• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 춘계학술발표대회
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• pp.133-136
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• 2000

In recent years, hybrid neural network approaches which combine neural networks and mechanistic models have been gaining considerable interests. These approaches are potentially very efficient to obtain more accurate predictions of process dynamics by combining mechanistic and neural models in such a way that the neural network model properly captures unknown and nonlinear parts of the mechanistic model. In this work, such an approach was applied in the modeling of a full-scale coke wastewater treatment process. First, a simplified mechanistic model was developed based on the Activated Sludge Model No.1 and the specific process knowledge, Then neural network was incorporated with the mechanistic model to compensate the errors between the mechanistic model and the process data. Simulation and actual process data showed that the hybrid modeling approach could predict accurate process dynamics of industrial wastewater treatment plant. The promising results indicated that the hybrid modeling approach could be a useful tool for accurate and cost-effective modeling of biochemical processes.

• Nuclear Engineering and Technology
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• 제44권8호
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• pp.889-896
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• 2012

Recent progress in the computational fluid dynamics methods of two- and multiphase phase flows has already started opening up new exciting possibilities for using complete multidimensional models to simulate boiling systems. Combining this new theoretical and computational approach with novel experimental methods should dramatically improve both our understanding of the physics of boiling and the predictive capabilities of models at various scale levels. However, for the multidimensional modeling framework to become an effective predictive tool, it must be complemented with accurate mechanistic closure laws of local boiling mechanisms. Boiling heat transfer has been studied quite extensively before. However, it turns out that the prevailing approach to the analysis of experimental data for both pool boiling and forced-convection boiling has been associated with formulating correlations which normally included several adjustable coefficients rather than based on first principle models of the underlying physical phenomena. One reason for this has been the tendency (driven by practical applications and industrial needs) to formulate single expressions which encompass a broad range of conditions and fluids. This, in turn, makes it difficult to identify various specific factors which can be independently modeled for different situations. The objective of this paper is to present a mechanistic modeling concept for both pool boiling and forced-convection boiling. The proposed approach is based on theoretical first-principle concepts, and uses a minimal number of coefficients which require calibration against experimental data. The proposed models have been validated against experimental data for water and parametrically tested. Model predictions are shown for a broad range of conditions.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 제3회 추계심포지움
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• pp.135-136
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• 1995

Resent advances in computer technology have introduced a sophisticated capability for computing the biological fate of toxicants in a biological system. This methodology, which has drastically altered risk assessment skill in toxicology, is designed using all the mechanistic information, and all claim better accuracy with extrapolating capability Iron animal to people than conventional pharmacokinetic methods. Biologically based mathematical models in which the specific mechanistic steps governing tissue disposition(pharmacokinetics) and toxic action (pharmacodynamics) of chemicals are constructed in quantitative terms by a set of equations loading to prediction of the outcome of specific toxicological experiments by computer simulation. pharmacokinetic and pharmacodynamic models are useful in risk assessment because their mechanistic biological basis permits the high-to-low dose, route to route and interspecies extrapolation of the tissue disposition and toxic action of chemicals.

• 한국농공학회논문집
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• 제64권5호
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• pp.27-39
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• 2022

The smart farm is recognized as a solution for future farmers having positive effects on the sustainability of the poultry industry. Intelligent microclimate control can be a key technology for broiler production which is extremely vulnerable to abnormal indoor air temperatures. Furthermore, better control of indoor microclimate can be achieved by accurate prediction of indoor air temperature. This study developed predictive models for internal air temperature in a mechanically-ventilated broiler house based on the data measured during three rearing periods, which were different in seasonal climate and ventilation operation. Three machine learning models and a mechanistic model based on thermal energy balance were used for the prediction. The results indicated that the all models gave good predictions for 1-minute future air temperature showing the coefficient of determination greater than 0.99 and the root-mean-square-error smaller than 0.306℃. However, for 1-hour future air temperature, only the mechanistic model showed good accuracy with the coefficient of determination of 0.934 and the root-mean-square-error of 0.841℃. Since the mechanistic model was based on the mathematical descriptions of the heat transfer processes that occurred in the broiler house, it showed better prediction performances compared to the black-box machine learning models. Therefore, it was proven to be useful for intelligent microclimate control which would be developed in future studies.

• Journal of Veterinary Science
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• 제24권2호
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• pp.21.1-21.5
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• 2023

Under the current African swine fever (ASF) epidemic situation, a science-based ASF-control strategy is required. An ASF transmission mechanistic model can be used to understand the disease transmission dynamics among susceptible epidemiological units and evaluate the effectiveness of an ASF-control strategy by simulating disease spread results with different control options. The force of infection, which is the probability that a susceptible epidemiological unit becomes infected, could be estimated by applying an ASF transmission mechanistic model. The government needs to plan an ASF-control strategy based on an ASF transmission mechanistic model.

• Nuclear Engineering and Technology
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• 제53권2호
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• pp.439-445
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• 2021

In view of the complex geometric structure of the rod bundle channel and the limitation of the current CHF visualization experiment technology, it is very difficult to obtain the rod bundle CHF mechanism directly through the phenomenon of the rod bundle CHF visualization experiment. In order to obtain the applicable CHF mechanism assumption for rod bundle channel, firstly, five most representative DNB type round tube CHF mechanistic models are obtained with evaluation and screening. Then these original round tube CHF mechanistic models based on inlet conditions are converted to local conditions and coupled with subchannel analysis code ATHAS. Based on 5 × 5 full-length rod bundle CHF experimental data independently developed by Nuclear Power Institute of China (NPIC), the applicability research of each model for CHF prediction performance in rod bundle channel is carried out, and the commonness and difference of each model are comparatively studied. The CHF mechanism assumption of superheated liquid layer depletion that is most likely to be applicable for the rod bundle channel is selected and two directions that need to be improved are given. This study provides a reference for the development of CHF mechanistic model in rod bundle channel.

• 한국과학교육학회지
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• 제38권5호
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• pp.599-610
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• 2018

이 연구의 목적은 파브르의 탐구 과정에서 나타난 메커니즘 추론을 분석하고, 분석 결과에 기반하여 메커니즘 추론 모델을 개발하는 것이다. 이를 위해 Russ et al.(2008)의 분석틀을 수정 보완한 메커니즘 추론 분석틀로 "파브르 곤충기 1~10" 가운데 추론요소가 등장하는 30개의 챕터를 분석하였다. 분석결과 첫째, 파브르의 탐구 과정에서 나타난 메커니즘 추론의 하위 과정 요소는 선지식확인, 대상속성확인, 시작조건확인, 활동확인 등의 과정이 반복적으로 일어났다. 뿐만 아니라 이 메커니즘 추론의 과정 요소들의 순서는 탐구 주제, 의문 유형, 선지식이나 주어진 상황 등에 따라 다르게 나타났으며, 비선형적이고 반복적인 형태로 나타났다. 둘째, 메커니즘 추론의 과정 요소가 나타난 순서에 기반하여 메커니즘 추론 모델을 개발하였다. 파브르의 탐구 과정 분석을 통해 제안되는 메커니즘 추론 모델은 실체확인형 메커니즘 추론 모델(MIE), 활동확인형 메커니즘 추론 모델(MIA), 실체 속성확인형 메커니즘 추론 모델(MIP) 3가지였다. 이러한 결과는 인과 메커니즘을 밝히고자 하는 탐구를 수행하는 학생들에게 교사가 Why 뿐만 아니라 How, If, What과 같은 다양한 발문을 통해 탐구를 진행하도록 유도할 수 있음을 시사해준다. 또한 교사는 자연 현상의 기저에 존재하는 여러 실체들을 인식하는 메커니즘적 이해가 요구되며 학생들에게 다양한 가설을 생성하도록 하는 기회를 제공해야함을 시사해 준다.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1997년도 추계학술발표회논문집(1)
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• pp.552-557
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• 1997

Based on the bubble coalescence adjacent to the heated wall as a flow structure for CHF condition, Chang and Lee developed a mechanistic critical heat flux (CHF) model for subcooled flow boiling. In this paper, improvements of Chang-Lee model are implemented with more solid theoretical bases for subcooled and low-quality flow boiling in tubes. Nedderman-Shearer's equations for the skin friction factor and universal velocity profile models are employed. Slip effect of movable bubbly layer is implemented to improve the predictability of low mass flow. Also, mechanistic subcooled flow boiling model is used to predict the flow quality and void fraction. The performance of the present model is verified using the KAIST CHF database of water in uniformly heated tubes. It is found that the present model can give a satisfactory agreement with experimental data within less than 9% RMS error.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1999년도 추계학술발표회요약집
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• pp.152.2-152
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• 1999

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.218-219
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• 2002

In the past, the development of pharmacokinetic/pharmacodynamic (PK/PD) models for quantitating the time course of drug responses was mainly based on two types of models, the empirical effect compartment model that simply accounts for the delay between effect and plasma concentration (hysteresis) and the mechanism-based so-called indirect response model. The first approach traces back to a paper by Segre (1) and its application was popularized by Holford and Sheiner (2); indirect response models were introduced by Jusko's group (3). (omitted)