• 한국해양학회지:바다
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• 제18권1호
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• pp.21-31
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• 2013

생태모델은 생태계 구성 요소간의 관계를 수치적으로 표현하여 생태계 내에 존재하는 다양한 요인들의 시간에 따른 내재적 변동과 외부 조건의 변화에 따른 반응을 예측하는데 유용한 도구다. 해양 생태모델은 학제간 공동 연구결과를 토대로, 보다 체계적이고 종합적인 접근 방법을 통해, 최근 수 십 년 동안 많은 발전을 이룩하였다. 이 글은 해양 생태모델의 이론적 배경을 살피고, 모델 수립 시 고려해야 할 사항 및 최근 동향에 대하여 소개한다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.218-219
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• 2002

In the past, the development of pharmacokinetic/pharmacodynamic (PK/PD) models for quantitating the time course of drug responses was mainly based on two types of models, the empirical effect compartment model that simply accounts for the delay between effect and plasma concentration (hysteresis) and the mechanism-based so-called indirect response model. The first approach traces back to a paper by Segre (1) and its application was popularized by Holford and Sheiner (2); indirect response models were introduced by Jusko's group (3). (omitted)

• Bulletin of the Korean Chemical Society
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• 제19권3호
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• pp.324-327
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• 1998

The mechanisms of Cu2+ adsorption onto goethite, hematite and kaolinite are different. Goethite and hematite showed a similar adsorption behavior (ionic-strength independent), but kaolinite gave somewhat different result (ionic-strength dependent). These experimenal results were successfully simulated using a surface complexation model, TLM, which defines the inner- or outer-sphere complex. The chemical nature of Cu2+ adsorption onto kaolinite was qualitatively identified by EPR spectroscopy.

• Journal of Microbiology and Biotechnology
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• 제16권9호
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• pp.1331-1337
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• 2006

A mathematical model has been proposed for the batch culture of Agaricus blazei with mixed carbon sources of glucose and dextrin. In the proposed model, the metabolism of A. blazei was divided into three parts: cell growth, exopolysaccharides (EPS) production, and another EPS production pathway activated by dextrin hydrolysis. Each pathway was described mathematically and incorporated into the mechanistic model structure. Batch cultures were carried out with six different carbon source compositions. Although parameters were estimated by using the experimental data from the two extreme cases such as glucose only and dextrin only, the model represented well the profiles of glucose, cell mass, and EPS concentrations for all the six different carbon source mixtures, showing a good interpolation capability. Of note, the lag in EPS production could be quite precisely predicted by assuming that the glucose-to-cell mass ratio was the governing factor for EPS production.

• Nuclear Engineering and Technology
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• 제37권3호
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• pp.265-272
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• 2005

Severe accidents in nuclear power plants can cause hydrogen-generating chemical reactions, which create the danger of hydrogen combustion and thus threaten containment integrity. For containment analyses, a three-dimensional mechanistic code, GOTHIC-3D has been applied near source compartments to predict whether or not highly reactive gas mixtures can form during an accident with the hydrogen mitigation system working. To assess the code applicability to hydrogen combustion analysis, this paper presents the numerical calculation results of GOTHIC-3D for various hydrogen combustion experiments, including FLAME, LSVCTF, and SNU-2D. In this study, a technical base for the modeling oflarge- and small-scale facilities was introduced through sensitivity studies on cell size and bum modeling parameters. Use of a turbulent bum option of the eddy dissipation concept enabled scale-free applications. Lowering the bum parameter values for the flame thickness and the bum temperature limit resulted in a larger flame velocity. When applied to hydrogen combustion analysis, this study revealed that the GOTHIC-3D code is generally able to predict the combustion phenomena with its default bum modeling parameters for large-scale facilities. However, the code needs further modifications of its bum modeling parameters to be applied to either small-scale facilities or extremely fast transients.

• Nuclear Engineering and Technology
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• 제56권3호
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• pp.846-854
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• 2024

FEMAXI-ATF is being developed for fuel performance modeling of SiC cladded UO2 fuel with focuses on modeling pellet-cladding mechanical interactions (PCMI). The code considers probability distributions of mechanical strengths of monolithic SiC (mSiC) and SiC fiber reinforced SiC matrix composite (SiC/SiC), while it models pseudo-ductility of SiC/SiC and propagation of cladding failures across the wall thickness direction in deterministic manner without explicitly modeling cracks based on finite element method in one-dimensional geometry. Some hypothetical BWR power ramp conditions were used to test sensitivities of different model parameters on the analyzed PCMI behavior. The results showed that propagation of the cladding failure could be modeled by appropriately reducing modulus of elasticities of the failed wall element, so that the mechanical load of the failed element could be re-distributed to other intact elements. The probability threshold for determination of the wall element failure did not have large influence on the predicted power at failure when the threshold was varied between 25 % and 75 %. The current study is still limited with respect to mechanistic modeling of SiC failure as it only models the propagation of the cladding wall element failure across the homogeneous continuum wall without considering generations and propagations of cracks.

• Structural Engineering and Mechanics
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• 제7권2호
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• pp.225-240
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• 1999

This paper presents a mechanistic approach to uniaxial viscoelastic constitutive modeling of asphalt concrete that accounts for damage evolution under cyclic loading conditions. An elasticviscoelastic correspondence principle in terms of pseudo variables is applied to separately evaluate viscoelasticity and time-dependent damage growth in asphalt concrete. The time-dependent damage growth in asphalt concrete is modeled by using a damage parameter based on a generalization of microcrack growth law. Internal state variables that describe the hysteretic behavior of asphalt concrete are determined. A constitutive equation in terms of stress and pseudo strain is first established for controlled-strain mode and then transformed to a controlled-stress constitutive equation by simply replacing physical stress and pseudo strain with pseudo stress and physical strain. Tensile uniaxial fatigue tests are performed under the controlled-strain mode to determine model parameters. The constitutive equations in terms of pseudo strain and pseudo stress satisfactorily predict the constitutive behavior of asphalt concrete all the way up to failure under controlled-strain and -stress modes, respectively.

• Bulletin of the Korean Chemical Society
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• 제9권1호
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• pp.44-48
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• 1988

The feasibility of the reduction of nortricyclanone (1) as a chemical probe for testing the proposed radical mechanism for NAD-dependent horse liver alcohol dehydrogenase (HLADH) reactions has been examined using computer graphics modeling. The resutls of this study suggest that the radical ring-opening of this probe molecule may involve too substantial a geometry reorganization for the molecule to serve as a chemical probe in detecting the possible presence of the radical intermediates in the HLADH reactions. This result suggests that one should exercise caution in extrapolating results obtained from chemically based radical probes in the solution phase to the topologically constrained systems such as enzyme-substrate reactions.

• 대한기계학회논문집A
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• 제20권3호
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• pp.765-774
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• 1996

Computer Integrated Manufacturing(CIM) requires models of manufacturing processes to be implemented on the computer. These models are typically used for determining optimal process control parameters or designing adaptive control systems. In spite of the progress made in the mechanistic modeling, however, empirical models derived from experimental data play a maior role in manufacturing process modeling. This paper describes the development of a meural metwork medel for injection molding. This paper describes the development of a nueral network model for injection molding process. The model uses the CAE analysis data based on Taguchi method. The developed model is, then, compared with the traditional polynomial regression model to assess the applicabilit in practice.

• The Korean Journal of Physiology and Pharmacology
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• 제18권3호
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• pp.217-223
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• 2014

Plasma ionized calcium ($Ca^{2+}$) concentrations are tightly regulated in the body and maintained within a narrow range; thus it is challenging to quantify calcium absorption under normal physiologic conditions. This study aimed to develop a mechanistic model for the parathyroid hormone (PTH) response after calcium intake and indirectly compare the difference in oral calcium absorption from PTH responses. PTH and $Ca^{2+}$ concentrations were collected from 24 subjects from a clinical trial performed to evaluate the safety and calcium absorption of Geumjin Thermal Water in comparison with calcium carbonate tablets in healthy subjects. Indirect response models (NONMEM Ver. 7.2.0) were fitted to observed $Ca^{2+}$ and PTH data, respectively, in a manner that absorbed but unobserved $Ca^{2+}$ inhibits the secretion of PTH. Without notable changes in $Ca^{2+}$ levels, PTH responses were modeled and used as a marker for the extent of calcium absorption.