• Title/Summary/Keyword: Medical Informatics

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Verifying Ontology Increments through Domain and Schema Independent Verbalization

  • Vidanage, Kaneeka;Noor, Noor Maizura Mohamad;Mohemad, Rosmayati;Bakar, Zuriana Aby
    • International Journal of Computer Science & Network Security
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    • v.21 no.1
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    • pp.34-39
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    • 2021
  • Collaborative ontology construction is the latest trend in developing ontologies. In this technique domain specialists and ontologists need to work together. Because of the complexity associated with ontology construction, it's done in an iterative and incremental fashion. After each iteration, an ontology increment will be produced. Current ontology increment is always an enhanced version of the previous increment. Each ontology increment has to be verified for its accuracy. Domain specialists' contribution is very significant in accomplishing this necessity. Unfortunately, non-computing domain specialists (i.e. medical doctors, bankers, lawyers) are illiterate on semantic concepts. Therefore, validating the accuracy of the ontology increment is a complex hurdle for them. This research proposes verbalization approach to address this complexity.

The OAuth 2.0 Web Authorization Protocol for the Internet Addiction Bioinformatics (IABio) Database

  • Choi, Jeongseok;Kim, Jaekwon;Lee, Dong Kyun;Jang, Kwang Soo;Kim, Dai-Jin;Choi, In Young
    • Genomics & Informatics
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    • v.14 no.1
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    • pp.20-28
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    • 2016
  • Internet addiction (IA) has become a widespread and problematic phenomenon as smart devices pervade society. Moreover, internet gaming disorder leads to increases in social expenditures for both individuals and nations alike. Although the prevention and treatment of IA are getting more important, the diagnosis of IA remains problematic. Understanding the neurobiological mechanism of behavioral addictions is essential for the development of specific and effective treatments. Although there are many databases related to other addictions, a database for IA has not been developed yet. In addition, bioinformatics databases, especially genetic databases, require a high level of security and should be designed based on medical information standards. In this respect, our study proposes the OAuth standard protocol for database access authorization. The proposed IA Bioinformatics (IABio) database system is based on internet user authentication, which is a guideline for medical information standards, and uses OAuth 2.0 for access control technology. This study designed and developed the system requirements and configuration. The OAuth 2.0 protocol is expected to establish the security of personal medical information and be applied to genomic research on IA.

Applying Traditional Korean Medical Terms to SUI in the Unified Medical Language System(UMLS) Metathesaurus

  • Hong, Seong-Cheon;Jeong, Heon-Young;Jeon, Byong-Uk
    • Journal of the Korean Institute of Oriental Medical Informatics
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    • v.16 no.1
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    • pp.1-8
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    • 2010
  • Objective: Various controlled vocabulary such as thesaurus and classification make us to reuse and share effectively by defining different concept and linking terms each other. The UMLS(Unified Medical Language System) is one of the most universal medical terminology systems. It is needed various methods to share and reuse information of traditional Korean medicine. We will research on method that adopt SUI of the UMLS(that is de facto standard in medical terminology system) in traditional Korean medical terminology. Method: We described major problems and applying process when we tried to add traditional Korean medicine in the part of meridian into the UMLS metathesaurus. Comparing western medical terms and traditional Korean medical terms for applying UMLS metathesaurus, there is not only many consistency, but also differences. Result: We confirmed what is the differences and consistency between western medical terms and traditional Korean medical terms. And then reviewed methods that apply the CUI, LUI, SUI in traditional Korean medical terms. Traditional Korean medical terms are not discriminated by singular or plural string. In addition, traditional Korean medical terms have vary string by initial law: the law of initial sound of a syllable. Character is described with Korean, traditional Chinese, modern Chinese, etc. According to meaning, language, initial law, SUI has a distinct value respectively. Conclusion: There are many differences to apply the UMLS between western medical terms and traditional Korean medical terms. For the better implementation to traditional Korean medicine into the UMLS, further research is needed in standardization and classification of traditional Korean medical terms, medical information system, etc. We hope this study helps the implementation UMLS, EHR, knowledge based system in Oriental medicine in the future.

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Antimicrobial Properties of Glass Surface Functionalized with Silver-doped Terminal-alkynyl Monolayers

  • Tahir, Muhammad Nazir;Jeong, Daham;Kim, Hwanhee;Yu, Jae-Hyuk;Cho, Eunae;Jung, Seunho
    • Bulletin of the Korean Chemical Society
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    • v.35 no.1
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    • pp.39-44
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    • 2014
  • Glass discs functionalized with alkynyl (GDA) terminated monolayers were prepared and incubated in $AgNO_3$ solution (GDA-Ag). The modified functional glass surfaces were characterized by X-ray photoelectron microscopy (XPS). The potential of GDA and GDA-Ag as antimicrobial surfaces was investigated. Anti-microbial efficacies of GDA against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, and Candida albicans was relatively low ranging from 4.67 to 17.00%. However, the GDA-Ag was very effective and its antimicrobial efficacy ranged from 99.90 to 99.99% against the same set of microbial strains except for C. albicans where it was 95.50%. The durability of the Ag bonded to the terminal alkynyl groups was studied by placing the GDA-Ag in PBS buffer solution (pH 7.4) for two weeks. Initially, the silver release was relatively fast, with 40.05 ppb of silver released in first 24 h followed by a very slow and constant release. To study the potential of GDA-Ag for medical applications, in vitro cytotoxicity of GDA-Ag against Human Embryonic Kidney 293 (HEK293) cell lines was studied using WST-assay. The cytotoxicity of the GDA-Ag was very low (5%) and was almost comparable to the control (blank glass disc) indicating that GDA-Ag has a promising potential for medical applications.