• 한국생활과학회지
• /
• 제20권1호
• /
• pp.91-100
• /
• 2011

This study was conducted in order to understand grandmothers' intent of caring for working mothers' children and the influence of related variables with regard to living arrangements. The data was collected from 245 grandmothers who have been caring for their grandchildren for more than 6 months. The data was analyzed by mean, t-test, x2-test, and logistic regression analysis. The results were as follows: first, as to whether the grandmothers were willing to take care of their grandchildren again, 56.5% answered "yes", while 43.5% were not willing to do so. Those who were not living together with their grandchildren were more likely to answer positively. Second, it was found upon analysis that the significant variables of the experience differed according to grandmothers' residential status. In the case of co-residing grandmothers, the significant variables were the number and age of the grandchildren, their relationship, satisfaction, and feeling of burden, while only satisfaction was significant in non-co-residing grandmothers' cases. This implies that the more satisfaction the non-co-residing grandmothers experience, the more likely they are willing to take care of their grandchildren again. As for the co-residing grandmothers, it implies that the characteristics of the grandchildren, satisfaction, and feeling of burden, all influence their caregiving intent for the next time.

• Journal of Pharmaceutical Investigation
• /
• 제29권1호
• /
• pp.21-27
• /
• 1999

Semi-solid poly(ortho esters) (POE) were prepared to provide bioerodible carriers for sustained drug delivery systems of naloxone (NLX) in the treatment of narcotic addiction. As the POE have viscous behavior at room temperature, a significant advantage of this polymer is that it can be injected without any surgical intervention. The POE was synthesized by a transesterification reaction between 1,2,6-hexanetriol and trimethyl orthoacetate, and the structure of the polymer was confirmed by IR. The in vitro release of the drug from POE was studied. The release rate of NLX decreased with increasing intrinsic viscosities of the polymer. In vivo biocompatibility studies were carried out in rats with NLX loaded POE. Histopathological analysis showed that NLX implants are well-tolerated by rats when used subcutaneously. Pharmacokinetic studies of POE-NLX implants of two different viscosities were carried out in rabbits. In all cases, plasma concentrations of NLX were maintained over 1 ng/ml for at least 168 hours, but initial burst effect was observed. Mean residence time(MRT) was found to depend on the viscosity of the polymer.

• Journal of Pharmaceutical Investigation
• /
• 제29권2호
• /
• pp.93-98
• /
• 1999

Semi-solid poly(ortho esters) (POE) were prepared to provide bioerodible carriers for sustained drug delivery systems of nifedipine in the treatment of cardiovascular disease. As the POE has viscous behavior at room temperature, a significant advantage of this polymer is that it can be injected without any surgical intervention. The POE was synthesized by a transesterification reaction between 1,2,6-hexanetriol and trimethyl orthoacetate and the nifedipine release from POE was studied in vitro. The release rate of nifedipine decreased with increasing the amount of nifedipine and the diethanolamine dispersed in the polymer. But the excess amounts, above 3%, of diethanolamine retarded the release of nifedipine. In vivo biocompatibility studies were carried out in rats with nifedipine loaded POE. Histopathological analysis showed that nifedipine loaded POE implants were well-tolerated by rats when used subcutaneously. In case of the rats implanted POE containing diethanolamine, tissue necrosis and inflammation were occured. Pharmacokinetic studies of nifedipine loaded POE implants were carried out in rabbits. In all cases, plasma concentrations of nifedipine were maintained over 15 ng/ml for at least 360 hours and biological half $life(t_{1/2})$ and mean residence time(MRT) were increased by addition of diethanolamine.

• Biotechnology and Bioprocess Engineering:BBE
• /
• 제7권6호
• /
• pp.357-361
• /
• 2002

Continuous production of lactic acid from glucose by Lactobacillus rhamnosus with cell recycling using an acoustic cell settler was carried out. The performance of the system, such as the concentration of cell and product were compared with the control experiment without recycling. The acoustic settler showed cell separation efficiency of 67% during the continuous operation and the cell concentration in the fermentor with recycle exceeded that of the control by 29%. Com-pared with the control, tactic acid production was increased by 40%, while glucose consumption was only increased by 8%. The higher value of lactic acid production to substrate consumption (Yp/s, product yield coefficient) achieved by cell recycling is interpreted to indicate that the recycled cell mass consumes less substrate to produce the same amount of product than the control Within system environmental changes due to the longer mean cell residence time induced the cells maintaining the metabolic pathways to produce Less by-Product but more product, lactic acid.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권9호
• /
• pp.5043-5047
• /
• 2013

Background: This is a part of a larger effort to characterize the effects on socio-economic factors (SEFs) on cancer outcome. Surveillance, Epidemiology and End Result (SEER) bone and joint sarcoma (BJS) data were used to identify potential disparities in cause specific survival (CSS). Materials and Methods: This study analyzed SEFs in conjunction with biologic and treatment factors. Absolute BJS specific risks were calculated and the areas under the receiver operating characteristic (ROC) curve were computed for predictors. Actuarial survival analysis was performed with Kaplan-Meier method. Kolmogorov-Smirnov's 2-sample test was used to for comparing two survival curves. Cox proportional hazard model was used for multivariate analysis. Results: There were 13501 patients diagnosed BJS from 1973 to 2009. The mean follow up time (SD) was 75.6 (90.1) months. Staging was the highest predictive factor of outcome (ROC area of 0.68). SEER stage, histology, primary site and sex were highly significant pre-treatment predictors of CSS. Under multivariate analysis, patients living in low income neighborhoods and rural areas had a 2% and 5% disadvantage in cause specific survival respectively. Conclusions: This study has found 2-5% decrement of CSS of BJS due to SEFs. These data may be used to generate testable hypothesis for future clinical trials to eliminate BJS outcome disparities.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2000년도 춘계학술대회논문집B
• /
• pp.404-409
• /
• 2000

Growth characteristics of silica particles have been studied experimentally using in situ sampling technique from $H_2/O_2TEOS$ diffusion flame with carefully devised sampling probe. Verification of sampling result was done through new method and effects of flame condition and TEOS flow rate on growth characteristics of silica particles were investigated. By comparing particles sampled by thermophoretic sampling in flame with those by collector sampling after probe, particles do not change before and after probe sampling, which was clearly proved from the fact that the result of TEM image analysis makes good agreement with that of SMPS measurement. As flame temperature increases, the effect of coalescence or sintering becomes important mechanism during growth of silica particles, resulting in canceling the effect of coagulation, which makes mean diameter of silica particles increase slowly. With increase in TEOS flow rate, the number concentration of generated silica particle increases but residence time of particles in flame decreases. As a result, there exists upper limit to which the diameter of silica particle increases under same flame condition.

• Biomolecules & Therapeutics
• /
• 제8권2호
• /
• pp.171-178
• /
• 2000

To evaluate the pharmacokinetic properties and tissue distribution of a newly developed recombinant human erythropoietin (GC-rhEPO), we analyzed the plasma and tissue levels of erythropoietin by an ELISA after intravenous (IV) and subcutaneous (SC) adminstration to the male rats at the doses of 20, 100, 500 or 2,500 unit/kg. After single IV bolus injection of GC-rhEPO, the plasma concentration was rapidly increased and decreased with two phases with half-lives of 13.4 min and 2.94 hours. AUC was increased dose- dependently but plasma half-lives remained constant regardless of GC-rhEPO doses. Following SC administration, the plasma concentration increased slowly with half-life of 9.2 hours and reached peak at 8 hours. Mean residence time and bioavailability were 18.2 hours and 44%, respectively. After single IV dose of 100 unit/kg, tissue GC-rhEPO level was higher in bone marrow and spleen, while the depletion rate was slower in liver and bone marrow, indicating the higher affinity of GC-rhEPO to bone marrow. Taken together, the experimental results indicate that GC-rhEPO contained the typical pharmacokinetic properties and the tissue distribution patterns inherent to human erythropoietin.

• 물과 미래
• /
• 제22권1호
• /
• pp.117-125
• /
• 1989

본 연구는 활성슬러지공법을 변형시킨 무산소일염기일호기반응조를 사용해서 질산화일탈질소반응 및 인의 방출인초과축적반응을 유도하여 합성페수의 유기물, 질소 및 인을 동시에 제거하였다. 무질소조, 무염기 및 호기호 각각에 대한 반응특성을 조사하기 위해 실험실규모의 반응조가 운영되었으며 MLSS농도를 5000, 4200, 3300, 2600, 1900mg/l로, 변화시켜 COD제거율에 대한 생물학적 동력학계수를 결정하였다. 연구결과, 유기물 및 영양염이 변형된 슬러지공법에 의해 동시에 제거될 수 있음을 알았고, ortho-p 제거효율은 66%∼99%로 높게 나타났다.

• Journal of Biosystems Engineering
• /
• 제37권2호
• /
• pp.82-89
• /
• 2012

Purpose: The simulation model of a pneumatic conveying drying (PCD) for sawdust was developed and verified with the experiments. Method: The thermal behavior and mass transfer of a PCD were modeled and investigated by comparing the experimental results given by a reference (Kamei et al. 1952) to validate the model. Momentum, energy and mass balance, one dimensional first order ordinary differential equations, were coded and solved into Matlab V. 7.1.0 (2009). Results: The simulation results showed that the moisture content reduced from 194% to 40% (dry basis), air temperature decreased from $512^{\circ}C$ to $128^{\circ}C$ with the particle residence time of 0.7 seconds. The statistical indicators, root mean square error and R-squared, were calculated to be 0.079, and 0.998, respectively, between the measured and predicted values of moisture content. The relative error between the measured and predicted values of the final pressured drop, air temperature, and air velocity were only 8.96%, 0.39% and 1.05% respectively. Conclusions: The predicted moisture content, final temperature, and pressure drop values were in good agreement with the experimental results. The developed model can be used for design and estimation of PCD system for drying of wood dust particles.

• 대한기계학회논문집
• /
• 제19권9호
• /
• pp.2342-2352
• /
• 1995

Deposition of flame-synthesized silica particles onto a target is utilized in optical fiber preform fabrication processes. The particles are convected and deposited onto the target. Falkner-Skan wedge flow was chosen as the particle laden flow. Typically the particles are polydisperse in size and follow a lognormal size distribution. Brownian diffusion, thermophoresis, and coagulation of the particles were considered and effects of these phenomena on particle deposition were studied. A moment model was developed in order to predict the particle number density and the particle size distribution simultaneously. Particle deposition with various wedge configurations was examined for conditions selected for a typical VAD process. When coagulation was considered, mean particle size and its standard deviation increased and particle number density decreased, compared to the case without coagulation. These results proved the fact that coagulation effect expands particle size distribution. The results were discussed with characteristics of thermal and diffusion boundary layers. As the boundary layers grow in thickness, overall temperature and concentration gradients decrease, resulting in decrease of deposition rate and increase of particle residence time in the flow and thus coagulation effect.