• 대한두경부종양학회:학술대회논문집
• /
• 2008.05a
• /
• pp.97-97
• /
• 2008

• Electronics and Telecommunications Trends
• /
• v.27 no.2
• /
• pp.59-69
• /
• 2012

모든 사물들을 네트워크를 통해 연결하므로 언제 어디서나 다양한 서비스를 손쉽게 이용할 수 있게 하는 M2M(Machine to Machine)/IoT(Internet of Things)가 차세대 통신을 위한 주요 이슈로 고려되고 있으며, 여러 네트워크 중 이동통신 네트워크를 기반으로 하는 M2M에 대한 관심이 고조되고 있다. UMTS(Universal Mobile Telecom. System), LTE(Long Term Evolution) 등 대표적인 이동통신 시스템을 위한 표준화 단체인 3GPP(3rd Generation Partnership Project)에서는 2005년 M2M을 위한 타당성 연구를 시작으로, 2008년부터 Machine Type Communications(MTC)를 위한 본격적인 표준화 작업이 진행되었으며, 현재 Release 10을 위한 규격 작업을 마무리하고 Release 11 및 12를 위한 표준규격을 작성하고 있다. 본고에서는 3GPP에서 진행하고 있는 MTC의 표준화 현황을 간략히 기술한다.

• Journal of Information Processing Systems
• /
• v.14 no.4
• /
• pp.1033-1048
• /
• 2018

This paper proposes an integrated lighting enabler system (ILES) based on standard machine-to-machine (M2M) platforms. This system provides common services of end-to-and M2M communication for smart lighting system. It is divided into two sub-systems, namely end-device system and server system. On the server side, the M2M platform OpenMTC is used to receive data from the sensors and send response for activating actuators. At the end-device system, a programmable smart lighting device is connected to the actuators and sensors for communicating their data to the server. Some experiments have been done to prove the system concept. The experiment results show that the proposed integrated lighting enabler system is effective to reduce the power consumption by 25.22% (in average). The proving of significance effect in reducing power consumption is measured by the Wilcoxon method.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2013.05a
• /
• pp.541-543
• /
• 2013

사람이 개입할 필요 없이 기기 및 사물들을 셀룰러 망으로 연결하여 언제 어디서나 다양한 서비스를 제공하는 MTC(Machine Type Communications)는 차세대 통신의 주요 이슈로 고려되고 있다. 하지만 MTC 환경은 다수의 단말들이 존재하기 때문에 LTE-Advanced 네트워크에 상당한 혼잡과 부하 문제를 줄 수 있다. 이 문제를 해결하기 위해 단말 간 직접 통신 기술이 등장하였다. 본 논문에서는 단말 간 직접 통신에서 eNB와의 통신을 줄이고, 그룹 간의 안전한 통신이 가능한 그룹 키 관리 기법을 제안하고, 이에 따른 연산 및 통신 오버헤드를 분석한다.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.16
• /
• pp.7089-7095
• /
• 2015

Clinical evidence shows that dual inhibition of kinases as well angiogenesis provides ideal therapeutic option in the treatment of medullary thyroid carcinoma (MTC) than inhibiting either of these with the events separately. Although treatment with dual inhibitors has shown good clinical responses in patients with MTC, it has been associated with serious side effects. Some inhibitors are active agents for both angiogenesis or kinase activity. Owing to narrow therapeutic window of established inhibitors, the present study aims to identify high affinity dual inhibitors targeting RET and VEGFR2 respectively for kinase and angiogenesis activity. Established inhibitors like Vandetanib, Cabozantinib, Motesanib, PP121, RAF265 and Sunitinib served as query parent compounds for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. All the parent inhibitors and respective similar compounds were docked against RET and VEGFR2 in order to retrieve high affinity compounds with these two proteins. AGN-PC-0CUK9P PubCID: 59320403 a compound related to PPI21 showed almost equal affinity for RET and VEGFR2 and unlike other screened compounds with no apparent bias for either of the receptors. Further, AGNPC- 0CUK9P demonstrated appreciable interaction with both RET and VEGFR2 and superior kinase activity in addition to showed optimal ADMET properties and pharmacophore features. From our in silico investigation we suggest AGN-PC-0CUK9P as a superior dual inhibitor targeting RET and VEGFR2 with high efficacy which should be proposed for pharmacodynamic and pharmacokinetic studies for improved treatment of MTC.

• Journal of Korean Foot and Ankle Society
• /
• v.9 no.1
• /
• pp.87-93
• /
• 2005

Purpose: We conducted this study to examine the clinical results of the proximal metatarsal wedge osteotomy using a single screw fixation and the distal soft tissue procedure in patients with moderate to severe hallux valgus deformity. Materials and Methods: Between February 2002 and February 2004, we performed these procedures on 12 patients (15 cases). The 6 cases of all patients had mild to moderate instability in the first MTC (metatarsocuneiform) joint. We estimated the clinical outcomes, the radiological findings and complications. Results: AOFAS score was improved from preoperative 41.5 points to 87.7 points lastly on average. The mean correction angle of HVA and IMA was $23.8^{\circ}$ and $6.6^{\circ}$, respectively. The mean position of tibial sesamoid was 2.67 before surgery and 0.87 after surgery. The mean shortening of the first metatarsal bone was 3.07 mm after surgery. There was no pain and complications on the first MTC joint except the breakage of screw in one case and instability of the first MTC joint was improved postoperatively. Conclusion: We obtained good clinical and radiographic outcomes in our series. So, proximal metatarsal wedge osteotomy using a single screw fixation and distal soft tissue procedure seems one of the good surgical treatments for moderate hallux valgus deformity.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.5
• /
• pp.2027-2033
• /
• 2014

Background: We aimed to assess RET proto-oncogene polymorphisms in three different Iranian families with medullary thyroid cancer (MTC), and performed molecular dynamics simulations and free energy stability analysis of these mutations. Materials and Methods: This study consisted of 48 patients and their first-degree relatives with MTC confirmed by pathologic diagnosis and surgery. We performed molecular dynamics simulations and free energy stability analysis of mutations, and docking evaluation of known RET proto-oncogene inhibitors, including ZD-6474 and ponatinib, with wild-type and mutant forms. Results: The first family consisted of 27 people from four generations, in which nine had the C.G2901A (P.C634Y) mutation; the second family consisted of six people, of whom three had the C.G2901T (P.C634F) mutation, and the third family, who included 12 individuals from three generations, three having the C.G2251A (P.G691S) mutation. The automated 3D structure of RET protein was predicted using I-TASSER, and validated by various protein model verification programs that showed more than 96.3% of the residues in favored and allowed regions. The predicted instability indices of the mutated structures were greater than 40, which reveals that mutated RET protein is less thermo-stable compared to the wild-type form (35.4). Conclusions: Simultaneous study of the cancer mutations using both in silico and medical genetic procedures, as well as onco-protein inhibitor binding considering mutation-induced drug resistance, may help in better overcoming chemotherapy resistance and designing innovative drugs.

• Journal of the Korea Society of Computer and Information
• /
• v.15 no.12
• /
• pp.57-66
• /
• 2010

In this paper, we propose the reliability constrained resource allocation scheduling algorithm in cellular network for uplink transmission, where uplink transmission is supported via packet switching schemes without the dedicated uplink circuit links. We evaluate the performance of the proposed algorithm, and compared with the conventional works to identify the pros and cons. The proposed uplink scheduling algorithm is to satisfy the constraints requirements of the MTC services which is considered as the core technology for future mobile wireless networks. It is different to conventional works which target to maximize the link capacity. The proposed algorithm provides reliable uplink transmission independent to the location and the quality of the wireless link of the mobile terminal. Based on the performance evaluation results, we conclude that the proposed method provides enhanced reliability performance than conventional works.

• Journal of Applied Biological Chemistry
• /
• v.65 no.4
• /
• pp.299-306
• /
• 2022

In this study, derivatives of trimethoxybenzene were investigated as inhibitors of melanogenesis. We examined the effects of methyl 3,4,5-trimethoxybenzoate (MTB), ethyl 3,4,5-trimethoxybenzoate (ETB), methyl 3,4,5-trimethoxycinnamate (MTC), and ethyl 3,4,5-trimethoxycinnamate (ETC). First, the inhibitory effects of these agents on melanin production were evaluated using α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 melanoma cells. We found that all derivatives decreased α-MSH-induced melanin production in B16F10 melanoma cells; ETC showed a strong inhibitory effect at half of the concentration of the other derivatives. As tyrosinase is considered a key enzyme of melanogenesis, we also examined whether the derivatives inhibited tyrosinase activity. MTC and ETC reduced mushroom tyrosinase activity and expression levels of α-MSH-induced B16F10 cellular tyrosinase protein. Inhibitory effects of all derivatives on α-MSH-induced B16F10 cellular tyrosinase activity were shown in a dose-dependent manner. Additionally, the derivatives were exposed to diphenylpicrylhydrazyl free radical to examine their antioxidant characteristics. All derivatives showed considerable antioxidant activity, which was 2-fold higher than that of arbutin. In conclusion, the trimethoxybenzene derivatives, including MTB, ETB, MTC, and ETC exerted anti-melanogenic and antioxidant effects on α-MSH-stimulated melanogenesis, demonstrating their potential for use as novel hypopigmenting agents and antioxidants.

• Journal of the Korean Magnetics Society
• /
• v.26 no.6
• /
• pp.219-225
• /
• 2016

In this study, for assessment of degenerative knee joint cartilage disease we acquired images by fat suppressed 3D spoiled gradient recalled (SPGR) and fat suppressed 3D $T2^*$ weighted imaging techniques. To do a quantitative evaluation, the knee joint cartilage was divided into medial femoral cartilage (MFC), medial tibial cartilage (MTC), lateral femoral cartilage (LFC), lateral femoral cartilage (LFC) and patella cartilage (Pat) to measure their respective signal intensity values, signal-to-noise ratio, and contrast-to-noise ratio. As for the measured values, statistical significance between two techniques was verified by using Mann-Whitney U-Test. To do a qualitative evaluation, two radiologists have examined images by techniques after which image artifact, cartilage surface, tissue contrast, and depiction of lesion distinguishing were evaluated based on 4-point scaling (1: bad, 2: appropriate, 3: good, 4: excellent), and based on the result, statistical significance was verified by using Kappa-value Test. 3.0T MR system and HD T/R 8ch knee array coil were used to acquire images. As a result of a quantitative analysis, based on SNR values measured by using two imaging techniques, MFC, LFC, LTC, and Pat showed statistical significance (p < 0.05), but MTC did not (p > 0.05). As a result of verifying statistical significance for measured CNR value, MFC, LFC, and Pat showed statistical significance (p < 0.05), while MTC and LTC did not show statistical significance (p > 0.05). As a result of a qualitative analysis, by comparing mean values for evaluated image items, 3D $T2^*$ weighted Image has indicated a slightly higher value. As for conformance verification between the two observers by using Kappa-value test, all evaluated items have indicated statistically significant results (p < 0.05). 3D $T2^*$ weighted technique holds a clinical value equal to or superior to 3D SPGR technique with respect to evaluating images, such as distinguishing knee joint cartilages, comparing nearby tissues contrast, and distinguishing lesions.