• Title/Summary/Keyword: Medical School

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Regulation of $[^3H]Norepinephrine$ Release by Opioids in Human Cerebral Cortex

  • Woo, Ran-Sook;Shin, Byoung-Soo;Kim, Chul-Jin;Shin, Min-Soo;Jeong, Min-Suk;Zhao, Rong-Jie;Kim, Kee-Won
    • The Korean Journal of Physiology and Pharmacology
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    • v.7 no.1
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    • pp.1-3
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    • 2003
  • To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for ${\mu}$-, ${\delta}$-, and ${\kappa}$-receptors on the high potassium (15 mM)-evoked release of [$^3H$]NE. [$^3H$]NE release induced by high potassium was calcium-dependent and tetrodotoxin-sensitive. [$D-Pen^2$, $D-Pen^5$]enkephalin (DPDPE) and deltorphin II (Delt II) inhibited the stimulated release of norepinephrine in a dose-dependent manner. However, Tyr-D-Ala-Gly-(Me)Phe-Gly-ol and U69,593 did not influence the NE release. Inhibitory effect of DPDPE and Delt-II was antagonized by naloxone, naltrindole, 7-benzylidenaltrexone and naltriben. These results suggest that both ${\delta}_1$ and ${\delta}_2$ receptors are involved in regulation of NE release in human cerebral cortex.

Primary Malignant Fibrous Histiocytoma of the Chest Wall Misdiagnosed as Traumatic Hemothorax

  • Hwang, Ki-Eun;Hwang, June-Seong;Kim, Kyung-Min;Jung, Jae-Wan;Oh, Su-Jin;Kim, Eun-Kyoung;Ryu, Dae-Woon;Choi, Keum-Ha;Jeong, Eun-Taik;Kim, Hak-Ryul
    • Tuberculosis and Respiratory Diseases
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    • v.76 no.6
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    • pp.289-291
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    • 2014
  • Malignant fibrous histiocytoma (MFH), a type of sarcoma, is a malignant neoplasm with uncertain origins that arise from both the soft tissues and the bone. The occurrence of MFH on the chest wall is extremely rare. We hereby report a case of a 72-year-old woman who was incidentally detected with MFH after a traffic accident.