• 대한의용생체공학회:의공학회지
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• 제39권3호
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• pp.109-115
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• 2018

Obesity is a worldwide disease caused by the excessive proliferation of adipocytes. Multiple factors, including melatonin and physical loading, are involved in the control of obesity. Melatonin has been shown to induce apoptosis on preadipocytes while physical loading such as fluid shear stress (FSS) affects the proliferation and differentiation of adipocytes. Here, we studied the combined effects of melatonin and FSS on 3T3-L1 preadipocytes. For physical loading, preadipocytes were stimulated with a maximum dynamic fluid shear stress of 1 Pa at 1 Hz for 2 hours with/without melatonin. The experiment conditions were divided into four groups: (1) control, (2) 1 mM melatonin treatment, (3) FSS, and (4) combined 1 mM melatonin and FSS. All groups had a fixed duration time of 2 hours. ERK, p-ERK, COX-2, $C/EBP{\beta}$, $PPAR{\gamma}$, osteopontin, Bax, caspase-3 and caspase-8 proteins were assessed by Western blot analysis. GAPDH was used as a control. Results showed that combined melatonin and FSS treatment activated the ERK/MAPK pathway but not COX-2. Furthermore, combined melatonin and FSS treatment significantly decreased $C/EBP{\beta}$ and $PPAR{\gamma}$ compared to other groups. However, caspase-3 and caspase-8 did not result in significant changes. In summary, combined melatonin and FSS appears to have the potential to inhibit adipogenesis and treat obesity.

• 한국철도학회논문집
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• 제17권6호
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• pp.415-422
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• 2014

철도에서 강화노반은 궤도의 변형에 직접적인 영향을 주는 중요한 노반층이다. 따라서 강화노반재료의 거동에 대한 깊은 이해가 요구된다. 이에 본 연구에서는 철도의 강화노반재료로 사용되는 재료를 대상으로 입도 특성과 시공조건 및 하중조건에 따른 회복탄성계수에 대한 실험적 연구를 대형삼축압축시험으로 수행하였다. 시험 결과 최대입경, 입도분포, 다짐함수비 등이 회복탄성계수로 평가된 재료 성능에 영향을 미치지만 하중 주파수는 큰 영향이 없다는 것을 확인할 수 있었다. 열차 운행 환경에 적합한 시험 결과를 제시하여 향후 강화노반 재료의 해석 등의 유용한 자료로 활용할 수 있을 것으로 판단된다. 또한 제한적이지만 회복탄성계수 예측 모델에 대한 상수값을 제시하여 다양한 하중조건에 따라 회복탄성계수를 적용하도록 하였다.

• Near Infrared Analysis
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• 제1권1호
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• pp.23-26
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• 2000

The objectives of this study were to examine the ability to predict soluble solid and firmness in intact apple based on the visible/near-infrared spectroscopic technique. Two cultivars of apples, Delicious and Gala, were handled, tested and analyzed. Reflectance spectra, Magness-Taylor (MT) Firmness, and soluble solids in apples were measured sequentially. Maximum and minimum diameters, height, and weight of apples were recorded before the MT firmness tests. Apple samples were divided in to a calibration set and a validation set. The method of partial least squares (PLS) analysis was used. a unique set of PLS loading vectors (factors) was development for soluble solid and firmness. The PLS model showed good relationship between predicted and measured soluble solids in intact apples in the wavelength range of 860∼1078 nm. However, the PLS analysis was not good enough to predict the apple firmness.

• Journal of Biosystems Engineering
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• 제24권3호
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• pp.243-252
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• 1999

The damage caused in the processes and distributions after harvesting the fruits and vegetables is attributed to the mechanical factors such as compressive and impact forces. Compression tests of biological materials provide an objective method for determining the apparent modulus of elasticity and mechanical properties which are significant in quality evaluation and control, and them maximum allowable compressive forces for minimizing mechanical damage. This study was performed to determine the mechanical properties of apple and pear, and to investigate effect of specimen shapes on the mechanical properties of them. A computer program was developed for measuring the mechanical properties and analyzing the data obtained from the measurement. Compression tests on the sample were performed with then replications at each treatment and at 25 mm/min loading rate. Mechanical properties of the apple was generally shown the higher value than those of the pear, and it was though that data obtained form the cylindrical specimen removed from the sample was more reliable than from the specimen cut in half.

• Structural Engineering and Mechanics
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• 제58권5호
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• pp.783-797
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• 2016

Exact solutions for stresses, strains, and displacements of a perforated rectangular plate by an arbitrarily located circular hole subjected to both linearly varying in-plane normal stresses on the two opposite edges and in-plane shear stresses are investigated using the Airy stress function. The hoop stress occurring at the edge of the non-central circular hole are computed and plotted. Stress concentration factors (the maximum non-dimensional hoop stresses) depending on the location and size of the non-central circular hole and the loading condition are tabularized.

• Journal of Welding and Joining
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• 제16권4호
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• pp.73-82
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• 1998

This paper is especially concerned with the weldment between support beam and square bar that plays important roles in control box of Expansion Joint as a brdige structure. Fatigue strength ({TEX}$$\sigma$_{ult}${/TEX}) of the weldment is dependent on notch factor ({TEX}$K_{f}${/TEX}) become important factors to predict fatigue life. The fatigue notch sensitivity (η) for metals can be divided into two types ; high and low notch sensitivity. In this work, the Expansion Joint weldment was found to have low notch sensitivity. The maximum strain distribution during static loading is similar to the FEM analysis. Fatigue test of real structure was performed up to {TEX}$10^{6}${/TEX} cycles to be compared with predicted endurance limit.

• 한국생산제조학회지
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• 제5권4호
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• pp.53-62
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• 1996

Recently, ceramic / metal bonded joints have led to inccreasing use of structural materials such as automobile, heat engine in various industries. In this paper, a method to analyze an interface crack under both residual stresses and applied loading was proposed. and some results of boundary element method(BEM) analysis Were presented, Fracture thoughness tests of ceramic/metals bonded joints with an interface crack Were carried out, and the stress intensity factors of these joints Ware analyzed by BEM. Also crack propagtion direction was simulated numerically by using BEM. Crack propagation angle was able to easily determine based on the maximum stress concept. The prediction of fracture strength by the fracture thoughness of the ceramics/metals bonded joints was proposed.

• Architectural research
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• 제24권2호
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• pp.53-61
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• 2022

Irregularities in the structure are crucial factors in screening structural vulnerability under extreme loadings. Numerical analyses were carried out considering wind and seismic loadings for four structures with discrete irregularity: continuous and discontinuous beams with varied story levels, and L-shaped irregular buildings. Structural responses such as maximum displacements, bending moments, axial forces, torsions, and story drifts are evaluated as per the criteria and limits defined by ACI 318. The outcomes indicate that the frame system with beam discontinuity on the upper half of the height exhibits the best structural performance. The results also indicate that the asymmetrical design of the L-shaped model makes it more susceptible to damage when subjected to strong lateral loading conditions.

• 대한설비공학회지:설비저널
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• 제14권1호
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• pp.31-38
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• 1985

By using the hollow shaft with $0.5^{\circ}$ internal taper, ball valve and rubber packing, charging the working fluid at engineering vacuum degree (vacuum pressure higher than 1 torr) and carrying out experiments, it was investigated the performance of rotating heat pipe with variant operating conditions. In this experiment, it was shown that it is impossible the internal liquid flow was laminar film flow which agree with the assumption of present theoretical analyses, but the internal vorticity makes the heat transfer increase and for the maximum heat transfer there is optimal mass loading for the given heat pipe geometry and operational conditions.

• 상하수도학회지
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• 제10권4호
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• pp.119-126
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• 1996

Influence factors and efficiency characteristics for treatment of wastewater containing phenol were studied with using Pseudomonas sp. B3. It took 130 hours to remove phenol, when only activated sludge of terminal disposal palnt of sewage was innoculated in batch culture, but it was required just 36 hours, when bacteria degrading phenol and activated sludge were simultaneously innoculated. If only phenol an carbon source was used, it necessary 36 hours for biodegradation of phenol, while glucose was added to medium, it took 73 hours. It was revealed as excellent effluent and SVI, when the F/M ratio, COD and phenol concentration were 53mg/l and 1.2mg/l, respectively, and optimum F/M ratio was revealed 0.31. The reactor were seriously shocked as reducing hydraulic retention time at constant phenol concentration more than increasing phenol concentration at constant hydraulic retention time, when volumetric loading rate was increased to $0.8kg\;phenol/m^3{\codt}d$ from $1.6kg\;phenol/m^3{\codt}d$. And also the effluent phenol concentration was 34mg/l after starting 12 hours of shocking and reactor was recovered as steady state after 65 hours of changing in the former test. Although the effluent phenol concentration was maximum value with 12mg/l after starting 20 hours of shocking and reactor was recovered as steady state after 54 hours of changing in the later test.