• Proceedings of the PSK Conference
• /
• 2003.04a
• /
• pp.138.1-138.1
• /
• 2003

$\beta$-Eudesmol is one of various compounds derived from the bark of Magnolia obovata Thunberg, a medicinal plant. It has been shown that $\beta$-eudesmol also markedly alleviated muscle fasciculation, tremor and convulsion induced by diisopropylfluorophosphate and prolonged the time to death in mice (Chiou et al., 1995). Actually, the extract of magnolia bark has been shown to have depressant actions on the cental nervous system (Watanabe et al., 1973). (omitted)

• 한국약용작물학회:학술대회논문집
• /
• 2011.09a
• /
• pp.332-333
• /
• 2011

• Journal of Applied Biological Chemistry
• /
• v.56 no.4
• /
• pp.257-257
• /
• 2013

• Landscaping Tree
• /
• s.112
• /
• pp.10-11
• /
• 2009

도입 수종이지만 우리나라에서 자라고 있는 나무 중 잎의 크기가 가장 크며 자라는 속도도 매우 빠르다. 특히나 지금까지 우리가 잘못알고 있는 후박피(厚朴皮) 즉 후박나무 껍질은 지금 소개드리는 중국목련과 일본목련의 걷껍질이 한방에서 사용되는 후박(厚朴)이다. 몇 년 전 경희대학교 한의학과 교수님이 중국에서 중국 후박나무 묘목 한그루를 가져다 주시면서 홍릉수목원에서 잘 키워보라며 놓고 간 중국목련이 어느덧 4m정도 자랐다.

• Proceedings of the Korean Society of Environment and Ecology Conference
• /
• 2007.04a
• /
• pp.223-227
• /
• 2007

• Journal of Applied Biological Chemistry
• /
• v.58 no.3
• /
• pp.233-236
• /
• 2015

The flowers of Magnolia obovata were extracted with aqueous MeOH and fractionated into EtOAc, n-BuOH, and $H_2O$ fractination. Three alkyl glycosides were isolated from the EtOAc fraction through repeated silica gel and ODS column chromatography. The structures were identified to be 2-methylbutan-1-ol-${\beta}$-$\small{D}$-galacto-pyranoside (1), 2-methylbutan-1-ol-${\beta}$-$\small{D}$-glucopyranoside (2), and 2-methylpropan-1-ol-${\beta}$-$\small{D}$-glucopyranoside (3) on the basis of spectroscopic analyses such as fast atom bombardment mass spectrometry, infrared spectroscopy, 1D nuclear magnetic resonance (NMR) ($^1H$ and $^{13}C-NMR$), and 2D NMR (gCOSY, gHSQC, and gHMBC). These compounds were isolated for the first time from the flower of M. obovata in this study.

• The Korea Journal of Herbology
• /
• v.23 no.4
• /
• pp.21-29
• /
• 2008

Objectives: To determine the standards for discrimination of Magnoliae Cortex, the experiment of specific external-internal characters and the physicochemical pattern analysis were performed. Methods: External characteristics was observed using a stereoscope. Paraffin-mediated sectioned materials were stained by Ju's method. Physicochemical patterns of materials were analyzed using HPLC. Results: 1. Botanical characteristics: Magnolia officinalis had one seed and a white flower, while M. obovata had two seeds and a white flower. Machilus thunbergii had berry and spherical fruits and yellowish green panicles. 2. External characteristics: M. officinalis and M obovata were dark and thick. M. officinalis was gray brown and greasy while M. obovata was light-gray, less oily and smoothly sectioned. Machilus thunbergii was thin and relatively light or yellow-brown, coarsely sectioned and faintly specific scents. 3. Internal characteristics: The bast parts of M. officinalis and M. obovata were commonly wider than Machilus thunbergii The cork cortex of M. officinalis was $10{\sim}mg/L$ cell layers with many oil cells, while that of M. obovata was $4{\sim}7$ cell layers with less oil cells. Machilus thunbergii's xylem which consisted of ring-shaped cambium at 1st and 2nd part was occupied in large portion. 4. Physicochemical pattern: Both M. officinalis and M. obovata involved honokiol and magnolol. All kinds of M. officinalis involved Magnatriol B but one kind of M. ovobata and all of Machilus thunbergii didn't. Machilus thunbergii showed different pattern of chromatogram from that of 2 species above. Conclusions: These results could be used as standards for discrimination of Magnoliae Cortex and as the method of objectification in medicinal herbs giving the basic resource for bioactivity research.

• The Korean Journal of Pharmacology
• /
• v.15 no.1_2 s.25
• /
• pp.45-56
• /
• 1979

With a view to searching after a new antihypertensive or hypotensive agents in the botanical crude plants, authors intended to reevaluate several natural products caltivated in Korea. This experiment was undertaken to compare pharmacogical actions of Machilus thunbergii Siebold et Zuccarini with those of Magnolia obovata Thunberg in anesthetized rats and in normal mice. Machilus thunbergii Sieb. et Zucc., a tree belonging to the Lauraceae family, is caltivated at Ull-ung Do, and their cortecies have been used as folk medicine mingled with those of Magnolia obovata Thunberg. These two cortecies have teen also applied in chinese medicine, it was advocated that these cortecies exerted good therapeutic effects on gastritis, convulsive abdominal pain, nausea, vomiting and urinary tract disorders. Therefore, we intended to determine the pharmacological action of two palnt of different family each other, especially their effects on blood pressure and heart rate, and also their mechanism of action were observed. We studied their action with extracts of hexane(MTHE), ether(MTEE), methanol(MTME) and water(MTWE) from Machilus thunhergii Sieb. et Zucc., and also fractionations of methanol(MOME), chloroform(MOCE) and water(MOWE) from Mapolia obovata Thunberg. The results of this experiment were as follows; 1) MTME, when intravenously administered to rats, elicited the significant hypotensive responses dependent on the administered dosage. 2) MOWE was also exhibited the hypotensive effect dependent on the treated dose. 3) Depressor effect of MTME was blocked by pretreatment with hexamethonium. 4) The hypotensive response of MOWE was blocked by pretreatment with hexamethonium or hrdralazine. 5) HTME and MOWE were also observed the anticonvulsive effect and sedative effect. These results suggested that MTME may induce the hypotensive response via central sympathetic effect, but the site of action in brain are not clarified, and the hypotensive effect of MOWE may be due to dual mechanism of central sympathetic action and direct vasodilation of blood vessel.

• Toxicological Research
• /
• v.23 no.1
• /
• pp.73-78
• /
• 2007

To evaluate the immuno-toxicity of magnolia extracts, mutagenicity of Salmonella, chromosome aberration of Chinese hamster ovary (CHO) cells and micronucleus formation in rats were examined. Magnolia extracts at the concentrations of $312{\sim}5,000{\mu}g/plate$ did not induce mutagenicity in Salmonella typhimurium TA 98, TA 100 and TA 1535 with and without metabolic activation of S-9 mixture. In chromosome aberration assay, Magnolia extracts at the concentrations of $50{\sim}800{\mu}g/plate$ did not cause a significant chromosome aberration in CHO cells with and without metabolic activation of S-9 mixture. Magnolia extracts were treated with dose of 0.5, 1 and 2 g/kg in ICR mice. After 48 hours, the frequencies of the micro-nucleided polychromasia erythrocytes (MNPCE) were determined in bone marrows isolated from the mice. Magnolia extracts did not increase the incidence of polychromasia erythrocytes of bone marrow in ICR mice. These results show that Mgnolia extracts did not induce any harmful genotoxic effects.

• Korean Journal of Pharmacognosy
• /
• v.32 no.2 s.125
• /
• pp.168-174
• /
• 2001

Induction of phase II enzymes is a major mechanism of chemoprevention. The induction levels of quinone reductase (QR) activity in cultured murine hepatoma (Hepa 1c1c7) cells by 80%-methanol extracts of traditional medicinal plants were measured. Among the tested 81 plants, the extracts of Aralia continentalis, Magnolia obovata, and Viscum album were found to induce QR activities over 250%. The maximum induction levels obtained were 401.9%, 270.5%, and 301.8% by treatments of the extracts of A. continentalis $(318\;{\mu}g/ml)$, M. obovata $(53.8\;{\mu}g/ml)$ and V. album $(80.6\;{\mu}g/ml)$, respectively. These QR induction activities were more potent than those of the known QR inducers, t-butylhydroquinone (170.1%) and ${\beta}-naphthoflavone$ (320.0%).