• Title/Summary/Keyword: Madras

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Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis

  • Vanitha, Manickam Kalappan;Priya, Kalpana Deepa;Baskaran, Kuppusamy;Periyasamy, Kuppusamy;Saravanan, Dhravidamani;Venkateswari, Ramachandran;Mani, Balasundaram Revathi;Ilakkia, Aruldass;Selvaraj, Sundaramoorthy;Menaka, Rajendran;Geetha, Mahendran;Rashanthy, Nadarajah;Anandakumar, Pandi;Sakthisekaran, Dhanapal
    • Journal of Pharmacopuncture
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    • v.18 no.3
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    • pp.68-74
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    • 2015
  • Objectives: The present study was undertaken to determine the modulatory effect of taurine on the liver mitochondrial enzyme system with reference to mitochondrial lipid peroxidation (LPO), antioxidants, major tricarboxylic acid cycle enzymes, and electron transport chain enzymes during 7,12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in Sprague-Dawley rats. Methods: Animals in which breast cancer had been induced by using DMBA (25 mg/kg body weight) showed an increase in mitochondrial LPO together with decreases in enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)), non-enzymic antioxidants (reduced glutathione (GSH), vitamin C, and vitamin E), in citric acid cycle enzymes (isocitrate dehydrogenase (ICDH), alpha ketoglutarate dehydrogenase (alpha KDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)), and in electron transport chain (ETC) complexes. Results: Taurine (100 mg/kg body weight) treatment decreased liver mitochondrial LPO and augmented the activities/levels of enzymic, and non-enzymic antioxidants, tricarboxylic acid cycle enzymes and ETC complexes. Conclusion: The results of our present study demonstrated the chemotherapeutic efficacy of taurine treatment for DMBA-induced breast carcinomas.

Absence of the TP53 Poly-A Signal Sequence Variant rs78378222 in Oral, Cervical and Breast Cancers in South India

  • Rao, Arunagiri Kuha Deva Magendhra;Vinothkumar, Vilvanathan;Revathidevi, Sundaramoorthy;Arunkumar, Ganesan;Manikandan, Mayakannan;Arun, Kanagaraj;Rajkumar, Kottayasamy Seenivasagam;Ramani, Rajendran;Ramamurthy, Rajaraman;Munirajan, Arasambattu Kannan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9555-9556
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    • 2014

The Anticancer Role of Capsaicin in Experimentally-induced Lung Carcinogenesis

  • Anandakumar, Pandi;Kamaraj, Sattu;Jagan, Sundaram;Ramakrishnan, Gopalakrishnan;Asokkumar, Selvamani;Naveenkumar, Chandrashekar;Raghunandhakumar, Subramanian;Vanitha, Manickam Kalappan;Devaki, Thiruvengadam
    • Journal of Pharmacopuncture
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    • v.18 no.2
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    • pp.19-25
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    • 2015
  • Objectives: Capsaicin (CAP) is the chief pungent principle found in the hot red peppers and the chili peppers that have long been used as spices, food additives and drugs. This study investigated the anticancer potential of CAP through its ability to modify extracellular matrix components and proteases during mice lung carcinogenesis. Methods: Swiss albino mice were treated with benzo(a) pyrene (50 mg/kg body weight dissolved in olive oil) orally twice a week for four successive weeks to induce lung cancer at the end of $14^{th}$ week. CAP was administrated (10 mg/kg body weight dissolved in olive oil) intraperitoneally. Extracellular matrix components were assayed; Masson's trichome staining of lung tissues was performed. Western blot analyses of matrix metalloproteases 2 and 9 were also carried out. Results: In comparison with the control animals, animals in which benzo(a)pyrene had induced lung cancer showed significant increases in extracellular matrix components such as collagen (hydroxy proline), elastin, uronic acid and hexosamine and in glycosaminoglycans such as hyaluronate, chondroitin sulfate, keratan sulfate and dermatan sulfate. The above alterations in extracellular matrix components were effectively counteracted in benzo(a)pyrene along with CAP supplemented animals when compared to benzo(a) pyrene alone supplemented animals. The results of Masson's trichome staining for collagen and of, immunoblotting analyses of matrix metalloproteases 2 and 9 further supported the biochemical findings. Conclusion: The apparent potential of CAP in modulating extracellular matrix components and proteases suggests that CAP plays a chemomodulatory and anti-cancer role working against experimentally induced lung carcinogenesis.

Poly(anthranilic acid) Microspheres: Synthesis, Characterization and their Electrocatalytic Properties

  • Ranganathan, Suresh;Raju, Prabu;Arunachalam, Vijayaraj;Krishnamoorty, Giribabu;Ramadoss, Manigandan;Arumainathan, Stephen;Vengidusamy, Narayanan
    • Bulletin of the Korean Chemical Society
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    • v.33 no.6
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    • pp.1919-1924
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    • 2012
  • Poly(anthranilic acid) was synthesized by rapid mixing method using 5-sulphosalicylic acid as a dopant. The synthesized polymer was characterized by various techniques like FT-IR, UV-Visible, and X-ray diffraction $etc.$, The FT-IR studies reveal that the 5-sulphosalicylic acid is well doped within the polymer. The morphological property was characterized by field emission scanning electron microscopic technique. The electrochemical properties of the polymer were studied by cyclic voltammetric method. The synthesized polymer was used to modify glassy carbon electrode (GCE) and the modified electrode was found to exhibit electrocatalytic activity for the oxidation of uric acid (UA).

An Aortic Root Abscess Presenting as a Suprasternal Pulsatile Mass

  • Raman, Karthik;Sheriff, Ejaz Ahmed;Jamesraj, Jacob;Kumar, Ram
    • Journal of Chest Surgery
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    • v.52 no.3
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    • pp.178-181
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    • 2019
  • Prosthetic valve endocarditis with aortic root abscess is a serious condition requiring urgent surgical intervention. We present a case caused by an infected Bentall mechanical valve conduit after cardiac surgery in a patient who was referred for a suprasternal pulsatile mass. The patient also had 1 episode of sentinel haemorrhage.

Madras Fashion of the American Women's Costume in the Sixties

  • Kim Hye Kyung;Choi Hyung-Min
    • International Journal of Human Ecology
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    • v.5 no.2
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    • pp.1-12
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    • 2004
  • This study aimed to explore how India madras fashion was diffused in the American women's costume of the different social levels from 1960 to 1975, by using fashion illustrations such as photographs, drawings and advertisements collected from fashion magazines. The purpose was to obtain data for high fashion(Vogue), mainstream fashion(Mademoiselle) and college newspapers for youth fashion. The data were incorporated from 439 clothing items classified by different categories over the 16-year period. The results indicated that the appearance of madras in the American women's fashion in all social classes supported the idea that fashion change during this period accompanied a concurrent change in social environment. In America during the 1960s when there was strong influence of youth counterculture and interest was high on Indian culture, this corresponded to the time of maximum popularity of madras observed in American fashion in general from 1965 to 1971. Though the Indian influence on fashion in the sixties was often ascribed solely to youth counterculture, it is evident that different social groups-high and mainstream social classes, responded to the appeal of Indian culture in different ways.

Cadmium Sulphide Nanorods: Synthesis, Characterization and their Photocatalytic Activity

  • Giribabu, Krishnamoorthy;Suresh, Ranganathan;Manigandan, Ramadoss;Vijayaraj, Arunachalam;Prabu, Raju;Narayanan, Vengidusamy
    • Bulletin of the Korean Chemical Society
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    • v.33 no.9
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    • pp.2910-2916
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    • 2012
  • Cadmium sulphide (CdS) nanorods were prepared by a single precursor thermal decomposition (SPTD) method. The formation of CdS nanorods and their structure, morphology and elemental composition were studied by means of FT-IR, XRD, FE-SEM, HR-TEM and EDAX analysis. Photoluminescence (PL) and lifetime measurements were recorded to study the luminescence properties of the material. The PL spectrum of the CdS nanorods showed one broad peak and four shoulders and the cause for this emission was discussed. The PL emissions from the band edge and deep trap state of the CdS nanorods were studied by lifetime measurements. Further, the synthesized CdS nanorods showed an increase in efficiency of photocatalytic degradation of methylene blue (MB) and rhodamine B (RhB). The increase in the photocatalytic activity was attributed to the mixed phase of the CdS nanorods.