• Journal of the Korean Society of Marine Environment & Safety
• /
• v.23 no.6
• /
• pp.603-612
• /
• 2017

Accidents associated with hazardous materials, including oil and HNS, in maritime transportation show increasing trend. Therefore, preventive countermeasures for such accidents should be provided. The purpose of this study is to analyze level of risk on human loss and potential damage to environment, using data on domestic marine accidents carrying hazardous materials (2002~2014), and identify high-risk accident types for urgent risk management which needs findings of accident causes and proper mitigation measures. High-risks on human loss are explosion and suffocation, occurred in process of ship maintenance and tank cleaning. On the other hand, high-risk on environmental damage is spill caused by ship accidents (collision, grounding and etc.). Especially, spill occurs during loading operation of oil and HNS onboard a ship. Strict operation supervision/management and safety education/training on a regular basis could prevent accidents, because human factors such as not wearing safety gear and careless cargo handling cause most of the marine accidents.

• Journal of Aerospace System Engineering
• /
• v.11 no.4
• /
• pp.48-53
• /
• 2017

Liquid rocket engines (LREs) are very complex systems that include combustion chambers, turbopumps, gas generators, ducts and tubes, valves and etc. Most components of the LREs require higher than or equal to level 6 IT (ISO Tolerance). The components along with pipe line and/or tubing must dispose not to interfere each other. In addition, effectiveness of maintenance and service after assembling should be considered when the allocation of the components are determined. Especially at the stage of the development, tolerance accumulations or unpredictable errors may result in misalignment and/or mismatches at interfaces of the parts. Namely, it is the engine assembling process that many inherent risks are realized and crises or incidents occur. Therefore, a rapid reaction system should be prepared. In this research, 7 tonf class liquid rocket assembling process was studied and actual building steps were introduced.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.41 no.4
• /
• pp.413-420
• /
• 2015

The skin is one of the largest organs in our body and participates in many of the human organism's physiological and pathological events. Skin function were known for self-maintenance and self-repair, mechanical and chemical stress protection, protection against UV and environmental pathogenic micro-organisms, production of vitamin D, and social and psychological function through the physical aspect. The aim of this study was to evaluate the variation of biophysical parameters and to find relation with skin biomarkers in different anatomical site and age in Korean women. About 70 healthy volunteers in age range 20 to 49 were participated in this test. Test areas were the forearms and the cheek. Investigation to determine biophysical parameters on human skin, was carried out using various non-invasive methods. For analysis to skin biomarkers, we studied to examine various biomarkers for the quantitative determination of cortisol, fibronectin, keratin-1, 10, and 11, involucrin, and keratin-6 in human face and forearm. And we measured to skin biophysical parameters for skin anatomical site and age difference with non-invasive methods. As results of measuring site, some parameters were have following significant difference, stratum corneum hydration, trans epidermal water loss and skin color (L and a value). As results of age difference, skin colors were had only significant difference with age. For cortisol, keratin-6, fibronectin, keratin-1, 10, 11 contents, there were no significant difference in age and site. However, involucrin level in the cheeks were the highest for age group 30 ~ 39 compared to other age groups. These results suggest that in individual skin condition may explain detailed skin state variation.

• Archives of Pharmacal Research
• /
• v.24 no.6
• /
• pp.546-551
• /
• 2001

We have previously shown that, in circular muscle cells of the lower esophageal sphincter (LES) isolated by enzymatic digestion, contraction in response to maximally effective doses of acetylcholine (ACh) or Inositol Triphosphate ($IP_3$) depends on the release of $Ca^{2+}$ from intracellular stores and activation of a $Ca6{2+}$-calmodulin (CaM)-dependent pathway. On the contrary, maintenance of LES tone, and response to low doses of ACh or $IP_3$ depend on a protein kinase C (PKC) mediated pathway. In the present investigation, we have examined requirements for $Ca6{2+}$ regulation of the interaction between CaM- and PKC-dependent pathways in LES contraction. Thapsigargin (TG) treatment for 30 min dose dependently reduced ACh-induced contraction of permeable LES cells in free $Ca6{2+}$ medium. ACh-induced contraction following the low level of reduction of $Ca6{2+}$ stores by a low dose of TG ($10^{-9}{\;}M$) was blocked by the CaM antagonist, CCS9343B but not by the PKC antagonists chelerythrine or H7, indicating that the contraction is CaM-dependent. After maximal reduction in intracellular $Ca{2+}$ from $Ca6{2+}$stores by TG ($10^{-6}{\;}M$), ACh-induced contraction was blocked by chelerythrine or H7, but not by CCS9343B, indicating that it is PKC-dependent. In normal $Ca^{2+}$medium, the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was also CaM-dependent, whereas the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was PKC-dependent. We examined whether PKC activation was inhibited by activated CaM. CCS 7343B Inhibited the CaM-induced contraction, but did not inhibit the DAC-induced contraction. CaM inhibited the DAC-induced contraction in the presence of CCS 9343B. This inhibition by CaM was $Ca{2+}$dependent. These data are consistent with the view that the switch from a PKC-dependent pathway to a CaM dependent pathway can occur and can be regulated by cytosolic $Ca{2+}$ in the LES.

• Animal Bioscience
• /
• v.34 no.6
• /
• pp.1078-1087
• /
• 2021

Objective: Skeletal muscle satellite cells (SMSCs) are significant for the growth, regeneration, and maintenance of skeletal muscle after birth. However, currently, few studies have been performed on the isolation, culture and inducing differentiation of goose muscle satellite cells. Previous studies have shown that C1q and tumor necrosis factor-related protein 3 (CTRP3) participated in the process of muscle growth and development, but its role in the goose skeletal muscle development is not yet clear. This study aimed to isolate, culture, and identify the goose SMSCs in vitro. Additionally, to explore the function of CTRP3 in goose SMSCs. Methods: Goose SMSCs were isolated using 0.25% trypsin from leg muscle (LM) of 15 to 20 day fertilized goose eggs. Cell differentiation was induced by transferring the cells to differentiation medium with 2% horse serum and 1% penicillin streptomycin. Immunofluorescence staining of Desmin and Pax7 was used to identify goose SMSCs. Quantitative realtime polymerase chain reaction and western blot were applied to explore developmental expression profile of CTRP3 in LM and the regulation of CTRP3 on myosin heavy chains (MyHC), myogenin (MyoG) expression and Notch signaling pathway related genes expression. Results: The goose SMSCs were successfully isolated and cultured. The expression of Pax7 and Desmin were observed in the isolated cells. The expression of CTRP3 decreased significantly during leg muscle development. Overexpression of CTRP3 could enhance the expression of two myogenic differentiation marker genes, MyHC and MyoG. But knockdown of CTRP3 suppressed their expression. Furthermore, CTRP3 could repress the mRNA level of Notch signaling pathway-related genes, notch receptor 1, notch receptor 2 and hairy/enhancer-of-split related with YRPW motif 1, which previously showed a negative regulation in myoblast differentiation. Conclusion: These findings provide a useful cell model for the future research on goose muscle development and suggest that CTRP3 may play an essential role in skeletal muscle growth of goose.

• Korean Journal of Remote Sensing
• /
• v.37 no.2
• /
• pp.305-319
• /
• 2021

The overseas calibration sites such as Mongolia used for Korea Multi-purpose Satellite (KOMPSAT-5 or K5), have a disadvantage in that maintenance and repair costs are high and immediate response is difficult when an unexpected problem occurs. Accordingly, the necessity of establishing a domestic SAR calibration site was suggested, but the progress of related research is insignificant. In this paper, we investigated what conditions should be satisfied in terms of backscattering characteristics to construct a site for SAR satellite image quality evaluation and calibration. First of all, it was selected first by applying general indicators such as accessibility and availability among places recommended as satellite image calibration candidate sitesin Korea. Next, three places, site A (Goheung-gun, Jeollanam-do), site B (Jeonju-si, Jeollabuk-do), and site C (Daedeok Research Complex, Daejeon), were selected as the final candidates because they are relatively wide and easy to install AT or CR. Site A, located in Goheung-gun, Jeollanam-do, was best considered in terms of slope measurements, minimum site area to obtain ISLR, uniformity of DN values and backscatter coefficients, interference by strong reflectors, and backscatter clutter level.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.8
• /
• pp.570-578
• /
• 2019

In this era of big data, a variety of government organizations are trying to create new added value via Information Integration. Therefore, several projects related to government agencies' information sharing have activated system connection/integration. The risk factors of system operation, however, have increased as the volume of Information Integration System grows. The interference in information sharing is predicted to affect the operation of the agencies, and the issue will grow even worse with massive impact on civil society when the agency operation is interrupted due to system failures in terms of infrastructure, software, data quality, and security. Diverse studies related to the maintenance of Information System have been conducted, but there is currently no evaluation framework for the operational system of Information Integration between various government agencies. In this respect, this study distinguishes each of the Information System components, Data, IT, People, Process, systematizes with Plan-Do-See, and finally presents a maturity model for Information Integration. Nine derived processes were analyzed through interview and questionnaires from Information Integration System officials, further suggesting maturity stage applying CMMI. This model allows diagnosis of the maturity level of an Information Integration System, and is expected to be utilized as resource for improving organizational processes.

• Journal of the Korean Recycled Construction Resources Institute
• /
• v.6 no.4
• /
• pp.324-330
• /
• 2018

In accordance with the amendment of the Industrial Safety and Health Act of 2007, Korea completely prohibited the import, distribution and manufacture of asbestos like Europe and Japan. Accordingly, the current problem of asbestos is the safe maintenance and disposal of asbestos construction material, the disposal of asbestos, and the final disposal of asbestos building materials. In the past, Korea used 100,000 tons of asbestos every year, and the building materials using it exceeded 1 million tons per year. These asbestos building materials continued to be used until 2006, and the Ministry predicted that these materials would continue to be maintained until 2044. When the permeable hardening agent is applied to the asbestos building material installed in the pre-pretreatment step for the harmless treatment of the asbestos waste and the dismantling is carried out, the scattering of the asbestos is suppressed in the disassembling step, detoxification treatment conditions can be improved. Therefore, permeable hardeners should be stably penetrated into asbestos building materials. In this study, it is suggested that pre - pretreatment methods for the harmlessization of waste asbestos building materials with medium density level can be presented. In order to efficiently perform pre - treatment for chemical harmlessness in the future, the mixing ratio of permeable hardener and middle water Optimization is the most important factor.

• Korean Journal of Heritage: History & Science
• /
• v.34
• /
• pp.222-267
• /
• 2001

The purpose of this document is to explain the revisions of the Protection of Cultural Properties Act and its sub-laws which have been mad from Jan. 1999 to Sep. 2001. The Protection of Cultural Properties Act and its sub-laws have been revised three times from 1999 to 2001, before and after the Office of Cultural Properties was raised to Cultural Properties Administration on May 24, 1999. The main points of the revisions are as follows. First of all, the role of the local autonomous entities has been increased. The governor of the local autonomous entities is entitled to announce administrative orders related to the preservation of State-designated Cultural Properties. Also, the local autonomous entities has the authorities to examine whether the construction work which will be made in the outer boundaries, which is provided by regulations, of the protected area of the cultural properties might have any effect on preservation of cultural properties or not. Second, preventive actions to protect the cultural properties have been strengthened. If the scale of construction work is more than some scale, the preliminary survey of the surface of the earth to confirm the existence of buried cultural properties and their distribution is obligated. One who is promoting the development plan more than some scale must discuss the plan with the Administrator of Cultural Properties Administration in the process of planning. These actions would be effective to prevent the cultural properties from being damaged because of the development. Third, relaxation of the restrictions has been proceeded. On the basis of regulations which specify the actions to affect the preservation of cultural properties, negative system that does not limit the actions which are not specified in the regulations is introduced. The appropriateness of both protected structure and area should be regularly reviewed and adjusted. Also, most of the restrictions which was made only for administrative convenience and over-regulated the people's living have been revised. Finally, the number of cultural properties to be protected has been increased. Besides the State-designated Cultural Properties, the other cultural properties which are worthy to be protected as City-or-Province-designated Cultural Properties can be designated provisionally and protected. The system of registration and maintenance of the buildings and facilities which are not designated as the Modern Cultural Heritages is established. The penalty for damaging and stealing the cultural Properties which are not designated to be protected was strengthened. Even a dead natural monument can be acknowledged as an natural monument and it is limited to make a specimen or stuffing of the dead natural monument. All of these actions are fit to the high level of understanding of the public about the cultural properties and as the result of these actions, the number of cultural properties to be preserved has been increased. To sum up, the directions of revisions of the Protection of Cultural Properties Act and its sub­laws which have been made from Jan. 1999 to Sep. 2001. are the localization of the protection of the cultural properties, the strengthening of protective actions, the relaxation of various regulations and the increasing of the number fo the protected cultural properties. Also, various problems raised in the processes of implementations of the laws have been reviewed and revised.

• The Journal of the Korea Contents Association
• /
• v.19 no.9
• /
• pp.112-121
• /
• 2019

Title of management of cultural asset architectures made of wood managed by nation or local government is separated and there is a high concern about the disappearance of many national cultural asset architectures by fire. This study investigated the effectiveness of major installed appliances in terms of disaster prevention, and problems by early suppression in the event of fire and by mobilization of fire engines in depth. Also, this study derived problems by conducting an in-depth individual interview on interested parties for installation of fire extinguishing system by related law and to improve system to make realistic maintenance. As a result, it was identified that they have reached the positive aspects of protecting cultural asset architectures from disaster as fire by maintaining and managing facilities by establishing proper disaster prevention measures because they are surrounded by mountain or buildings are contiguous. Wooden cultural asset architectures are often excluded from regulation for installation of fire-fighting facilities under the Fire Services Act because most of wooden cultural assets are detached buildings, occupy small area, and are one-storied architecture. The best method is having extinguishing ability themselves according to the manual by making fire manual as management policy before the outbreak of fire. This study intends to suggest a follow-up study for practical considerations to establish or designate a professional management agency for them to protect important national cultural heritage buildings at the state level before they are destroyed by fire.