• Nuclear Medicine and Molecular Imaging
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• 제40권4호
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• pp.193-199
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• 2006

Infectious and inflammatory bone diseases include a wide range of disease process, depending on the patient's age, location of infection, various causative organisms, duration from symtom onset, accompanied fracture or prior surgery, prosthesis insertion, and underlying systemic disease such as diabetes, etc. Bone infection may induce massive destruction of bones and joints, results in functional reduction and disability. The key to successful management is early diagnosis and proper treatment. Various radionuclide imaging methods including three phase bone scan, Ga-67 scan, WBC scan, and combined imaging techniques such as bone/Ga-67 scan, WBC/bone marrow scan add complementary role to the radiologic imaging modalities including plain radiography, CT and MRI. F-18 FDG PET imaging also has recently been introduced in diagnosis of infected prosthesis and chronic active osteomyelitis. Selection of proper nuclear medicine imaging method will improve the diagnostic accuracy of infections and inflammatory bone diseases, based on understading of pathogenesis and radiologic imaging findings.

• 유기물자원화
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• 제31권4호
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• pp.29-39
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• 2023

본 연구에서는 의료폐기물에 대해 평상시 상황과 대규모 감염병 발병 상황으로 구분하여 발생 특성을 분석하였다. 평상시 상황에서는 회귀분석을 통해 의료폐기물 종류별 발생량 예측 모델을 수립하였으며, 유의값(p)은 모두 < 0.0001로 통계적으로 유의미하였다. 각 분류별 예측 모델식의 결정계수(R²) 값은 I-MW(R²=0.9943) > G-MW(R²=0.9817) > H-MW(R²=0.9310) 순으로 분석되었다. 또한, 기존 문헌과 유사한 결과로 영향인자로 사용된 GDP(G-MW), 의료기관 수(H-MW), 고령 인구비(I-MW)는 모두 높은 상관성을 나타내었다. 각 모델식을 종합한 총 의료폐기물 발생량의 MAE는 2,615, RMSE 3,353로 평가되어 H-MW(2,491, 2,890)와 I-MW(2,291, 3,267) 의료폐기물 모델식과 유사한 수준의 정확도를 나타내는 것이 확인되었다. 단기간 내 대량 발생하는 감염병 사태 시기의 의료폐기물 발생 특성은 정확한 추정이 제한적이므로 격리의료폐기물의 발생원단위를 분석하였다. 감염병 초기인 불안정기 8.74 kg/인·일, 안정기 2.69 kg/인·일, 감소기 시기 평균 0.08 kg/인·일의 발생원단위를 나타내었다. 격리의료폐기물 발생원단위와 치명률 간의 상관분석 결과, 불안정기 +0.99, 안정기 +0.52, 감소기 +0.96으로 나타났으며, 감염병 발병 전체시기에서 +0.95 이상의 매우 높은 양의 상관성을 나타내는 것이 확인되었다. 본 연구에서 도출된 연구결과는 보건 의료상에 적절한 의료폐기물 관리시스템을 구축하는 데 유용한 역할을 수행할 수 있을 것으로 기대된다.

• Tuberculosis and Respiratory Diseases
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• 제63권5호
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• pp.430-434
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• 2007

저자들은 71세 여자환자가 대량객혈을 주소로 내원하여 폐동맥과 기관지의 누공을 확인한 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국물환경학회지
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• 제28권2호
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• pp.305-312
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• 2012

Avian influenza (AI) and foot and mouth disease (FMD) are two main contagious pathogenic viruses causing massive mortality burial, as burial is a primary measure to quaranteen the causative viruse(s). Biosecurity is a set of preventive measures designed to reduce the risk of propagation of infectious diseases. Main objectives of this paper were to discuss the needs of biosecurity and develop protocol outlines for environmental management of burial sites. Pathological characteristics of contagious viruses should be considered during environmental management practices. Current practice prescribes to minimize the potential for on-farm pollution and the spread of infectious diseases, policy makers should understand robust knowledge regarding biosecurity to make informed decisions on future legislation.

• Clinical and Experimental Pediatrics
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• 제56권7호
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• pp.304-307
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• 2013

Polyclonal gammopathy represents the diffuse activation of B cells and is usually related to inflammation or immune-related diseases. However, the mechanisms leading to polyclonal gammopathy are essentially speculative. Generally, infectious, inflammatory, or various other reactive processes may be indicated by the presence of a broad-based peak or band in the gamma region on serum protein electrophoresis results. A 15-year-old girl, who had been receiving peritoneal dialysis, presented with polyclonal gammopathy and massive gross hematuria. Renal artery embolization was performed, after which the continuous bleeding subsided and albumin-globulin dissociation resolved. This is a rare case of polyclonal gammopathy related to renal bleeding.

• Journal of Preventive Medicine and Public Health
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• 제53권3호
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• pp.168-170
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• 2020

On December 31, 2019, the Chinese government officially announced that the country had some cases of pneumonia with an unknown cause. By February 8, 2020, there were 24 confirmed cases in Korea, and the number of cases has steadily increased since then. On March 9, 2020, the cumulative number of confirmed cases in Korea was 7382, with 51 deaths. This study examines the characteristics of the coronavirus disease 2019 (COVID-19) outbreak from the perspective of the large-scale number of confirmed COVID-19 cases and deaths. This study is significant in that it emphasizes the precautionary principle in preventing and managing infectious diseases, and makes suggestions for urgently needed public health policies.

• 한국응용곤충학회지
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• 제22권2호
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• pp.130-137
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• 1983

A wide variety of pathogens are known io be seedborne, carried either as infectious mycelium internally or as contaminants on the seed coat. When seed is infected with a pathogen, the seed nay be rendered nonviable or it may remain viable but produce weak seedling. In some cases, the Infected seedling nay not be severely weakened, but nay serve as a source of primary inoculum within a community of plants. A recent problem nay be the dissemination of seedborne pathogens occurring as a result of the massive movements of seed, as a part of the 'Green revolution' Disease of great danger to agriculture may be introduced with seed from other parts of world. Seed treatment with organic mercury compounds in liquid form had become popular since about 1955. Organic mercury compounds contributed considerably to the increase in production of many crops and vegetables. In 1975, however, the use of organic mercury compound was forbidden because of doubts regarding their residual mammalian toxicity in agricultural products. Benomyl-thiram mixture, thiophanate methyl-;hiram mixture and TCMB have now been registered as seed disinfectants for the use of rice blast, brown spot and Bakanae disease. Oxathiinsthiram mixture has been registered as seed disinfectant for barley and wheat loose smut and leaf stripe of barley. Agricultural techniques have made such rapid progress that the nursery methods changed from the use of paddy nursery to box nursery designed for machine-transplanting. The spread of rice transplanting machines has caused increase of seedborne diseases. Among seedborne diseases, Bakanae disease has remarkably increased and causes much damage recently. In order to counter this trend, seed disinfectants must also be diversified. First, effective non-selective disinfectants need to be developed, and second, appropriate control methods always need to be prepared in parallel with the development of new techniques for cultivation.

• Pediatric Infection and Vaccine
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• 제4권2호
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• pp.282-287
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• 1997

Malaria due to Plasmodium vivax had been known as an indigenous protozoan disease in Korea. However, massive use of insecticides and improvement of sanitation for several decades have led to rapid reduction of malaria incidence, then it was recognized to have been almost eradicated in recent years. However in 1993, one case was reported in Phajoo, Kyungki-do, and then, reported cases have been increasing annually. Recently we encountered one case of malaria in a 3 year old male child living in Dorim-dong, Seoul, who had never been abroad and had no history of transfusion, drug abuse, and travel to endemic area in Korea. He had characteristic fever, chill and splenomegaly and was confirmed as Plasmodium vivax malaria with peripheral blood smear finding. He was successfully treated with hydroxy chloroquine and primaquine. We report this case with brief review of related literature.

• BMB Reports
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• 제52권9호
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• pp.540-547
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• 2019

Immune repertoire is a collection of enormously diverse adaptive immune cells within an individual. As the repertoire shapes and represents immunological conditions, identification of clones and characterization of diversity are critical for understanding how to protect ourselves against various illness such as infectious diseases and cancers. Over the past several years, fast growing technologies for high throughput sequencing have facilitated rapid advancement of repertoire research, enabling us to observe the diversity of repertoire at an unprecedented level. Here, we focus on B cell receptor (BCR) repertoire and review approaches to B cell isolation and sequencing library construction. These experiments should be carefully designed according to BCR regions to be interrogated, such as heavy chain full length, complementarity determining regions, and isotypes. We also highlight preprocessing steps to remove sequencing and PCR errors with unique molecular index and bioinformatics techniques. Due to the nature of massive sequence variation in BCR, caution is warranted when interpreting repertoire diversity from error-prone sequencing data. Furthermore, we provide a summary of statistical frameworks and bioinformatics tools for clonal evolution and diversity. Finally, we discuss limitations of current BCR-seq technologies and future perspectives on advances in repertoire sequencing.

• Tuberculosis and Respiratory Diseases
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• 제57권6호
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• pp.579-583
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• 2004

환자는 지속적인 객담을 동반한 기침 및 발열이 있었고, 방사선학적 검사에서 좌측폐에 air-fluid level을 동반한 거대한 공동이 관찰되었다. 임상 양상이 폐농양에 부합되어 항생제 투여와 배농을 시행 하였으나 호전이 없어 개흉술을 시행하였다. 수술 소견상 폐농양이 아닌 농흉이 관찰되었으며, 조직병리검사에서 폐방선균증으로 진단되었다.