• Korean Journal of Radiology
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• 제22권8호
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• pp.1253-1265
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• 2021

Objective: To investigate the prognostic value of preoperative cardiac magnetic resonance imaging (MRI) for long-term major adverse cardiac and cerebrovascular events (MACCEs) in patients undergoing tricuspid valve (TV) surgery for functional tricuspid regurgitation (TR). Materials and Methods: The preoperative cardiac MR images, New York Heart Association functional class, comorbidities, and clinical events of 78 patients (median [interquartile range], 59 [51-66.3] years, 28.2% male) who underwent TV surgery for functional TR were comprehensively reviewed. Cox proportional hazards analyses were performed to assess the associations of clinical and imaging parameters with MACCEs and all-cause mortality. Results: For the median follow-up duration of 5.4 years (interquartile range, 1.2-6.6), MACCEs and all-cause mortality were 51.3% and 23.1%, respectively. The right ventricular (RV) end-systolic volume index (ESVI) and the systolic RV mass index (RVMI) were higher in patients with MACCEs than those without them (77 vs. 68 mL/m², p = 0.048; 23.5 vs. 18.0%, p = 0.011, respectively). A high RV ESVI was associated with all-cause mortality (hazard ratio [HR] per value of 10 higher ESVI = 1.10, p = 0.03). A high RVMI was also associated with all-cause mortality (HR per increase of 5 mL/m² RVMI = 1.75, p < 0.001). After adjusting for age and sex, only RVMI remained a significant predictor of MACCEs and all-cause mortality (p < 0.05 for both). After adjusting for multiple clinical variables, RVMI remained significantly associated with all-cause mortality (p = 0.005). Conclusion: RVMI measured on preoperative cardiac MRI was an independent predictor of long-term outcomes in patients who underwent TV surgery for functional TR.

• Fisheries and Aquatic Sciences
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• 제13권1호
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• pp.79-83
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• 2010

Since 1998, a new viral disease with high mortality has been consistently recorded in Korea in cultured carp, Cyprinus carpio. In this study, we investigated an epizootic of the disease that caused high mortality rates in carp obtained from 11 farms in Korea between 1999 and 2007. Assessment of koi herpesvirus (KHV) levels in diseased carp was carried out to determine if this virus was the etiologic agent of disease in this instance. High mortality rates in carp were recorded mainly in the spring and autumn at water temperatures between $19^{\circ}C$ and $24^{\circ}C$. Diseased fish typically showed surface discoloration, with a thick opaque mucus covering the body and gills. Protozoan parasites and bacteria were recovered from 7/29 (24%) and 2/26 (8%) of fish, respectively. Evidence of viral infection was marked; cytopathic effects (CPEs), characterized by cell rounding and an extended cytoplasm in fathead minnow (FHM) cells, were detected in 40/41 fish (98%). A high mortality rate (80%) resulted when supernatants of cell cultures showing CPEs were applied to previously healthy fish. KHV was detected by polymerase chain reaction in 6/41 fish (15%), but was not detected in supernatants obtained from cell cultures showing CPEs. These results suggest that KHV may not be the etiologic agent of the high mortality occurring among cultured carp in Korea; therefore, some other-as yet unidentified-infective agent must be responsible.

• 디지털융복합연구
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• 제16권10호
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• pp.343-350
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• 2018

본 연구의 목적은 한국 지역사회 거주 노인의 영양상태가 사망위험에 영향을 미치는지 파악하기 위함이다. 본 연구에서는 2008년도 노인실태조사 참여자 8,532명의 자료와 2011년 사망자 자료를 분석하였다. 콕스 회귀 분석 결과, 남성(Hazard Ratio [HR], 2.03; 95% Confidence Interval [CI], 1.74~2.37), 당뇨 (HR, 1.35; 95% CI, 1.12~1.64), 저체중 (HR, 2.68; 95% CI, 2.16~3.31), 연하곤란 (HR, 1.23; 95% CI, 1.02~1.47), 씹기 능력 (HR, 1.33; 95% CI, 1.11~1.59), 영양불량 (HR, 1.47; 95% CI, 1.23~1.75)이 사망위험에 영향을 주는 것으로 나타났다. 한국 노인의 사망위험을 줄이기 위해 체계적인 영양 지원프로그램을 개발해야 할 것이다.

• Journal of Korean Medical Science
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• 제33권48호
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• pp.312.1-312.10
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• 2018

Background: Obesity is related to several comorbidities and mortality, but its relationship with acute kidney injury (AKI) and long-term mortality remain undetermined in patients undergoing coronary artery bypass grafting. Methods: Data from 3,018 patients (age ${\geq}18$ years) who underwent coronary artery bypass graft surgery from two tertiary referral centers were retrospectively reviewed between 2004 and 2015. Obesity was defined using the body mass index, according to the World Health Organization's recommendation. The odds and hazard ratios in post-surgical, AKI, and all-cause mortality were calculated after adjustment for multiple covariates. Patients were followed for $90{\pm}40.9$ months (maximum: 13 years). Results: Among the cohort, 37.4%, 2.4%, 21.1%, 35.1%, and 4.0% of patients were classified as normal weight, underweight, overweight-at-risk, obese I, and obese II, respectively. Post-surgical AKI developed in 799 patients (26.5%). Patients in the obese groups (overweight-at-risk to obese II) had a higher risk of AKI than did those in the normal-weight group. During the follow-up period, 787 patients (26.1%) died. Underweight patients had a higher risk of mortality than did normal-weight patients, whereas overweight-at-risk, obese I, and obese II patients showed better survival rates. Conclusion: After coronary artery bypass graft surgery, obese patients encountered a high risk of AKI, and underweight patients exhibited a low chance of survival. Awareness of both obese and underweight statuses should be raised in these patients.

• Mass Spectrometry Letters
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• 제10권3호
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• pp.71-78
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• 2019

For several decades, cancer has been the primary cause of mortality worldwide. New diagnosis and regimens have been developed to improve the chemotherapeutic efficacy and the quality of life of the patients. However, cancer tissues are complex and difficult to assess. Understanding the various properties of the tumor and its environment is crucial for cancer and pharmaceutical research. Several analytical techniques have been providing new insights into cancer research. Recently, matrix-assisted laser desorption ionization (MALDI)-mass spectrometry imaging (MSI), an advanced analytical technique, has been applied to translational research. Proteomic and lipidomic profiling obtained by MALDI-MSI has been critical for biomarker discovery and for monitoring heterogenous tumor tissues. In this review, we discuss technical approaches, benefits and recent applications of MALDI-MSI as a valuable tool in cancer research, namely for diagnosis, therapy, prognosis.

• 한국대기환경학회:학술대회논문집
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• 한국대기환경학회 2006년도 추계학술대회 논문집
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• pp.189-190
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• 2006

• 한국어병학회지
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• 제4권2호
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• pp.87-94
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• 1991

1. 자연감염(自然感染) 능성어는 외관적으로 먹이를 먹지 않고 분색이 옅은 밤색이나 짙은 밤색으로 변하며 몸이 휘어져 힘없이 가두리 바닥이나 수면에 누워서 폐사(斃死)하였는데, 해부(解剖)를 해보면 뇌출혈(腦出血)과 비장(脾臟) 및 담관(膽管)이 팽대(膨大)되어 있었다. 2. 자연감염어(自然感染魚) 아가미에서 Trichodina sp. 기생충(寄生蟲)이 다수 검출(檢出)되지만 대량(大量) 폐사(斃死)의 직접(直接) 원인생물(原因生物)은 아니며, 또한 병어(病魚)의 장기(臟器)에서 우점적(優占的)으로 분리(分離)되는 Vibrio속(屬) 세균(細菌)은 병원성(病原性)이 없는 해수상존(海水常存) Vibrio 균(菌)이었다. 3. RTG-2 및 CHSE-214 어류(魚類) 주화세포(株化細胞)에서 바이러스는 분리(分離)되지 않았지만, 병어(病魚)의 장기마쇄여과액(臟器磨碎濾過液)으로 인위감염(人爲感染)시켰을 때 자연감염어(自然感染魚)와 유사(類似)한 증상(症狀)을 나타내면서 폐사(斃死)하였다. 4. 자연감염어(自然感染魚) 및 인위감염어(人爲感染魚)의 간(肝) 세포질내(細胞質內) 공포부위(空胞部位)에 크기가 45-60nm 정도되며 육각형(六角形) 내지 다각형모양(多角形模樣)을 한 virion들이 무수히 존재하였다. 5. 따라서 1990년(年)과 1991년(年) 고수온기(高水溫期)에 우리나라 남해안(南海岸) 일원 해상가두리 양식장에서 사육중이던 능성어가 대량(大量) 폐사(斃死)한 것은 바이러스성(性) 질병(疾病)에 의한 것으로 생각된다.

• 한국패류학회지
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• 제30권1호
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• pp.9-15
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• 2014

완도에서 주로 사용되는 4열 10행의 가두리 1조를 조합한 형태로 구성된 PE프레임의 내파성 전복가두리를 1/20로 축소하여 모형을 만들고 유체흐름 가시화 실험을 통해 전복가두리 주위의 해수의 흐름을 파악했다. 실험의 결과를 검증하기 위해 노화도 현장의 전복양식 가두리의 내부와 외부의 유속을 측정하였다. 연구의 결과는 아래와 같다. 1. 모형실험에서 전복가두리에 입사하는 해수는 대부분 첫 번째 단위 가두리 (칸) 를 통과하지 못하였다. 2. 모형 전복가두리 중앙 부위에서는 가두리에서 수조바닥으로 향하는 흐름을 관측하였다. 3. 모형 전복가두리의 외측 열을 빠져나가는 유체의 유속이 내측 열을 빠져나가는 유체의 유속보다 빨랐다. 4. 노화도의 현장 양식가두리의 2 m앞의 조류의 유속은 0.11 m/sec였지만 가두리 칸 내부의 유속은 0.0009 m/sec로 거의 움직임이 없었다. 5. 현재의 전복가두리 형태는 해수의 유통이 원활하지 않아 가두리 내부로 새로운 해수를 공급하기 어려울 것으로 판단된다.

• Journal of Preventive Medicine and Public Health
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• 제45권6호
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• pp.394-401
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• 2012

Objectives: Diabetes and obesity each increases mortality, but recent papers have shown that lean Asian persons were at greater risk for mortality than were obese persons. The objective of this study is to determine whether an interaction exists between body mass index (BMI) and diabetes, which can modify the risk of death by cardiovascular disease (CVD). Methods: Subjects who were over 20 years of age, and who had information regarding BMI, past history of diabetes, and fasting blood glucose levels (n=16 048), were selected from the Korea Multi-center Cancer Cohort study participants. By 2008, a total of 1290 participants had died; 251 and 155 had died of CVD and stroke, respectively. The hazard for deaths was calculated with hazard ratio (HR) and 95% confidence interval (95% CI) by Cox proportional hazard model. Results: Compared with the normal population, patients with diabetes were at higher risk for CVD and stroke deaths (HR, 1.84; 95% CI, 1.33 to 2.56; HR, 1.82; 95% CI, 1.20 to 2.76; respectively). Relative to subjects with no diabetes and normal BMI (21 to 22.9 $kg/m^2$), lean subjects with diabetes (BMI <21 $kg/m^2$) had a greater risk for CVD and stroke deaths (HR, 2.83; 95% CI, 1.57 to 5.09; HR, 3.27; 95% CI, 1.58 to 6.76; respectively), while obese subjects with diabetes (BMI ${\geq}25kg/m^2$) had no increased death risk (p-interaction <0.05). This pattern was consistent in sub-populations with no incidence of hypertension. Conclusions: This study suggests that diabetes in lean people is more critical to CVD deaths than it is in obese people.

• 한국어병학회지
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• 제23권3호
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• pp.335-342
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• 2010

2008년 3월 인도네시아로부터 수입된 paradise fish에서 대량폐사가 발생하여 병원체 검사를 실시한 결과, megalocytivirus 및 Mycobacterium sp.가 검출되었으며, CHSE-214세포에서 미동정 바이러스가 분리되었다. 본 연구에서는 미동정 바이러스의 특성을 조사하였으며, 또한 병원성 실험을 통해 paradise fish의 대량 폐사와의 연관성을 조사하였다. 분리 바이러스는 CHSE-214, BF-2, GF, SSN-1, FSP 및 FFN 세포에서 합포체의 세포변성효과를 나타내었고 IUdR 및 chloroform 처리에 감염성이 상실되지 않으며, 산 (pH 3), 알카리 (pH 11) 및 열 ($56^{\circ}C$, 30분)에 안정하였다. 핵산 분석 결과에서는 적어도 10개의 segment (0.7-3.6 kb)를 지닌 RNA 바이러스로 확인되었으며, 전자현미경 관찰 결과, 약 65 nm 크기로 인벨롭이 없으며 2중의 capsid를 지닌 바이러스가 세포질에서 관찰되었다. 이상의 결과는 Reoviridae family에 속하는 바이러스의 전형적인 특성과 일치하므로 paradise fish에서 분리된 바이러스는 reovirus로 확인되었다. Reovirus를 사용한 감염실험에서는 병원성이 나타나지 않아, reovirus는 paradise fish의 대량 폐사의 직접적인 원인이 아닐 것으로 사료되었다.