• 약학회지
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• 제57권2호
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• pp.125-131
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• 2013

Biologically active peptides, including growth factors and cytokines, participate in various biological processes in human skin. They could provide a great advantage of maintaining healthy skin. Many peptide growth factors like epidermal growth factor (EGF) and human growth hormone (hGH) have been used in cosmetic formulations. The delivery of peptide growth factors across the Stratum corneum, however, seems not sufficient because of their physical properties such as high molecular weight and hydrophilicity. So increasing the penetration of growth factors of interest into skin would be a major concern for ensuring their maximum biological efficacy. In this study, we have identified several skin penetration-enhancing peptides which facilitate delivery of growth factors, when fused at N-terminus of the target protein, into skin. For efficient and rapid screening, we constructed a skin-penetrating assay system using Franz cell and porcine skin. Next, we carried out phage display screening using M-13 bacteriophage with random 12 -amino acid library on its coat protein P3 on that system. After several selection rounds, peptide sequences facilitate the penetration of phages through the porcine skin were identified from a large population of phages. We found that phages with the most potent peptide (S3-2, NGSLNTHLAPIL) could penetrate the porcine skin eight times more than those with control peptide (12 mino acids scrambled peptide). Furthermore, growth factors conjugated with S3-2 peptide penetrate porcine skin three to five times efficiently than non-conjugated growth factors. In conclusion, our data shows that the skin penetration-enhancing peptide we have characterized could increase the delivery of growth factors and is useful for cosmeceutical application.

• Journal of Electrical Engineering and Technology
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• 제12권4호
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• pp.1397-1405
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• 2017

As the introduction of wind power is steadily increasing, negative effects of wind power become more important. To operate a power system more reliable, the system operator needs to recognize the maximum required capacity of available generators for a certain period. For recognizing the maximum capacity, this paper proposes a methodology to determine an optimal reserve requirement considering wind power, for the certain period in the mid-term perspective. As wind speed is predicted earlier, the difference of the forecasted and the actual wind speed becomes greater. All possible forecast errors should be considered in determining optimal reserve, and they are represented explicitly by the proposed matrix form in this paper. In addition, impacts of the generator failure are also analyzed using the matrix form. Through three main stages which are the scheduling, contingency and evaluation stages, costs associated with power generation, reserve procurement and the usage, and the reliability cost are calculated. The optimal reserve requirement is determined so as to minimize the sum of these costs based on the cost/reliability analysis. In case study, it is performed to analyze the impact of wind power penetration on the reserve requirement, and how major factors affect it.

• 한국레이저가공학회지
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• 제16권2호
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• pp.1-6
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• 2013

Picosecond lasers are a very effective tool for micromachining metals, especially when high accuracy, high surface roughness and no heat affected zone are required. However, low productivity has been a limit to broadening the spectrum of their industrial applications. Recently it was reported that in the micromachining of copper with a 1064nm picosecond laser, there exist the optimal pulse energy and repetition rate to achieve the maximum volume ablation rate. In this paper, we used a 515nm picosecond laser, which is more efficient for micromachining copper in terms of laser energy absorption, to obtain its optimal pulse energy and repetition rate. Theoretical analysis based on the experimental data on copper ablation showed that using a 515nm picosecond laser instead of a 1064nm picosecond laser is more favorable in that the calculated threshold fluence is 75% lower and optical penetration depth is 50% deeper.

• Geomechanics and Engineering
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• 제2권3호
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• pp.177-190
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• 2010

This paper presents the details of indigenous development of the piezovibrocone and calibration chamber. The developed cone has a cylindrical friction sleeve of $150cm^2$ surface area, capped with a $60^{\circ}$ apex angle conical tip of $15cm^2$ cross sectional area. It has a hydraulic shaker, coupled to the cone penetrometer with a linear displacement unit. The hydraulic shaker can produce cyclic load in different types of wave forms (sine, Hover sine, triangular, rectangular and external wave) at a range of frequency 1-10 Hz with maximum amplitude of 10 cm. The piezovibrocone can be driven at the standard rate of 2 cm/sec using a loading unit of 10 ton capacity. The calibration chamber is of size $2m{\times}2m{\times}2m$. The sides of the chamber and the top as well as the bottom portions are rigid. It has a provision to apply confining pressure (to a maximum value of $4kg/cm^2$) through the flexible rubber membrane inlined with the side walls of the calibration chamber. The preliminary static as well as dynamic cone penetration tests have been done sand in the calibration chamber. From the experimental results, an attempt has been made to classify the soil based on friction ratio ($f_R$) and the cone tip resistance ($q_c$).

• 한국전산구조공학회논문집
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• 제29권2호
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• pp.161-167
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• 2016

이 논문에서는 벽체의 형상(평면벽체, 곡면벽체) 및 벽체에 도입된 긴장력이 충돌저항성능에 미치는 영향을 수치해석적 기법을 사용하여 평가하고자 하였다. 벽체의 곡률 및 긴장력 도입률을 변수로 총 12 케이스의 충돌해석을 수행하였으며, 충돌체로는 상용 민항기엔진의 3차원 상세모델을 사용하였다. 충돌저항성능을 평가하기 위해 관입깊이와 벽체 중앙부 후면의 최대 변위를 비교하였다. 긴장력의 도입에 의해 관입깊이는 약 60~80% 수준으로 감소하는 것으로 나타났으나, 후면 변위는 큰 차이가 나타나지 않았으며, 벽체 형상에 따른 차이는 상대적으로 크지 않은 것으로 나타났다.

• 한국작물학회지
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• 제49권3호
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• pp.155-159
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• 2004

This experiment was carried out to evaluate the microclimate of wheat canopy, growth and yield characteristics of wheat under north-south and east-west row orientation. The variety used in this experiment was "AG South 2000", which was developed in USA. Solar radiation, air temperature, relative humidity, and soil temperature were monitored by data logger from March to May in 2002, The ratio of light penetration to the bottom from the upper canopy was 36.8% in north-south and 21.4% in east-west row orientation. Temporal march of light penetration to the bottom from March to May decreased as wheat developed canopy structure and decreased a little from May as plant were matured. The highest light penetration to the bottom from upper canopy occurred at 13：00 in both north-south and east-west row orientations, respectively which were 36 times in north-south and 27 times in east-west row orientation, respectively. Daily maximum temperature at the bottom of canopy occurred at 14：00 with 29 times in north-south, while 19 times were obtained at 14：00 and 15：00, respectively in east-west row orientation. Relative humidity at the bottom of the canopy in east-west yow orientation showed higher than that of north-south row orientation. Occurrence of daily maximum soil temperature of north-south showed one hour later compared with east-west yow orientation. 1000 grain weight and test weight of north-south row orientation was higher than those of east-west vow orientation. Correlation coefficient between solar radiation of upper canopy and 1000 grain weight showed r=$0.8132^{*}$, and between air temperature of upper canopy and number of spikes per $\textrm{m}^{2}$ and 1000 grain weight showed significant positive correlation with r=$0.8139^{*}$, and r=$0.8293^{*}$, respectively.

• 약학회지
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• 제58권3호
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• pp.171-180
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• 2014

To enhance the in vitro permeation of lovastatin through excised hairless mouse and human cadaver skins, solubility was determined in various hydrophilic and lipophilic vehicles, and the effects of vehicles and penetration enhancers on the skin permeation from solution formulations were investigated. Solubility of lovastatin was highest in N-methyl-2-pyrrolidone (NMP) ($278.2{\pm}10.1$ mg/ml) and dimethyl sulfoxide (DMSO) ($162.2{\pm}9.7$ mg/ml). Among different pure vehicles used, NMP, DMSO, propylene glycol and isopropyl myristate provided some drug permeation ($6.9{\pm}1.1$, $5.9{\pm}1.6$, $3.0{\pm}0.5$ and $2.2{\pm}0.3{\mu}g/cm^2$ at 24 hr, respectively) through hairless mouse skin. The addition of oleic acid, linoleic acid and oleyl alcohol to DMSO showed the maximum permeation at around 5 v/v%, however, capric acid and caprylic acid had no enhancing effect. The increase of enhancer concentrations showed bell-shaped permeation rate, suggesting the presence of optimal concentration in lovastatin penetration. Increasing donor concentration from 10 mg/ml to 80 mg/ml in DMSO and a cosolvent of DMSO, NMP and DGME (3 : 3 : 4 v/v) did not show significant dose dependent permeation in both hairless mouse and human cadaver skins. The maximum lovastatin flux through human cadaver skin was found to be $0.87{\pm}0.46{\mu}g/cm^2$/hr with 5 v/v% linoleic acid and donor dose of 4 mg/0.64 $cm^2$ in the cosolvent. These results suggest that transdermal delivery of lovastatin would be feasible by establishing the optimal concentrations of donor dose and unsaturated fatty acids in appropriate vehicles.

• 한국의학물리학회지:의학물리
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• 제20권2호
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• pp.72-79
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• 2009

I-131은 갑상선에 주로 집적되어 갑상선의 기능을 평가하는데 활용됨은 물론 높은 에너지의 베타선을 방출함으로써 암의 치료에도 널리 사용되고 있는 방사선 핵종이다. 그러나 I-131은 다양한 에너지의 감마선을 방출함으로써 핵의학 영상의 정량화가 어렵다. 특히 고에너지 영역의 감마선에 의한 격벽투과(septal penetration)와 산란선은 핵의학 진단영상에 악 영향을 미치게 된다. 본 연구에서는 격벽투과가 영상에 미치는 영향과 I-131의 산란보정 방법을 몬테카를로 시뮬레이션을 활용하여 알아보고자 하였다. 본 실험을 위하여 임상에서 사용되고 있는 범용성 고에너지 조준기를 장착한 핵의학 영상 기기인 FORTE 시스템(Philips, Netherlands)에 대해 모사하였다. 격벽투과가 영상에 미치는 영향을 알아보기 위하여 고에너지 조준기의 격벽을 두 가지 종류로 모사하여 보았다. 한 종류는 실제로 사용하고 있는 납으로 격벽을 모사하였으며, 다른 한 종류는 높은 에너지의 감마선이 투과할 수 없는 밀도와 원자번호가 아주 높은 임의의 물질로 구성하여 모사하였다. 각 각의 조준기를 통해 물팬텀안의 I-131 선 선원의 영상을 획득한 결과 납 격벽에서 획득한 선 선원의 반치폭 (Full Width at Half with Maximum, FWHM)과 십치폭(Full width at Tenth with Maximum, FWTM)은 각 각 41.2 mm, 206.5 mm였으며, 높은 에너지의 감마선이 투과할 수 없는 임의의 물질로 만든 격벽의 조준기에서는 반치폭과 십치폭이 각 각 27.3 mm, 47.6 mm로 측정되었다. 이는 고에너지의 감마선에 의한 격벽투과가 핵의학 영상의 선예도를 나쁘게 한다는 것을 알 수 있다. 또한 I-131을 이용한 핵의학 영상의 산란보정을 위하여 물 팬텀 속의 점 선원을 모사하고 영상을 획득하였다. 산란보정 방법으로는 삼중광봉우리창(Triple Energy Window method, TEW)을 이용하여 획득 영상 내의 산란선을 유추하는 방법을 사용하였다. 그러나 이러한 방법은 중심에너지 창의 범위에 따라 유추된 산란선의 양에 영향이 있으므로 더 정확한 산란선 유추를 위해 확장된 삼중광봉우리창(Extended Triple energy Window method, ETEW)을 적용, 기존의 방법과 비교하였다. 실험 결과 시뮬레이션의 데이터 분류를 통한 산란선으로만 획득된 점 선원 영상과 TEW와 ETEW 방법을 통해 유추된 산란선 영상결과, ETEW 방법으로 산란선을 유추한 방법이 기존의 TEW 방법보다 더 정확함을 알 수가 있었다. 본 연구는 시뮬레이션을 통한 I-131의 특성을 평가함으로써 I-131을 이용한 동위원소 치료 및 GATE 프로그램 연구의 기초자료로 활용될 수 있을 것으로 기대된다.

• 한국자동차공학회논문집
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• 제9권1호
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• pp.8-19
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• 2001

A number of atomization and droplet breakup models have been developed and used to predict the diesel spray characteristic. Most of these models could not provide reasonable computational result of the diesel spray characteristic because they have only considered the primary breakup. A hybrid model is, therefore, required to develop by considering the primary and secondary breakup of liquid jet. according to this approach, wave breakup(WB) model was used compute the primary breakup of the liquid jet and droplet deformation and breakup(DDB) model was used for the secondary breakup of droplet. Development of hybrid model by using KIVA-II code was performed by comparing with the experimental data of spray tip penetration and SMD from the literature. A hybrid model developed in this study could provide the good agreement with the experimental data of spray tip penetration. The prediction results of SMD were in good agreement between 0.5 and 1.0 ms after the start of injection. Numerical results obtained by the present hybrid model have the good agreement with the experimental data with the breakup time constant in WB model of 30, and DDB model constant Ck of 1.0 when the droplet becomes less than 95% of maximum droplet diameter injected.

• 전기학회논문지
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• 제57권3호
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• pp.369-374
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• 2008

This paper presents the evaluation procedures and the estimation method for the estimation of optimal rebate level for EE(Energy Efficiency) programs. The penetration amount of each appliance is estimated by applying price function to preferred diffusion model resulted from model compatibility test. To estimate the optimal rebate level, two objective functions which express the maximum energy saving and operation benefit are introduced and by multi-objective function which can simultaneously consider two objective functions the optimal rebate level of each appliance is estimated. And then, using the decided rebate level and each penetration amount, the priority order for reasonable investment of each high-efficiency appliance is estimated compared to the results of conventional method. Finally, using a benefit/cost analysis based on California standard practice manual, the economic analysis is implemented for the four perspectives such as participant, ratepayer impact measure, program administrator cost and total resource cost.