• Toxicological Research
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• v.35 no.2
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• pp.201-207
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• 2019

Nanoxel-$PM^{TM}$ (Nanoxel) is a docetaxel-loaded methoxy-poly(ethylene glycol)-block-poly(D,L-lactide) (mPEG-PDLLA). This newly developed and marketed nanoformulation exhibits an improved pharmacokinetic profile, efficacy, and safety. Although the safety of Nanoxel to docetaxel as well as its bioequivalence must be clinically confirmed, all biological activities have not been examined in in vitro or in vivo studies. Here, the toxicity in a cultured cell system and the effects on blood cells were tested with Nanoxel and docetaxel. The in vitro cytotoxicity of Nanoxel was found to be comparable to or slightly lower than that of docetaxel depending on the concentrations tested or the cell types. Neither docetaxel nor Nanoxel induced erythrocytes hemolysis and produced reactive oxygen species up to $100{\mu}M$. However, Nanoxel was able to enhance the aggregatory response of platelets to collagen, whereas docetaxel attenuated such aggregation in a range of $50-100{\mu}M$, while thrombin-induced aggregation was not affected by either of them. Docetaxel or Nanoxel did not alter basal level of $Ca^{2+}$ and 5-hydroxytryptamine-evoked $Ca^{2+}$ transient in vascular smooth muscle cells. These results suggest that the mPEG-PDLLA micellar formulation alters the toxicological properties of docetaxel, and that extra cautions are needed when evaluating the safety of nanomedicine.

• Research in Community and Public Health Nursing
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• v.30 no.2
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• pp.243-255
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• 2019

Purpose: The purpose of this study is to examine effects of a multifactorial program for preventing the frailty of older adults and effects of a follow-up program applying a capacity building strategy. Methods: A quasi-experimental pretest-posttest design was used for the nonequivalent control group. The follow-up group (n=75) and non-follow-up group (n=68) received the same multifactorial program comprising muscle strength exercise, cognitive training, and psychosocial programs for 12 weeks. After completion of multifactorial program, the follow-up group took follow-up programs applying the capacity building strategy for following 12 weeks. The data of physical function, cognitive function, and psychological function, and self-rated health were collected from both groups three times: before intervention, after intervention, and 12 weeks after intervention. The data were analyzed using $x^2$ test and t-test. Results: In comparison with the non-follow-up group, the scores of Timed Up & Go Test, and physical activities energy expenditure were significantly improved in the follow-up group. Conclusion: These results indicate that a multifactorial program with follow-up adapting the strategies of capacity building for the older adults group is feasible to prevent the physical frailty in community.

• Journal of Korea Multimedia Society
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• v.24 no.8
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• pp.1035-1043
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• 2021

The shoulder is less stable than other joints, making it easier to onset of various shoulder disorders. In addition, limited range of motion and pain in the shoulder due to shoulder disorders restricts daily life and social activities. The problem with exercise therapy can be reduced in exercise effect by causing boredom through simple repetition of motion, thus reducing the patient's willingness to participate. Therefore, this paper aims to provide a treatment method that can induce active participation of patients by developing devices capable of passive, active, and resistance exercise and serious game contents using them. Furthermore, sEMG was used to verify whether the rotational exercise in the horizontal and vertical using serious game contents helps the shoulder movement actually. The measured sEMG signal was classified as 5 phases according to the angle of rotation and calculated the mean integrated EMG. The mean integrated EMG for the experimental results was higher in all phases when rotational was performed compared to those when both horizontal and vertical rotational exercise remained initial posture, indicating an increase in muscle activity.

• Electronics and Telecommunications Trends
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• v.37 no.2
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• pp.30-41
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• 2022

As the society is superaging, the number of patients with movement disabilities due to musculoskeletal or nervous system illness is rapidly increasing. To improve public health and reduce medical expenses, it is essential to develop rehabilitation systems that allow patients to resume their daily-life activities. However, the existing musculoskeletal illness diagnosis and rehabilitation method is limited in terms of precision and efficiency because it is based on an empirical diagnosis and prescription without regard for individual characteristics. To overcome these limits, it is critical to design a novel concept of routine rehabilitation therapy device that is capable of inducing musculoskeletal balance by the precise analysis of musculoskeletal usage patterns via the motion and the muscle activity tracking of linked muscles. This study introduces the trend of on-skin sensor device technology for routine musculoskeletal monitoring and therapy. For on-skin rehabilitation systems, skin-adhesive and stretchable motion/posture, electromyography, pressure sensors, small-size and low-power wireless sensor interfaces, and user-friendly rehabilitation contents based on new algorithms are combined.

• Journal of Wellbeing Management and Applied Psychology
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• v.5 no.1
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• pp.1-7
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• 2022

Purpose: This study aimed to investigate spatial and temporal features of motor control in an individual with hemiparesis during the curvilinear gait (CG) and proposed an exercise guideline. Research design, data and methodology: An individual aged 63 with hemiparesis by stroke disease was participated in the study. Autoencoder (AE) was used to extract four motor modules from eight muscle activities of the paretic leg during CG. After extraction, each module of four modules was operationally defined by numbering from M1 to M4 according to spatial and temporal features and compared with results reported in a previous study. Results: As a result, an individual with hemiparesis had motor module problems related to difficulty of weight acceptance (module 1), compensation for the weakness of ankle plantar flexor (module 2), a spastic synergistic pattern (module 3) and difficulty with transition from the swing to stance phase (module 4) in terms of spatial features. Also, a delayed activation timing of temporal motor module (module 2) related to the forward propulsion during CG was observed. Conclusions: Gait rehabilitation for the stroke will need to consider clinical significances in respect of the deterioration of motor module and provide the tailored approaches for each gait phase.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.6_2
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• pp.1009-1015
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• 2022

The purpose of this study was to investigate the effects of protease in Letinus edodes, Agaricus bisporus and Pear powder after freeze drying which has the ratio of 3% on the Tenderness of the Beef Eye of Round muscle. It were marinated in distilled water (Control), 3% Letinus edodes powder (L3), 3% Agaricus bisporus powder (A3), and 3% Pear powder (P3). As a result, enzyme activities were highest in Agaricus bisporus (p<0.001). There are significant difference in pH (p<0.001), color of the beef were slightly different between the C (control) group and the sample groups. The cooking loss showed the lowest value in the control and the highest value in the water holding capacity of Agaricus bisporus. In addition, Agaricus bisporus showed the lowest shear force values than the other sample groups(p<0.001).

• Herbal Formula Science
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• v.31 no.3
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• pp.183-191
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• 2023

Objective : UVB damages skin health by causing skin redness and intense inflammation, sunburn, and skin cancer. Paeoniae Radix Alba has been used to relieve gynecological symptoms, muscle spasms, and skin ailments. This study was conducted to confirm whether it has a protective effect against UVB photodamage. Methods : Ethanol extract of Paeoniae Radix Alba (PRA) was prepared by extracting 100 g Paeoniae Radix Alba in 1 L of ethanol for 48 h. Apoptosis was monitored by the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and expression levels of apoptosis indicator proteins, and tyrosinase activity was measured with a colorimetric commercial kit. Results : In human keratinocyte HaCaT cells, PRA reduced UVB-induced cell death through apoptosis by inhibiting PARP cleavage and caspase-3 and -9. UVB-induced increase in cellular reactive oxygen species (ROS) was suppressed by PRA pretreatment. PRA also showed dose-dependent ABTS and DPPH radical scavenging activities. Furthermore, the inhibitory effect of tyrosinase activity by PRA was confirmed. Conclusion : These results demonstrated the protective role of PRA in UVB photodamage of human keratinocytes, mainly due to its antioxidant and antiapoptotic properties. We also suggest that PRA can be considered as an effective natural agent to prevent skin photodamage.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.465-472
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• 2022

Manual material handling is the one of the leading causes for musculoskeletal disorders (MSDs) and lower back discomfort. According to a study, construction formworkers suffer greater rates of muscular injuries and related illness due to manual activities. However, there is still a paucity of information on MSD, preventive posture issues, and corresponding solutions for construction aluminum formworkers. As a result, MSD and disregard of worker health and safety continue to exist at construction sites. Although preventive measures and strategies have been studied in previous research, we believe it is imperative to shed light on this problem through this study. This study aims to 1) implement a simple and cost-effective elevated bench to reduce MSDs, and 2) determine the rapid upper limbs assessment (RULA) and Ovako working posture analyzing system (OWAS) action catagory of workers in different postures to assess their MSD conditions and obtain an optimal position and posture using the Jack human modeling software and simulation tool. The study findings reveal a considerable reduction in MSD discomfort and which posture is acceptable in post-intervention instances.Thus results provide inexpensive and simple ergonomic interventions with favorable RULA and OWAS ratings that can be applied at construction sites. This study demonstrates workstation ergonomic intervention cases that can aid in understanding the urgency of applying existing research strategies into practice.

• The Korean Journal of Food & Health Convergence
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• v.8 no.1
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• pp.21-30
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• 2022

This study proposed a multiple regression equation for predicting VO2max of elderly men and women using functional performance variables required to conduct daily activities. The subjects of this study were 58 elderly men (72.4±5.9 yrs) and 117 elderly women (73.4±4.5 yrs) aged 65-90 who belong to the senior welfare center. The maximal graded exercise test using a cycle ergometer and functional performance representing muscle strength, endurance, static and dynamic flexibility, mobility, and agility were measured. For statistical processing, multiple regression analysis was performed, and the statistical significance level was α = .05. As a result, the VO2max estimation formula for the elderly was 0.419 (standing up and sitting down a chair) + 0.199 (leg endurance against wall) + 5.383, and R2=0.406. In addition, the VO2max estimation formula for elderly women is - 0.737 (standing up from a supine position) - 0.144 (waking around two cones in a figure 8) - 0.135 (%body fat) + 0.042 (one leg balance with eyes open) + 29.395, R2=0.367 was calculated. The conclusion is that if the maximal graded exercise test is not available, it is considered that VO2max of the elderly can be predicted properly by using the estimation formula calculated based on the functional performance variable.

• Physical Therapy Korea
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• v.30 no.4
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• pp.275-280
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• 2023

Background: Although warm-ups before exercise are widely accepted, research on sex differences in improving hamstring flexibility is limited. Differences in the physical and physiological characteristics between males and females may result in different responses to warm-ups. Objects: This study aimed to examine sex differences in the effects of specific warm-up on hamstring flexibility. Methods: This study included 24 young adults with hamstring tightness. The participants performed five maximal knee extensions and flexions at 90° flexion of the hip, and the maximal knee extension angle was measured in real-time using a smartphone clinometer application. Results: The groups did not significantly affect the maximal knee extension angle but showed a significant effect for repetition (p = 0.002) and group-repetition interaction (p = 0.002). Males had no significant change in hamstring flexibility; however, females showed a significant increase in flexibility in the 5^th trial compared with the 1^st trial (p = 0.041). These results demonstrated sex-specific differences in flexibility improvement over time. Conclusion: The findings of this study suggest that specific warm-up can successfully improve hamstring flexibility in females. This may be due to various factors, such as muscle stiffness of the lower extremity, estrogen levels, and temperature sensitivity. In clinical settings, specific warm-up might be helpful for females who participate in sports or activities, such as running or jumping, which require a full range of motion in the hip and knee joints.