• The Journal of the Korea institute of electronic communication sciences
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• v.8 no.8
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• pp.1271-1276
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• 2013

This study selected 22 male subjects to examine the maintenance period of static and ballistic stretching applied to rectus femoris, divided them into 11 static stretching group and 11 ballistic stretching group and analyzed changes in median frequency and in maximal voluntary isometric contraction before stretching and at 30 sec, 1 min, 3 min, 5 min, and 10 min after stretching. Median frequency showed significant differences in changes according to time and groups after the test of main effects. It was reduced after 3 min. in both static stretching and ballistic stretching groups and then increased again. Maximal voluntary isometric contraction showed significant differences in changes according to time and groups from the results of the main effect test. Static stretching group was reduced at 3 min after the experiment and then increased after that and ballistic stretching group was reduced at 5 min after the experiment and then increased again. In conclusion, changes were shown according to time after stretching and the effects of ballistic stretching were maintained a little longer than those of static stretching.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.6
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• pp.517-524
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• 2014

Phasic and tonic ${\gamma}$-aminobutyric acidA ($GABA_A$) receptor-mediated inhibition critically regulate neuronal information processing. As these two inhibitory modalities have distinctive features in their receptor composition, subcellular localization of receptors, and the timing of receptor activation, it has been thought that they might exert distinct roles, if not completely separable, in the regulation of neuronal function. Inhibition should be maintained and regulated depending on changes in network activity, since maintenance of excitation-inhibition balance is essential for proper functioning of the nervous system. In the present study, we investigated how phasic and tonic inhibition are maintained and regulated by different signaling cascades. Inhibitory postsynaptic currents were measured as either electrically evoked events or spontaneous events to investigate regulation of phasic inhibition in layer 2/3 pyramidal neurons of the rat visual cortex. Tonic inhibition was assessed as changes in holding currents by the application of the $GABA_A$ receptor blocker bicuculline. Basal tone of phasic inhibition was maintained by intracellular $Ca^{2+}$ and $Ca^{2+}$/calmodulin-dependent protein kinase II (CaMKII). However, maintenance of tonic inhibition relied on protein kinase A activity. Depolarization of membrane potential (5 min of 0 mV holding) potentiated phasic inhibition via $Ca^{2+}$ and CaMKII but tonic inhibition was not affected. Thus, phasic and tonic inhibition seem to be independently maintained and regulated by different signaling cascades in the same cell. These results suggest that neuromodulatory signals might differentially regulate phasic and tonic inhibition in response to changes in brain states.

• Biotechnology and Bioprocess Engineering:BBE
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• v.8 no.1
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• pp.41-46
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• 2003

Difficulties associated with bioartificial liver (BAL) preservation limit not only the commercialization of BAL, but also its clinical trials. In this study, the possibility of cold preservation of BAL cartridges containing porcine hepatocytes was examined at 4$^{\circ}C$. In an in vitro perfusion culture System, BAL cartridges maintained cytochrome P450 metabolic function for at least 50 days. However, all BAL cartridges completely lost their ammonia eliminating ability when stored at 4$^{\circ}C$. We a1so studied the effect of cell density on the maintenance of BAL liver function In a highly differentiated and healthy state. As expected, BALs containing a larger number of hepatocytes demonstrated higher metabolic functions. When metabolic functions were compared per gram of hepatotytes, no large differences were observed between devices containing different densities of hepatocytes. Decreased cell density did not Successfully prolong BAL function. The viability and function of isolated hepatotytes highly depend on the culture conditions, such as cell density, substrata, culture media, and additives to the culture media. Perfusion culture of BAL cartridges at 4$^{\circ}C$ gave a promosing result with respect to the maintenance of P450 activity. However, as indicated by the rapid loss of ammonia metabolic activity, many factors still remain to be optimized for preservation of BAL keeping high metabolic functions for a longer time.

• Convergence Security Journal
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• v.15 no.7
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• pp.69-74
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• 2015

Korea has established diplomatic relations with 190 countries in the world. It opened its diplomatic offices in 113 countries. Korea raised its status in international society through multinational force peace activities, national defense cooperation activity and UN peace maintenance activity for the maintenance of world peace. But there have been vio lent crimes by terrorist organizations and armed groups that try to achieve their political, religious and ideological go als greatly damaging Koreans working in overseas countries. This research studied the tendency of international terr orism against Koreans. The suggestion and conclusion are as follows. First, the study shows that armed groups and extremists have threatened and attacked Koreans in overseas countries. But there aren't enough personnel who can i mmediately and correctly analyze and respond the threats and attacks. So it is urgent to raise experts continually an d develop manuals to respond the attacks. Next, the damaging targets in overseas countries have been changed from hard targets to soft targets. There could be a limit in the restriction of basic rights of people by governmental agenc ies. So it is necessary for people to show mature civic awareness not going to a tourism-prohibited area.

• Journal of the Korea institute for structural maintenance and inspection
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• v.26 no.5
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• pp.74-85
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• 2022

The purpose of this paper is to review the applicability of the current standards for the evaluation method of input variables and performance level in seismic performance evaluation by dynamic plastic analysis of the concrete gravity-type dam to which MCE is applied, and to suggest improvements. To this end, a domestic concrete gravity-type dam was selected as a target facility, dynamic plasticity analysis was performed under various conditions, and applicability to input variables such as concrete tensile strength and breaking energy, was reviewed. By analyzing the effect of cracks at the bottom of the gravity dam on the stability of the activity, an improvement plan for the performance level evaluation method required to secure the water storage function was derived. If the proposed improvement plan is applied, it will have the effect of deriving more reasonable evaluation results than the current seismic performance evaluation method to which MCE is applied.

• Journal of Microbiology and Biotechnology
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• v.32 no.7
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• pp.918-926
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• 2022

Proteins related to DNA replication have been proposed as cancer biomarkers and targets for anticancer agents. Among them, minichromosome maintenance (MCM) proteins, often overexpressed in various cancer cells, are recognized both as notable biomarkers for cancer diagnosis and as targets for cancer treatment. Here, we investigated the activity of cedrol, a single compound isolated from Juniperus chinensis, in reducing the expression of MCM proteins in human lung carcinoma A549 cells. Remarkably, cedrol also strongly inhibited the expression of all other MCM protein family members in A549 cells. Moreover, cedrol treatment reduced cell viability in A549 cells, accompanied by cell cycle arrest at the G1 phase, and enhanced apoptosis. Taken together, this study broadens our understanding of how cedrol executes its anticancer activity while demonstrating that cedrol has potential application in the treatment of human lung cancer as an inhibitor of MCM proteins.

• The Korean Journal of Physiology
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• v.20 no.1
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• pp.89-102
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• 1986

It has long been suggested that the change of renin-angiotensin system is responsible for the increased arterial blood pressure in the experimental hypertension. But the exact nature of the cause and maintenance of early and late Phase of renal hypertension is still controversial. Increased renin-angiotensin system has been suggested. To clarify the altered renin-angiotensin system in the early phase of two kidney one clip Goldblatt hypertension(2K1C GH), experiments were carried out in the rats of 3,7, and 14 days of 2K1C GH rats, sham-operated, and control rats. Responses of the plasma renin activity to the intravenous infusion of L-isoproterenol were dose-dependent. Responses of the plasma renin activity to the intravenous L-isoproterenol in 2K1C GH rats were not different from sham-operated control rats. Hypotensive responses of the 2K1C GH rats were not different from sham-operated rats. Suppression by intravenous infusion of angiotensin II of plasma renin activity showed a dose-dependent manner. Suppression by angiotensin ll of plasma renin activity was attenuated or abolished in the early phase of 2K1C GH rats. Intravenous infusion of arginine vasopressin(AVP) showed a dose-dependent suppression of plasma renin activity, Attenuated responses by AVP of plasma renin activity were noticed in the early phase of 2K1C GH rats. These results suggest that the altered renin-angiotensin system in the early phase of the two kidney one clip Goldblatt hypertension may be caused by failure of the short loop negative feedback control mechanism.

• Journal of Families and Better Life
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• v.11 no.2
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• pp.13-29
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• 1993

The Purpopse of this study are to classify the lifestyles of urban housewives with automobiles living in Gwangju to see their relationship between lifestyle and demographic social and econo-mic variables and to see the relationship between lifestyle and prepurchase information search activity. For these purpose a survey was conducted using questionaires on 410 The data was collected from March 8 to March 20 1993 and analyzed by factor analysis cluster analysis Duncan test {{{{ chi ^2 }} }}- t e s t a nd ANOVA. The findings are classified into 7 types: enjoyable convenience type (15.6%) conservative sound and thrifty type(17.3%) rationative type (13.2%) thrifty life type (11.0%) passive-inactive type(8.3%) fashion-pursuity type(12.9%) 2) The lifestyles of he respondents showed significant difference according to their age education level employment status. length marriage consumer education and type of housing. 3) The lifestyles of the respondents showed a difference only automobile attitude While showing no significant difference by automobile size information sources of automobile priority of automobile attitude and time spent in searching information The lifestyle of respondents showed a difference by automobile price size quality secuity warranty service and maintenance cost. 4) Among the lifestyle patterns of the respondents the passive-inactive type and rationative typ were positive about all the prepurchase information activity of automobile.

• Journal of the Korean Institute of Landscape Architecture
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• v.19 no.3
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• pp.87-97
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• 1991

The primary purpose of this study is to investigate factors and variables which have significant effects on user's satisfaction with recreational activities in Daeshin Natural Park, thereby establishing directions of development of urban parks. To test the causal models of this research, the data were gathered by self-administered questionnaires form 627 households in Pusan City which were selected by the multi-stage probability sampling method. The analysis of the data primarily consists of two-phase: The first analysis dealt exploratory factor analysis which identified major factors involved in satisfaction with recreational activities in Daeshin Natural Park and the second analysis tested the fit of the causal models of this research by employing LISREL methodology. The factor analysis identified that three factors are involved in satisfaction with recreational actitives. The three factors of satisfaction with recreational activities are facilities for health and phisical exercise, group recreational activity, maintenance activity. The second phase analysis tested the fit of the causal models for satisfaction with recreational activity to the data and identified statistically significant causal linkage among overall satisfaction with Daeshin Natural Park, other endogenous factors and exogenous variables.

• The Korean Journal of Pharmacology
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• v.8 no.2
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• pp.63-69
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• 1972

The effects of omission of buffers from Krebs-Ringer medium on contractile activity, membrane potentials and ATP content of electrically stimulated isolated rat atria were investigated. 1) Contractile status: A rapid and marked depression of the contractile activity of atria occurred when buffer-free medium was substituted for the normal Krebs-Ringer medium. 2) Electrical status: The omission of buffers from medium did not alter the resting or action potential magnitudes of atria. However, the action potential duration was on initial increase followed by a decrease in the buffer-free medium. 3) ATP concentration: The omission of buffers from medium resulted in a marked decrease in the ATP levels of atria. It has been also found in the present study that bicarbonate buffer plays an important role for the maintenance of the contractility and ATP levels of the heart. The contractile depression by the omission of buffers was not directly associated with electrical alterations in resting or action potentials of the heart. In the absence of bicarbonate-buffer, glucose no longer plays to maintain the contractile activity and the ATP levels of rat atria.