• IMMUNE NETWORK
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• v.7 no.1
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• pp.31-38
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• 2007

Background: Mizoribine (MZR) is an imidazole nucleoside isolated from Eupenicillium brefeldianum. MZR is currendy in clinical use for patients who have undergone renal transplantation. Therapeutic efficacy of MZR has also been demonstrated in rheumatoid arthritis and lupus nephritis. MZR has been shown to inhibit the proliferation or lymphocytes by interfering with inosine monophosphate dehydrogenase. Since the exact mechanism by which MZR benefits rheumatoid arthritis (RA) is not clear, we investigated the ability of MZR to direct its immunosuppressive influences on other antigen presenting cells, such as macrophages. Methods: Mouse macrophage RAW264.7 cells were stimulated with lipopolysaccharide in the presence of MZR. To elucidate the mechanism of the therapeutic efficacy in chronic inflammatory diseases, we examined the effects of MZR on the production of pro-inflammatory cytokines, nitric oxide (NO) and prostaglandin $E_2\;(PGE_2)$ in macrophages. Results: MZR dose-dependendy decreased the production of nitric oxide and pro- inflammatory cytokines such as tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukins $1{\beta}$ (IL-${\beta}$ and IL-6 $PGE_2$. Examination of gene expression levels showed that the anti-inflammatory effect correlated with the down-regulation of inducible nitiric oxide synthase expression, cycloxygenase-2 expression and TNF-${\alpha}$ gene expression. Conclusion: In this work, we resulted whether MZR $(1.25{\sim}10{\mu}g/ml)$ inhibited macrophage activation by inhibiting secretion of pro-inflammatory cytokines, NO and $PGE_2$. These findings provide an explanation for the therapeutic efficacy of MZR in chronic inflammation-associated diseases.

• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1147-1153
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• 2006

Mizoribine (MZR) has been shown to possess immunosuppressive activity that selectively inhibits the proliferation of lymphocytes by interfering with inosine monophosphate dehydrogenase. The efficacy of MZR is not only in patients who have had renal transplantation, but also in patients with rheumatoid arthritis (RA), lupus nephritis, and primary nephritic syndrome. Because the exact mechanism of its immunosuppressive action is not clear, the object of this study was to examine the ability of MZR to regulate the antigen presenting cells (APCs), dendritic cells (DCs). In this work, we tested whether MZR ($1{\sim}10\;{\mu}g/mL$) could inhibit the cross-presentation of DCs. DC2.4 cells ($H-2K^{b}$) or bone marrow-derived DCs (BM-DCs) generated from BM cells of C57BL/6 mouse ($H-2K^{b}$) were cultured in the presence of MZR with OVA-microspheres, and the amount of OVA peptide-class I MHC complexes was measured by a T cell hybridoma, B3Z, that recognizes OVA (257-264 : SIINFEKL)-$H-2K^{b}$ complex and expresses-galactosidase. MZR profoundly inhibited the expression of SIINFEKL-$H-2K^{b}$ complexes. This inhibitory activity of MZR appeared to affect the phagocytic activity of DCs. MZR also decreased IL-2 production when we examined the effects of MZR on $CD4^{+}$ T cells. These results provide an understanding of the mechanism of immunosuppressive activity of MZR on the inhibition of MHC-restricted antigen presentation and phagocytic activity in relation to their actions on APCs.

• The Transactions of the Korea Information Processing Society
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• v.4 no.12
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• pp.2971-2984
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• 1997

In this paper, we propose an efficient video block Placement scheme that utilize the current disk product that has MZR disk characteristic and users' skewed access pattern on VOD. Also, we evaluate its performance through simulation and modeling of VOD server. The basic placement rule is to place on MZR disks by LP, SHP methods according to the Zipf distribution of popularity. To verify the proposed scheme, we examined its performance on workstation with 2 MZR disks under varied skewed factors. The proposed placement scheme showed better response time than the random method. To extend proposed placement scheme to disk group, we analyzed the theoretical maximum numbers of concurrent users and the required buffer size per user. For performance parameters for the proposed scheme, we considered the disk head scheduling methods, the placement methods and the striping unit. The result of experiments showed that the proposed scheme was effective.

• Journal of IKEEE
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• v.23 no.1
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• pp.14-21
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• 2019

In this paper, we implemented an on-board miniaturization antenna operating 2.4 GHz using MZR(Mu Zero Resonator). It is must be operating under the constraint that the size of the small terminal PCB should be $78{\times}38{\times}0.8mm^3$ and the size of the system should be $63{\times}38{\times}0.8mm^3$ and the size of the radiating part should be $15{\times}38{\times}0.8mm^3$. The feeding structure uses a CPW structure for stable feeding and a feeding point at the upper left of the system board. A magnetic field coupling structure is used for coupling the feeding part and the antenna. The resonance frequency of the MZR is determined by the series inductance and capacitance of the cell, so the gap between the cells, the length of the cell, the length of the interdigital capacitor, and the spacing between the radiation part and the ground plane are analyzed. The antenna was designed and fabricated using the results. The total size of the antenna including the feed structure is $20.8{\times}9.0{\times}0.8mm^3$, and the electrical length is $0.1664{\lambda}_0{\times}0.072{\lambda}_0{\times}0.0064{\lambda}_0$. The measurement result for 10 dB bandwidth, gain and directivity are 440 MHz(18.3%), 0.4405 dB, and 2.722 dB respectively. It is confirmed that the radiation pattern has omnidirectional characteristics and it can be applied to ultra small terminal antenna.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10a
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• pp.124-126
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• 1998

동시 지원 사용자 수를 최대 목표로 하는 VOD와 같은 연속 매체 서버는 증가하는 사용자의 요구를 만족시키기 위해 디스크의 추가가 필요하다. 디스크 제조 기술의 급속한 발전으로 새로이 추가되는 디스크들을 이전의 디스크에 비해 저장용량과 전송 능력면에서 더 좋은 성능을 가진다. 그러나 이전의 저장 기법들은 각 디스크들의 성능차를 무시하고, 일률적인 분산 배치의 방법을 사용하였다. 또한, 디스크들간의 이질적인 환경을 고려한 다른 연구에서도 현재 주종을 이루고 있는 MZR(Multi Zoned Recording) 방식의 디스크들에 대한 고려가 부족한 게 현실이다. 본 논문에서는 이러한 이질적인 디스크간의 성능차와 MZR디스크의 특성을 고려한 ZBSR( Zone Bandwidth to Space Ration)를 사용한 배치 기법으로 디스크 자원을 효율적 사용하는 방법을 제시한다.

• Journal of electromagnetic engineering and science
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• v.18 no.4
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• pp.267-269
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• 2018

In this letter, the null steering of a circular array is presented using a modified array factor (AF) for a global positioning system (GPS) anti-jam. The seven radiating elements were designed using a mu-zero resonance (MZR) circularly polarized (CP) antenna arranged toward the center. Since the radiating elements, which are arranged toward the center, have a CP characteristic, the AF of the seven radiating elements has to be modified considering the rotation angle of the nth radiating element. The phases of input ports can be calculated to implement a nulling of radiation patterns where the modified AF is zero. To verify the modified AF for null steering in the desired direction, two cases of power dividers operating in $L_2$ band (1.2276 GHz) were fabricated to achieve pattern nulling at a certain angle. The modified AF can be confirmed by a comparing the simulated and measured radiation patterns.

• Journal of IKEEE
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• v.22 no.1
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• pp.127-135
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• 2018

This paper was studied the tri-band folded monopole antenna design with Mu-negative metamaterial unit cell, which operates at 700 MHz UHD broadcast band and 2.45 GHz/5 GHz WiFi band. The MNR metamaterial is fabricated by forming a capacitor on the backside of the antenna substrate and connecting it to the ground plane through a strip line and a via hole so that a single cell can operate in the MZR (Mu zero resonator). Through this, the resonance point can be controlled to resonate in the zero mode in 700 MHz band, and the bandwidth is improved. Experimental results show that the 10dB bandwidth and gain are 309 MHz (41.2%) and 5.298 dB at the first resonance point, and the 10dB bandwidth and gain at the second resonance point are 821.9 MHz (33.5%) and 2.7840 dB respectively. At the third resonance point, the gain and bandwidth were 1.1314 GHz (20.6%) and 2.9484 dB respectively. We confirmed that the resonance point with theoretical value is in agreement with experimental value. And the radiation pattern is generally omnidirectional, and it has been confirmed that the radiation pattern is good in both forward and backward directions at 0.75 GHz and 2.45 GHz, and has a radiation pattern with multiple lobes at 5.5 GHz.

• The Journal of Advanced Prosthodontics
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• v.10 no.1
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• pp.65-72
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• 2018

PURPOSE. The aim of this in vitro study was to investigate the fracture resistance under chewing simulation of implant-supported posterior restorations (crowns cemented to hybrid-abutments) made of different all-ceramic materials. MATERIALS AND METHODS. Monolithic zirconia (MZr) and monolithic lithium disilicate (MLD) crowns for mandibular first molar were fabricated using computer-aided design/computer-aided manufacturing technology and then cemented to zirconia hybrid-abutments (Ti-based). Each group was divided into two subgroups (n=10): (A) control group, crowns were subjected to single load to fracture; (B) test group, crowns underwent chewing simulation using multiple loads for 1.2 million cycles at 1.2 Hz with simultaneous thermocycling between $5^{\circ}C$ and $55^{\circ}C$. Data was statistically analyzed with one-way ANOVA and a Post-Hoc test. RESULTS. All tested crowns survived chewing simulation resulting in 100% survival rate. However, wear facets were observed on all the crowns at the occlusal contact point. Fracture load of monolithic lithium disilicate crowns was statistically significantly lower than that of monolithic zirconia crowns. Also, fracture load was significantly reduced in both of the all-ceramic materials after exposure to chewing simulation and thermocycling. Crowns of all test groups exhibited cohesive fracture within the monolithic crown structure only, and no abutment fractures or screw loosening were observed. CONCLUSION. When supported by implants, monolithic zirconia restorations cemented to hybrid abutments withstand masticatory forces. Also, fatigue loading accompanied by simultaneous thermocycling significantly reduces the strength of both of the all-ceramic materials. Moreover, further research is needed to define potentials, limits, and long-term serviceability of the materials and hybrid abutments.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.4
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• pp.350-357
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• 2016

In this paper, a small mu-zero zeroth order resonance(ZOR) antenna based on meta structure is proposed using parasitic patch at 5.8 GHz. The mu-zero ZOR antenna is designed by utilizing the resonance of series inductance and capacitance of mu-negative transmission line and its size can be further reduced by a simple parasitic patch. The parasitic patch can increase series capacitance of mu-negative transmission line related to a resonant frequency. We have simulated and optimized dimension of the parasitic patch using Ansys commercial simulator(HFSS). As a result, the antenna has the following characteristics: kr of 0.59, efficiency of 92 %, and gain of 6.57 dBi. Also, its size is reduced by 24 % compared to a conventional mu-zero ZOR antenna. The measured results are in good agreement with the simulated results.