure out the medical state of ancient society.

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A Study in the Influence of The Treasured Mirror of Eastern Medicine (Donguibogam) upon the Koryo Medicine in North Korea (최근 북한 고려 의학에 반영된 『동의보감』 연구)

  • Zhang, Zili;Jin, Jun
    • Journal of Korean Medical classics
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    • v.31 no.3
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    • pp.99-107
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    • 2018
  • Objectives: This article aims to clarify the understanding and publication status of both The Treasured Mirror of Eastern Medicine (Donguibogam) and some of its recent research progress made in North Korea, as well as their influences upon the academic of Koryo medicine in North Korea. Methods: Analysis was carried out based on various reference books, dictionaries and Korean translation of Donguibogam (1964 Ver.) published by North Korea, as well as the North Korean quarterly medical journal, Koryo Medicine. Results: The academic of Koryo medicine in North Korea regards Donguibogam, a Korean medical classic as it was written by native Korean physicians and it became an important ground material for basic research and clinical study. Various terminologies used in the original version of Donguibogam were defined as unscientific and superstitious by North Korean academics, which were then subsequently removed from the Korean translation of Donguibogam (1964 Ver.) published by North Korea. Therefore, this version cannot be seen as a complete edition of Donguibogam. Conclusions: The Donguibogam is known as one of the 'three major books of Koryo medicine' in North Korea. As a treasure of East-Asian traditional medical classic, Donguibogam is expected to become the medium for a closer research collaboration between the North and South Koreas including China in the future.

Study on Medical Application of Divination of Six Yinyang-strokes (육효의 의학적 응용)

  • Pyoun Sung Bum;Kang Jung Soo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.6
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    • pp.1558-1568
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    • 2004
  • In ancient times, the society was unity of church and state and this social leader took medical treatment, too. As he ruled over a people with a Chinese classic on divination, many oriental doctors have considered that the medicine and a Chinese classic on divination(周易) have same origine, and have used it. The divination of six yinyang-strokes(六爻) must be made up of some established rules, for example, division of fifty sticks(葉蓍法), use of three coins(擲錢法), use of numbering sticks and number of time(時間作卦法). six yinyang-strokes is one trigram. As we divine good or bad luck through investigation of six yinyang-strokes, we can know good or bad luck of patient's diseases and cares. A purpose of divination is called use-spirit(用神), a spirit to weaken use-spirit is called dislike-spirit (忌神), and a spirit to help use-spirit is called pleasure-spirit(喜神). As use-spirit is a state of disease in divination of disease and patient, use-spirit is patient and dislike-spirit is disease. If supports of use-spirit are more than supports of dislike, it's good luck, but if not, it's bad luck. As use-spirit is a prognosis of disease in divination of care, use-spirit is patient, dislike-spirit is a state of disease, and pleasure-spirit are medicine and doctor. we inspect condition of patient with good or bad luck of use-spirit, state of disease with good or bad luck of dislike-spirit, and medicine with good or bad luck of pleasure-spirit. Finally, we take a bird's-eye-view of the balance of them and decide on course of action.

Indications for an Immediate Laparotomy in Patients with Abdominal Stab Wounds (복부 자상 환자에서 즉각적 개복술을 위한 적응증)

  • Kim, Hyeong Ju;Hwang, Seong Youn;Choi, Young Cheol
    • Journal of Trauma and Injury
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    • v.20 no.2
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    • pp.106-114
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    • 2007
  • Purpose: There is little controversy that a classic indication such as hemodynamic instability or any sign of peritoneal irritation requires an immediate laparotomy in the management of abdominal stab wounds. However, omental herniation or bowel evisceration as an indication for an immediate laparotomy is controversial. The purpose of this study was to evaluate the significance of these factors as indications for an immediate laparotomy. Methods: The medical records of 98 consecutive abdominal stab wounds patients admitted to the Emergency Center of Masan Samsung Hospital from January 2000 to December 2006 were carefully examined retrospectively. Using multivariate logistic regression analysis, thirty-nine factors, including the classic indication and intraabdominal organ evisceration, were evaluated and were found to be associated with a need for a laparotomy. Also, the classic indication was compared with a new indication consisting of components of the classic indication and intra-abdominal organ evisceration by constructing a contingency table according to the need for a laparotomy. Results: Multivariate logistic regression analysis revealed any sign of peritoneal irritation, base deficit, and age to be significant factors associated with the need for a laparotomy (p<0.05). The sensitivity, specificity, and accuracy rates of the classic indication were 98.6%, 72.0%, and 91.8%, respectively, and those of the new indication were 93.2%, 84.0%, and 90.8%, respectively. The differences in those rates between the above two indications were not significant. Conclusion: Intra-abdominal organ evisceration was not a significant factor for an immediate laparotomy. Moreover, the new indication including intra-abdominal organ evisceration was not superior to the classic indication. Therefore, in the management of abdominal stab wounds, the authors suggest that an immediate laparotomy should be performed on patients with hemodynamic instability or with any sign of peritoneal irritation.

The Essential Prescriptions of the Golden Chamber (金匮要略) use of Shen Qi Pill(肾气丸)'s for qi's transformation(气化), truly embodies the analysis found in the Yellow Emperor internal classic(黃帝内经) describing the kidney functions (종"황제내경"신지공능탐석"금궤요략"신기환기화작용적체현(从"黃帝内经"肾之功能探析"金匮要略"肾气丸气化作用的体现))

  • Park, Eun Hee;Xie, Jing;Jia, Chunhua
    • Journal of Korean Medical classics
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    • v.26 no.1
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    • pp.39-45
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    • 2013
  • Objective : This article is based on a formula taken from Essential Prescriptions of the Golden Chamber(金匮要略). Shen Qi Pill(肾气丸) is generally used for such deficiency cases as: consumptive diseases, xiaoke(消渴) (waisting, thirst), beriberi, urinary problems during pregnancy, phlegm and so forth, and its main purpose is to treat Kidney Qi depletion, Qi transformation disorders, without obvious hot/cold appearance patterns. Method : Mainly through the literature study of related treatise on IInner Canon of the Yellow Emperor's internal classic(黃帝内经) and The Essential Prescriptions of the Golden Chamber. Result : According to the Yellow Emperor's internal classic, the Kidney has three main functions, storing essence, controlling the waters and holding Qi. Shen Qi Pill's(肾气丸) source formula is intended to supplement even though its constituent herbs aren't the warming type. To reinforce the Qi's transformation ability is considered to be a main function of the kidney organ, and in clinic, diagnosed kidney related problems and its treatment process are mainly associated with warming to help the Qi transforming. Conclusion : Thus recovering the kidneys Qi's transformation function is part of the process to eliminate diseases. Just cause the Kidney is deficient we shouldn't think immediately of using warming supplement herbs.

A Study on the Characteristics of Eight Extra Meridians:Focused on the Chapter of Pyoung Gi Kyoung Pal Maek Byoung of the Pulse Classic and the 27, 28 and 29th Question of the Classic of Difficult Issues (『맥경』 평기경팔맥병편과 『난경』 27, 28, 29난을 중심으로 한 기경팔맥에 관한 고찰)

  • Youn, Daehwan;Shin, Wook;Sheen, Yeong il;Lee, Namgu;Na, Changsu
    • Korean Journal of Acupuncture
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    • v.32 no.2
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    • pp.41-50
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    • 2015
  • Objectives : In this study we investigated characteristics of eight extra meridians based on the chapter of Pyoung Gi Kyoung Pal Maek Byoung(PGKPMB) of the Pulse Classic(Maijing; PC) and the 27, 28, and $29^{th}$ question of the Classic of Difficult Issues(Nanjing; CDI). Methods : We searched out the contents of eight extra meridians in historical background, the principal and circulation of eight extra meridians, and the symptoms and pulse diagnosis of eight extra meridians on the PGKPMB of the PC and the 27, 28, and $29^{th}$ question of the CDI. Results and Conclusions : About development of eight extra meridians, content which was scattered in the CDI was supplemented and developed in the CDI. Also taking over the content in the CDI, the meaning of the eight extra meridians was expanded and supplemented in the PC. In the PC, the mechanism about symptom of eight extra meridians especially has been described. Also materialization of symptom which linked to pathogenic pulse of eight extra meridians had a great impact on future generation.

Classic of Oriental Medicines in the San-Cheong Region (산청지역의 전통의학 문헌)

  • Ahn, Sang Woo
    • The Journal of Korean Medical History
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    • v.21 no.1
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    • pp.1-12
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    • 2008
  • San-Cheong region is the mountainous region in the southeastern part of Jiri-San where herbs with superior quality has been produced and famous doctors in history of Oriental Medicins such as Eui-Tae Ryu, Yi-Tae Yu, Cho-Gek Huh, and Cho-Sam Huh has lived. The most famous of all is Eui-Tae Ryu, who was a court physician under the reign of Suk-Jong in late 1660s. He wrote many classics on Oriental Medicines such as 痲疹編, a professional literature on measles, 實驗單方, a classic on miscellaneous diseases, 麟西聞見錄. Also, Cho-Gek Huh, and Cho-Sam Huh brothers wrote 晋陽神方, 晋寓神方, and various tales on medicines.

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A Study on the Yin-Yang Theory in 『Tongsokanuihagwollon(通俗韓醫學原論)』 (통속한의학원론(通俗韓醫學原論) 음양편(陰陽篇)에 관한 고찰(考察))

  • Kim, Hoon;Lee, Hai-Woong
    • The Journal of Korean Medical History
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    • v.24 no.2
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    • pp.17-24
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    • 2011
  • Cho Heon Yeong's 'Tongsokanuihagwollon' is an introductory and essential book on Traditional Korean Medicine(TKM), and now we can nearly take it as classic. It contains almost whole contents of TKM : physiology, pathology, herbology, meridian & acupoint, internal medicine, diagnostics, formula science, etc. He wanted to help people get TKM services easily on their own through this book. In the first chapter following the introduction, he inserted Yin-Yang theory, and his lecture on Yin-Yang theory continues for 88 pages, taking 17% of the whole book. Yin-Yang theory chapter is composed of 14 parts which tells about concept, definition and meaning of Yin-Yang, change of Yin-Yang according to time, season, constitution, body region, meridian, herb, etc. Last part refers to disharmony & dysfunction of Yin-Yang in body, so he showed both theoretical and clinical view of Yin-Yang theory. He wrote some quotations from the book 'Complete Works of Jingyue(景岳全書)', 'Huangdi's Internal Classic(黃帝內徑)', 'Introduction to Medicine(醫學入門)', etc. He tried to explain easily about Yin-Yang theory with modern but rough language of science. He seemed to already know clearly that without modern science TKM cannot progress and will soon be overwhelmed by western medicine, and acted his own way to spread spirit of TKM in the period of rapid change & conflict between two civilizations.