• The Journal of Korean Medical History
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• v.20 no.2
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• pp.133-148
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• 2007

Yoshimasu Todo(吉益東洞) said in his book Yakucho, that Ramulus Cinamoni(桂枝) cures ascending impulsively & adversely of poison(衝逆). Here, the meaning of ascending impulsively & adversely of poison(衝逆) is not obvious. The objective of this thesis was to discover the exact meaning of ascending impulsively & adversely of poison(衝逆), through the analysis of Todo's books, and specifically the publication Yakucho(藥徵). Todo hadn't used the term ascending impulsively & adversely of poison(衝逆) from the beginning. He had used the term together with ascending adversely of poison(上逆) and ascending adversely of qi(上氣) in the early stage and had united the term into ascending impulsively & adversely of poison(衝逆) in the middle stage. From this study, it was determined that ascending impulsively & adversely of poison(衝逆) is the combined terms of ascending impulsively of poison(上衝) and ascending adversely of poison(上逆). Considering his view of illness, Todo had explained that every disease is caused by poison in the body. It was appropriate for him to use the term ascending impulsively & adversely of poison(衝逆) when he described the state of attacking and resisting in the body.

• The Journal of Korean Medical History
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• v.20 no.2
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• pp.149-168
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• 2007

This study compared the figures of viscera (臟腑圖) in the seventh volume titled "Body" of Sancaituhui (三才圖會), the illustrated Encyclopedia published in the Ming Dynasty (明代), and the figures of viscera in Leijingtuyi (類經圖翼). One hundred and six volume Sancaituhui was compiled by Wang Qi (王圻) and his son Wang Siyi (王思義) in the Ming Dynasty. It was first published in 1607 and republished in 1609. Sancaituhui is somewhat different from other existing medical books in terms of form and content. Thus, this study examined the difference. Another comprehensive medical book, Leijingtuyi, was written by Zhang Jing-yue (張景岳) in 1624. Both Sancaituhui and Leijingtuyi were published in China before Terrenz's Taixirenshenshuogai (泰西人身說槪), the book which first introduced Western anatomy. Therefore, this study accessed the two medical books to examine the development of figures of viscera before the instruction of Western medicine.

• The Journal of Korean Medical History
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• v.20 no.2
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• pp.169-236
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• 2007

${\ll}$Bangyakhappyeon(方藥合編)${\gg}$ was written by Hwang Do-Yeon (黃度淵) and his son Hwang Pil-Soo (黃泌秀) in the late days of Chosun Dynasty, when the country was in a state of social confusion by the first introduced western civilization and invasion of the foreign powers. In response to this situation where realistic knowledge and solution was of importance than theological review, Hwang and his son wrote the book to satisfy the needs. The book, ${\ll}$Bangyakhappyeon(方藥合編)${\gg}$ furthered new publishment of abstract asian medical science in a more compact form, emphasizing more realistic means of it. This new publishment were a significant counter-measure to cope with the inflow of practical western medicine, which the move has moreover enhanced popularization of Han Medicine(韓醫學). After reviewing ${\ll}$Bangyakhappyeon(方藥合編)${\gg}$ in xylographical approach, I have acquired conclusions as below.

• Development and Reproduction
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• v.20 no.2
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• pp.81-90
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• 2016

The effect of sudden changes of water temperature (WT) on the survival rate and physiological responses of the red spotted grouper (Epinephelus akaara) were examined by manipulating WT control system for 9 days. Experimental condition was divided in two different regimes at low (from $10^{\circ}C$ to $4^{\circ}C$, decreased $1^{\circ}C/d$) and high (from $28^{\circ}C$ to $34^{\circ}C$, increased $1^{\circ}C/d$) WT. Survival rate of experimental fishes were observed, and determined the changes of hematological characteristics by analyzing plasma levels of cortisol, glucose, total protein, and electrolytes ($Na^+$, $Cl^-$, $K^+$). No mortality was observed until low WT $6^{\circ}C$ (144 h) and high WT $32^{\circ}C$ (96 h), and 100% mortality was observed at low WT $4^{\circ}C$ (216 h) and high WT $35^{\circ}C$ (171 h). Plasma levels of cortisol and glucose increased rapidly as decreasing WT, and the loss of swimming ability and respiration response was observed at low WT $7^{\circ}C$ and high WT $34^{\circ}C$ conditions.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.4
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• pp.981-989
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• 2015

This study aims to investigate how ovulation induction of sevenband grouper, Epinephelus septemfasciatus varies when treated with different hormonal substances such as ovaprim, pimozide, LHRHa, and HCG. As for LHRHa, we injected it in different concentrations: $50{\mu}g/kg$, $100{\mu}g/kg$, $150{\mu}g/kg$, and $200{\mu}g/kg$. All hormonal substances including LHRHa were injected into back muscles. As a result, ovulation occurred in all sample groups. The sample group injected with HCG released the largest amount of eggs, and the dimeter of eggs and oil globules were also significantly bigger than those of others. Fertilization rate, embryonic survival rate, and hatching rate were the highest in a LHRHa ($100{\mu}g/kg$) +pimozide ($1,000{\mu}g/kg$) group and buoyant rate in a LHRHa group. Ovulation rate was 100% when LHRHa was injected in different concentrations. The largest amount of eggs was released in $200{\mu}g/kg$. The diameter of eggs and oil globules were the biggest in $200{\mu}g/kg$ and the smallest in $50{\mu}g/kg$. Fertilization rate showed no significant difference through all different levels of concentration: 94.6-95.3%. Buoyant rate was the highest in $100{\mu}g/kg$ and embryonic survival rate and hatching rate in $150{\mu}g/kg$. Based on these experimental results, we concluded that LHRHa in $100{\mu}g/kg$ is the most efficient for the ovulation induction of sevenband grouper.

• The Journal of Korean Medical History
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• v.24 no.1
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• pp.97-110
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• 2011

Rhinitis, inflammation of the nasal cavity caused by the disease in our country that a recent trend is the rapidly increasing number of patients. It causes multiple complications and interfere with daily life and social life in case of being viewed as a mild cold. The rhinitis treatment for symptomatic therapy in modern medicine is staying because the situation is exposing the limitations. so traditional medicine is trying to find a solution but that is not easy. In modern medicine, rhinitis is defined as a set of histological lesions and clinical symptoms, but traditional medicine has developed in dealing with each symptoms in disease. The treatment that doesn't distinguish any treatment in growing numbers of patients does not seem to validate, because doctors treat without considering the difference of recognition. Looking at the symptoms for each, I found that each symptoms and causes are varied according to doctors and era. In spite of considering all of that in treatment, it was ignored or underestimated in modern medicine. Furthermore, in traditional medicine, they just conjugated certain period theory and only had limited treatment by a lack of integrated awareness about definition and mechanism. In addition, in case of mentioning about the causes of prescription in each medical books, there were not enough explain about pathological states. Therefore, these causes should be made to further the research about the validity, pathogenesis and treatment. We can see that theory could be established and modified by the accumulation of clinical experience, observations through classification by each of the causes, prescription and treatment. In traditional medicine simply does not pay attention only to nasal inflammation, such as the impact of Meridian and organs considered to have focused on the fundamental treatment. This increased immune resistance to the modern rhinitis patients may offer new therapeutic approaches. I hope this paper would be helpful to find the treatment with uncovered theory in modern medicine.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.6
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• pp.281-286
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• 2002

To understand the cytotoxic mechanism of $MPP^+,$ we examined the involvement of ceramide in $MPP^+-induced$ cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to $MPP^+,\;MPP^+$ induced dose-dependent cytotoxicity accompanied by 2-fold elevation of intracellular ceramide levels in SH-SY5Y cells. Three methods were used to test the hypothesis that the elevated intracellular ceramide is related to $MPP^+-induced$ cytotoxicity: $C_2-ceramide$ was directly applied to cells, sphingomyelinase (SMase) was exogenously added, and oleoylethanolamine (OE) was used to inhibit degradation of ceramide. Furthermore, inhibition of ceramide-activated protein phosphatase (CAPP), the effector of ceramide, using okadaic acid (OA) attenuated cell death but treatment of fumonisin $B_1,$ the ceramide synthase inhibitor, did not alter the cytotoxic effect of $MPP^+.$ Based on these, we suggest that the elevation of intracellular ceramide is one of the important mediators in $MPP^+-induced$ cell death.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.43 no.6
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• pp.747-750
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• 2010

This study investigated the effect of wheat flour content in the diet on the growth of the snail Semisulcospira gottschei. Six diets were prepared containing wheat flour contents of 35, 40, 45, 50, 55, and 60%. Three replicate groups of snails (average weight 0.61 g) were fed each experimental diet for 8 weeks. The survival was above 85% in all groups, and did not differ significantly among treatments. The weight gain of snails fed the diets containing 35 and 40% wheat flour was significantly higher than that of snails fed the other diets (P<0.05), and the weight gain decreased when the dietary wheat flour content increased beyond 45%. The crude protein and ash contents in snails were significantly affected by the dietary wheat flour content (P<0.05). Therefore, a diet containing 35~40% wheat flour produces the optimal growth of snails. The results of this study will be used to develop cost-effective diets for commercial snail production.

• Journal of Korean Medicine Rehabilitation
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• v.25 no.4
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• pp.47-54
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• 2015

Objectives This study aimed to research current trends of acupuncture treatment of whiplash associated disorder (WAD). Methods Clinical studies about acupuncture therapy on WAD were searched in 7 databases. The included studies were classified according to their publication dates, methods, interventions, outcome measures. Interventions were analyzed by accompanied intervention, acupoint, acupuncture retaining time and treatment period. Results 14 articles were included. The number of studies on acupuncture for WAD shows increasing tendency since 1990. The included studies consist of 6 randomized controlled trials (RCTs), 2 non-randomized controlled trials (nRCTs), 2 cohort studies, 1 before and after study, 1 case study and 2 case reports. Most studies used visual analogue scale (VAS) as primary outcome. Conclusions This review demonstrates that further clinical studies need to be carried out under the formal clinical practice guidelines of acupuncture therapy for WAD in order to support clinical treatment objectively.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.4
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• pp.990-997
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• 2015

The condition factor (CF) were calculated by the morphometric data, and gonadal maturation and reproductive potential associated with fecundities of indoor cultured Hapalogenys nitens were investigated by microscopic and morphometric analysis from August 2011 to October 2012. Monthly changes in the GSI and CF were closely related to gonadal maturation and spawning. The ovary consisted of a pair of saccular structure with many ovarian lobules, the testis is a pair of lobular structure with many testicular lobules. The relationship between total fecundity (F) and total length (TL) of fish was expressed as $F=0.0449TL^{2.7926}$($r^2=0.0653$), and body weight (BW) was expressed as $F=1.4492BW^{0.8964}$($r^2=0.0863$). In this study, some exceptional special cases and phenomena were observed: absolute and relative fecundities were not increased with the increases of total length and body weight, respectively. Absolute and relative fecundities were no concerned with the increases of age classes of total length (cm) and of body weight (g).