• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권4호
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• pp.209-213
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• 2014

Purpose: Pathologic aerophagia (PA) may lead to bowel perforation or volvulus in mentally retarded patients. The authors investigated the effects of clonazepam on the management of PA in children with severe to profound mental retardation (MR). Methods: This study was undertaken as a retrospective case analysis of 21 PA patients with MR who were followed for over 12 months and diagnosed as having PA. Patients were assigned to two management groups, that is, to a clonazepam randomized open-labeled, treatment group or a reassurance group. The following were recorded and analyzed; age, response, remission rate to clonazepam treatment, and the side effect of clonazepam. It was defined positive response (response+) as being symptom-free for a whole week within 1 month of commencing treatment and remission(+) as being symptom-free for a whole month within 6 months of treatment. Results: The average age of the 21 PA children with MR was 10 years and 13 patients were female. Symptom duration before diagnosis of PA was 7 months. Clinical features of the clonazepam-trial group (n=11) and the reassurance group (n=10) were non-significantly different. Response(+) was achieved by 2 patients (18.2%) in the clonazepamtrial group and by no patient in the reassurance group. Remission(+) was achieved by 6 patients (54.5%) in the clonazepam-trial group and by one patient (10%) in the reassurance group (p=0.040). Conclusion: When PA children with MR with severe bowel distention are considered for surgical treatment to prevent acute abdomen, a trial of clonazepam could be recommended.

• 정신신체의학
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• 제9권1호
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• pp.93-102
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• 2001

이완반응은 갚은 휴식상태를 말하며, 소위 스트레스반응으로 불리는 투쟁-도피 반응의 생리적 변화와 반대되는 생리적 변화를 일으키게 된다. 따라서 인위적으로 이완반응을 일으킴으로써 이러한 스트레스 반응을 상쇄시킬 수 있다. 이러한 이완반응을 일으킬 수 있는 복식호흡, 명상, 점진적 근육이완기법, 자율이완훈련, 생체되먹이기법 등의 다양한 이완기법들이 제시되어 왔으며, 이들은 다양한 신체, 정신 질환뿐만 아니라 정상적인 스트레스 관리 프로그램에 있어서도 마음과 신체의 안녕을 위해 유익한 도움을 줄 수 있음이 알려져 있다. 이러한 이완기법들은 스트레스 관리를 위한 전체적 과정의 한 부분으로 이해되어야 할 것이며, 자신에 맞는 적절한 기법을 찾아 지속적인 훈련을 함으로써 효과적인 스트레스 관리 방법으로서의 역할을 할 수 있을 것이다. 이에 본 저자는 명상, 점진적 근육이완기법, 자율이완훈련 및 기타 이완기법에 대한 보다 구체적이고 실제적인 방법을 제시하고자 한다. 스트레스와 관련된 다양한 신체, 정신 질환들에 대한 치료적 접근을 함에 있어서, 전통적 치료 방법에 병합하여 이완기법을 사용함으로써 스트레스와 질병 사이의 조절자로 이용할 수 있을 것이다.

• 한국방재학회 논문집
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• 제10권5호
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• pp.55-66
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• 2010

국민들의 생활수준과 삶에 대한 기대 수준이 높아지면서 첨단 기술을 도시에 적용함으로써 생활의 편리성과 안전성을 높이고 자 하는 요구가 점차 확대되고 있다. 이에 따라 최첨단 정보통신기술이 융합된 유비쿼터스 도시가 다가오는 미래도시의 유력한 대안으로 보고 국가 차원의 대규모 사업이 이루어지고 있다. 국가 재난관리를 위해서 재난 분야별 방재에 대한 준비가 어느 정도 되어 있는지 대응역량을 점검하여 부족한 분야에 대해 해결방안을 도출하고자 하였다. 본 연구 결과 현재의 재난 분야별 대응역량이 어느 정도 차이가 있음을 확인할 수 있었다. 이를 통해 재난 분야별, 단계별 대응역량이 부족한 분야에 대해서 정책적 제언과 유비쿼터스 시대를 맞이하여 기존의 재난관리 방식보다는 유비쿼터스 기술 접목한 새로운 패러다임의 방재시스템 구축을 제안하고자 한다.

• 품질경영학회지
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• 제40권3호
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• pp.359-371
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• 2012

Purpose: Due to the explosive growth and widespread use of smartphones, new business opportunities are emerging. Despite the importance of creating customer value in using smartphone applications, past studies on have mainly focused on functions or factors and specifications that influence users to use the device. Methods: This study is intended to identify how customer dissatisfaction from the use of smartphone application services affects customer sentiment and behavior. The research model is tested via a survey of 290 smartphone application users. Results: The result of this empirical study indicates that customer dissatisfaction significantly affects the user's disappointment and regret in using a service, which are subordinate values of customer emotion. The user's anger is positively associated with 'Negative word of mouth' and 'Complaint', which are subordinate values of customer behavior, but not with an intention to switch to another service. 'Regret' and 'Disappointment' are positively associated with 'Negative word of mouth' and 'Switching intention', but not with 'Making direct complaints'. Finally, customer's negative sentiments are a significant intermediary in the relationship between customer dissatisfaction and behavioral response. Conclusion: Finally, the study offers a more systematic understanding on the phasal response process of customer dissatisfaction in relation to the provision of smartphone application services.

• Asian Journal of Atmospheric Environment
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• 제12권1호
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• pp.1-16
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• 2018

Ground-level ozone ($O_3$) can be a menace for vegetation, especially in Asia where $O_3$ levels have been dramatically increased over the past decades. To ensure food security and maintain forest ecosystem services, such as nutrient cycling, carbon sequestration and functional diversity of soil biota, in the over-populated Asia, environmental standards are needed. To set proper standards, dose-response relationships should be established from which critical levels are derived. The predictor of the response in the dose-response relationship is an $O_3$ metric that indicates the dose level to which the plant has been exposed. This study aimed to review the relevant scientific literature and summarize the $O_3$ metrics used worldwide to provide insights for Asia. A variety of $O_3$ metrics have been used, for which we discuss their strengths and weaknesses. The most widely used metrics are based only on $O_3$ levels. Such metrics have been adopted by several regulatory agencies in the global. However, they are biologically irrelevant because they ignore the plant physiological capacity. Adopting AOT40 ($O_3$ mixing ratios Accumulated Over the Threshold of $40nmol\;mol^{-1}$) as the default index for setting critical levels in Asia would be a poor policy with severe consequences at national and Pan-Asian level. Asian studies should focus on flux-based $O_3$ metrics to provide relevant bases for developing proper standards. However, given the technical requirements in calculating flux-based $O_3$ metrics, which can be an important limitation in developing countries, no-threshold cumulative exposure indices like AOT0 should always accompany flux-based indices.

• 한국화재소방학회논문지
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• 제28권6호
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• pp.90-98
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• 2014

최근 우리나라의 유해화학물질 사고는 반복적으로 재현되고 있다. 본 연구에서는 2008년~ 2014년 기간 동안 유해화학 물질 사고사례의 분석을 통해 유해화학물질의 문제점 및 대처방안에 대하여 조사했다. 우리나라의 유해화학물질 사고의 현황 중 유출에서는 작업장 내에서 유출이 2008년 58.6% (10건)으로 가장 높았고, 폭발에 따른 유출은 2004년 50%(5건), 2007년 25% (4건), 2011년 33.3% (4건)로 불규칙적으로 발생하였다. 유해화학물질의 대부분의 원인은 안전관리 미흡에서 발생하는 것으로 이해된다. 유해화학물질은 다양한 양상을 띠며 잔류성이 매우 높고 비가시적인 특징 때문에 대응 및 복구에 어려움이 많고, 먼 거리까지 이동해 제2의 피해인 환경오염을 일으킨다. 이에 유관기관의 공조체제 및 통합적인 시스템을 구축하여야 하고, 화학사고대응전문기관과 화학물질 대응 치료전문기관을 설립해 효율적이고 신속한 대응을 하여야 한다.

• 약학회지
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• 제26권4호
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• pp.215-222
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• 1982

Among the environmental pollutants, parathion, chloroform and 2, 6-dichlorophenol may impair human health; they may inhibit or reduce the metabolic function of human body and may furthermore cause diseases directly or indirectly. This study was undertaken to investigate the effects on the immune response by intoxication of parathion, chloroform or 2, 6-dichlorophenol. Parathion(1.3mg/kg, olive oil 10ml), chloroform (100mg/kg, olive oil 10ml) were administered via intraperitoneal injection to rats. And 2, 6-dichlorophenol (13mg/kg, olive oil 10ml) was administered via oral injection. After 3 weeks, the rats were intoxicated with the above chemicals and immunized with sheep RBC. After 4 weeks the immune response of rat spleen cells was measured by the Jerne's technique. The results were obtained as follows. 1. There was no change of leukocyte counts by the intoxication of parathion, chloroform and 2, 6-dichlorophenol. 2. Parathion, chloroform and 2, 6-dichlorophenol reduced hemoglobin contents for most intoxicated and immunized groups. 3. Hematocrits were decreased by the intoxication of parathion, chloroform or 2, 6-dichlorophenol significantly. 4. It was determined that total protein, A/G (albumin/globulin), .alpha.-, .betha.-and .gamma.-globulins in rat serum were not changed. 5. Intoxication by parathion, chloroform or 2, 6-dichorophenol reduced the number of hemolytic plaque to the sheep RBC in rat spleen cells. Therefore, the capacity of erythrocyte production and the immune response of rat spleen cells were decreased by the intoxication of parathion, chloroform, or 2, 6-dichlorophenol.

• 한국조리학회지
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• 제21권1호
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• pp.116-128
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• 2015

본 연구는 부산 경남권의 호텔레스토랑을 방문하여 이용 중인 고객을 대상으로 식공간 연출이 고객감정반응을 통해 고객 행동의도를 높이는지의 간접효과 및 고객감정반응의 매개효과를 검증하여, 지속적으로 호텔 레스토랑을 방문할 수 있는 마케팅 전략의 기초 자료를 제시하고자 하였으며, 식공간 연출은 고객감정반응을 통해 행동 의도에 긍정적인 효과를 미쳤으며, 식공간 연출과 행동의도 간의 관계에서 고객감정반응은 부분매개효과를 가지는 것으로 나타났다. 이를 통해 파악할 수 있는 시사점은 다음과 같다. 첫째, 호텔 레스토랑을 찾는 고객이 다시 찾거나, 다른 사람에게 홍보할 수 있는 행동을 유도하기 위해서는 기본적으로 레스토랑의 식공간이 미각적, 시각적, 청각적, 촉각적, 후각적으로 좋은 연출이 이루어질 수 있도록 전략을 수립하여야 할 것이다. 둘째, 호텔 레스토랑의 식공간이 미각적, 시각적, 청각적, 촉각적, 후각적으로 좋은 연출이 이루어질 수 있기 위해서는 고객의 감정이 즐겁고, 설레이며, 분위기에 끌려야 하고, 분위기에 압도 당하는 기분이 들어 놀라움을 느낄 수 있도록 해야 한다. 셋째, 고객의 긍정적인 감정 반응을 끌어올리는 식공간 연출은 호텔레스토랑을 다시 찾고, 홍보하는 행동 유도를 극대화 할 수 있다.

• Radiation Oncology Journal
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• 제7권2호
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• pp.227-233
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• 1989

From April 1986 to Dec 1988, fifty one patients with carcinoma of lung were treated by radiation therapy in Department of Therapeutic Radiology, Yeungnam University Hospital Of the 51 patients, $31(61\%)$ were squamous cell ca, $8(15.7\%)$ were small cell ca, and remained $4(7.9\%)$ were other cell types. Total radiation dose was average $64Gy (60\~75 Gy)$ for group A and 45Gy $(40\~59Gy)$ for group B. The mass regression and the response of airway obstruction to radiation therapy was established on the basis of follow up chest X-ray. The mass regression above $50\%$ of total volume was noted in 23 patients $(74.2\%)$ among 31 patients and the difference between two groups was not seen. In squamous cell ca, however, the mass regression rate (above $50\%$ of total volume) was $83.3\%$ (10/12) in group A compared to $50\%$ (3/6) in group B(p<0.05). The alleviation of airway obstruction was noted as follows. In group A, CR $42.9\%$, PR $35.7\%$, no response $21.4\%$ and in group B, CR $55.6\%,\;PR\;33.3\%$, no response $11.1\%$. But, in squamous cell ca, responsiveness is higher than group B. The study indicates that the importance of higher radiation dose in the management of primary tumor mass and airway obstruction caused by lung cancer especially squamous cell ca. So, meticulous treatment planning and multimodality combination therapy without increasing si.do elect or complication is recommended in management of inoperable bronchogenic carcinoma.

• Journal of Nutrition and Health
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• 제55권4호
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• pp.450-461
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• 2022

Purpose: DNA damage and repair responses are induced by metabolic diseases and environmental stress. The balance of DNA repair response and the antioxidant system play a role in modulating the entire body's health. This study uses a high-fat and high-calorie (HFC) drink to examine the new roles of a plant-based multivitamin/mineral supplement with phytonutrients (PMP) for regulating the antioxidant system and cellular DNA repair signaling in the body resulting from metabolic stress. Methods: In a double-blind, randomized, parallel-arm, and placebo-controlled trial, healthy adults received a capsule containing either a PMP supplement (n = 12) or a placebo control (n = 12) for 8 weeks. Fasting blood samples were collected at 0, 1, and 3 hours after consuming a HFC drink (900 kcal). The blood samples were analyzed for the following oxidative stress makers: areas under the curve reactive oxygen species (ROS) levels, plasma malondialdehyde (MDA), erythrocytes MDA, urinary MDA, oxidized low-density lipoprotein, and the glutathione:oxidized glutathione ratio at the time points. We further examined the related protein levels of DNA repair signaling (pCHK1 (Serine 345), p-P53 (Serine 15), and 𝛄H2AX expression) in the plasma of subjects to evaluate the time-dependent effects of a HFC drink. Results: In a previous study, we showed that PMP supplementation for eight weeks reduces the ROS and endogenous DNA damage in human blood plasma. Results of the current study further show that PMP supplementation is significantly correlated with antioxidant defense. Compared to the placebo samples, the blood plasma obtained after PMP supplementation showed enhanced DNA damage response genes such as pCHK1(Serine 345) (a transducer of DNA response) and 𝛄H2AX (a hallmark of DNA damage) during the 8 weeks trial on metabolic challenges. Conclusion: Our results indicate that PMP supplementation for 8 weeks enhances the antioxidant system against oxidative stress and prevents DNA damage signaling in humans.