• 한국응용곤충학회지
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• 제33권1호
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• pp.19-25
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• 1994

식물휘발성 물질에 대한 벼멸구 촉각의 반응을 전기 생리학적인 반응을 관찰하였다. 식물휘발성 물질은 일반적으로 곤충이 그들의 먹이나 산란 장소를 찾는데 아주 중요한 요소로 작용하고 있다. 이러한 기주 특이적인 성질을 파악하기 위하여 벼멸구 촉각에 분포하고 있는 화학감각기의 반응을 AC반응을 통하여 기록하였다. 벼멸구의 plaque organ에서 기된 spike 의 모양은 positive-going biphasic형으로 background spike는 초당 1~22개로 다양하였다. 벼멸구 촉각은 실험한 화학물질들에 광범위하게 반응하고 있는 것을 보여주었으며 농도가 높아짐에 따라 더욱 흥분되지만 일정 수준이상의 농도에서는 더 이상 흥분되지 않거나 억제되는 것을 보여주었다. 본 실험에서는 검정된 대부분의 식물 휘발성물질에서 가장 큰 반응을 보인 농도는 단위 용기 안에 100$\mug$의 물질이 있을 때였고, 가장 큰 반응을 보인 화합물은 hexanal 과 acetophenone이었다.

• 한국대기환경학회지
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• 제4권2호
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• pp.57-66
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• 1988

Sandy dust phenomena was observed from April 19 to 23, 1988 in Seoul and suspended particulate was collected by Andersen air sampler during this period. The samples were analyzed for 16 components $(SO_n^{2-}, NO_3^-, Cl^-, PO_4^{3-}, NH_4^+, F^-, Al, Fe, K, Cu, Mn, Na, Pb, Mg, Ca, Cd)$. The conclusions are as follwes: 1. Total suspended particulate concentation during the period of sandy dust phenomena was 489 $\mug/m^3$ (ordinary times: 140-125 $mug/m^3$) 2. The water - soluble ion component concentration of suspended particulate during the period of sandy dust phenomena was few and the metal concentration of that was more than that of ordinary times. 3. The cumulative frequency distribution of suspended particulates in logarithmic diagram did not show similar to normal log distribution during the period of sandy dust phenomena. 4. $SO_4^{2-}, NO_3^-, Cl^-, and PO_4^{3-}$ was onsided to coarse particle, and $NH_4^+$ and F to fine particle in the size distribution of water - soluble ion components during the period of sandy dust phenomena. 5. Metal concentration was high and Al, Fe, Cu, Mn, Na, Mg, and Ca was onsided to coarse particle, and K, Pb, and Cd to fine particle in the size distribution of metal components. 6. During the period of sandy dust phenomena the quantity of respirable particle (< 1 $\mum$) was about 3 times and that of metal components were about 2 - 11 times than that of ordinary times. 7. The concentrations of $NO_3^-, Cl^-, NH_4^+$ at ordinary times were 1.1 - 4 time than that of the period of sandy dust phenomena.

• Bulletin of the Korean Chemical Society
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• 제34권12호
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• pp.3923-3926
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• 2013

• 대한방사선협회지
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• 제29권1호
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• pp.12-24
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• 2003

Purpose : The aim of this study was to investigate the variables affecting video display terminal (VDT) syndrom and prevent the harm of VDT syndrom Materials and Methods : A questionnarie study was performed with 170 radiotechnologists working at CT room

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.240.2-240.2
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• 2003

A strategy for synthesis of the furan-fused tetracyclic core of xestoquinone and halenaquinone was explored through a model study. Methyl 8-oxo-4-methyl-4-phenyl-2,7-nonadiynoate was prepared from hydratroponitrile and 3-butyn-1-ol as starting materials. The intramolecular cycloaddition of this intermediate as a key step will be involved.

• 한국환경보건학회지
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• 제9권1호
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• pp.85-88
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• 1983

캄덴 카운티 청사에 있는 transformer에 화재가 난 후 건물내에 있는 60명의 혈야에서 PCB를 측정하였다. 화재가 발생한 건물내의 공기에서는 거의 검출되지 않았으나 transformer가 있는 방의 Swab Sample에서는 $52.6 \mug/cm^2$가 검출되었다. 건물을 재사용하기 전에 환기를 최대로 시킨후 다시 Swab Sample을 취했을때 12 Sample중 10주에서 PCB가 검출되지 않았다. 또한 혈야에서 PCB수준은 미검출에서 16ppb였으나 일반인에서도 69.2ppb까지 검출된것과 그밖에 17.6ppb까지 검출된 것으로 보아 화재후 PCB가 혈야중에서 증가했다는 증거는 없다고 본다. 이와 같이 혈청내에서 PCB가 증가하지 않은것은 화재후 즉시 청소와 환기를 실시한 결과로 본다.

• 생명과학회지
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• 제13권5호
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• pp.675-683
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• 2003

홍어 발효에 따른 부위별 생리기능성을 측정하기 위하여 홍어 발효과정의 일반성분의 변화, pH, 암모니움 이온농도, 항균성, 항산화성, 항암성을 측정하였다. 발효 온도(4, 10, $20^{\circ}C$)에 따른 기간별 홍어의 일반성분 분석의 결과 큰 차이를 나타내지 않았다. 홍어 유출액의 pH 변화는 $4^{\circ}C$에서 발효한 경우는 pH의 상승폭이 10, $20^{\circ}C$에 비해 낮았고, 1$0^{\circ}C$에서는 발효 1일만에 급격하게 증가하다가 5일까지 일정하게 유지한 후 2차 증가를 나타내었다. $20^{\circ}C$에서는 발효 초기부저 급격하게 증가하기 시작하여 발효 4일에 8.9를 나타내었다. 홍어 유출액의 암모니움 이온 농도 변화에서도 pH의 경우와 비슷하였는데, $4^{\circ}C$발효 온도에서는 시간별 암모니움 이온 농도 함량에 큰 차이를 나타내지 않았고, $10^{\circ}C$에서 발효시킨 홍어의 경우 5일에, $20^{\circ}C$에서 발효시킨 홍어의 경우 4.5일에 암모니움 이온 농도가 약 $10.2\mug/mL$로 발효 진행 초기인 것으로 나타났다. 홍어 가식부 및 내장 열수 추출물의 발효기간별 생리기능성을 측정한 결과 가식부 열수 추출물의 항균성은 거의 없는 것으로 나타났고, 내장은 발효 8일째에 시료 2%첨가한 군에서 43.3%로 가장 높은 항균효과를 나타내었다. 항산화성은 가식부 열수 추출물 2%첨가한 군에서 발효 0일째에 61.2%로 가장 높았고, 내장 동일 농도에서도 발효 0일째에 54.4%로 비교적 높았다. 항암성은 시료 농도 $1,000 \mug/mL$에서 가식부는 발효 8일에 52.7%였고, 내장은 발효 10일에 58.3%로 가장 높게 나타났다. 따라서 항균성과 항암성은 발효가 진행될수록 비교적 높게 나타났고, 항산화성은 발효시키지 않은 원료 자체에서 높은 효과를 나타내었다. 홍어 뇌 및 연골 열수 추출물의 농도별 생리기능성은 항균성은 뇌 시료 2%첨가한 군에서 균 배양 4시간째에 41.0%였고, 동일 농도에서 연골은 균 배양 14시간째에 35.8%를 나타내었다. 항산화성은 뇌 열수 추출물에서는 효과가 없었고, 연골 시료 2%첨가한 군에서는 25.0%로 가식부나 내장에 비해 낮게 나타났다.

• 한국환경성돌연변이발암원학회지
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• 제24권2호
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• pp.99-107
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• 2004

The validation of many synthetic chemicals that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this respect, the regulation and evaluation of the chemical hazard playa very important role to environment and human health. The clastogenicity of 11 synthetic chemicals was evaluated in Chinese hamster lung (CHL) fibroblast in vitro. Benzoyl chloride (CAS No. 98-88-4) induced chromosomal aberrations with statistical significance at the concentration of 31-123 $\mug/ml$ and 43 $\mug/ml$ in the absence and presence of S-9 metabolic activation system, respectively. 2-Propyn-l-o1 (CAS No. 107-19-7) and 2-Phenoxy ethanol (CAS No. 122-99-6) revealed clastogenicity only at the highest concentration in the presence of S-9 mixture. However, 1-naphthol (CAS No. 90-15-3) which is one of the most cytotoxic chemical among 11 chemicals tested revealed no clastogenicity both in the presence and absence of S-9 metabolic activation system. From the results of chromosomal aberration assay with 11 synthetic chemicals in CHL fibroblast in vitro, Benzoyl chloride (CAS No. 98-88-4), 2-Propyn-l-01 (CAS No. 107-19-7) and 2-Phenoxy ethanol (CAS No. 122-99-6) revealed positive clastogenic results in this study.

• Journal of Microbiology and Biotechnology
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• 제8권5호
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• pp.455-460
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• 1998

In the course of screening for new antitumor substances, a novel cytotoxic agent inducing apoptotic cell death was isolated from the culture broth of marine bacterial strain SCRC A-20. Strain SCRC A-20 was separated from a mollusk and was chemotaxonomically identified as a Streptomyces sp. The cytotoxic substance was purified by organic solvent extraction followed by silica gel column chromatography and preparative TLC. HRFAB-MS determined its molecular formula to be $C_{30}H_{40}N_2O_5$ (MW 508). The 1D and 2D NMR spectral data demonstrated that the substance has a novel lactam structure of a 20-membered macrocycle coupled with a unique acyl tetramine and bicyclo［3.3.0］ octane, which includes three methyl groups, six olefinic protons, five carbonyl groups, a conjugated diene and a dienone. The substance, named aburatubolactam C, appeared to be cytotoxic for various continuously proliferating tumor cells of human and murine origins. The $IC_{50}$ values determined by MIT assay were in the range of 0.3 to $5.8\mug/ml$. When Jurkat T cells were treated with $3\mug/ml$. of aburatubolactam C, the apoptotic DNA fragmentation was detectable within 3 h, indicating that the cytotoxic effect of aburatubolactam C on tumor cells is attributable to the induced apoptosis.

• 한국대기환경학회지
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• 제5권1호
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• pp.68-78
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• 1989

The heavy metal of suspended particulates with human health has long been studied in environmental interest concerned. This study was intended to identify harmful heavy metals of the ambient air borne dusts which were related with the respirable sizes in the aerodynamics. Two sampling sites were selected comparatively; one was in the Shinchon area, which is the commercial district with heavy traffic and the other site was in the Bulgwang area which is residential area. The supended particulates were sampled by high volume air sample with 6 cascade impactor stages. The heavy metals in terms of As, Cd, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se, V and Zn were determined by stomic absorption spectrometry or inductively coupled plasma emission spectrometry. The samples weretaken bimothly for seven consecutive days from May 1987 to March 1988. The annual average concentration of the respirable suspended dust of which diameter is less than 10$\mum$ was 152.59 $\mug/m^3$ of the Shinchon air samples; the respirable dust was equivalent to approximately 85% of the total suspended particulates. The annual average concentration of the respirable suspended dust of the Bulgwang air samples was 112.56 $\mug/m^3$; that was approximately 86% of the total suspended particulates. The concentration of heavy metals was investigated in relation to the particle size. The concentration of Cr, Fe, Mn and V were tended to be much more in the coarse particles than in the fine particles. Cd and Pb in the fine particles were more than in the coarse particles. In the partial correlation coefficients; in the Shinchon area, high correlations among Fe, Se and Mn were determined; it is assumed that those sources would be originated from coal, gasolineand diesel. In Bulgwang area, would be high correlation among Fe, Se, Hg and Mn considered to be originated from coal, Bunker-C and heavy oil as well. From the above results, the hazardous heavy merals in air should be measured and controlled in originally their sources.