• Korean Journal of Acupuncture
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• v.24 no.4
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• pp.163-180
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• 2007

Objective : Oriental medicines have been applied to Membranous nephropathy(MN) for the purpose on increasing renal blood flow and modulating immune activity in according to Oriental medicine theories. Magsungsinyeom-bang (MSSYB) is one of the prescription which is known to show positive results in clinic with lack of laboratorial evidence. Thus, this study was aimed to evaluate the effects of MSSYB and partially investigate the mechanisms of it. Methods : The effect of MSSYB was evaluated by the morphology for the GBM thickening, protein excretion in urine and biochemical parameters in serum using cBSA-induced MN mice model. Mice were administered with MSSYB(250 or 500 mg/kg) or PBS for control group from experimental week 3 for 4 weeks. Results : 24 hrs proteinuria and the concentrations BUN was significantly decreased in the MS groups compared to the control group while the concentrations of serum albumin was higher in the MS groups than control group. MSSYB didn't affect the ratio of CD3e+/CD or 19CD4+/CD8 in the spleen and kidney, but inhibit the expression of IL-1${\beta}$, TNF-${\alpha}$, IL-6, and production of IgG and IgM. In histological analysis of kidney tissue, thickening of GBM was significantly decreased in the MS group compared to control group. Conclusions : MSSYB showed the positive results on the cBSA-induced membranous nephropathy in mice, thus, it could be a useful candidate for oriental drug for treating the membranous nephropathy in clinic.

• The Journal of Internal Korean Medicine
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• v.30 no.3
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• pp.632-638
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• 2009

The patient was hospitalized for treatment of cerebral infarction (Lt. BG). He was a 61-year-old man who was diagnosed with membranous nephropathy (MN) in 2000. Before admission, he was admitted for treatment for cerebral infarction at another hospital. During that admission, his MN symptoms went from bad to worse, and medication for MN was started (steroid and cyclophosphamide therapy). In our hospital, we started herbal medicine and western medicine combination therapy as well as oriental rehabilitation therapy. Our main herbal medicine was Magsungsinyeom-bang(Moxingshenyanfang). After 5 months, levels of 24 hrs proteinuria, total cholesterol, LDL-cholesterol and triglyceride decreased, levels of serum albumin, total protein increased, and clinical symptoms (lower limb edema, general body weakness) improved.