• Journal of Periodontal and Implant Science
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• 제31권2호
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• pp.317-332
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• 2001

The purpose of this study was to investigate effects of the natural coral(NC) and the hydroxyapatite/calcium sulfate hemihydrate(HA/CS) on an early stages of wound healing in the rat periodontal fenestration defects. In this experiment, twelve male rats(Mean : 520g in BW) aged 8 to 9 months were used. Experimental periodontal fenestration defects were surgically created with tapered fissure bur at the buccal surface of the left mandibular 1st, 2nd molars. The buccal aspects of molar roots were carefully denuded of their periodontal ligament through a bony window created in the left mandibles of rats under general anesthesia. Each experimental periodontal fenestration defect was grafted with natural coral and HA/CS, randomly. An area without bone graft was assigned for negative control group. At 10,35 days, rats were serially sacrificed via intracardiac perfusion with 2.5% glutaraldehyde and specimens were processed with Hematoxylin-Eosin stain for light microscopic evaluation. The results of this study were as follows : 1. The defect areas were filled with dense connective tissues at 10 days in control group. But in the test(NC, HA/CS)groups, the connective tissues around graft materials were formed more loosely and the response of inflammation by graft materials itself was not found. 2. The defect areas were filled with new osteoid tissues and new cementum was not formed on the cut root surface at 35 days in the control group. 3. New osteoid tissue formation was more prominent at 35 days in control than test groups. 4. The NC and HA/CS particles were encapsulated by loose connective tissues at 10 days and by dense connective tissues at 35 days, respectively. 5. In the test groups, resorption of graft particles was not found through the experimental time. From the above results, natural coral and hydroxyapatite/calcium sulfate hemihydrate may be biocompatible and osteoconductive and have a weak adverse reaction to the periodontal tissues.

• Restorative Dentistry and Endodontics
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• 제36권1호
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• pp.12-18
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• 2011

목적: 본 후향적 연구의 목적은 의도적 재식술로 치료한 상하악 대구치의 단기간의 치료 결과를 평가하고자 하는 것이다. 환자 및 방법: 본 연구의 대상은 해부학적인 접근의 어려움 및 두꺼운 피질골 또는 하치조 신경, 상악동등과의 근접으로 인해 통상적인 치근단 수술이 불가능하거나 환자가 거부하는 경우 의도적 재식술을 시행한 35개의 상하악 대구치를 대상으로 하였다. 증례들의 경과 관찰 기간은 1년에서 2년 4개월이었다. 성공률은 임상적 성공과 방사선학적 성공을 기준으로 평가하였다. 결과: 의도적 재식술 과정중 발치 실패가 1증례(3%), 치주 질환 및 염증성 흡수로 발치한 경우가 2증례(6%)였고 구강내에서 기능하고 있으나 약간의 동요도와 치근의 흡수상이 관찰되는 경우가 3증례(9%)였고 특이한 이상없이 잘 유지되고 있는 경우는 29증례(82%)였다. 결론: 의도적 재식술은 접근성 및 해부학적인 구조등으로 인해 치근단 수술이 불가능한 경우 적절한 증례 선택과 숙련된 술자에 의해 시술이 이루어진다면 재현성 있고 예지성있는 치료가 될 수 있다.

• 대한두개안면성형외과학회지
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• 제12권1호
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• pp.43-47
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• 2011

Purpose: Romberg's disease manifests as progressive hemifacial atrophy of the skin, soft tissue and bone, which usually begins in the first or second decade of life. When present, atrophy may originate from the cutaneous stigmata and may become so sharply delimited by the midline. Methods: A 10-year-old girl, who had suffered from right mandibular area atrophy for 3 years, visited us and was diagnosed with Romberg's disease. The depressed lesion of the face was augmented successfully using a deepithelialized groin free flap. The superficial circumflex iliac vessels were used as the donor pedicle and the facial artery and vein were used as the recipient vessels. Results: After surgery, the flap survived well and she was satisfied with the result. Although there are various methods of facial augmentation using free flaps, this flap has some advantages. First, there is a considerable amount of fat tissue components for augmentation. Second, flap elevation with thinning is possible. Third, the donor site can be hidden. Conclusion: The groin dermo-fat free flap is a good method for the facial augmentation of Romberg's disease.

• 대한치과교정학회지
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• 제51권5호
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• pp.321-328
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• 2021

Objective: To examine the accuracy of computer-aided intraoperative navigation (Ci-Navi) in bimaxillary orthognathic surgery by comparing preoperative planning and postoperative outcome. Methods: The study comprised 45 patients with congenital dentomaxillofacial deformities who were scheduled to undergo bimaxillary orthognathic surgery. Virtual bimaxillary orthognathic surgery was simulated using Mimics software. Intraoperatively, a Le Fort I osteotomy of the maxilla was performed using osteotomy guide plates. After the Le Fort I osteotomy and bilateral sagittal split ramus osteotomy of the mandible, the mobilized maxilla and the distal mandibular segment were fixed using an occlusal splint, forming the maxillomandibular complex (MMC). Real-time Ci-Navi was used to lead the MMC in the designated direction. Osteoplasty of the inferior border of the mandible was performed using Ci-Navi when facial symmetry and skeletal harmony were of concern. Linear and angular distinctions between preoperative planning and postoperative outcomes were calculated. Results: The mean linear difference was 0.79 mm (maxilla: 0.62 mm, mandible: 0.88 mm) and the overall mean angular difference was 1.20°. The observed difference in the upper incisor point to the Frankfort horizontal plane, midfacial sagittal plane, and coronal plane was < 1 mm in 40 cases. Conclusions: This study demonstrates the role of Ci-Navi in the accurate positioning of bone segments during bimaxillary orthognathic surgery. Ci-Navi was found to be a reliable method for the accurate transfer of the surgical plan during an operation.

• 대한치과보철학회지
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• 제57권1호
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• pp.42-48
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• 2019

하악 편측에 소수의 잔존치만 있는 증례에서 통상적인 국소의치로 수복하는 경우에 충분한 유지 및 저항을 얻기 어렵고, 무치악 치조제의 흡수에 따른 의치의 안정성 저하로 인해 잔존지대치에 유해한 힘이 가해질 것으로 예상된다. 이러한 경우에 다수의 임플란트를 이용한 고정성 보철로 수복하게 되면 여러 가지 장점이 있을 수 있으나, 해부학적, 경제적 요인에 의해 치료 방법으로 선택이 제한될 수 있다. 이에, 적은 수의 임플란트를 전략적 위치에 식립하여 임플란트 보조 국소의치(Implant-assisted removable partial denture, IARPD)의 제작을 대안으로 고려해 볼 수 있다. 본 증례보고에서는 전통적인 가철성 국소의치만으로는 적절한 지지, 유지, 안정이 어려운 두 임상증례에서 소수의 임플란트를 전략적 위치에 식립하고 로케이터(Locator) 부착장치를 적용하여 3년간 경과관찰을 통해 좋은 임상 결과를 확인하였기에 이를 보고하고자 한다.

• 대한치과보철학회지
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• 제57권2호
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• pp.171-175
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• 2019

치조제가 심하게 흡수된 하악의 정확한 해부학적 구조를 채득하는 것은 매우 어렵다. 이 경우 보다 정확한 인상을 채득하기 위하여 수정모형 제작법을 통한 기능 인상 채득이 추천된다. 이를 위해서는 양측에 2개의 임플란트 크라운을 이용하여 적절한 고정원을 얻을 필요가 있다. 이를 통해 임플란트 피개의치에서는 불가능하였던 수정모형 제작법을 시행할 수 있다. 본 증례에서는 하악의 치조제가 심하게 흡수된 80세 여환을 하악 양측 견치 부위의 임플란트 크라운을 지대치로 한 가철성 국소의치를 이용하여 수복하였다. 가철성 국소의치의 금속구조물을 이용하여 개인 트레이를 제작하고 수정모형 제작을 위한 이차 인상을 채득하였다. 환자는 앞선 2회의 피개의치 실패 후 제작된 최종 보철물에 만족하였다. 치료 초기에 행해진 피개의치 치료에서는 부정확한 인상법에 따른 부적절한 보철물로 인해 술자와 환자 모두 만족하지 못했지만, 2개의 임플란트를 적절한 고정원으로 이용함으로써 성공적인 수복이 가능하였다.

• Journal of Periodontal and Implant Science
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• 제51권5호
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• pp.329-341
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• 2021

Purpose: Periodontal treatment aims at complete regeneration of the periodontium, and developing strategies for periodontal regeneration requires a deep understanding of the tissues composing the periodontium. In the present study, the stemness characteristics and gene expression profiles of cementum-derived cells (CDCs) were investigated and compared with previously established human stem cells. Candidate marker proteins for CDCs were also explored. Methods: Periodontal ligament stem cells (PDLSCs), pulp stem cells (PULPSCs), and CDCs were isolated and cultured from extracted human mandibular third molars. Human bone marrow stem cells (BMSCs) were used as a positive control. To identify the stemness of CDCs, cell differentiation (osteogenic, adipogenic, and chondrogenic) and surface antigens were evaluated through flow cytometry. The expression of cementum protein 1 (CEMP1) and cementum attachment protein (CAP) was investigated to explore marker proteins for CDCs through reverse-transcription polymerase chain reaction. To compare the gene expression profiles of the 4 cell types, mRNA and miRNA microarray analysis of 10 samples of BMSCs (n=1), PDLSCs (n=3), PULPSCs (n=3), and CDCs (n=3) were performed. Results: The expression of mesenchymal stem cell markers with a concomitant absence of hematopoietic markers was observed in PDLSCs, PULPSCs, CDCs and BMSCs. All 4 cell populations also showed differentiation into osteogenic, adipogenic, and chondrogenic lineages. CEMP1 was strongly expressed in CDCs, while it was weakly detected in the other 3 cell populations. Meanwhile, CAP was not found in any of the 4 cell populations. The mRNA and miRNA microarray analysis showed that 14 mRNA genes and 4 miRNA genes were differentially expressed in CDCs vs. PDLSCs and PULPSCs. Conclusions: Within the limitations of the study, CDCs seem to have stemness and preferentially express CEMP1. Moreover, there were several up- or down-regulated genes in CDCs vs. PDLSCs, PULPSCs, and BMSCs and these genes could be candidate marker proteins of CDCs.

• Journal of Oral Medicine and Pain
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• 제46권4호
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• pp.161-164
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• 2021

The foramen of Huschke (FH) or foramen tympanicum is a persistent bony defect connecting the external auditory canal (EAC) to the temporomandibular joint (TMJ). It arises from an incomplete ossification of the tympanic part of the temporal bone that persists after the age of 5. If a herniation exists in the TMJ, otological symptoms may occur. An 80-year-old female patient complained of noise in her left TMJ and otorrhea in her left ear. On her cone beam computed tomography images, there were only degenerative joint disease signs on her left mandibular condyle. However, her computed tomography images revealed that the soft tissue of the TMJ herniate into the EAC. Additional examination was planned for the further evaluation. But the patient no longer visited the hospital due to her systemic health status, and symptoms disappeared spontaneously without any treatments. Usually this type of herniation is very rare, but years of mechanical stress from mastication may result in weakening and widening of the foramen with age. Therefore, although FH is usually congenital, sometimes it may be acquired in the elderly. The treatment plan should be determined in consideration of the patient's symptom level and the patient's general health status. If the clinical symptoms are not severe, no treatment is required.

• 한국임상수의학회지
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• 제39권5호
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• pp.264-271
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• 2022

Two Korean short-haired cats were admitted to the Veterinary Medical Teaching Hospital, Chonnam National University, with severe lower lip avulsion. In the first case, the treatment was performed using the tension-free suture technique with rubber tube stents. The second case was treated using the tension-free suture technique with rubber tube stents for lip avulsion and using the cerclage wiring technique for alveolar fracture. The teeth around the alveolar fracture were extracted and bone graft and collagen membrane were applied at the alveolar fracture site to stabilize the mandibular alveolar fracture. Thereafter, the cerclage wire was placed circumferentially around the mandible. In both cases, normal function of the oral cavity was successfully recovered by repairing the anatomic abnormality. In conclusion, tension-free suture technique can be a treatment option for bilateral lower lip avulsion in cats.

• 대한치과보철학회지
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• 제60권4호
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• pp.347-353
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• 2022

상악 완전 무치악과 하악 양측 후방 무치악 상태의 환자에서 전통적인 의치를 제작하는 방법은 흔히 볼수 있는 치료 방법이다. 그러나 장기적으로 볼 때 이와 같은 구강내 환경에서는 복합증후군(Combination syndrome)이라는 합병증이 발생할 수 있다. 이때 임플란트를 동반한 국소의치(Implant Assisted Removable Partial Denture, IARPD)의 적용으로 치조골 보존과 함께 Combination syndrome의 예방을 도모할 수 있다. 본 증례에서는 무치악 부위에 임플란트의 추가 식립 시 국소의치의 움직임에 의해 최후방 지대치에 가해지는 응력을 줄일 수 있으므로 금속이 아닌 레진 클라스프를 계획하였고 flexible 의치 레진을 사용하였다. 상악 총의치, 하악 flexible IARPD를 계획하여 최소한의 비용과 수술로서 심미적, 기능적인 장기적 예후를 얻어 보고하고자 한다.