• Title/Summary/Keyword: Magnetic Resonance Spectroscopy

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[ $^1H$ ] Magnetic Resonance Spectroscopy of Primary Central Nervous System Lymphoma (일차성 중추신경 림프종의 수소 자기공명분광법)

  • Kim Yong Sun;Lee Hui Joong
    • Investigative Magnetic Resonance Imaging
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    • v.8 no.2
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    • pp.86-93
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    • 2004
  • Purpose: We evaluated $^1H$ MR spectroscopy improves the preoperative diagnosis of diffuse infiltrative type of primary central nervous system lymphomas. Materials and methods: After review of conventional MR images and medical records, we retrospectively reviewed proton MR spectra in seven patients with primary central nervous system lymphoma diagnosed by means of biopsy. Relative ratio of choline (Cho), N-acetylaspartate (NAA), and lipid-lactate (Lip-Lac) to creatine (Cr) were measured for quantitative analysis. Results: The average ratio of Cho/Cr was $1.80{\pm}0.95$, NAA/Cr was $1.34{\pm}0.41$, and Lip-Lac/Cr was $1.12{\pm}0.16$. All cases of lymphomas showed increased Lip-Lac peak. Two case of mass forming lymphoma showed decreased NAA/Cr significantly, whereas five cases of lymphoma without mass formation showed preserved NAA/Cr. Conclusion : We thought the presence of Lip-Lac peak without significant reduction of NAA on the MR spectroscopy was helpful for diagnosis of diffuse infiltrative type of central nervous system lymphoma.

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Immediate Decrease in γ-AminoButyric Acid after Caffeine Intake in Adolescents: a Preliminary MRS Study

  • Hahn, Sanghyun;Kim, Yun Ho;Seo, Hyung Suk
    • Investigative Magnetic Resonance Imaging
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    • v.21 no.2
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    • pp.102-105
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    • 2017
  • In adolescents, sleep deprivation problem is getting worse, and increased caffeine consumption is considered to relieve the stress caused by sleep deprivation and academic burden. In this study, immediate neurologic effects of caffeine intake on adolescents were evaluated in three high school students using the ${\gamma}-aminobutyric$ acid (GABA)/creatine ratio on magnetic resonance spectroscopy (MRS). MEGA-PRESS MRS and TE 135 ms single voxel MRS were performed in the anterior cingulate cortex before and after drinking a cup of coffee, which contained 104 mg of caffeine. GABA and creatine were measured on LCModel 6.3, respectively. In all three students, GABA/creatine ratios were decreased after caffeine intake. The GABA/creatine ratios obtained before caffeine intake were decreased after caffeine intake in all the three adolescents. In this preliminary study, caffeine intake caused an immediate decrease in the GABA/creatine ratio in the brain and it may be related to the neurologic effects of caffeine on an adolescent's brain.