• The Korean Journal of Zoology
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• 제9권1호
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• pp.1-6
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• 1966

Frequently , large masses of the young short necked clam, Tapes japonica , die at their tidal flats in summer and this phenomenon has not been explained clearly. The purpose of the present investigation is to study the thermal condition and the chlorinity level of tidal flats in which the young clam appears to be injured. A study is also mad efor the burrowing organism in the lower layer of the esturay over which the fresh water flow during the low tide. Observation are made at five places of the tidal flat near Ikawazu Fixheries Laboratory of Tokyo University during the ebb and flow tide period of the spring tide. The diurnal and monthly changes of tidal temperatures and chlorinities are measured. Results of the study are ; 1. The surface temperature of the tidal flat increases with the ebb tide, reaches the highest between 12-14PM, and gradually decreases thereafter. The temperatures of tidal flat below 5 and 10 cm increase gradually until the flow tide reaches the surface. 2. At the spring tide in summer , the diurnal change of surface of the tidal flat temperature is very extensive ; it reaches 37-39$^{\circ}C$ in August. At the depths of 5 and 10 cm the temperature remains at 33 $^{\circ}C$ and 31$^{\circ}C$ , respectively. 3. The chlorinity of the tidal flat is higher during May through June and lower July through August, and this seems to be related to the amount of rainfall. 4. The chlorinity of the surface of tidal flat increases slightly during the ebb and flow tide periods. The observed higher chlorinity of surface of the tidal flat was 18.82% Cl. 5. At near the esturay, the fresh water that overflows the tidal flat affects the chlorinity of the surface but no such influence to the depth of the flat. 6. From above observations, it is assumed that the young short necked clam in the tidal flat could be exposed to the severe change of environmental conditions. The high temperature of the tidal flat in summer and the low chlorinity of it at flood period may be considered as the change in environment.

• The Journal of Pediatrics of Korean Medicine
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• 제21권3호
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• pp.125-143
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• 2007

Objective The purpose of this study was to investigate health and life style of pediatric outpatients who visited the oriental hospital. Methods The study was composed of 363 students from elementary school, middle school and high school who visited the pediatrics department in $\bigcirc\;\bigcirc$ university oriental medicine hospital between 2005 and 2006. Results 1. The group wasconsisted with 56% of male and 44% of female student and for the age distribution, 7.4% were elementary school students, 55.6% were middle school students, and 36.9% were high school students. 2. Usually the eldest child tends to visit hosipital more than the younger ones. 3. More than a half of those students' parent had University education or beyond that. 4. There were more students who had below the level of the height-weight curve than in the higher level. 5. The average study hours of the students were 3.67 hours. An average sleep hours was 6.18 hours. An average exercise hour was 1.16 hours and an average time for watching TV was 1.71 hours. 6. Many students had hard time to concentrate on the studying for a long time. 7. For the question about the reason why they got the poor grade, they answered because of the lower concentration, and they didn't put much effort on the studying. The most they concern about was their grade. 8. Most of the students who visited the clinic said they did not feel refreshed when they woke up in the morning, and, many of them said that they don't feel okay. 9. More than an half of the students wear glasses. 10. More than an half of the students answered that they often catch a cold when the weather changes a lot. 11. A lot of them had some digestive problems. 12. As they getting older, they said they often feel back pain and shoulder pain. 13. Many students felt irritated and got mad easily. Many of them felt bored about their study and stressed out because of their tests and the university entrance exams. 14. Most of the female students answered that they have irregular period or cramps. 15. 21% of them usually skip breakfast. 16. Many students enjoyed snacks. Most of them enjoyed snacks after school. As they go into higher grade, they would like to eat at night especially cookies, bread and fruits. Conclusions Further studies with larger sample size of students will be neededfor accurate results, and it would be better if we can compare the conditions of the students before treatments and after those.

• Proceedings of the Korea Water Resources Association Conference
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• 한국수자원학회 2018년도 학술발표회
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• pp.359-359
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• 2018

이상치는 표본자료에서 크게 어긋나 다른 자료들로부터 떨어져 표시되는 자료로써, 실제로 발생할 확률이 매우 낮은 자료로 정의되고 있다. 설계홍수량을 산정하기 위하여 적용하고 있는 극치계열의 연최대치 강우자료에는 기계오작동 및 엔지니어의 표독오류가 발생하고 있으며, 기후변화에 따른 거대태풍 및 국지적인 집중호우 발생 등으로 인한 극치값 등에서 이상치가 관측되고 있다. 통상 이상치들은 통계분석시 자료 본연의 특성을 왜곡시켜 편향된 결과를 산정할 수 있으므로 빈도해석시 이상치해석 절차를 수행하여 자료의 적정성을 확인하여야 한다. 현재 실무에서는 설계홍수량 산정요령과 하천설계기준 해설 등에서 관련 내용을 기술하고 있지만, 국내 강우자료의 기록연수의 부족으로 인하여 빈도해석시 이상치 해석이 미수행되고 있어 이상치에 따른 자료편의가 발생하면 결과물인 확률강우량이 왜곡되게 산정될 수 있다. 따라서, 본 연구에서는 국내 주요 도시의 강우자료를 이용하여 이상치검정을 수행하였다. 대상지점으로는 서울, 부산, 대전, 대구, 인천, 광주, 울산 등의 비교적 긴 관측년수를 보유하고 있는 광역시를 선정하였으며, 지속기간은 10분, 1~24시간의 25개 강우자료를 적용하였다. 이상치검정 방법으로는 타 방법에 비하여 이상치 검정력이 뛰어난 것으로 알려진 2가지 방법을 채택하였으며, 표본자료의 평균과 표준편차로 표준화된 z값을 이용하여 상 하 한계선를 초과하는 값을 확인하는 z-Score 방법중 향상된 중위수 절대편차(MAD)에 의한 수정 z-Score 방법(Hoaglin, 1993)과 Box-Plot 방법(Tukey, 1969)을 적용하였다. Box-Plot 방법(Tukey, 1969)은 전체 자료를 25%씩 사분위로 구분하는 방법으로 정렬된 자료계열을 중앙값, 박스, 수염(whiskers), 이상치로 구분한다. 정렬된 25~75% 값들을 박스로 포함하여 외곽의 수염값들을 이상치로 분류하며, 특히 사분위수의 도식화로 데이터의 분포를 파악하기 좋으며, 이상치들의 위치와 자료의 비대칭 여부를 쉽게 파악할 수 있다. 본 연구의 수행으로 수정 z-Score 방법의 경우에는 서울과 대구지점에는 이상치가 없으며, 부산지점에는 13개, 대전지점 7개, 인천지점 5개, 광주지점 32개, 울산지점 26개가 나타났다. Box-Plot 방법으로는 서울지점 35개, 부산지점 39개, 대전지점 32개, 대구지점 38개, 인천지점 51개, 광주지점 61개, 울산지점 65개의 이상치가 분석되었다. 연구를 수행한 결과, 수정 z-Score 방법에 비하여 Box-Plot 방법에 의한 이상치가 더 많이 발생하였으며, 각각의 방법으로 지속기간 및 연도별 이상치 발생자료를 확인하였다. 방법별 이상치 발생현황 등을 분석하여 지점별 발생횟수를 분석하였으며, 추후 지점 및 자료의 보완이 수행되면 활용성을 증대시킬 수 있을 것으로 판단된다.

• The Journal of Korean Society for Radiation Therapy
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• 제16권2호
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• pp.81-89
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• 2004

Introduction : The setup error due to the patient and the staff from radiation treatment as the reason which is important the treatment record could be decided is a possibility of effect. The SET-UP ERROR of the patient analyzes the effect of dose distribution and DVH from radiation treatment of the patient. Material & Methode : This test uses human phantom and when C-T scan doing, It rotated the Left direction of the human phantom and it made SET-UP ERROR , Standard plan and 3mm, 5mm, 7mm, 10mm, 15mm, 20mm with to distinguish, it made the C-T scan error. With the result, The SET-UP ERROR got each C-T image Using RTP equipment It used the plan which is used generally from clinical - Box plan, 3Dimension plan( identical angle 5beam plan) Also, ( CTV+1cm margin, CTV+0.5cm margin, CTV+0.3,cm margin = PTV) it distinguished the standard plan and each set-up error plan and The plan used a dose distribution and the DVH and it analyzed Result : The Box4 the plan and 3Dimension plan which it bites it got similar an dose distribution and DVH in 3mm, 5mm From rotation error and Rectilinear movement( $0\%{\sim}2\%$ ). Rotation error and rectilinear error 7mm, 10mm, 15mm, 20mm appeared effect it will go mad to a enough change in treatment ( $2\%{\sim}^11\%$ ) Conclusion : The diminishes the effect of the SET-UP ERROR must reduce move with tension of the patient Also, we are important accessory development and the supply that it reducing of reproducibility and the move

• Journal of Plant Biotechnology
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• 제33권3호
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• pp.195-207
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• 2006

Stem cells are the primordial, initial cells which usually divide asymmetrically giving rise to on the one hand self-renewals and on the other hand progenitor cells with potential for differentiation. Zygote (fertilized egg), with totipotency, deserves the top-ranking stem cell - he totipotent stem cell (TSC). Both the ICM (inner cell mass) taken from the 6 days-old human blastocyst and ESC (embryonic stem cell) derived from the in vitro cultured ICM have slightly less potency for differentiation than the zygote, and are termed pluripotent stem cells. Stem cells in the tissues and organs of fetus, infant, and adult have highly reduced potency and committed to produce only progenitor cells for particular tissues. These tissue-specific stem cells are called multipotent stem cells. These tissue-specific/committed multipotent stem cells, when placed in altered environment other than their original niche, can yield cells characteristic of the altered environment. These findings are certainly of potential interest from the clinical, therapeutic perspective. The controversial terminology 'somatic stem cell plasticity' coined by the stem cell community seems to have been proved true. Followings are some of the recent knowledges related to the stem cell. Just as the tissues of our body have their own multipotent stem cells, cancerous tumor has undifferentiated cells known as cancer stem cell (CSC). Each time CSC cleaves, it makes two daughter cells with different fate. One is endowed with immortality, the remarkable ability to divide indefinitely, while the other progeny cell divides occasionally but lives forever. In the cancer tumor, CSC is minority being as few as 3-5% of the tumor mass but it is the culprit behind the tumor-malignancy, metastasis, and recurrence of cancer. CSC is like a master print. As long as the original exists, copies can be made and the disease can persist. If the CSC is destroyed, cancer tumor can't grow. In the decades-long cancer therapy, efforts were focused on the reducing of the bulk of cancerous growth. How cancer therapy is changing to destroy the origin of tumor, the CSC. The next generation of treatments should be to recognize and target the root cause of cancerous growth, the CSC, rather than the reducing of the bulk of tumor, Now the strategy is to find a way to identify and isolate the stem cells. The surfaces of normal as well as the cancer stem cells are studded with proteins. In leukaemia stem cell, for example, protein CD 34 is identified. In the new treatment of cancer disease it is needed to look for protein unique to the CSC. Blocking the stem cell's source of nutrients might be another effective strategy. The mystery of sternness of stem cells has begun to be deciphered. ESC can replicate indefinitely and yet retains the potential to turn into any kind of differentiated cells. Polycomb group protein such as Suz 12 repress most of the regulatory genes which, activated, are turned to be developmental genes. These protein molecules keep the ESC in an undifferentiated state. Many of the regulator genes silenced by polycomb proteins are also occupied by such ESC transcription factors as Oct 4, Sox 2, and Nanog. Both polycomb and transcription factor proteins seem to cooperate to keep the ESC in an undifferentiated state, pluripotent, and self-renewable. A normal prion protein (PrP) is found throughout the body from blood to the brain. Prion diseases such as mad cow disease (bovine spongiform encephalopathy) are caused when a normal prion protein misfolds to give rise to PrP$^{SC}$ and assault brain tissue. Why has human body kept such a deadly and enigmatic protein? Although our body has preserved the prion protein, prion diseases are of rare occurrence. Deadly prion diseases have been intensively studied, but normal prion problems are not. Very few facts on the benefit of prion proteins have been known so far. It was found that PrP was hugely expressed on the stem cell surface of bone marrow and on the cells of neural progenitor, PrP seems to have some function in cell maturation and facilitate the division of stem cells and their self-renewal. PrP also might help guide the decision of neural progenitor cell to become a neuron.