• Proceedings of the Korean Information Science Society Conference
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• 2006.10a
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• pp.53-58
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• 2006

MicroRNA (miRNA)는 약 22 nt의 작은 RNA 조각으로 이루어져 있으며 stem-loop 구조의 precursor 형태에서 최종적으로 만들어 진다. miRNA는 mRNA의 3‘UTR에 상보적으로 결합하여 유전자의 발현을 억제하거나 mRNA의 분해를 촉진한다. miRNA를 동정하기 위한 실험적인 방법은 조직 특이적인 발현, 적은 발현양 때문에 방법상 한계를 가지고 있다. 이러한 한계는 컴퓨터를 이용한 방법으로 어느 정도 해결될 수 있다. 하지만 miRNA의 서열상의 낮은 보존성은 homology를 기반으로 한 예측을 어렵게 한다. 또한 기계학습 방법인 support vector machine (SVM) 이나 naive bayes가 적용되었지만, 생물학적인 의미를 해석할 수 있는 generative model을 제시해 주지 못했다. 본 연구에서는 우수한 miRNA 예측을 보일 뿐만 아니라 학습된 모델로부터 생물학적인 지식을 얻을 수 있는 Bayesian network을 적용한다. 이를 위해서는 생물학적으로 의미 있는 특질들의 선택이 중요하다. 여기서는 position weighted matrix (PWM)과 Markov chain probability (MCP), Loop 크기, Bulge 수, spectrum, free energy profile 등을 특질로서 선택한 후 Information gain의 특질 선택법을 통해 예측에 기여도가 높은 특질 25개 와 27개를 최종적으로 선택하였다. 이로부터 Bayesian network을 학습한 후 miRNA의 예측 성능을 10 fold cross-validation으로 확인하였다. 그 결과 pre-/mature miRNA 각 각에 대한 예측 accuracy가 99.99% 100.00%를 보여, SVM이나 naive bayes 방법보다 높은 결과를 보였으며, 학습된 Bayesian network으로부터 이전 연구 결과와 일치하는 pre-miRNA 상의 의존관계를 분석할 수 있었다.

• The Journal of the Acoustical Society of Korea
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• v.21 no.6
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• pp.552-558
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• 2002

Recently, based on the human speech recognition (HSR) model of Fletcher, the multi-band speech recognition has been intensively studied by many researchers. As a new automatic speech recognition (ASR) technique, the multi-band speech recognition splits the frequency domain into several sub-bands and recognizes each sub-band independently. The likelihood scores of sub-bands are weighted according to reliabilities of sub-bands and re-combined to make a final decision. This approach is known to be robust under noisy environments. When the noise is stationary a sub-band SNR can be estimated using the noise information in non-speech interval. However, if the noise is non-stationary it is not feasible to obtain the sub-band SNR. This paper proposes the inverse sub-band distance (ISD) weighting, where a distance of each sub-band is calculated by a stochastic matching of input feature vectors and hidden Markov models. The inverse distance is used as a sub-band weight. Experiments on 1500∼1800㎐ band-limited white noise and classical guitar sound revealed that the proposed method could represent the sub-band reliability effectively and improve the performance under both stationary and non-stationary band-limited noise environments.

• The Korean Journal of Applied Statistics
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• v.25 no.2
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• pp.363-376
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• 2012

Excessive zeroes are often observed in ordinal categorical response variables. An ordinary ordered Probit model is not appropriate for zero-inflated data especially when there are many different sources of generating 0 observations. In this paper, we apply a two-stage zero-inflated ordered Probit (ZIOP) model which incorporate the zero-flated nature of data, propose a Bayesian analysis of a ZIOP model, and apply the method to alcohol consumption data collected by the National Bureau of Statistics, Korea. In the first stage of a ZIOP model, a Probit model is introduced to divide the non-drinkers into genuine non-drinkers who do not participate in drinking due to personal beliefs or permanent health problems and potential drinkers who did not drink at the time of the survey but have the potential to become drinkers. In the second stage, an ordered probit model is applied to drinkers that consists of zero-consumption potential drinkers and positive consumption drinkers. The analysis results show that about 30% of non-drinkers are genuine non-drinkers and hence the Korean alcohol consumption data has the feature of zero-inflated data. A study on the marginal effect of each explanatory variable shows that certain explanatory variables have effects on the genuine non-drinkers and potential drinkers in opposite directions, which may not be detected by an ordered Probit model.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.3
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• pp.197-205
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• 2020

Korean language has the characteristics that the pronunciation of phoneme units such as vowels and consonants are fixed and the pronunciation associated with a notation does not change, so that foreign learners can approach rather easily Korean language. However, when one pronounces words, phrases, or sentences, the pronunciation changes in a manner of a wide variation and complexity at the boundaries of syllables, and the association of notation and pronunciation does not hold any more. Consequently, it is very difficult for foreign learners to study Korean standard pronunciations. Despite these difficulties, it is believed that systematic analysis of pronunciation errors for Korean words is possible according to the advantageous observations that the relationship between Korean notations and pronunciations can be described as a set of firm rules without exceptions unlike other languages including English. In this paper, we propose a visualization framework which shows the differences between standard pronunciations and erratic ones as quantitative measures on the computer screen. Previous researches only show color representation and 3D graphics of speech properties, or an animated view of changing shapes of lips and mouth cavity. Moreover, the features used in the analysis are only point data such as the average of a speech range. In this study, we propose a method which can directly use the time-series data instead of using summary or distorted data. This was realized by using the deep learning-based technique which combines Self-organizing map, variational autoencoder model, and Markov model, and we achieved a superior performance enhancement compared to the method using the point-based data.

• Smart Media Journal
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• v.5 no.2
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• pp.15-23
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• 2016

In this paper we propose the depth-poselets using body-part-poses and also propose the method to recognize the gesture. Since the gestures are composed of sequential poses, in order to recognize a gesture, it should emphasize to obtain the time series pose. Because of distortion and high degree of freedom, it is difficult to recognize pose correctly. So, in this paper we used partial pose for obtaining a feature of the pose correctly without full-body-pose. In this paper, we define the 16 gestures, a depth image using a learning image was generated based on the defined gestures. The depth poselets that were proposed in this paper consists of principal three-dimensional coordinates of the depth image and its depth image of the body part. In the training process after receiving the input defined gesture by using a depth camera in order to train the gesture, the depth poselets were generated by obtaining 3D joint coordinates. And part-gesture HMM were constructed using the depth poselets. In the testing process after receiving the input test image by using a depth camera in order to test, it extracts foreground and extracts the body part of the input image by comparing depth poselets. And we check part gestures for recognizing gesture by using result of applying HMM. We can recognize the gestures efficiently by using HMM, and the recognition rates could be confirmed about 89%.