• Asian Pacific Journal of Cancer Prevention
• /
• 제16권13호
• /
• pp.5159-5162
• /
• 2015

Background: Chronic myeloproliferative diseases are clonal stem cell diseases which occur as a result of uncontrollable growth and reproduction of hematopoietic stem cells, which are the myeloid series source in bone marrow. Recent studies have suggested that chronic inflammation can be a triggering factor in the clonal change in chronic myeloproliferative neoplasia (CMPN). In our study, we evaluated the existence of a chronic inflammation process in our Philadelphia negative (Ph-)CMPN patients using inflammation parameters in combination with demographic, laboratory and clinical characteristics of the patients. Materials and Methods: Demographic characteristics, clinical and laboratorial data, and thrombosis histories of 99 Ph-CMPN patients, who were diagnosed at our outpatient clinic of hematology in accordance with WHO 2008 criteria, were analyzed retrospectively,with 80 healthy individuals of matching gender and age included as controls. Complete blood counts, sedimentation, C reactive protein (CRP), JAK V617F gene mutations, abdomen ultrasound images and previous thrombosis histories of these patients were retrospectively analyzed. Results: Ph-CMPN and healthy control groups included 99 and 80 cases, respectively. PV, ET and MF diagnoses of patients were 43 (%43.4), 44 (44.4%) and 12 (12.1%), respectively. JAK V617F gene mutation was found to be positive in 64 (71.1%) of all cases and in 27(65.8%), 32 (82%), 5 (50%) of the cases in PV, ET and PMF groups, respectively. Thrombosis was determined as 12 (12%) in the entire group, 12.5% in the JAK V617F negative and 15.3% in the positive patients, with no statistical significance (p=0.758). No significant difference was observed between patients with and without previous thrombosis history in respect to hemogram parameters, sedimentation and CRP (p>0.05), neutrophil to lymphocyte ratio (NLR), erythrocyte distribution width (RDW), mean platelet volume (MPV) and sedimentation levels of the patient.

• Asian-Australasian Journal of Animal Sciences
• /
• 제31권10호
• /
• pp.1558-1564
• /
• 2018

Objective: We report monitoring conservation effect for a Chinese indigenous chicken (Langshan) breed using major histocompatibility complex (MHC) and DNA barcords. Methods: The full length of MHC B-G gene and mitochondrial cytochrome oxidase I (COI) gene in generations 0, 5, 10, 15, 16, and 17 was measured using re-sequencing and sequencing procedures, respectively. Results: There were 292 single nucleotide polymorphisms of MHC B-G gene identified in six generations. Heterozygosity (He) and polymorphic information content (PIC) of MHC B-G gene in generations 10, 15, 16, and 17 remained stable. He and PIC of MHC B-G gene were different in six generations, with G10, G15, G16, G17 >G5>G0 (p<0.05). For the COI gene, there were five haplotypes in generations 0, 5, 10, 15, 16, and 17. Where Hap2 and Hap4 were the shared haplotypes, 164 individuals shared Hap2 haplotypes, while Hap1 and Hap3 were the shared haplotypes in generations 0 and 5 and Hap5 was a shared haplotype in generations 10, 15, 16, and 17. The sequence of COI gene in 6 generations was tested by Tajima's and D value, and the results were not significant, which were consistent with neutral mutation. There were no differences in generations 10, 15, 16, and 17for measured phenotypic traits. In other generations, for annual egg production, with G5, G10, G15, G16, G17>G0 (p<0.05). For age at the first egg and age at sexual maturity, with G10, G15, G16, G17>G5>G0 (p<0.05). Conclusion: Combined with the results of COI gene DNA barcodes, MHC B-G gene, and phenotypic traits we can see that genetic diversity remained stable from generations 10 to 17 and the equimultiple random matching pedigrees conservation population conservation effect of Langshan chicken was effective as measured by these criteria.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제23권4호
• /
• pp.319-328
• /
• 2020

Purpose: To examine the prevalence and clinical manifestations of eosinophilic esophagitis (EoE) in Korea children. Methods: The study was designed as a 1:2 matching case-control study. Using information from the endoscopic database of a tertiary center, we retrospectively reviewed the medical records of patients aged 18 years or younger who underwent upper gastrointestinal endoscopy between January 2014 and December 2017. A total of 21 patients were diagnosed with EoE based on current diagnostic criteria. In addition, 42 controls with normal esophageal biopsy findings matched to each EoE case by sex, age (±1 months), and season were randomly selected during the study period. Results: The mean age of EoE diagnosis was 12.1±4.0 years and the male-to-female ratio was 2:1. The proportion of allergic diseases in patients with EoE (28.6%) was higher than that in the controls (6.8%) (p=0.04). Most EoE patients tested for allergy were positive for at least one antigen, which was significantly different to the controls (88.2% vs. 47.4%, p=0.01). Characteristic endoscopic findings of EoE were noted in 19 patients (90.5%), but 2 patients (9.5%) showed normal esophageal mucosa. The clinical symptoms of EoE were improved by a proton-pump inhibitor in 10 patients (50.0%), and by an H₂ blocker in 9 patients (45.0%). Only one patient (5.0%) required inhaled steroids. Conclusion: While EoE is rare in the Korean pediatric population, the results of this study will improve our understanding of the clinical manifestations of the disease.

• 한국ITS학회 논문지
• /
• 제10권6호
• /
• pp.40-52
• /
• 2011

최근 지능형교통체계(ITS)는 다기능 검지기, 도시교통정보시스템, 단거리 전용 통신 등 첨단 검지장비가 도입되면서 교통정보의 신뢰성이 중요하게 대두되고 있다. 이 연구는 구간교통정보 산정과 같은 정량적 연구와 다르게 교통류 안정성을 반영한 정성적 소통상황 판단 알고리즘을 개발하였다. 이를 위해서 제한속도별 정성적 소통상황 분류기준을 재정립하고, 실시간 소통상황 판단 유형과 판단지표를 새롭게 제시하였다. 실시간 소통상황 판단 유형은 정성적 소통상황에서 속도추이의 상승, 진동, 하락에 따라 크게 9가지 유형으로 세분화하였다. 소통상황 판단지표는 속도변화추이를 파악하기 위해 과거 5주기 2분 단위 속도, 가속도를 나타내는 값과 부호로 정의한 3개 지표와 시간대별, 속도대별 불안정범위를 설정한 영역으로 정의하였다. 이 연구에서 개발된 소통상황 판단 알고리즘의 성능평가는 실제 검지자료를 이용하여 현장 적용성을 검증하였으며, 교통정보가공체계, 상황판 운영모니터링, 과거이력자료 활용 등에 적용이 가능할 것으로 판단된다.

• 한국산학기술학회논문지
• /
• 제11권7호
• /
• pp.2579-2585
• /
• 2010

본 논문은 단안 카메라로부터 입력된 영상에서 모션 기반의 검색을 사용한 동적인 사람 자세 추적 방법을 제안한다. 제안된 방법은 3차원 공간에서 하나의 사람 자세 후보를 생성하고, 생성된 자세 후보를 2차원 이미지 공간으로 투영하여, 투영된 사람 자세 후보와 입력 이미지와의 특징 값 유사성을 비교한다. 이 과정을 정해진 조건을 만족 할 때까지 반복하여 이미지와의 유사성과, 신체 부분간 연결성이 가장 좋은 3차원 자세를 추정한다. 제안된 방법에서는 입력 이미지에 적합한 3차원 자세를 검색할 때, 2차원 영상에서 추정된 신체 각 부분들의 모션 정보를 사용해 검색 공간을 정하고 정해진 검색 공간에서 탐색하여 사람의 자세를 추정한다. 2차원 이미지 모션은 비교적 높은 제약이 있어서 검색 공간을 의미있게 줄일 수 있다. 이 방법은 모션 추정이 검색 공간을 효율적으로 할당 해주고, 자세 추적이 여러 가지 다양한 모션에 적응할 수 있다는 장점을 가진다

• Journal of Chest Surgery
• /
• 제49권5호
• /
• pp.366-373
• /
• 2016

Background: The aim of the study was to test the hypothesis that in patients with chronic complex sternum dehiscence, the use of muscle flap repair minimizes the occurrence of paradoxical motion of the chest wall (CWPM) when compared to sternal rewiring, eventually leading to better respiratory function and clinical outcomes during follow-up. Methods: In a propensity score matching analysis, out of 94 patients who underwent sternal reconstruction, 20 patients were selected: 10 patients underwent sternal reconstruction with bilateral pectoralis muscle flaps (group 1) and 10 underwent sternal rewiring (group 2). Eligibility criteria included the presence of hemisternum diastases associated with multiple (${\geq}$3) bone fractures and radiologic evidence of synchronous chest wall motion (CWSM). We compared radiologically assessed (volumetric computed tomography) ventilatory mechanic indices such as single lung and global vital capacity (VC), diaphragm excursion, synchronous and paradoxical chest wall motion. Results: Follow-up was 100% complete (mean $85{\pm}24months$). CWPM was inversely correlated with single lung VC (Spearman R=-0.72, p=0.0003), global VC (R=-0.51, p=0.02) and diaphragm excursion (R=-0.80, p=0.0003), whereas it proved directly correlated with dyspnea grade (Spearman R=0.51, p=0.02) and pain (R=0.59, p=0.005). Mean CWPM and single lung VC were both better in group 1, whereas there was no difference in CWSM, diaphragm excursion and global VC. Conclusion: Our study suggests that in patients with complex chronic sternal dehiscence, pectoralis muscle flap reconstruction guarantees lower CWPM and greater single-lung VC when compared with sternal rewiring and it is associated with better clinical outcomes with less pain and dyspnea.

• 한국정보과학회논문지:소프트웨어및응용
• /
• 제32권7호
• /
• pp.650-662
• /
• 2005

어노테이션 시스템에서 원본문서가 갱신되었을 경우 어노테이션이 항상 적절한 위치를 유지하기 위해서는 로버스트(robust)한 위치재생성(repositioning) 기능이 필요하다. XML 문서환경에서 어노테이션에 대한 위치재생성을 위해서는 텍스트 정보뿐만 아니라 구조문서 특성을 포함할 수 있어야 한다. 이를 위하여 본 논문에서는 XML 기반의 원본문서 및 어노테이션 정보를 논리구조트리(logical structure tree)로 표현하고, 각 트리간의 대응관계를 분석하여 복수의 후보 앵커들을 생성한다 또한 복수의 후보 앵커들 중 최적의 후보 앵커를 선택하기 위하여 논리구조트리 앵커 노드의 문자열(textual data) 및 레이블 정보에 기반한 단계별 앵커링 기준을 제시한다. 그 결과 본 논문에서는 구조문서 환경에서 다양한 형태의 컨텍스트 갱신이 발생하였을 경우에도 로버스트한 위치재생성이 가능하다.

• 한국융합학회논문지
• /
• 제10권11호
• /
• pp.501-510
• /
• 2019

본 논문은 당뇨병의 관리전략 수립을 위해 일상생활에서 조절가능한 혈당조절 요인을 파악하고자 하였다. 개인이 조절하기 어려운 성별, 당뇨병 유병기간, 당뇨병 치료방법, 교육수준, 가구소득 등을 매칭한 코호트내 환자-대조군 디자인으로 분석을 하였다. 7기 국민건강영양조사(2016-2017) 원시자료를 이용하여, 983명의 당뇨병 환자를 분석한 결과, 289명(30%)만이 당화혈색소가 6.5% 미만으로 혈당이 조절되었다. 일상생활에서 조절이 가능한 당화혈색소 조절 요인 파악하기 위해 조건부 다변량 로짓스틱 회귀분석 시행한 결과, 매칭전 코호트에서는 당뇨병 유병기간, 당뇨병 치료 여부, 매칭 코호트에서는 체질량지수, 흡연, 안저검사가 당화혈색소 달성에 유의한 영향을 미치는 것으로 파악되었다. 본 결과는 집중 관리가 필요한 대상선정(장기 유병기간, 약물치료 대상자) 및 생활습관(체질량지수, 흡연, 안저검사 등) 관리전략을 마련하는데 근거자료로 활용되고, 지역사회내 국민건강 증진에 기여할 것으로 사료된다.

• 대한이식학회지
• /
• 제32권4호
• /
• pp.108-112
• /
• 2018

Antibody-mediated rejection (AMR) is a major complication after ABO-incompatible liver transplantation. According to the 2016 Banff Working Group on Liver Allograft Criteria for the diagnosis of acute AMR, a positive serum donor specific antibody (DSA) is needed. On the other hand, the clinical significance of the histological findings of AMR in the absence of DSA is unclear. This paper describes a 57-year-old man (blood type, O+) who suffered from hepatitis B virus cirrhosis with hepatocellular carcinoma. Pre-operative DSA and cross-matching were negative. After transplantation, despite the improvement of the liver function, acute AMR was observed in the protocol biopsy on postoperative day 7; the cluster of differentiation 19+ (CD19+) count was 0% and anti-ABO antibody titers were 1:2. This paper presents the allograft injury like AMR in the absence of DSA after ABOi living donor liver transplantation with low titers of anti-ABO antibody and depleted serum CD19+ B cells.

• Journal of Trauma and Injury
• /
• 제32권1호
• /
• pp.40-46
• /
• 2019

Purpose: We perform an analysis of infection risk factors for fracture patients and confirm that the risk factors reported in previous studies increase the risk of actual infection among fractured patients. In addition, injury severity score (ISS) which is used as an evaluation tool for morbidity of trauma patients, confirms whether there is a relationship with infection after orthopedic fracture surgery. Methods: We retrospectively reviewed 1,818 patients who underwent fixation surgery at orthopedic trauma team, focused trauma center from January 1, 2015 to December 31, 2017. Thirty-five patients were infected after fracture surgery. We analyzed age, sex, open fracture criteria based on Gustilo-Aderson classification 3b, anatomical location (upper extremity or lower extremity) of fracture, diabetes, smoking, ISS. Results: Of 1,818 patients, 35 (1.9%) were diagnosed with postoperative infection. Of the 35 infected patients, nine (25.7%) were female and five (14.0%) were upper extremity fractures. Three (8.6%) were diagnosed with diabetes and eight (22.8%) were smokers. Thirteen (37.1%) had ISS less than nine points and six (17.1%) had ISS 15 points or more. Of 1,818 patients, 80 had open fractures. Surgical site infection were diagnosed in 12 (15.0%) of 80. And nine of 12 were checked with Gustilo-Aderson classification 3b or more. Linear logistic regression analysis was performed using statistical analysis program Stata 15 (Stata Corporation, College Station, TX, USA). In addition, independent variables were logistic regression analyzed individually after Propensity scores matching. In all statistical analyzes, only open fracture was identified as a risk factor. Conclusions: The risk factors for infection in fracture patients were found to be significantly influenced by open fracture rather than the underlying disease or anatomical feature of the patient. In the case of ISS, it is considered that there is a limitation. It is necessary to develop a new scoring system that can appropriately approach the morbidity of fracture trauma patients.