• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1917-1923
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• 2016

Background: Lynch Syndrome (LS) is a familial cancer condition caused by germline mutations in DNA mismatch repair genes. Individuals with LS have a greatly increased risk of developing colorectal cancer (CRC) and it is therefore important to identify mutation carriers so they can undergo regular surveillance. Tumor DNA from LS patients characteristically shows microsatellite instability (MSI). Our aim here was to screen young CRC patients for MSI as a first step in the identification of unrecognized cases of LS in the Saudi population. Materials and Methods: Archival tumor tissue was obtained from 284 CRC patients treated at 4 institutes in Dammam and Riyadh between 2006 and 2015 and aged less than 60 years at diagnosis. MSI screening was performed using the BAT-26 microsatellite marker and positive cases confirmed using the pentaplex MSI analysis system. Positive cases were screened for BRAF mutations to exclude sporadic CRC and were evaluated for loss of expression of 4 DNA mismatch repair proteins using immunohistochemistry. Results: MSI was found in 33/284 (11.6%) cases, of which only one showed a BRAF mutation. Saudi MSI cases showed similar instability in the BAT-26 and BAT-25 markers to Australian MSI cases, but significantly lower frequencies of instability in 3 other microsatellite markers. Conclusions: MSI screening of young Saudi CRC patients reveals that approximately 1 in 9 are candidates for LS. Patients with MSI are strongly recommended to undergo genetic counselling and germline mutation testing for LS. Other affected family members can then be identified and offered regular surveillance for early detection of LS-associated cancers.

• Journal of Gastric Cancer
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• v.19 no.4
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• pp.427-437
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• 2019

Purpose: We aimed to evaluate the clinical characteristics of microsatellite instability in early gastric cancer. Materials and Methods: The microsatellite instability status of resected early gastric tumors was evaluated using two mononucleotide repeat markers (BAT25 and BAT26) and three dinucleotide repeat markers (D5S346, D2S123, and D17S250). Tumors with instability in two or more markers were defined as microsatellite instability-high (MSI-H) and others were classified as microsatellite stable (MSS). Results: Overall, 1,156 tumors were included in the analysis, with 85 (7.4%) classified as MSI-H compared with MSS tumors. For MSI-H tumors, there was a significant correlation with the female sex, older age, tumor location in the lower gastric body, intestinal histology, lymphovascular invasion (LVI), and submucosal invasion (P<0.05). There was also a trend toward an association with lymph node (LN) metastasis (P=0.056). In mucosal gastric cancer, there was no significant difference in MSI status in tumors with LN metastasis or tumors with LVI. In submucosal gastric cancer, LVI was more frequently observed in MSI-H than in MSS tumors (38.9% vs. 25.0%, P=0.027), but there was no difference in the presence of LN metastases. The prognosis of MSI-H tumors was similar to that of MSS tumors (log-rank test, P=0.797, the hazard ratio for MSI-H was adjusted by age, sex, pT stage, and the number of metastatic LNs, 0.932; 95% confidence interval, 0.423-2.054; P=0.861). Conclusions: MSI status was not useful in predicting prognosis in early gastric cancer. However, the frequent presence of LVI in early MSI-H gastric cancer may help guide the appropriate treatment for patients, such as endoscopic treatment or limited LN surgical dissection.

• Korean Journal of Clinical Laboratory Science
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• v.46 no.2
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• pp.59-63
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• 2014

The death toll of Colorectal Carcinoma in Korea was 1,826 and 7,721 in the years 1992 and 2011, respectively. This rate of increase was shown to be more than 4.23 times higher than that of any other form of cancer. Therefore, Colorectal Carcinoma requires various diagnostic methods, and Microsatellite Instability (MSI) was applied as a new diagnostic tool. From this study with several microsatellite markers, only marker #13 was detected and observed D13S160 13% (4/30), D13S292 13% (4/30), D13S153 10% (3/30) in order. From the results of amplication with microsatellite marker, D13S292 37% (11/30), D13S153 33% (10/30), D13S160 33% (10/30) in order were shown. The appearance of a genetic mutation, which depends on the loci of Colorectal Carcinoma, was shown amplication from rectal cancer (3.77) which was higher than that of right Colorectal Carcinoma (2.08) (p<0.018). The genetic mutation with lymph node (4.13) appeared higher than normal (1.93) (p<0.001). There were no great differences in the genetic mutation dependent on disease, histological classification and increased group of serum CEA. Accordingly, it is suggested that the correct primers, which can evaluate MSI well from colorectal carcinoma, should be chosen and that MSI be considered a good prognosis and quality control tool.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8027-8034
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• 2014

Genetic instability contributes to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Microsatellite instability (MSI) has been hypothesized to be involved in carcinogenesis, althgough its mechanisms and exact roles in gastric cancer remain largely unknown. Our aim was to identify associated clinicopathological characteristics and prognostic value of MSI in gastric cancer and precancerous lesions including gastritis, metaplasia, dysplasia, and adenoma. Because mitochondrial DNA has a different genetic system from nuclear DNA, the results of both nuclear MSI and mitochondrial MSI in gastric cancer were reviewed. This review provides evidence that genetic instability of nuclear and mitochondrial DNAs contributes to early stages of gastric carcinogenesis and suggests possible roles in predicting prognosis.

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.8
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• pp.749-753
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• 2007

In this paper, a generalized version of the Motion Silhouette Image(MSI) called the Generic Motion Silhouette Image (GMSI) is proposed for gait recognition. The GMSI is a gray-level image and involves the spatiotemporal information of individual motion. The GMSI not only generalizes the MSI but also reflects a flexible feature of a gait sequence. Along with the GMSI, we use the Principal Component Analysis(PCA) to reduce the dimensionality of the GMSI and the Nearest Neighbor(NN) for classification. We apply the proposed feature to NLPR database and compare it with the conventional MSI. Experimental results show the effectiveness of the GMSI.

• The Journal of Korean Medicine
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• v.33 no.1
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• pp.79-89
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• 2012

Objectives: Sahrmann, an American physical therapist, has developed a set of movement-related diagnoses on musculoskeletal pain syndromes (MPS). We reviewed articles for studies of objectification and quantification of Oriental medicine diagnosis system about MPS. Methods: The authors reviewed a total of 12 studies found on PubMed to obtain movement system impairment (MSI)-based classification categories. Results: The MSI system has been developed for objectification and quantification of physical therapists' MPS diagnoses. The MSI system of classification is based on the basic premise that loss of precise movement is the result of specific repetitive movements and positions in everyday life. The MSI system defines 8 categories in the shoulder region, 5 in the lumbar region, and 7 in the knee region. Treatment involves (1) educating the person about the specific directions of alignment and movement that appear to be contributing to the musculoskeletal problem, (2) modifying the direction - specific alignment and movement patterns during daily activities, and (3) exercises to address the impairments. Conclusions: The authors propose that MSI studies could help to advance an Oriental medical diagnosis system on musculoskeletal pain syndromes, because MSI shares similarity with Oriental medicine in terms of holism, views of constant motion, and mi-byung (subhealth) treatment.

• Applied Biological Chemistry
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• v.21 no.3
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• pp.193-196
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• 1978

Wheat quality score index was proposed as a new criterion of wheat_quality for evaluation of the laboratory testing value such as milling rate (Xm), flour ash content (Xa), flour protein content (Xp) and sedimentation value (Xs). 1) Wheat quality score index was expressed as follows; Milling score index (MSI) $=2.3X_m-72.4X_a$ Protein score index (PSI) =$5.2X_p+0.9X_{psi}$ Composite quality score index (QSI) =$0.63X_{msi}+0.37X_{psi}$ 2) The samples with the more than 100 of MSI would be the good milliability, and the samples with more than 100 of PSI would be the good bread making properties, while that with less than 100 of PSI be good pastry type properties. Whereas most of the samples with higher value of QSI would be related to the good milliability and good bread making properties. 3) MSI, PSI and QSI were significantly correlated to the each related quality components.

• Journal of the Korean Society of Marine Environment & Safety
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• v.20 no.2
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• pp.228-233
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• 2014

In this paper, the motion performance in waves for the training ship Kaya of Pukyong National University is obtained by using a computer program based on Strip method. To guarantee the pleasant seafaring in ocean, the vertical acceleration of ship motion is calculated according to the location of the ship. The results of calculation by changes of ship speed are compared with the guideline of MSI(Motion Sickness Incidence). The degree of motion sickness is shown and discussed through the comparison between calculated vertical acceleration spectrum and MSI guideline. The computational results of MSI were as follow; when ship speed increased in the order of 5 knots, 10 knots, 12 knots and encounter angle became the bow quartering sea of $120^{\circ}$ compared to $180^{\circ}$ and $150^{\circ}$, the vertical acceleration values grew higher.

• Journal of the Korean Society of Marine Environment & Safety
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• v.20 no.4
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• pp.412-418
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• 2014

In this paper, for better boarding performance and pleasant boarding sensitivity of the ship, comparison and analysis was performed of motion sickness questionnaire with MSI(Motion Sickness Incidence) calculation based on ship motion theory(Strip Method) due to sea condition, incident angle in main sail way, economic speed, and calculation position of the training ship Kaya of Pukyong National University. On theses works, the rougher sea conditions became, the higher total motion sickness rate was occurred. The weights of vertical acceleration and the rates of MSI were higher at the bridge and the accommodation, which were located farther from the center of gravity of the ship. And effects of the vertical acceleration of the ship were increased in rolling then in head sea. In comparison between motion sickness questionnaire with MSI calculation, when the vertical acceleration increased, the motion sickness rate increased. The location to increase vertical acceleration and the location to cause motion sickness were agreed.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2013.10a
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• pp.142-144
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• 2013

선박 안전항해를 위해 항해용 해도와 같은 수로 정보와 함께 해사안전정보(MSI), 항행통보(NM), 항행경보와 같이 임의적인 안전관련 정보들이 이용될 수 있다. 현재 GMDSS 제도의 시행에 따라 해사안전정보와 항행경보 등의 정보들이 NAVTEX 등의 장비를 통해 텍스트 형태로 선박에 전달되고 있으나 이런 형식의 정보들은 기존 종이해도 또는 전자해도를 사용하는 ECDIS의 다양한 첨단 항해 지원 기능과 연계하기 어려운 단점이 있다. 이를 해결하기 위해 사례로 유럽은 e-Navigation Test-bed 프로젝트에서 IHO의 S-100 표준을 기반으로 하는 해사안전정보 데이터 표준을 수립하고 이를 활용한 서비스 연구 및 검증을 수행하고 있다. 본 연구에서는 국제수로기구의 S-100 표준에 따라 해사안전정보를 객체화 하여 모델링하고 이를 전자해도 정보와 연계하여 활용할 수 있는 방안을 모색하기 위해 유럽의 e-Navigation Test-bed 프로젝트에서의 해사안전정보 연구 사례(S-100 표준 기반의 해사안전정보 제품 표준), 국제수로기구의 해사안전정보 매뉴얼 등을 분석하여 국내 해사안전정보 서비스를 위해 필요한 기술개발 내역 및 방안을 제안 하였다.