• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.11
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• pp.856-862
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• 2008

This paper presents the characterization of a continuous magnetophoretic microseparator for separating white and red blood cells from peripheral whole blood cells based on their native magnetic properties. The magnetophoretic microseparator separated the blood cells using a high gradient magnetic separation (HGMS) method without the use of additives such as magnetic beads or probing materials. Experimental results show that the paramagnetic capture mode microseparator can continuously separate out 93.5% of red blood cells and 97.4% of white blood cells from diluted whole blood, and the diamagnetic capture mode microseparator can continuously separate out 89.7% of red blood cells and 72.7 % of white blood cells by using applying an external magnetic flux of 0.2 T using a permanent magnet.

• Progress in Superconductivity
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• v.3 no.1
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• pp.56-59
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• 2001

We have constructed a multi-channel SQUID magnetometer system for localization and classification of magnetic targets. Ten SQUID magnetometers were arranged to measure 5 independent components of 3 $\times$ 3 magnetic field gradient tensor. To get gradient from the difference of magnetic field measurements, we carefully balanced magnetometers. SQUIDs with slotted washer were used for operation in an unshielded laboratory environment, and noise characteristic in the laboratory was measured. With the multi-channel SQUID magnetometer system, we have successfully traced the motion of a bar magnet moving around it at a distance of about 1 m. In the urban environment, the drift of uniform magnetic field due to the irregular motion of a large magnetic body at distance and earth field causes an error in the position calculation, and this results in the distortion of the calculated trajectory. In this paper, we present the architecture and the performance of the system.

• Progress in Superconductivity and Cryogenics
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• v.25 no.4
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• pp.60-64
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• 2023

The manufacturing process of antibody drugs comprises two main stages: the upstream process for antibody cultivation and the downstream process for antibody extraction. The domestic bio industry has excellent technology for the upstream process. However, it relies on the technology of foreign countries to execute downstream process such as affinity chromatography. Furthermore, there are no domestic companies capable of producing the equipment for affinity chromatography. High gradient magnetic separation technology using a high temperature superconducting magnet as a novel antibody separation and purification technology is introduced to substitute for the traditional technology of affinity chromatography. A specially designed magnetic filter was equipped in the bore of the superconducting magnet enabling the continuous magnetic separation of nano-sized paramagnetic beads that can be used as affinity magnetic nano beads for antibodies. To optimize the magnetic filter that captures superparamagnetic nanoparticles effectively, various shapes and materials were examined for the magnetic filter. The result of magnetic separation experiments show that the maximum separation and recovery ratio of superparamagnetic nanoparticles are 99.2 %, and 99.07 %, respectively under magnetic field (3 T) and flow rate (600 litter/hr).

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.24-28
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• 2007

Presuming that firing neurons have motions inside the MRI magnet due to the interaction between the neuronal magnetic field and the main magnetic field, we applied motion encoding gradients to dissected snail ganglia to observe faster responding MRI signal than the BOLD signal. To activate the snail ganglia in synchronization with the MRI pulse sequence, we used electrical stimulation with the frequency of 30 Hz and the pulse width of 2s. To observe the fast responding signal, we used the volume selected MRI sequence. The magnetic resonance signal intensity, measured with 8 ms long motion encoding gradient with a 20mT/m gradient strength, decreased about $3.46{\pm}1.48%$ when the ganglia were activated by the electrical stimulation.

• Proceedings of the KIPE Conference
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• 1998.10a
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• pp.569-574
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• 1998

This paper presents a two-paralleled 4 quadrant DC chopper type PWM power conversion circuit in order to generate a gradient magnetic field in the Magnetic Resonance Imaging (MRI) system. This power amplifier is connected in parallel with the conventional 4-quadrant DC chopper using IGBTs at their inputs/outputs to realize further high-power density, high speed current tracking control, and to get a low switching ripple amplitude in a controlled current in the Gradient Coils (GCs). Moreover, the power conversion circuit has to realize quick rise/fall response characteristics in proportion to various target currents in GCs. It is proposed in this paper that a unique control scheme can achieve the above objective. DSP-based control systems realize a high control facility and accuracy. It is proved that the new control system will greatly enlarge the diagnostic target and improve the image quality of MRI.

• Structural Engineering and Mechanics
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• v.75 no.6
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• pp.659-674
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• 2020

The present paper employs nonlocal strain gradient theory (NSGT) to study buckling behavior of functionally graded magneto-electro-thermo-elastic (FG-METE) nanoshells under various physical fields. NSGT modeling of the nanoshell contains two size parameters, one related to nonlocal stress field and another related to strain gradients. It is considered that mechanical, thermal, electrical and magnetic loads are exerted to the nanoshell. Temperature field has uniform and linear variation in nanoshell thickness. According to a power-law function, piezo-magnetic, thermal and mechanical properties of the nanoshell are considered to be graded in thickness direction. Five coupled governing equations have been obtained by using Hamilton's principle and then solved implementing Galerkin's method. Influences of temperature field, electric voltage, magnetic potential, nonlocality, strain gradient parameter and FG material exponent on buckling loads of the FG-METE nanoshell have been studied in detail.

• Structural Engineering and Mechanics
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• v.69 no.5
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• pp.487-497
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• 2019

Rapid advances in the engineering applications can bring further areas to provide the opportunity to manipulate anisotropic structures for direct productivity in design of micro/nano-structures. For the first time, magnetic affected wave characteristics of nanosize plates made of anisotropic material is investigated via the three-dimensional bi-Helmholtz nonlocal strain gradient theory. Three small scale parameters are used to predict the size-dependent behavior of the nanoplates more accurately. After owing governing equations of wave motion, an analytical approach based harmonic series is utilized to fine the wave frequency as well as phase velocity. It is observed that the small scale parameters, magnetic field and wave number have considerable influence on the wave characteristics of anisotropic nanoplates. Due to the lack of any study on the mechanics of three-dimensional bi-Helmholtz gradient plates made of anisotropic materials, it is hoped that the present exact model may be used as a benchmark for future works of such nanostructures.

• 한국초전도학회:학술대회논문집
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• 2009.07a
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• pp.123-123
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• 2009

• Journal of Magnetics
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• v.8 no.4
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• pp.164-168
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• 2003

In high density recording system, the recording head field on a medium should be focused in small bit area and should have a sufficient value to overcome the medium coercivity, which resulted in head saturation. In this paper, an efficient method to access the head field and field gradient considering head saturation is presented. The magnetic vector potential on the head surface is pre-calculated considering head saturation in several cases and accumulated into database. The head field on the recording media is easily produced solving Laplace equation using accessed magnetic vector potential boundaries. The computed head field is compared with a quantified magnetic force microscopy measurement.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.11
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• pp.33-35
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• 1993

A new low-power, high-order optimization scheme to design surface gradient coils (SGC) is proposed for magnetic resonance imaging (MRI). Although previous SGCs have been designed and constructed just to get strong linear gradients, this paper proposes more systematic ways of SGC design by minimizing electrical power consumption in the gradient coil and by removing unnecessary high-order field distortions in the imaging region. By assuming continuous current flow on the coil surface which may be or may not be planar, power consumption in the coil is minimized. According to the simulation results, the SGC designed by using the proposed scheme seems to produce much more uniform linear gradient field using less electrical power compared to the previously proposed SGCs.