• 대한본초학회지
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• 제27권6호
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• pp.7-13
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• 2012

Objectives : Reactive oxygen species (ROS) have been associated with pathogenic processes including carcinogenesis through direct effect on DNA directly and by acting as a tumor promoter. Therefore, it has been regarded that ROS may be a major target for cancer prevention. The root of Paeonia lactiflora pall (PL), a traditional Chinese herb, has been a component of effective prescriptions for treatment of liver disease. Also, there are some reports about the antioxidant activities of the extracts from PL. However, little has been known about the effects of PL against oxidative damage. This work aimed to elucidate the anti-oxidant effects of Paeonia lactiflora pall (PL) in the non-cellular system and cellular system. Methods : Antioxidant activities of PL were evaluated by hydroxyl radical scavenging assay and $Fe^{2+}$ chelating assay. Anti-oxidative effect of PL was evaluated by ${\varphi}X$-174 RF I plasmid DNA cleavage assay in non-cellular system. In addition, DNA migration assay, expression level of phospho-H2AX, MTT assay and lipid peroxidation assay were performed for evaluate the anti-oxidative effect of PL in cellular system. Results : PL had a dose-dependent hydroxyl radical scavenging and $Fe^{2+}$ chelating capacity. In addition, PL inhibited oxidative DNA and cell damage induced by hydroxyl radical in non-cellular system and cellular system. Conclusion : Taken together, P. lactiflora pall may be possible for the application to a potential drug for treating the oxidative diseases such as cancer.

• Geomechanics and Engineering
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• 제36권2호
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• pp.121-130
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• 2024

Many foundation projects are built on red-bed soft rocks, and the damage evolution of this kind of rocks affects the safety of these projects. At present, there is insufficient research on the damage evolution of red-bed soft rocks, especially the progressive process from mesoscopic texture change to macroscopic elastoplastic deformation. Therefore, based on the dual-porosity characteristics of pores and fissures in soft rock, we adopted a cellular automata model to simulate the propagation of these voids in soft rocks under an external load. Further, we established a macro-mesoscopic damage model of red-bed soft rocks, and its reliability was verified by tests. The results indicate that the relationship between the number and voids size conformed to a quartic polynomial, whereas the relationship between the damage variable and damage porosity conformed to a logistic curve. The damage porosity was affected by dual-porosity parameters such as the fractal dimension of pores and fissures. We verified the reliability of the model by comparing the test results with an established damage model. Our research results described the progressive process from mesoscopic texture change to macroscopic elastoplastic deformation and provided a theoretical basis for the damage evolution of these rocks.

• 한국식품영양학회지
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• 제33권3호
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• pp.309-316
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• 2020

In this study, we investigated the protective effects of Ulva lactuca methanol extracts against ultraviolet B (UVB)-induced DNA damage in HaCaT cells. First, the contents of general and antioxidative nutrient contents of Ulva lactuca were measured. The moisture, carbohydrate, crude protein, crude fat and ash were 14.01%, 44.80%, 23.19%, 3.10% and 14.90%, respectively. Magnesium that acts as DNA repair enzyme cofactor was the most abundant mineral followed by Ca, P and Fe. The total phenolic and anthocyanoside contents of Ulva lactuca were 2.69 mg/g and 0.13 mg/g, respectively. Cells treated with Ulva lactuca methanol extracts for 24 hours post UVB exposure increased cell viability in a concentration-dependent manner compared to the non-treated control. Also, Ulva lactuca methanol extracts decreased the levels of UVB-induced DNA damage such as cyclobutane pyrimidine dimer and DNA damage response (DDR) proteins such as p-p53 and p21. These results suggest that Ulva lactuca methanol extracts comprising physiological active substances such as Mg, polyphenols and anthocyanosides promote DNA repair by regulating genes related with DDR.

• 해양환경안전학회지
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• 제27권3호
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• pp.439-446
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• 2021

Environmental damage caused by marine plastic debris occurs and has become a major contributor to marine pollution. This study analyzed the current state of marine plastic debris pollution and proposed essential strategies to reduce damage. To assess the current state of pollution arising from marine plastic debris, this study investigated the properties of plastic debris, reviewed case studies of ecological impacts, and examined the inflow and distribution of marine plastic debris. The results of this study indicate that the major deleterious effects of marine plastics are entanglement and ingestion. In addition, the amount of plastic waste entering the sea was estimated to be 230 Mt in 2015 and may increase to 554 Mt in 2050. In this study, three key strategies were proposed to reduce damage and preserve the ecosystem, including: 1) removing plastic debris in the marine environment, 2) limiting the release of plastic debris to the marine environment, and 3) preventing damage to humans and marine life from plastic debris. To minimize the environmental damage caused by marine plastic debris, the proposed response strategies should be implemented in parallel.

• International Journal of Contents
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• 제11권3호
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• pp.14-23
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• 2015

This paper presents the findings of a study in which students at a four-year university were surveyed in an effort to analyze and verify the differences in perceived security awareness, security-related activities, and security damage experiences when using smartphones, based on demographic variables such as gender, academic year, and college major. Moreover, the perceived security awareness items and security-related activities were tested to verify whether they affect the students' security damage experience. Based on survey data obtained from 592 participants, the findings indicate that demographic differences exist for some of the survey question items. The majority of the male students replied "affirmative" to some of the questions related to perceived security awareness and "enthusiastic" to questions about security-related activities. Some academic year differences exist in the responses to perceived security awareness and security-related activities. On the whole, freshmen had the lowest level of security awareness. Security alert seems to be very high in sophomores, but it decreases as the students become older. While the difference in perceived security awareness based on college major was not significant, the difference in some security-related activities based on that variable was significant. No significant difference was found in some items such as storing private information in smartphones and frequency of implementation of security applications based on the college major variable. However, differences among the college majors were verified in clicking hyperlinks in unknown SMS messages and in the number of security applications in smartphones. No differences were found in security damage experiences based on gender, academic year, and college major. Security awareness items had no impact on the experience of security damage in smartphones. However, some security activities, such as storing resident registration numbers in a smartphone, clicking hyperlinks in unknown SMS messages, the number of security apps in a smartphone, and the frequency of implementation of security apps did have an impact on security damage.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2002년도 춘계학술발표대회 논문집
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• pp.167-172
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• 2002

During the operation of military aircraft, maintenance is divided into organizational, intermediate and depot maintenance. In the depot maintenance, after removal of major parts and removable doors, damage assessment is performed. Locating damage, charactering the damage and determining its extent, zoning the damage on the part being repaired and re-evaluation of the damaged area after damage removal. Repair joints are classified by bonded joints and bolted joints, depending on joining material. In this paper, repair method in aging aircraft is investigated and the possibility of application of copmposite patch is surveyed.

• 패션비즈니스
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• 제11권3호
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• pp.59-68
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• 2007

This study examined knowledge and hair care behaviors of hair and scalp on UV(ultraviolet) comparing beauty care major and non-major female students. Results were obtained by questionnaire in 159 students majoring in beauty care and 198 students not majoring, was used frequency analysis, varimax rotation, t-test, F-test, Tukey post test. The analysis was statistically processed by using SPSS 12.0 program. The knowledge of hair and scalp on UV associated with a major showed significant on hair damage, in the UV, hair, scalp, hair damage, and UV and hair-related items, suggesting higher level in major female students. The results of care behaviors of UV and hair and scalp knowledge associated with a major. Correlation of care behaviors with a major showed significant results. For correlation by subfactor, there was significant difference in self-care, habitual care, and washing care between two groups, but there was no significant difference in protection care. It was found that both major and non-major students did not receive professional care.

• 시큐리티연구
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• 제2호
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• pp.83-98
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• 1999

The LPG station's explosion at Bucheon city was a major accident which with rare frequency of occurrence but large damage effect. Therefore, to prevent similar accident in the future from LPG chargings stations which located at inner urban area, it needs to identify the damage effects of such facilities by comparing theoretically quantities risks-PHAST. The BLEVE effects from the accident showed similar level in case of heat flux, however, the over pressure level reflected at reduced distance. The structure damage to the nearby area showed comparatively large reduction of concrete strength and shape changes through by heat effect while the overpressure effect was small.

• 한국안전학회지
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• 제21권2호
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• pp.1-6
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• 2006

It is well known that pipelines have the highest capacity and are the safest and least environmentally disruptive form of transporting oil and gas. However, pipeline damage caused by both internal and external corrosion is a major concern threatening the reliability of oil and gas transportation and the soundness of the pipeline structure. In this study, we estimate the allowable damage by comparing the ASTM B31G code to a modified theory considering diverse detailed corrosive forms. The ASTM B31 G code has been developed as the evaluation method for reliability and incident prevention of damaged pipelines based on the amount of loss due to corrosion and the yield strength of materials. Furthermore, we suggest a method for estimating the expected life span of used pipelines by utilizing the reliability method based on major variables such as the depth and length of damage and the corrosion rate affecting the life expectancy of the pipelines.

• Smart Structures and Systems
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• 제5권4호
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• pp.415-426
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• 2009

This study focuses on the concept of multi-scale wireless sensor networks for damage detection in civil infrastructure systems by first over viewing the general network philosophy and attributes in the areas of data acquisition, data reduction, assessment and decision making. The data acquisition aspect includes a scalable wireless sensor network acquiring acceleration and strain data, triggered using a Restricted Input Network Activation scheme (RINAS) that extends network lifetime and reduces the size of the requisite undamaged reference pool. Major emphasis is given in this study to data reduction and assessment aspects that enable a decentralized approach operating within the hardware and power constraints of wireless sensor networks to avoid issues associated with packet loss, synchronization and latency. After over viewing various models for data reduction, the concept of a data-driven Bivariate Regressive Adaptive INdex (BRAIN) for damage detection is presented. Subsequent examples using experimental and simulated data verify two major hypotheses related to the BRAIN concept: (i) data-driven damage metrics are more robust and reliable than their counterparts and (ii) the use of heterogeneous sensing enhances overall detection capability of such data-driven damage metrics.