• Title/Summary/Keyword: Margin of exposures(MOE)

Search Result 4, Processing Time 0.018 seconds

Determination and risk characterization of polycyclic aromatic hydrocarbons of tea by using the Margin of Exposure (MOE) approach

  • Lee, Joon-Goo;Lim, Taesuk;Kim, Sheen-Hee;Kang, Dong-Hyun;Yoon, Hae-Jung
    • Food Science and Biotechnology
    • /
    • v.27 no.6
    • /
    • pp.1843-1856
    • /
    • 2018
  • Tea is one of the most frequently consumed drinks due to its favourite taste and the health benefit. Tea is produced by several processes and drying is very important step to develop the flavour and destroys the enzymes in tea. However, during drying tea, polycyclic aromatic hydrocarbons some of which are carcinogen and genotoxin are naturally produced. The risk of PAHs by drinking tea was characterized by determining contents of 4 PAHs in tea. 4 PAHs including Benz(a)anthracene (BaA), Chrysene (CHR), Benzo(b)fluoranthene (BbF) and Benzo(a)pyrene (BaP) were investigated by GC-MS in total 468 tea products, which were contaminated up to $4.63ng\;g^{-1}$. Mate tea was the most highly contaminated by BaA, CHR, BbF and BaP and followed by Solomon's seal and Chrysanthemum. The Margin of Exposures calculated by the concentration of BaA, CHR, BbF and BaP and consumption amount of tea were higher than 10,000, and the risk of PAHs in tea were low concern to public health.

Study on the Assessment of PAHs Content and Risk Exposure of Convergence Herbal Pills (융합 환제의 PAHs 함량 및 위해성 노출 평가에 대한 연구)

  • Kim, Ga-Yeon;Kim, Hyo-Jin;Lee, Sung Deuk;Lee, Young Ki;Yuk, Young Sam
    • Journal of the Korea Convergence Society
    • /
    • v.9 no.4
    • /
    • pp.75-84
    • /
    • 2018
  • This study investigated the pollution status of polycyclic aromatic hydrocarbons (PAHs) such as benzopyran, which is a harmful substance, in convergence herbal pills distributed in Seoul. During 2010 ~ 2013, 31 items and 93 samples were collected from the herbal medicines vendors in Seoul, and the samples were extracted, filtered, concentrated, and then spun out with SPE (Sep-pak florisil) and concentrated again and analyzed by liquid chromatography. The results of the analysis showed that the average contents of PAHs were below $10{\mu}g/kg$, and the PAHs were lower than those of daily life exposure, and MOEs was evaluated as safe to a negligible level. In the future, comparative fusion studies on the harmful substances of medicinal pills and food pills are needed.

Analysis of Exposure Characteristics and Exposure Rating of Participants with Injuries from CMIT/MIT Humidifier Disinfectants (CMIT/MIT 가습기살균제 사용에 따른 피해구제 신청자의 노출등급 및 노출특성 분석)

  • Gihong Min;Junghyun Shin;Eun-Kyung Jo;Seula Lee;Jihun Shin;Dongjun Kim;Jaemin Woo;Yoon-Hyeong Choi;Wonho Yang
    • Journal of Environmental Health Sciences
    • /
    • v.49 no.3
    • /
    • pp.169-177
    • /
    • 2023
  • Background: The Korea Centers for Disease Control and Prevention (KCDC) has identified cases of people suspected of suffering lung disease potentially caused by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) used in humidifier disinfectants (HDs). The Korean Ministry of Environment (MoE) epidemiological investigation and toxicity test study found that HDs caused health damage such as asthma and lung disease. Objectives: The main purposes of this study were to classify the HD exposure rating and to analyze the exposure characteristics that affect exposure to CMIT/MIT HDs. Methods: The exposure characteristics and socio-demographic characteristics of victim participants using CMIT/MIT HDs were investigated through questionnaires. An inhalation no observed adverse effect level (NOAEL) for CMIT/MIT was produced based on inhalation toxicity values. Exposure ratings (class 1~class 2) were cross-tabulated with clinical ratings (acceptable~unacceptable). A correlation analysis was conducted with the main exposure characteristics that affect the exposure concentration of CMIT/MIT HDs. Results: The concentration in indoor air of CMIT/MIT was 8.75±25.40 ㎍/m3, and the exposure concentration was 2.30±6.29 ㎍/m3. The CMIT/MIT exposure rating of 67 participants with high exposures of not more than MOE 100 were evaluated as 14.5%, while the damage participants who matched the clinical rating made up 4.5%. The exposure concentration of CMIT/MIT showed a positive correlation with the daily usage amount and usage frequency, and a negative correlation with volume of the indoor environment. Conclusions: A new exposure rating could be suggested and calculated based on the MOE, and the factors affecting the exposure concentration could be identified.

Analysis and Risk Assessment of Benzo(a)pyrene in Edible Oils (식용유지류 중 벤조피렌의 함량 분석 및 안전성 평가)

  • Jang, Mi-Ra;Hong, Mi-Sun;Jung, So-Young;Choi, Bu-Chuhl;Lee, Kyeong-Ah;Kum, Jin-Young;Kim, Il-Young;Kim, Jung-Hun;Chae, Young-Zoo
    • Journal of Food Hygiene and Safety
    • /
    • v.29 no.2
    • /
    • pp.141-145
    • /
    • 2014
  • To assess the health risk for benzo(a)pyrene by the intake of edible oils, 288 cases of edible oils collected from food markets were analysed using the high performance liquid chromatography with fluorescence detector. The levels of benzo(a)pyrene were from non-detection to $4.78{\mu}g/kg$, and the average was $0.11{\mu}g/kg$. The chronic daily exposures of benzo(a)pyrene for total population group and consumer-only group were estimated using the food consumption data in the fifth Korea National Health and Nutrition Examination Survey in 2011. The estimated daily intake of benzo(a)pyrene was $4.26{\times}10^{-3}ng/kg$ b.w./day for total population group and $7.64{\times}10^{-3}ng/kg$ b.w./day for consumer-only group. The MOE (margin of exposure) of benzo(a)pyrene for total population group and consumer-only group was $7.28{\times}10^7{\sim}1.74{\times}10^8$ and $3.95{\times}10^7{\sim}9.42{\times}10^7$, respectively. Accordingly, the health risk from benzo(a)pyrene caused by the intake of edible oils was considered as a very low level.