• Journal of Integrative Natural Science
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• v.11 no.2
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• pp.107-112
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• 2018

p38 MAP kinase belongs to the Mitogen-activated protein (MAP) kinase family; a serine/threonine kinase. It plays an important role in intracellular signal transduction pathways. It is associated with the development and progression of various cancer types making it a crucial drug target. Present study involves the HQSAR analysis of recently reported imidazo[1,2-b]pyridazine derivatives as p38 MAP kinase antagonists. The model was generated with Atom (A), bond (B), chirality (Ch), and hydrogen (H) parameters and with different set of atom counts to improve the model. An acceptable HQSAR model ($q^2=0.522$, SDEP=0.479, NOC=5, $r^2=0.703$, SEE=0.378, BHL=97) was developed which exhibits good predictive ability. A contribution map for the most active compound (compound 17) illustrated that hydrogen and nitrogen atoms in the ring A and ring B, as well as nitrogen atom in ring C and the hydrogen atom in the ring D provided positive activity in inhibitory effect while, the least active compound (compound 05) possessed negative contribution to inhibitory effect. Hence, analysis of produced HQSAR model can provide insights in the designing potent and selective p38 MAP kinase antagonists.

• East Asian mathematical journal
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• v.14 no.2
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• pp.269-279
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• 1998

For a codimension 1 submanifold in a Euclidean 2n-space, the degree of the gauss map mod 2 is the semi-characteristic of the manifold in $Z_2$ coefficient.

• Biomedical Science Letters
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• v.2 no.2
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• pp.175-185
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• 1996

The mitogen-activated protein(MAP) kinase signal transduction pathway represents an important mechanism by which mitogen, such as serum and PMA, regulate cell proliferation and differentiation. Target substrates of the MAP kinase are located within several compartments containing plasma membranes and nucleus. We now report that serum addition induces proliferation of the P388 murine leukemia cell, but PMA does not, while both serum and PMA treatment cause translocation of the MAP kinase, mainly p42$^{mapk}$ isoform, from cytosol into the nucleus, which was monitored by immunoblot analysis using polyclonal anti-ERK1 antibodies. We investigated whether the MAP kinase was capable of phosphorylating c-Jun protein and GST-fusion proteins, the P562$^{kk}$N-terminal peptides (1-77 or 1-123 domain) of the T cell tyrosine kinase, using the partially purified MAP kinase by SP-sephadex C-50, phenyl superose and Mono Q column chromatography. We found that the partially purified MAP kinase was able to phosphorylate c-Jun protein and the GST-fusion protein expressed using E.coli DH5$\alpha$ which is transformed with pGEX-3Xb plasmid vector carrying of p562$^{kk}$N-terminal peptide-encoding DNA. These results imply that tyrosine kinase receptor/Ras/Raf/MAP kinase pathway is a major mechanism for mitogen-induced cell proliferation in P388 murine leukemia cell and that the various MAP kinase isoforms may have their own target substrates located in distinct subcellular compartments.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.298-303
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• 2013

Magnetic abrasive polishing is one of the most promising finishing methods applicable to complex surfaces. Nevertheless this process has a low efficiency when applied to very hardened materials. For this reason, EP-MAP hybrid process was developed. EP-MAP process is expected to machine complex and hardened materials. In this research, deburring process using EP-MAP hybrid process was proposed. EP-MAP deburring process is applied to micro channel, thereby it can obtain both deburring process and polishing process. EP-MAP deburring process on the micro channel was performed. Through design of experiment method, error of height in this process according to process parameter is analyzed. When the level 1 parameter A(magnetic flux density) and level 2 parameter B(electric potential), C(working gap) and level 3 parameter D(feed rate) are applied in the deburring process using EP-MAP hybrid process, it provides optimum result of EP-MAP hybrid deburring process.

• Journal of the Korean Mathematical Society
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• v.35 no.2
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• pp.315-330
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• 1998

Chen and Piccinni [7] have classified all compact surfaces in a Euclidean space $R^{2＋p}$ with 1-type generalized Gauss map. Being motivated by this result, the purpose of this paper is to consider the Lorentz version of the classification theorem and to obtain a complete classification of space-like surfaces in indefinite Euclidean space $R_{p}$ $^{2＋p}$ with 1-type generalized Gauss map.p.

• The Journal of Korea Robotics Society
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• v.9 no.2
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• pp.96-103
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• 2014

Global localization is one of the essential issues for mobile robot navigation. In this study, an indoor global localization method is proposed which uses a Kinect sensor and a monocular upward-looking camera. The proposed method generates an environment map which consists of a grid map, a ceiling feature map from the upward-looking camera, and a spatial feature map obtained from the Kinect sensor. The method selects robot pose candidates using the spatial feature map and updates sample poses by particle filter based on the grid map. Localization success is determined by calculating the matching error from the ceiling feature map. In various experiments, the proposed method achieved a position accuracy of 0.12m and a position update speed of 10.4s, which is robust enough for real-world applications.

• International Journal of Contents
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• v.7 no.2
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• pp.11-16
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• 2011

In this paper, we develop a mobile MAP open API using HTML5 local storage and the W3C geolocation API. The mobile MAP open API consists of the basic JavaScript MAP API, offline navigation API, and multimedia POI (mPOI) API. The basic JavaScript MAP API creates a map and controls, rotates, and overlays data on the map. The offline navigation API is developed using HTML5 local storage and web storage. The mobile web application downloads and stores mPOIs of works of art to local storage or web storage from a web server. The mPOI API is developed using HTML5 video and audio APIs. We develop a mobile art park guidance application using the developed mobile MAP open API.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2018.06a
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• pp.193-194
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• 2018

본 논문은 Point Cloud 데이터 압축을 위해 사용되는 MPEG PCC TMC2의 Occupancy map coding을 효과적으로 압축하기 위해 내부 블록 스킵 방식을 제안한다. TMC2에서 생성된 patch들을 2차원 그리드에 packing 하여 생성된 occupancy map은 patch 내부의 대부분의 occupancy가 'full'이라는 특징을 갖는다. 따라서 이러한 특징을 이용하여 patch 내부의 occupancy를 간소화 하면 occupancy map을 표현하기 위한 비트를 절약 할 수 있다. 이러한 방법을 통해 본 논문에서는 기존 TMC2의 occupancy map의 비트양 대비 평균 -1.37%의 성능을 얻었다.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.8
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• pp.586-590
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• 2009

The objective of this paper describes the design of MapReduce over Peer-to-Peer network for dynamic environments applications. MapReduce is a software framework used for Cloud Computing which processing large data sets in a highly-parallel way. Based on the Peer-to-Peer network character which node failures will happen anytime, we focus on using a DHT routing protocol which named Pastry to handle the problem of node failures. Our results are very promising and indicate that the framework could have a wide application in P2P network systems while maintaining good computational efficiency and scalability. We believe that, P2P networks and parallel computing emerge as very hot research and development topics in industry and academia for many years to come.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.12
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• pp.1699-1705
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• 2011

Magnesium ammonium phosphate (MAP) was recovered from swine wastewater and the feasibility of reutilizing it as a slowly-releasing fertilizer was evaluated. Maize growth was investigated with normal and high application rates of MAP and a fused super phosphate (FSP) fertilizer. A total of 5 treatments ($T_0$ = control, $T_1$ = MAP based on 30 kg P $ha^{-1}$, $T_2$ = FSP based on 30 kg P $ha^{-1}$+urea equivalent to nitrogen of MAP applied in $T_1$, $T_3$ = MAP based on 40 kg P $ha^{-1}$, $T_4$ = FSP based on 40 kg P $ha^{-1}$+urea equivalent to nitrogen of MAP applied in $T_3$) were arranged with 3 replications. In the case of height and circumference, significant differences were found between controls and treated maize plants (p<0.01). However, no statistical differences were found between MAP- and FSP-urea treated maize. Leaf area and green biomass yield were significantly (p<0.01) higher in the treated group than control. Leaf area was also found significantly higher (p<0.01) in the higher MAP- treated group (2,374 $cm^2$ $plant^{-1}$) than other treatments. $N_2O$ emission was found to be lower in MAP treated soil than that from FSP-urea treated soil, which might be due to the slow releasing pattern of MAP. It could be assumed from the results that MAP would be an eco-friendly sustainable fertilizer source for crop production.