• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.11A
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• pp.1925-1938
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• 2001

In this paper, a new block-matching algorithm for standard video encoder is presented. The slice competition method is proposed as a new scheme, as opposed to a coarse-to-fine approach. The order of calculating the SAD(Sum of Absolute Difference) to fad the best matching block is changed from a raster order to a dispersed one. Based on this scheme, the increasing SAD curve during its calculation is more linear than that of other curves. Then, the candidates of low probability can be removed in the early stage of calculation. And new MV prediction technique with an adaptive search range scheme also assists the proposed block-matching algorithm. As a result, an average of 13% improvement in computational power is recorded by only the proposed MV prediction technique. Synthetically, the computational power is reduced by 3977∼77% than that of the conventional BMAs. The average MAD is always low in various sequences. The results are also very close to the MAD of the full search block-matching algorithm.

• Journal of the Semiconductor & Display Technology
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• v.16 no.1
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• pp.97-101
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• 2017

In this paper, IGZO thin film transistor (TFT) was fabricated with cross-linked Poly (4-vinylphenol) (PVP) gate dielectric for flexible, transparent display applications. The PVP is one of the candidates for low-temperature gate insulators. MIM structure was fabricated to measure the leakage current and evaluate the insulator properties according to the annealing temperature. Low leakage current ( <0.1nA/cm2 @ 1MV/cm ) was observed at $200^{\circ}C$ annealing condition and decreases much more as the annealing temperature increases. The electrical characteristics of IGZO TFT such as subthreshold swing, mobility and ON/OFF current ratio were also improved, which shows that the performance of IGZO TFTs with PVP can be enhanced by reducing the amount of incomplete crosslinking in PVP.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.53.3-54
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• 2016

We present a preliminary result of the Fornax cluster survey as a part of the KMTNet Intensive Nearby Southern Galaxy Group Survey (KINGS). We discovered about 200 new dwarf galaxy candidates from the survey of the $8^{\circ}{\times}6^{\circ}$ area around the Fornax cluster. They have magnitudes ranging from V=17.5 to 22 mag (Mv = -13.8 to -9.3), and they are almost complete to V = 20 mag. Surface brightness profiles of most of these galaxies are fit well by a Sersic law with n ~ 1.0. Structural parameters of these galaxies follow well the scaling relations of dwarf galaxies in the fundamental plane. The color-magnitude diagram of these galaxies shows that they are mostly located at the faint end of the red sequence, indicating that they are the probable member of the Fornax cluster. We also derive a luminosity function of the Fornax cluster by combining the new galaxies with the known galaxies in the previous catalogs. We will discuss the future of the KINGS-Fornax.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.12C
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• pp.1232-1239
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• 2006

In video standards such as MPEG-1/2/4 and H.264/AVC, motion estimation / compensation(ME/MC) process causes the most encoding complexity of video encoder. The full search method, which is used in general video codecs, exhausts much encoding time because it compares current macroblock with those at all positions within search window for searching a matched block. For the alleviation of this problem, the fast search methods such as TSS, NTSS, DS and HEXBS are exploited at first. Thereafter, DS based MVFAST, PMVFAST, MAS and FAME, which utilize temporal or spacial correlation characteristics of motion vectors, are developed. But there remain the problems of image quality degradation and algorithm complexity increase. In this thesis, the proposed algorithm maximizes search speed and minimizes the degradation of image quality by determining initial search point correctly and using simple one-dimension search patterns considering motion characteristics of each frame.

• Journal of Radiation Industry
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• v.17 no.2
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• pp.127-134
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• 2023

Pharmacokinetic (PK) data provide pivotal information in drug development, and they are usually first studied in the preclinical stage using various animals. However, quite often, animal PK data may not match with human PK, especially in metabolites. Thus, most regulatory agencies in the world make it mandatory to obtain metabolite information using ¹⁴C radiolabeled drug in human for small molecule drug candidates. However, such studies are expensive and time consuming and they are usually done at the end of Phase II trials using ~3.7 MBq of ¹⁴C labeled drug in a limited number of human subjects. Introduction of accelerator mass spectrometry (AMS) in this kind of study has revolutionized it. Since AMS can measure ¹⁴C level as close as natural abundance, it can quantify the amounts of ¹⁴C labeled drugs and their metabolites produced in human body that consumes less than the amount of 0.0037 MBq of ¹⁴C labeled drug, a very safe level of radioactive dose in human. Therefore, it is now possible to conduct human ¹⁴C studies safely in early clinical trials without spending hefty amount of money and time. Korea Radioisotope Center for Pharmaceuticals(KRICP) at Korea Institute of Biological and Medical Sciences(KIRAMS) has established an AMS facility in 2018, housing a 0.5MV AMS manufactured at the US National Electrostatics Corps (NEC). The AMS instrument has been validated using various standard samples that have been prepared at Lawrence Livermore National Laboratory in the US, a worldly reputable provider of AMS standards. In this paper, we present a mass balance study for acetaminophen in rats using AMS and prove that the study results are equivalent with those of literature, which shows the AMS facilities at KRICP has successfully installed and be ready to be used in the various PK studies using ¹⁴C labelled compounds for new drug development.

• Radiation Oncology Journal
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• v.26 no.4
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• pp.257-262
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• 2008

Purpose: Oral mucositis induced by radiotherapy to the head and neck area, is a common acute complication and is considered as the most severe symptom for cancer patients in the early stages of treatment. This study was proposed to establish the oral mucositis mouse model induced by a single dose of radiation for the facility of testing therapeutic candidates which can be used for the oral mucositis treatments. Materials and Methods: Fifty-five BALB/c mice were divided into four groups: control, 16 Gy, 18 Gy, and 20 Gy. Oral mucositis was induced by a single dose of radiation to the head and neck using 6 MV x-Ray from linear accelerator. After irradiation, body weight and physical abnormalities were checked daily. Tongue tissues from all groups were taken on days 1, 2, 3, 5, 7, 9, and 14, respectively and H&E staining was conducted to examine morphological changes. Results: Body weight dramatically decreased after day 5 in all irradiated mice. In the 16 Gy treatment group, body weight was recovered on day 14. The histology data showed that the thickness of the epithelial cell layer was decreased by the accumulated time after radiation treatment, up to day 9. Severe ulceration was revealed on day 9. Conclusion: A single dose of 16 Gy is sufficient dose to induce oral mucositis in Balb/C mice. Significant changes were observed in the Balb/C mice on days 7 and 9 after radiation. It is suggested that this mouse model might be a useful standard tool for studying oral mucositis induced by radiation.