• Journal of the East Asian Society of Dietary Life
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• v.12 no.1
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• pp.15-22
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• 2002

This study was carried out to investigate antimutagenic and cytotoxic effects of Korean traditional Mackjang added with sea tangle powder. The content percentage of most of minerals among general composition increased by adding sea tangle powder. By the Ames test, the antimutagenic effect of ethanol extract of Korean traditional Mackjang added with 5% sea tangle powder was strongest exceeding the control, 10%, and 15% sea tangle additions. The ethanol extract (400$\mu$g/plate) of Mackjang added with 5% sea tang1e powder in the S. typhimurium TA 100 strain showed inhibition rate of 95.0% against the mutagenesis induced by MNNG. The inhibition rate of ethanol extract (400$\mu$g/plate) of Mackjang added with 5% sea tang1e powder in the S. typhimurium TA98 and TA100 strains was 81.4% and 88.8%, respectively, against the mutagenesis induced by 4NQO. Under the same conditions, the suppression against B($\alpha$)P and Trp-P-1 in the TA98 and TA100 strains were 85.3% and 91.0%, and 96.5% and 96.5%, respectively. For the anticancer effects, an investigation was done on the cytotoxicity of Mackjang added with 5% sea tangle powder on the cell lines with human lung carcinoma (A549), human hepatocellular carcinoma (HepG2), and human gastric carcinoma (KATOIII). The cytotoxicities were inhibited with increasing the extract concentration. The treatment of 1.0 mg/mL Mackjang added with 5% sea tang1e powder showed relatively strong cytotoxicity of 61.2%, 61.8% and 66.8% against A549, KATOIII, and HepG2, respectively.