• Title/Summary/Keyword: Medical

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A 40 Kb Genomic Deletion Including tmie (Transmembrane Inner Ear Protein) Gene Causes Deafness, Circling and Head Tossing in Circling Mice

  • Kyoung In Cho;Jeong Woong Lee;Eun Ju Lee;Sol Ha Hwang;Myoung Ok Kim;Sung Hyun Kim;Jun Hong Park;Boo Kyoung Jung;Hee Chul Kim
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.226-226
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    • 2004

  • Circling (cir) mouse is a spontaneous mutant in the inner ear that was first reported in Korea. The mutation is transmitted by an autosomal recessive gene with 100 %- penetrance.. Homozygous mice are characterized by head-tossing, bi-directional circling behavior and deafness. Histologicalexamination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. (omitted)

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A Study of the History of Medical Administration in Ming(明) Dynasty (명대(明代) 의정사(醫政史)에 관한 연구)

  • Kim, Ki-Wook;Park, Hyun-Kuk;Kim, Jeong-Ho
    • Journal of Korean Medical classics
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    • v.20 no.2
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    • pp.201-230
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    • 2007

  • Basic summary of the medical administration : First of all Ming dynasty was at its last stage of dynastic era that the politics reached absolute autocracy. The influence of centralized power lead to systematical medical administration management system that was generally formed around Tai Yi Yuan(太醫院). Criticizing treatments via shamanism with supernatural powers and advent of strengthening medical concepts were steps toward a new phase. Medical education in regional areas showed drastic development and preventative medicine on epidemics as well as relief work succeeded to a certain amount. Overall Ming(明) dynasty has somewhat of a growth in some areas keeping the basics of Tang(唐) Song(宋) and Yuan(元)'s medical administration, however basically, unique contribution was not shown much. But on the other hand, measures such as common medical system, reserving incompetent doctors, positioning medical officers by the amount of contributions, paying salary with medicine instead of currency brought losses on medical development.

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Identification of the DNA Binding Element of the Human ZNF333 Protein

  • Jing, Zhe;Liu, Yaping;Dong, Min;Hu, Shaoyi;Huang, Shangzhi
    • BMB Reports
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    • v.37 no.6
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    • pp.663-670
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    • 2004

  • ZNF 333 is a new and sole gene containing two KRAB domains which has been identified currently. It is a member of subfamilies of zinc finger gene complex which had been localized on chromosome 19p13.1. The ZNF333 gene mainly encodes a 75.5 kDa protein which contains 10 zinc finger domains. Using the methods of random oligonucleotide selection assay, electromobility gel shift assay and luciferase activity assay, we found that ZNF333 recognized the specific DNA core binding sequence ATAAT. Moreover, these data indicated that the KRAB domain of ZNF333 really has the ability of transcriptional repression.

  • https://doi.org/10.5483/BMBRep.2004.37.6.663 인용 PDF