• Proceedings of the KIEE Conference
• /
• 2007.07a
• /
• pp.154-155
• /
• 2007

Put Recently, development of micro valves that operate by compressed air has received significant attention in the fields of the micro fluid chip for medical applications or production lines of semi-conduct chip for electronic goods. Especially it is required that high-speed responsibility and lower power in optimal design of these micro valves. The primary objective of this study is to compare the optimally designed Solenoid Valve with the actually produced one which can highly improve the efficiency by providing optimal current according to mechanical load.

• Journal of Drive and Control
• /
• v.18 no.4
• /
• pp.35-42
• /
• 2021

A personal mobility withstanding function for the disabled and vulnerable groups with difficulties in mobility was developed and structural and dynamics analysis was conducted. Personal mobility devices are a very helpful means of transportation for the disabled and vulnerable groups. In addition, the standing function allows individuals to perform a difficult task in while seated and offers a medical advantage to the user. In this study, a personal mobility device was designed and developed to help vulnerable groups and disabled people overcome limited mobility, and communicate with the general people at eye level through standing functions. Through structural and dynamic analysis, the structural safety, optimal speed during rotation, and lateral acceleration of the personal mobility device was analyzed. The analysis results are expected to contribute to the improvement of the users' convenience and stability of personal mobility.

• 유체기계공업학회:학술대회논문집
• /
• 2006.08a
• /
• pp.403-406
• /
• 2006

A new medical X-ray PIV technique was developed using a conventional medical X-ray tube. To acquire images of micro-scale particles, the X-ray PIV system consists of an x-ray CCD camera with high spatial resolution, and a X-ray tube with small a focal spot. A new X-ray exposure control device was developed using a rotating disc shutter to make double pulses which are essential for PIV application. Synchronization methodology was also developed to apply the PIV technique to a conventional medical X-ray tube. In order to check the performance and usefulness of the developed X-ray PIV technique, it was applied to a glycerin flow in an opaque silicon tube. Tungsten particles which have high X-ray absorption coefficient were used as tracer particles. Through this preliminary test, the spatial resolution was found to be higher than ultrafast MRI techniques, and the temporal resolution was higher than conventional X-ray PIV techniques. By improving its performance further and developing more suitable tracers, this medical X-ray PIV technique will have strong potential in the fields of medical imaging or nondestructive inspection as well as diagnosis of practical thermo-fluid flows.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.40 no.10
• /
• pp.681-687
• /
• 2016

It is essential for micro jet injectors in the biomedical sector to operate under high pressure. High pressure injection, however, is accompanied by high volumes. On/Off valves that can be operated at high speeds have been used to address this problem. In this research, piezoelectric actuators which have a response frequency of the order of hundreds of kilohertz were used as the On/Off valve and experiments were applied. Researchers developed a controller to precisely manipulate the piezoelectric valve with various waveforms. They also fabricated five types of nozzles to consider the effect of nozzle type on injection. This allowed researchers to manipulate and confirm factors that can affect the injection volume and force. Results of this experiment have shown how to decrease the injection volume and increase the injection force. and it is predicted that the optimized injection volume and force value can be determined depending on the skin type.

• Parasites, Hosts and Diseases
• /
• v.57 no.2
• /
• pp.185-189
• /
• 2019

To identify the component(s) involved in cell cycle control in the protozoan Giardia lamblia, cells arrested at the G1/S- or G2-phase by treatment with nocodazole and aphidicolin were prepared from the synchronized cell cultures. RNA-sequencing analysis of the 2 stages of Giardia cell cycle identified several cell cycle genes that were up-regulated at the G2-phase. Transcriptome analysis of cells in 2 distinct cell cycle stages of G. lamblia confirmed previously reported components of cell cycle (PcnA, cyclin B, and CDK) and identified additional cell cycle components (NEKs, Mad2, spindle pole protein, and CDC14A). This result indicates that the cell cycle machinery operates in this protozoan, one of the earliest diverging eukaryotic lineages.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.38 no.10
• /
• pp.1171-1177
• /
• 2014

An electromagnetic shielding doorset must satisfy requirements associated with both mechanical strength/durability and electromagnetic shielding. Among the primary components of the doorset, a finger strip-a leaftype spring normally made of beryllium copper-is a core part to shield electromagnetic waves as well as to endure repetitive dry sliding friction. This study presented a reliability demonstration test method for the doorset system and, by a simple and simultaneous implementation, of the replacement interval of the finger strip. A rigorous evaluation for the qualification of maintenance or replacement interval is included in the reliability demonstration test of any series system that holds critical maintenance sub-units.

• Transactions of the KSME C: Technology and Education
• /
• v.3 no.3
• /
• pp.217-223
• /
• 2015

The patterning of microbead in microfluidics channel is a practical technique for application in bio and medical areas. An approach is described for a direct patterning of magnetically active microbeads in microfluidic devices without inner structure. Local magnet arrangements - flat arrangement and stack arrangement - contacting same poles or opposite poles of magnet were utilized for generating trapping magnetic fields. The arrangement of magnets contacting same poles generated isolated patterns by repelling of magnetic field. The flat arrangement of vertically reverse magnet arrays shaped trapping patterns repelling magnetic field line between same poles. Spatially, the stack compositions of magnet arrangements allow diverse isolated trapped patterns of magnetic particles. Trapped magnetic particles in fluidic channels were stable on the $18m{\ell}/hr$ flow conditions and magnetic force of 1.08 mT in the all experiments. This experimental study suggests the simple and versatile methods to pattern magnetic particles, and has potential of wide application to bio and medical area.

• Proceedings of the KAIS Fall Conference
• /
• 2009.05a
• /
• pp.517-519
• /
• 2009

최근에는 저탄소, 녹색성장과 같은 정책 추진으로 태양광을 비롯한 신재생 에너지 분야에 대한 관심이 증가하고 있다. 이들 산업과는 다른 특성을 가진 기계업종은 전통적인 산업에 속한다. 본 연구에서는 이들 기계업종의 정보화 현황조사를 바탕으로 문제점 및 개선방안에 대하여 살펴본다.

• Journal of Microbiology and Biotechnology
• /
• v.23 no.12
• /
• pp.1785-1790
• /
• 2013

The synthetic machinery of ATF4 (activating transcription factor 4) is activated in response to various stress conditions involved in nutrient restriction, endoplasmic reticulum homeostasis, and oxidation. Stress-induced inhibition of proteasome activity triggers the unfolded protein response and endoplasmic reticulum stress, where ATF4 is crucial for consequent biological events. In the current study, we showed that the $NAD^+$-dependent deacetylase, SIRT1, suppresses ATF4 synthesis during proteasome inhibition. SIRT1 depletion via transfection of specific siRNA into HeLa cells resulted in a significant increase in ATF4 protein, which was observed specifically in the presence of the proteasome inhibitor MG132. Consistent with SIRT1 depletion data, transient transfection of cells with SIRT1-overexpressing plasmid induced a decrease in the ATF4 protein level in the presence of MG132. Interestingly, however, ATF4 mRNA was not affected by SIRT1, even in the presence of MG132, indicating that SIRT1-induced suppression of ATF4 synthesis occurs under post-transcriptional control. Accordingly, we propose that SIRT1 serves as a negative regulator of ATF4 protein synthesis at the post-transcriptional level, which is observed during stress conditions, such as proteasome inhibition.

• Parasites, Hosts and Diseases
• /
• v.59 no.6
• /
• pp.573-583
• /
• 2021

Toxoplasma gondii, an intracellular protozoan parasite that infects one-third of the world's population, has been reported to hijack host cell apoptotic machinery and promote either an anti- or proapoptotic program depending on the parasite virulence and load and the host cell type. However, little is known about the regulation of human FHs 74 small intestinal epithelial cell viability in response to T. gondii infection. Here we show that T. gondii RH strain tachyzoite infection or ESP treatment of FHs 74 Int cells induced apoptosis, mitochondrial dysfunction and ER stress in host cells. Pretreatment with 4-PBA inhibited the expression or activation of key molecules involved in ER stress. In addition, both T. gondii and ESP challenge-induced mitochondrial dysfunction and cell death were dramatically suppressed in 4-PBA pretreated cells. Our study indicates that T. gondii infection induced ER stress in FHs 74 Int cells, which induced mitochondrial dysfunction followed by apoptosis. This may constitute a potential molecular mechanism responsible for the foodborne parasitic disease caused by T. gondii.