• Tuberculosis and Respiratory Diseases
• /
• 제47권4호
• /
• pp.478-487
• /
• 1999

연구배경 : 전자현미경적 관찰에 의해 진단된 흉막의 악성중피종과 전이성선암 환자를 대상으로 하여 7종의 단일클론항체를 이용한 면역조직화학염색을 시행하고 이들의 발현양상을 비교하여 두 질환을 감별할 수 있는 가장 효과적인 염색방법을 알아보고자 하였다. 방 법 : 면역조직화학염색법은 Fisher사(Fisher scientific)의 1-hour immunohistochemistry방법을 이용하였다. 종양조직은 포르말린으로 고정된 파라핀 조직을 이용하여, $3{\mu}m$ 두께로 잘라서, $85^{\circ}C$에서 가열시킨 후 파라핀을 제거하고, 희석액과 단클론항체를 $45^{\circ}C$에서 15분간 반응시켰다. 각 단계마다 automation buffer로 실온에서 세척하였고, avidin-biotin-peroxidase system을 이용한 immunoperoxidase method로 염색하였다. 조직절편은 $45^{\circ}C$에서 10분간 색소원반응을 시행하였고, 대조염색은 hematoxylin으로 실시하였다. 조직 절편은 최소한 각기 다른 두 구역에서 세포질 또는 세포막이 분명하게 염색될 때 양성으로 판정하였다. 결 과 : 7종의 단일클론항체중 CK, EMA, vimentin, S-100 단백과 Leu-M1은 악성중피종과 전이성선암에서 발현율의 차이는 없었으나, B72-3은 전이성선암에서만 발현되었고, CEA는 전이성선암 전례와 악성중피종 42.9%에서 발현되어서 민감도는 높았으나 특이도는 낮았다. 결 론 : B72-3을 이용한 면역조직화학염색은 악성중피종과 전이성선암의 감별진단에 가장 유용한 방법으로 시사되었으며, 기존에 사용되고 있는 CEA와 B72-3을 함께 이용한다면 악성중피종과 전이성선암에 대한 감별진단력을 높일 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권9호
• /
• pp.4745-4749
• /
• 2012

The diagnosis of malignant mesothelioma (MM) remains a clinical challenge and the fluorescence in situ hybridization (FISH) assay has been reported to be one promising tool. The present meta-analysis aimed to establish the overall diagnostic accuracy of FISH for diagnosing MM. After a systematic review of English language studies, the sensitivity, specificity and other measures of accuracy of FISH in the diagnosis of MM were pooled using random-effects models. Summary receiver operating characteristic curves were applied to summarize overall test performance. Nine studies met our inclusion criteria, the pooled sensitivity and specificity for FISH for diagnosing MM being 0.72 (95% CI 0.67-0.76) and 1.00 (95% CI 0.98-1.00), respectively. The positive likelihood ratio was 34.5 (95% CI 14.5-82.10), the negative likelihood ratio was 0.24 (95% CI 0.16-0.36), and the diagnostic odds ratio was 204.9 (95% CI 76.8-546.6), the area under the curve being 0.99. Our data suggest that the FISH assay is likely to be a useful diagnostic tool for confirming MM. However, considering the limited studies and patients included, further large scale studies are needed to confirm these findings.

• Journal of Chest Surgery
• /
• 제51권3호
• /
• pp.195-201
• /
• 2018

Background: We investigated the surgical outcomes of patients who underwent therapeutic surgery for malignant pleural mesothelioma (MPM) at a single center. Methods: A retrospective review of 21 patients who underwent therapeutic surgery for MPM from January 2001 to June 2015 was conducted to assess their outcomes. The patients' characteristics and postoperative course, including complications, mortality, overall survival, and recurrence-free survival, were analyzed. Results: Of the 21 patients who underwent therapeutic surgery, 1 5 (71.4%) underwent extrapleural pneumonectomy, 2 pleurectomy (9.5%), and 4 excision (1 9.1 %). The median age was 57 years (range, 32-79 years) and 15 were men (71.4%). The mean hospital stay was 1 6 days (range, 1-63 days). Median survival was 14.3 months. The survival rate was 54.2%, 35.6%, and 21.3% at 1, 3, and 5 years, respectively. In patients' postoperative course, heart failure was a major complication, occurring in 3 patients (14.3%). The in-hospital mortality rate was 2 of 21 (9.5%) due to a case of severe pneumonia and a case of acute heart failure. Conclusion: A fair 5-year survival rate of 21.3% was observed after surgical treatment. Heart failure was a major complication in our cohort. Various surgical methods can be utilized with MPM, each with its own benefits, taking into consideration the severity of the disease and the comorbidities of the patient. Patients with local recurrence may be candidates for surgical intervention, with possible satisfying results.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권4호
• /
• pp.1403-1407
• /
• 2015

Background: New tumour biomarkers are being intensely investigated for malignant mesothelioma (MM). Fibulin-3 is produced in MM but its role remains uncertain. The aim of this study was to evaluate the validity of measuring serum fibulin-3 in the diagnosis and prognosis of MM. Materials and Methods: This prospective study was performed on 43 patients and 40 healthy controls who were admitted to our hospital between January 2012 and January 2014. Data from MM patients, including demographic and clinical features, routine laboratory data, levels of serum fibulin-3, and treatment outcomes were defined as potential prognostic factors. The receiver operating characteristic (ROC) curve for fibulin-3 was used to detect the cut-off value with highest sensitivity and specificity. Univariate survival analysis was performed using the Kaplan-Meier method in patients with MM. Afterwards, the possible factors identified with univariate analyses were entered into the cox regression analysis. Results: Our results revealed that patients with MM had significantly higher serum levels of fibulin-3 than controls. The results showed that the best cut-off point was 36.6 ng/ml with an AUC (area under the curve)=0.976, sensitivity=93.0% and specificity=90.0. In our study, the initial significant poor prognostic factors were advanced stage, high white blood cell count, high platelet count, high C-reactive protein (p<0.05 for each variable). Later, according to multivariate analysis the results showed only advanced stage as significant parameter (p=0.040). Conclusions: We determined that real use for serum fibulin-3 was not for prognosis but for diagnosis in MM. Also advanced stage was associated with poor MM prognosis.

• Journal of Chest Surgery
• /
• 제51권1호
• /
• pp.35-40
• /
• 2018

Background: The treatment of malignant pleural mesothelioma (MPM) is challenging, and multimodal treatment including surgery is recommended; however, the role of surgery is debated. The treatment outcomes of MPM in Korea have not been reported. We analyzed the outcomes of MPM in the context of multimodal treatment, including surgery. Methods: The records of 29 patients with pathologically proven MPM from April 1998 to July 2015 were retrospectively reviewed. The treatment outcomes of the surgery and non-surgery groups were compared. Results: The overall median survival time was 10.6 months, and the overall 3-year survival rate was 25%. No postoperative 30-day or in-hospital mortality occurred in the surgery group. Postoperative complications included tachyarrhythmia (n=4), pulmonary thromboembolism (n=1), pneumonia (n=1), chylothorax (n=1), and wound complications (n=3). The treatment outcomes between the surgery and non-surgery groups were not significantly different (3-year survival rate: 31.3% vs. 16.7%, respectively; p=0.47). In a subgroup analysis, there was no significant difference in the treatment outcomes between the extrapleural pneumonectomy group and the non-surgery group (3-year survival rate: 45.5% vs. 16.7%, respectively; p=0.23). Conclusion: Multimodal treatment incorporating surgery did not show better outcomes than non-surgical treatment. A nationwide multicenter data registry and prospective randomized controlled studies are necessary to optimize the treatment of MPM.

• Journal of Chest Surgery
• /
• 제26권6호
• /
• pp.483-487
• /
• 1993

From July 1990 to August 1992,78 Hickman catheters and 22 chemoports were inserted in 98 patients for chemotherapy.We analyzed the clinical data of these patients. The results were as follows: 1]Mean age of patients was 42.8$\pm$1.6[SE] years 2]Male to female ratio was 1.09:1 3]The diseases of the cases were leukemia[66] ,lymphoma[8], stomach cancer[8],uterine cervix cancer[5],ovarian cancer[4],lung cancer[3],aplastic anemia[2],maxillary gland cancer[1],pancreas cancer[1],malignant mesothelioma[1] and multiple myeloma[1] 4]Mean values of preoperative WBC counts,platelet counts,PT and APTT were 31,500$\pm$ 8,132[SE]/mm,104,000$\pm$ 12,200 [SE]/mm,82$\pm$ 1.9[SE]% and 32$\pm$ 0.8[SE] sec,respectively. 5]The average duration of catheter uses was 121.7$\pm$ 17.3[SE]days. 6]The complications were subcutaneous tunnel bleeding or hematoma[2],exit site or subcutaneous tunnel infection[2] and catheter related septicemia[1]. 7]The causes of catheter removal were patient`s death or hopeless discharge[22],completion of treatment[6],subcutaneus hematoma or bleeding[2],exit site or subcutaneous tunnel infection[2] and catheter related septicemia[1].So,we concluded that Hickman catheter and chemoport were useful vascular access for chemotherapy in patients with malignant diseases, with low rate of complication and longterm duration.

• 한국환경보건학회지
• /
• 제35권2호
• /
• pp.71-77
• /
• 2009

In Korea, asbestos related diseases (ARDs) associated with occupational and environmental asbestos exposures have been reported, and commercial products contaminated with asbestos have gathered huge public attentions recently. Review of previous studies was conducted. Whereas asbestos consumptions among developed countries have decreased, those of Asian countries have increased, which showed typical international transfer of hazardous industries. In Korea residents around former asbestos mines had ARDs, which were reported in many countries such as South Africa, Canada and Australia. ARDs among residents around asbestos factories were found in many countries such as United Kingdom, United States and Italia, and increased relative risks were reported among residents around asbestos textile factories in Korea. Increased air asbestos concentrations by environmental asbestos leakages from factories were correlated with higher malignant mesothelioma incidence rates. When air dispersion model applied, excess incidence rate as far as 2.5 km from a factory were observed. As mesothelioma incidence rate, a representative index of ARD, in Korea has not reported systemically, mandatory reporting system by health personnel who diagnose the disease needs to be introduced. It is hard to conclude that commercials with contaminated asbestos do not have adverse health effects, and further studies are needed to solve these public questions.

• Journal of Chest Surgery
• /
• 제33권12호
• /
• pp.978-981
• /
• 2000

중피종은 늑막의 중피세포에서 발생되는 매우 드문 종양이며, 저혈당은 비섬세포(Non-islet cell) 종양에서 발생되는 매우 드문 증상으로 알려져 있다. 본 저자들은 좌측 흉강을 차지하며 저혈당을 동반한 환자에서 종양의 수술적 제거직후 증상이 사라졌으며, 조직학적으로는 국소섬유종의 소견을 보일 경우를 치험하여 보고하는 바이다.

• Journal of Chest Surgery
• /
• 제43권4호
• /
• pp.437-440
• /
• 2010

심장에서 발생한 중피종은 아주 드문 질환으로 초기에 비특이적인 증상으로 진단이 어렵다. 본원에서는 협착성 심막염으로 진단하여 심막 절제술을 시행후 중피종으로 확진된 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 4개월과 10년간의 호흡곤란을 호소하였고 흉부 전산화 촬영상 소량의 심낭 삼출액과 전체 심장을 둘러싸는 심막의 비후를 보였으나 뚜렷한 종괴의 소견은 보이지 않았다. 정중 흉골 절개하에 수술을 진행했으며 전반적으로 심막의 두께가 10 mm 이상 두꺼워져 있었다. 양측 횡격막신경을 경계로 하여 부분 심막 절제술을 시행하였다. 술후 조직검사상 악성 중피종으로 진단되었다. 첫번째 환자는 술후 7개월째 심막 주위로 재발하였으며 호흡 부전증으로 술후 11개월 째 사망하였고 두번째 환자는 항암치료후 술후 16개월째 생존하고 있다. 심막의 중피종은 아주 드문 질환이나 협착성 심막염과 비슷한 임상 양상으로 초기 감별 진단되어야 할 질환으로 보인다.

• Journal of Yeungnam Medical Science
• /
• 제3권1호
• /
• pp.301-306
• /
• 1986

저자들은 1986년 7월 2일 본 영남대학교 의과대학 부속 병원 내과에 입원한 혈액성 심낭 삼출액및 심막 비후 환자에서 심낭 개창술시 심막 조직 검사상 심막 악성 중피종으로 진단되고 급격한 임상 경과를 보이고 사망한 예를 경험하였다.