• 대한골관절종양학회지
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• 제9권2호
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• pp.155-161
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• 2003

1990년이래 치험한 5례의 수부 전이암은, 남자 1명, 여자 4명이었고, 원발성 종양은 폐암 2례, 유방암, 위암 및 직장암이 각 1례씩이 었으며, 근위지골 발생이 4례, 원위지골 발생이 1례 였고, 단발 수지 발생 4례, 다발 수지 발생이 1례 였다. 수부 전이암이 X-선상 진단되기 전 약 3~6개월전부터 동통과 부종 및 X-선상 수부 골조송증의 소견이 있어 이들이 수부 전이암의 초기 증상으로 판단되였다. 이들은 열 전단술 3례, 견관절 이단 및 보존적 치료를 각 1례씩 시행 하였으며, 진단이후 생존 기간은 평균 5개월 이었다.

• Radiation Oncology Journal
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• 제4권1호
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• pp.63-66
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• 1986

흉폐부위에서 발생하는 악성소세포종양은 1979년 Askin이 보고했고 이를 Askin종양이라고 부른다. Askin종양은 상당히 희귀하며 흉벽에 연조직이나 폐가장자리에서 잘 생기며 특히 젊은 층에 호발한다. 임상적, 병리학적으로 Ewing's sarcoma와 Rhabdomyosarcoma와 상당히 흡사하나 정밀한 전자현미경 관찰시 병리학적으로 별개에 종양으로 간주되었다. Askin종양은 국소재발이 많고 전신으로 잘 터지지 않는 경향이 있으나 생존율은 상당히 나쁜 것으로 되어 있다. 임상적으로나 병리학칙으로 Askin종양에 해당되는 24계 환자를 치료결과와 더불어 보고한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8577-8579
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• 2014

Osteosarcoma is a common malignant tumor of bone, but mechanisms underlying its development are still unclear. At present, it is believed that the inhibition of normal apoptotic mechanisms is one of the reasons for the development of tumors, so specific stimulation of tumor cell apoptosis can be considered as an important therapeutic method. Livin, as a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family, has specifically high expression in tumor tissues and can inhibit tumor cell apoptosis through multiple ways, which can become a new target for malignant tumor treatment (including osteosarcoma) and might of great significance in the clinical diagnosis of tumors and the screening of anti-tumor agents and carcinoma treatment.

• 대한핵의학회지
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• 제17권1호
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• pp.25-31
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• 1983

Serum thyroglobulin(Tg) was measured by radioimmunoassay in 81 patients with thyroid tumor who were treated in the department of Internal medicine of National Medical Center from January, 1981 to June, 1982. The results were as follows: 1) The mean serum thyroglobulin level in thyroid tumor was significantly higher than normal subjects (p<0.001). 2) The mean serum thyroglobulin level in benign tumor was lower than malignant tumor (p<0.05). 3) The thyroid carcinoma with metastasis had significant high level of serum thyroglobulin than without metastasis (p<0.001). 4) The mean postoperative serum thyroglobulin level was significantly lower than preoperative level (p<0.001). Data from our study show that serum thyroglobulin determination is useful for assessing the presence of malignant thyroid tumor, metastasis and the extent of residual or recurrent thyroid cancer after surgery.

• 대한골관절종양학회지
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• 제2권1호
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• pp.33-37
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• 1996

From January 1994 to August 1995 we performed 270 cases of fine needle aspiration cytology for bone and soft tissue lesions. Among them 137 cases were diagnosed histologically. Sixty-seven cases were benign and 70 cases were malignant. We analysed these on the aspect of sensitivity, specifity, positive predictive value, negative predictive value of the cytologic examination. Malignant cases consisted of bone tumor 29 cases; soft tissue tumor 25 cases; and metastatic tumor 16 cases. The sensitivity and specifity of the aspiration cytology for malignant tumor were 67.8% and 97%, respectively. The positive and negative predictive value of aspiration cytology were 97.4% and 72.7%, respectively. Among them 40 cases were primary bony lesions; 14 benign lesions, 26 malignamt bone tumors. Sensitivity of aspiration cytology for these primary bony lesion was 90%(18/20) and its specifity was 100%(13/13). Three cases showed atypical cells in cytology but with biopsy we could find them as one benign and two malignancies. Two cases of manignancy showed negative result in cytology; one was parosteal sarcoma of proximal femur and the other was osteosarcoma of proximal tibia which was biopsied already at other hospital. Although the overall sensitivity and specifity for malignant bone and soft tissue tumors were relatively low and not so predictable, the fine needle aspiration cytology for primary bony lesion was useful in the differential diagnosis of benign or malignancy.

• Journal of Korean Neurosurgical Society
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• 제53권3호
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• pp.190-193
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• 2013

A malignant peripheral nerve sheath tumor (MPNST) is a type of sarcoma that arises from peripheral nerves or cells of the associated nerve sheath. This tumor most commonly metastasizes to the lung and metastases to the spinal cord and brain are very rare. We describe a case of young patient with spinal cord and brain metastases resulting from MPNST. An 18-year-old man presented with a 6-month history of low back pain and radiating pain to his anterior thigh. Magnetic resonance imaging showed a paraspinal mass that extended from the central space of L2 to right psoas muscle through the right L2-3 foraminal space. The patient underwent surgery and the result of the histopathologic study was diagnostic for MPNST. Six months after surgery, follow-up images revealed multiple spinal cord and brain metastases. The patient was managed with chemotherapy, but died several months later. Despite complete surgical excision, the MPNST progressed rapidly and aggressively. Thus, patients with MPNST should be followed carefully to identify local recurrence or metastasis as early as possible.

• Radiation Oncology Journal
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• 제6권1호
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• pp.75-80
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• 1988

Twenty seven lesions of 25 patients with locally advanced malignant tumors were treated with combined hyperthermia introduced by microwave and ultrasound and radiotherapy. Most of all patients were failed with previous conventional therapeutic trial. Hyperthermia had been done immediately after radiotherapy, twice a week, $43^{\circ}C$ for one hour and radiotherapy had been done 5 fractions per week with fraction size of 2Gy upto 30 to 60Gy. Conclusions are as follows. 1. Total response rate (PR+PR) to thermoradiotherapy with microwave and ultrasound was $81\%$. 2. Tumor depth, minimum temperature of tumor center, number of heat fraction and radiation dose were statistically significant factors affecting response. 3. Hyperthermia with microwave and ultrasound can be used efficiently to control locally advanced malignant disease whether previously received near tolerance dose of radiotherapy or not.

• Journal of Chest Surgery
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• 제27권4호
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• pp.297-302
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• 1994

This report is a review of 98 cases of the primary mediastinal tumors which are treated in the Department of Thoracic and Cardiovascular Surgery, Chonnam University Hospital from January, 1985 to February, 1993 and divided two groups. One group is from January, 1985 to January, 1989 and named it Group 1[G1]. Another group is from February, 1989 to February, 1993 and named it Group 2[G2]. Chest pain is the most common clinical manifestation in the two groups. The common mediastinal tumors are teratoma 11 cases[29.7%], neurogenic tumor 7 cases[18.9%], thymoma 6 cases[16.2%], primary cyst 3 cases[8.1%] in Group 1 and thymoma 16 cases[26.2%], teratoma 15 cases[24.6%], neurogenic tumor 9 cases[14.8%], primary cyst 9 cases[14.8%] in Group 2. Therefore this result shows that the incidence of thymoma is increased in group 2. In benign tumors, the subjective symptoms are 64.3% in group 1 and 63.6% in group 2. In malignant tumors, they are 100% in group 1 and 82.4% in group 2. this result shows that asymptomatic malignant tumors are increased in group 2. The successful excision is done in all of the 71 benign tumors except one. In malignant tumors, the complete surgical excision is increased from 11.1% in group 1 to 41.2% in group 2.

• Journal of Korean Neurosurgical Society
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• 제47권1호
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• pp.51-54
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• 2010

Surgery has a key role in the treatment of malignant peripheral nerve sheath tumors (MPNSTs), but the resectability of paraspinal MPNSTs is only 20%. Therefore, spinal MPNSTs show frequent recurrence and poor prognosis. Local recurrence is much more common than metastasis for MPNSTs, and surgery still has a key role in the treatment of local recurrence. Therefore, it is important that recurrence must be detected before resectability is lost. However, no evidence-based follow-up protocol has been established for MPNST. The authors performed gross total resection in a 34-year-old woman presented with thoracic MPNST. Adjuvant radiotherapy and chemotherapy were not administered since these adjuvant therapies generally do not improve survival in MPNST and may cause additional neurovascular damage. Instead, the authors monitored the primary site every 3 months using magnetic resonance imaging to detect local recurrence at the earliest opportunity. The tumor recurred locally on two occasions without overt symptoms at 21 and 24 months postoperatively. These recurrences were treated successfully by gross total removal.

• 대한수의학회지
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• 제54권1호
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• pp.7-12
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• 2014

Peripheral nerve sheath tumors (PNSTs) are heterogeneous tumor groups of peripheral nerves that originate from either Schwann cells or modified Schwann cells, fibroblasts, or perineural cells. In this study, signalment and clinical data such as tumor location and size were evaluated for 15 cases of PNSTs collected from local animal hospitals. The mean age of dogs with malignant PNST was higher than that of dogs with benign PNST. Additionally, the male to female ratio in dogs with PNST was 1 : 4. In dogs with PNST, the primary sites of involvement were the hindlimb, forelimb, around the mammary glands, the neck, and the abdomen. Histiopathologic examination revealed that eight PNSTs were benign and seven were malignant. The tumor cells were composed of loosely to densely arranged interlacing bundles and wavy spindle cells arranged in short bundles, palisading, and whirling. High mitotic figures, local invasion, multifocal necrosis and atypical multinucleated giant cells were observed in malignant PNST cases. All PNSTs showed immunoreactivity for vimentin and S-100. However, only 93.3% and 73.3% were immunoreactive for NSE and GFAP, respectively. Overall, these results indicated that immunohistochemical markers such as vimentin, S-100 and NSE could help confirm the diagnosis of canine PNSTs.