• 동의생리병리학회지
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• 제21권1호
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• pp.231-234
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• 2007

Dichlororinated bibenzyl compound (4) has been isolated from the New Zealand liverwort. This compound was elucidated using 1D/2D-NMR and mass spectral method. The compound (3) inhibited the growth of the Gram positive bacterium Bacillus subtilis ATCC 19659, (2 mm inhibition zone and 2 mm inhibition zone at 30 ${\mu}$g/disc), Candida albicans ATCC 14053, (2 mm inhibition zone and 2 mm inhibition zone at 30 ${\mu}$g/disc), and the dermatophytic fungi Trichophyton mentagrophytes ATCC 28185, (12 mm inhibition zone at 30 ${\mu}$g/disc) and Cladosporium resinae ATCC 52833 (2 mm inhibition zone at 30 ${\mu}$g/disc). This bibenzyl compound (4) exhibited antimicrobial activity.

• Journal of Microbiology and Biotechnology
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• 제25권11호
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• pp.1954-1959
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• 2015

Bacillus subtilis HM1 was isolated from the rhizosphere region of halophytes for its antifungal activity against Colletotrichum acutatum, the causative agent of anthracnose. Treatment of postharvest apples with the cell culture or with a cell-free culture supernatant reduced disease severity 80.7% and 69.4%, respectively. Both treatments also exhibited antifungal activity against various phytopathogenic fungi in vitro. The antifungal substances were purified and analyzed by acid precipitation, gel filtration, high-performance liquid chromatography, and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Three compounds were identified as fengycin, iturin, and surfactin. The MALDI-TOF/TOF mass spectrum revealed the presence of cyclized fengycin homologs A and B, which were distinguishable on the basis of the presence of either alanine or valine, respectively, at position 6 of the peptide sequence. In addition, the cyclized structure of fengycin was shown to play a critical role in antifungal activity.

• 미생물학회지
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• 제42권1호
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• pp.54-58
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• 2006

항생제 내성균에 대처 할 수 있는 새로운 항생제의 개발에는 많은 시간과 인력 및 개발비가마 필요하며 새로운 항생제들이 생산되어도 균들은 빠르면 수개월내에 내성을 획득한다. 이 문제의 해결방법의 하나로 전통적으로 감염질환의 치료에 사용되어온 백작약 추출물의 methicillin-resistant Staphylococcus aureus(MRSA)에 대한 항균활성 보유여부를 조사한 결과 백작약의 dichloromethane 추출물이 MRSA에 대하여 높은 항균활성을 나타내어 앞으로 새로운 항균재로서의 개발 및 사용 가능성이 있을 것으로 판단된다.

• Mass Spectrometry Letters
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• 제4권2호
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• pp.34-37
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• 2013

Honokiol and magnolol, the major bioactive neolignans of magnolia officinalis, are the most important constituents of the crude drug prescriptions that are used in the therapy of neuroses and various nervous disorders. There have been limited reports on the effects of neolignoid compounds on human cytochrome P450 activity. Therefore, the inhibitory effects of honokiol and magnolol on seven human cytochrome P450 s were evaluated in human liver microsomes. Honokiol and magnolol showed the most potent inhibition of CYP1A2-mediated phenacetin O-deethylase activity ($IC_{50}$ values of 3.5 and 5.4 mM, respectively) among the seven P450s tested. These in vitro data indicate that neolignan compounds can inhibit the activity of CYP1A2 and suggest that these compounds should be examined for potential pharmacokinetic drug interactions in vivo.

• 한국엔터테인먼트산업학회논문지
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• 제13권8호
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• pp.401-409
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• 2019

본 연구는 2019년 2월-9월까지 서울 및 경기도 소제 3개 대학병원에 내원한 중년여성(40-60대) 110명을 대상으로 일상생활 속에서의 생활움직임과 신체조성의 관계를 파악하고자 하는 목적으로 진행되었으며 다음과 같은 결론을 도출하였다. 첫째, 총 칼로리 소비량, 활동평균 칼로리 소비량, 평균 보행 수를 군집화한 결과 각각 3가지 군집으로 분류되었으며 일일 총 칼로리 소비량은 BMI, 근육량, 체지방량에서 차이를 보였다. 보행 수는 BMI와 체지방량에서 차이를 보였으며, 활동 평균 칼로리는 유의한 차이가 없었다. 둘째, BMI에는 활동 평균 칼로리 소비량이 정(+)적 영향을 미쳤고 평균 보행 수는 부(-)적 영향을 미쳤다. 근육량에는 일일 총 칼로리 소비량이 정(+)적 영향을 미쳤으며, 활동 평균 칼로리 소비량은 부(-)적 영향을 미쳤다. 체지방량과 체지방률에는 활동 평균 칼로리 소비량이 정(+)적 영향을 미쳤으며, 일일 총 칼로리 소비량과 평균 보행 수는 부(-)적 영향을 미쳤다. 이러한 결과를 통하여 중년여성의 일상생활 속에서의 움직임만으로도 신체조성의 개선에 효과가 있다는 것이 밝혀졌다.

• Journal of Chest Surgery
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• 제35권1호
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• pp.27-35
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• 2002

배경: 술후 심근경색(perioperative myocardial infarction;PMI)은 관상동맥 우회술 후 중요한 합병증 중 하나이다. PMI의 진단 방법 중 CK-MB 활성도(CK-MB activity) 측정보다 민감하고, 간단한 측정 방법을 가진 CK-MB 농도(CK-MB mass)의 측정으로 점차 대체되고 있다. 또한, cardiac troponin I(cTnl)는 심근경색의 표지자로 민감도와 특이도가 가장 높은 것으로 소개되고 있다. 본 연구는 관상동맥 우회술 후 심근경색의 표지자로서 CK-MB농도와 cTnl의 임상적 의의성에 대한 평가를 보고하고자 한다. 대상 및 방법: 2000년 4월부터 2001년 4월까지 강동성심병원에서 관상동맥 우회술을 받은 32명의 환자를 대상으로 하였다. 술후 CK-MB 활성도, CK-MB농도, cTnl, 심전도, 심초음파, 임상적 자료를 전향적으로 기록하였다. 술후 심근경색의 진단은 심전도에서 새로운 Q파 출현, CK-MB 활성도가 72시간안에 200 lU/L 이상, 심초음파에서 심근벽의 새로운 심근벽 운동이상 등의 3가지 중 2가지 이상인 경우로 정의하였다 결과: 관상동맥 우회술 후 3례에서 진단 기준에 부합된 경우였다. 시간 경과에 따라, 술후 12시간의 CK-MB활성도와 술후 24시간의 CK-MB농도(R=0.946), 술후 48시간의 cTnl(R=0.933)는 매우 상관성이 있었다(p=0.000). PM의 진단기준치를 찾기 위해 ROC(receiver operating characteristics) 곡선을 이용하였으며, PMI의 환자중 술후 24시간에서 CK-MB 농도가 30.05 ug/L보다 높은 측정값에서 PMI를 발견할 수 있었고, 이 때의 ROC 곡선의 하단 단면적은 1이었으며, 민감도 100%, 특이도 100%, 양성 예측도 100%, 음성 예측도 100% 이었다. cTnI의 경우 술후 48시간에서 17.15ug/L보다 높은 측정값에서 PMI를 발견할 수 있었고, 이 때의 ROC 곡선의 하단 단면적은 0.98이었으며, 민감도 100%, 특이도 96.6%, 양성 예측도 75%, 음성 예측도 100% 이었다. 결론: 관상동맥 우회술 후 심근경색의 진단적 표지자로서 CK-MB농도와 cTnl의 측정은 간단하고 정확한 방법으로 판단되며, 진단기준치를 제시함으로서 술후 심근경색의 조기 발견을 가능하게 할 수 있을 것이라 생각된다. 그러나 본 연구에서는 대상환자 수가 적었고, 적은 수의 환자에서 심근경색이 발생하여 통계적인 제한이 있을 수 있어 향후 더 많은 대상의 수가 필요할 것으로 사료된다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제41회 하계 정기 학술대회 초록집
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• pp.206-206
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• 2011

Nanoparticles have been received great attention from many researchers for several decades because of their good and unique properties. In particular, researches in the field of synthesis of bimetallic nanoparticles showed good results for the past ten years. In this research, Pd thinlayer on Au nanoparticles were synthesized by electrochemical deposition method. Well-defined Au(111) nanoparticles were synthesized by solution based reduction method. Electrochemical deposition conditions for Pd thinlayer on Au(111) nanoparticles surface were carefully regulated by controlling parameters of cyclic voltammetry. To calculate exact mass and surface area catalytic activities of deposited Pd thinlayer on Au(111) nanoparticle, electrochemically active surface area (ECSA) and mass of the deposited Pd thinlayer were measured by cyclic voltammetry in 0.1 M HClO4 solution. Afterward, catalytic activities of the deposited Pd thinlayer were measured in 0.1 M HClO4 + 0.2 M formic acid solution. In case of less negative deposition potential, the amounts of deposited Pd mass and surface area were small. However, mass and ECSA activity of the deposited Pd to oxidize formic acid were increased.

• Advances in aircraft and spacecraft science
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• 제9권6호
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• pp.493-506
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• 2022

The study presents the results of the research of heat and heat exchange processes on the heat-stressed elements of the structure of an advanced TsAGI descent vehicle. The studies were carried out using a mathematical model based on solving discrete analogs of continuum mechanics equations. Conclusions were drawn about the correctness of the model and the dependence of the intensity of heat and mass transfer processes on the most heat-stressed sections of the apparatus surface on its geometry and the catalytic activity of the surface.

• 한방비만학회지
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• 제11권2호
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• pp.15-24
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• 2011

Objectives: The aim of the study was to investigate the relationship between oriental obesity pattern, life habitual factors(eating attitude, physical activity) and psychological factors(depression, stress, self-esteem) in korean obese and overweight women. Methods: This study was performed in obese and overweight(BMI ${\geq}$ 23 kg/$m^2$) women in Korea (n=56). Simple anthropometry including weight, BMI, waist circumference, BIA(bioelectrical impedance analysis) were done. To assess psychological factors, the Rosenberg self-esteem scale (SES) questionnaire, Beck depression inventory (BDI) questionnaire and stress response inventory (SRI) questionnaire were administered. Regarding diet, Korean eating attitude test(KEAT-26) was done. International physical activity questionnaire(IPAQ) was administered for exercise and physical activity intensity and quantities. All values were verified using correlation analysis. Results: 1. The subjects had stagnation of the liver qi>food accumulation>yang deficiency>blood stasis>spleen vacuity in the order. 2. Stagnation of the liver qi score had significant relationships with self-esteem(r=-0.520, p<0.05) and depression(r=0.688, p<0.01) in stagnation of the liver qi group. There was a relationship between food accumulation score and eating attitude(r=0.784, p<0.01) in food accumulation group. 3. Lean mass had a significant relationship with self-esteem(r=0.434, p<0.05) fat mass had a significant relationship with stress (r=0.633, p<0.01) and in stagnation of the liver qi group. 4. Physical activity had significant relationships with lean mass(r=0.628, p<0.01) and with fat mass(r=-0.478, p<0.05) in group. Conclusions: This study maintained that psychological factors play major roles in obesity with symptoms of stagnation of the liver qi and life habit(dietary factors and physical activity) in food accumulation.

• 운동영양학회지
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• 제24권1호
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• pp.9-13
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• 2020

[Purpose] This preliminary study aimed to develop a regression model to estimate the resting metabolic rate (RMR) of young and middle-aged Koreans using various easy-to-measure dependent variables. [Methods] The RMR and the dependent variables for its estimation (e.g. age, height, body mass index, fat-free mass; FFM, fat mass, % body fat, systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse pressure, and resting heart rate) were measured in 53 young (male n = 18, female n = 16) and middle-aged (male n = 5, female n = 14) healthy adults. Statistical analysis was performed to develop an RMR estimation regression model using the stepwise regression method. [Results] We confirmed that FFM and age were important variables in both the regression models based on the regression coefficients. Mean explanatory power of RMR₁ regression models estimated only by FFM was 66.7% (R²) and 66.0% (adjusted R²), while mean standard errors of estimates (SEE) was 219.85 kcal/day. Additionally, mean explanatory power of RMR₂ regression models developed by FFM and age were 70.0% (R²) and 68.8% (adjusted R²), while the mean SEE was 210.64 kcal/day. There was no significant difference between the measured RMR by the canopy method using a metabolic gas analyzer and the predicted RMR by RMR₁ and RMR₂ equations. [Conclusion] This preliminary study developed a regression model to estimate the RMR of young and middle-age healthy Koreans. The regression model was as follows: RMR₁ = 24.383 × FFM + 634.310, RMR₂ = 23.691 × FFM - 5.745 × age + 852.341.