• 대한의용생체공학회:의공학회지
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• 제41권1호
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• pp.28-34
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• 2020

In this paper, we introduce motion artifact reduction algorithm for interleaved MRI using an advanced 3D approximation algorithm. The motion artifact framework of this paper is data corrected by post-processing with a new 3-D approximation algorithm which uses data structure for each voxel. In this study, we simulate and evaluate our algorithm using Shepp-Logan phantom and T1-MRI template for both scattered dataset and uniform dataset. We generated motion artifact using random generated motion parameters for the interleaved MRI. In simulation, we use image coregistration by SPM12 (https://www.fil.ion.ucl.ac.uk/spm/) to estimate the motion parameters. The motion artifact correction is done with using full dataset with estimated motion parameters, as well as use only one half of the full data which is the case when the half volume is corrupted by severe movement. We evaluate using numerical metrics and visualize error images.

• International Journal of Computer Science & Network Security
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• 제22권8호
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• pp.343-351
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• 2022

A brain tumor forms when some tissue becomes old or damaged but does not die when it must, preventing new tissue from being born. Manually finding such masses in the brain by analyzing MRI images is challenging and time-consuming for experts. In this study, our main objective is to detect the brain's tumorous part, allowing rapid diagnosis to treat the primary disease instantly. With image processing techniques and deep learning prediction algorithms, our research makes a system capable of finding a tumor in MRI images of a brain automatically and accurately. Our tumor segmentation adopts the U-Net deep learning segmentation on the standard MICCAI BRATS 2018 dataset, which has MRI images with different modalities. The proposed approach was evaluated and achieved Dice Coefficients of 0.9795, 0.9855, 0.9793, and 0.9950 across several test datasets. These results show that the proposed system achieves excellent segmentation of tumors in MRIs using deep learning techniques such as the U-Net algorithm.

• 스마트미디어저널
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• 제13권6호
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• pp.90-97
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• 2024

This paper focuses on detecting Alzheimer's Disease (AD). The most usual form of dementia is Alzheimer's disease, which causes permanent cause memory cell damage. Alzheimer's disease, a neurodegenerative disease, increases slowly over time. For this matter, early detection of Alzheimer's disease is important. The purpose of this work is using Magnetic Resonance Imaging (MRI) to diagnose AD. A Convolution Neural Network (CNN) model, Reset, and VGG the pre-trained learning models are used. Performing analysis and validation of layers affects the effectiveness of the model. T1-weighted MRI images are taken for preprocessing from ADNI. The Dataset images are taken from the Alzheimer's Disease Neuroimaging Initiative (ADNI). 3D MRI scans into 2D image slices shows the optimization method in the training process while achieving 96% and 94% accuracy in VGG 16 and ResNet 18 respectively. This study aims to classify AD from brain 3D MRI images and obtain better results.

• Korean Journal of Radiology
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• 제22권11호
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• pp.1918-1928
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• 2021

Objective: With the recent development of various MRI-conditional cardiac implantable electronic devices (CIEDs), the accurate identification and characterization of CIEDs have become critical when performing MRI in patients with CIEDs. We aimed to develop and evaluate a deep learning-based algorithm (DLA) that performs the detection and characterization of parameters, including MRI safety, of CIEDs on chest radiograph (CR) in a single step and compare its performance with other related algorithms that were recently developed. Materials and Methods: We developed a DLA (X-ray CIED identification [XCID]) using 9912 CRs of 958 patients with 968 CIEDs comprising 26 model groups from 4 manufacturers obtained between 2014 and 2019 from one hospital. The performance of XCID was tested with an external dataset consisting of 2122 CRs obtained from a different hospital and compared with the performance of two other related algorithms recently reported, including PacemakerID (PID) and Pacemaker identification with neural networks (PPMnn). Results: The overall accuracies of XCID for the manufacturer classification, model group identification, and MRI safety characterization using the internal test dataset were 99.7% (992/995), 97.2% (967/995), and 98.9% (984/995), respectively. These were 95.8% (2033/2122), 85.4% (1813/2122), and 92.2% (1956/2122), respectively, with the external test dataset. In the comparative study, the accuracy for the manufacturer classification was 95.0% (152/160) for XCID and 91.3% for PPMnn (146/160), which was significantly higher than that for PID (80.0%,128/160; p < 0.001 for both). XCID demonstrated a higher accuracy (88.1%; 141/160) than PPMnn (80.0%; 128/160) in identifying model groups (p < 0.001). Conclusion: The remarkable and consistent performance of XCID suggests its applicability for detection, manufacturer and model identification, as well as MRI safety characterization of CIED on CRs. Further studies are warranted to guarantee the safe use of XCID in clinical practice.

• Korean Journal of Radiology
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• 제23권7호
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• pp.720-731
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• 2022

Objective: We aimed to develop and test a deep learning algorithm (DLA) for fully automated measurement of the volume and signal intensity (SI) of the liver and spleen using gadoxetic acid-enhanced hepatobiliary phase (HBP)-magnetic resonance imaging (MRI) and to evaluate the clinical utility of DLA-assisted assessment of functional liver capacity. Materials and Methods: The DLA was developed using HBP-MRI data from 1014 patients. Using an independent test dataset (110 internal and 90 external MRI data), the segmentation performance of the DLA was measured using the Dice similarity score (DSS), and the agreement between the DLA and the ground truth for the volume and SI measurements was assessed with a Bland-Altman 95% limit of agreement (LOA). In 276 separate patients (male:female, 191:85; mean age ± standard deviation, 40 ± 15 years) who underwent hepatic resection, we evaluated the correlations between various DLA-based MRI indices, including liver volume normalized by body surface area (LV_BSA), liver-to-spleen SI ratio (LSSR), MRI parameter-adjusted LSSR (aLSSR), LSSR × LV_BSA, and aLSSR × LV_BSA, and the indocyanine green retention rate at 15 minutes (ICG-R15), and determined the diagnostic performance of the DLA-based MRI indices to detect ICG-R15 ≥ 20%. Results: In the test dataset, the mean DSS was 0.977 for liver segmentation and 0.946 for spleen segmentation. The Bland-Altman 95% LOAs were 0.08% ± 3.70% for the liver volume, 0.20% ± 7.89% for the spleen volume, -0.02% ± 1.28% for the liver SI, and -0.01% ± 1.70% for the spleen SI. Among DLA-based MRI indices, aLSSR × LV_BSA showed the strongest correlation with ICG-R15 (r = -0.54, p < 0.001), with area under receiver operating characteristic curve of 0.932 (95% confidence interval, 0.895-0.959) to diagnose ICG-R15 ≥ 20%. Conclusion: Our DLA can accurately measure the volume and SI of the liver and spleen and may be useful for assessing functional liver capacity using gadoxetic acid-enhanced HBP-MRI.

• Korean Journal of Radiology
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• 제20권5호
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• pp.854-861
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• 2019

Objective: To evaluate quantitative magnetic resonance imaging (MRI) parameters for differentiation of cysts from and solid masses in the anterior mediastinum. Materials and Methods: The development dataset included 18 patients from two institutions with pathologically-proven cysts (n = 6) and solid masses (n = 12) in the anterior mediastinum. We measured the maximum diameter, normalized T1 and T2 signal intensity (nT1 and nT2), normalized apparent diffusion coefficient (nADC), and relative enhancement ratio (RER) of each lesion. RERs were obtained by non-rigid registration and subtraction of precontrast and postcontrast T1-weighted images. Differentiation criteria between cysts and solid masses were identified based on receiver operating characteristics analysis. For validation, two separate datasets were utilized: 15 patients with 8 cysts and 7 solid masses from another institution (validation dataset 1); and 11 patients with clinically diagnosed cysts stable for more than two years (validation dataset 2). Sensitivity and specificity were calculated from the validation datasets. Results: nT2, nADC, and RER significantly differed between cysts and solid masses (p = 0.032, 0.013, and < 0.001, respectively). The following criteria differentiated cysts from solid masses: RER < 26.1%; nADC > 0.63; nT2 > 0.39. In validation dataset 1, the sensitivity of the RER, nADC, and nT2 criteria was 87.5%, 100%, and 75.0%, and the specificity was 100%, 40.0%, and 57.4%, respectively. In validation dataset 2, the sensitivity of the RER, nADC, and nT2 criteria was 90.9%, 90.9%, and 72.7%, respectively. Conclusion: Quantitative MRI criteria using nT2, nADC, and particularly RER can assist differentiation of cysts from solid masses in the anterior mediastinum.

• 한국컴퓨터정보학회논문지
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• 제26권7호
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• pp.37-44
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• 2021

뇌 MRI 영상의 자동 분류는 뇌종양의 조기 진단을 하는 데 있어 중요한 역할을 한다. 본 연구에서 우리는 심층 특징 앙상블을 사용한 MRI 영상에서의 딥 러닝 기반 뇌종양 분류 모델을 제안한다. 우선 사전 학습된 3개의 합성 곱 신경망을 사용하여 입력 MRI 영상에 대한 심층 특징들을 추출한다. 그 이후 추출된 심층 특징들은 완전 연결 계층들로 구성된 분류 모듈의 입력 값으로 들어간다. 분류 모듈에서는 우선 3개의 서로 다른 심층 특징들 각각에 대해 먼저 완전 연결 계층을 거쳐 특징 차원을 줄인다. 그 이후 3개의 차원이 준 특징들을 결합하여 하나의 특징 벡터를 생성한 뒤 다시 완전 연결 계층의 입력값으로 들어가서 최종적인 분류 결과를 예측한다. 우리가 제안한 모델을 평가하기 위해 웹상에 공개된 뇌 MRI 데이터 셋을 사용하였다. 실험 결과 우리가 제안한 모델이 다른 기계학습 기반 모델보다 더 좋은 성능을 나타냄을 확인하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권10호
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• pp.5179-5196
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• 2019

To explore an effective non-invasion medical imaging diagnostics approach for hepatocellular carcinoma (HCC), we propose a method based on adopting the multiple technologies with the multi-parametric data fusion, transfer learning, and multi-scale deep feature extraction. Firstly, to make full use of complementary and enhancing the contribution of different modalities viz. multi-parametric MRI images in the lesion diagnosis, we propose a data-level fusion strategy. Secondly, based on the fusion data as the input, the multi-scale residual neural network with SPP (Spatial Pyramid Pooling) is utilized for the discriminative feature representation learning. Thirdly, to mitigate the impact of the lack of training samples, we do the pre-training of the proposed multi-scale residual neural network model on the natural image dataset and the fine-tuning with the chosen multi-parametric MRI images as complementary data. The comparative experiment results on the dataset from the clinical cases show that our proposed approach by employing the multiple strategies achieves the highest accuracy of 0.847±0.023 in the classification problem on the HCC differentiation. In the problem of discriminating the HCC lesion from the non-tumor area, we achieve a good performance with accuracy, sensitivity, specificity and AUC (area under the ROC curve) being 0.981±0.002, 0.981±0.002, 0.991±0.007 and 0.999±0.0008, respectively.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2012년도 춘계학술발표대회
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• pp.336-339
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• 2012

VTK is a free but professional development platform for images three-dimensional (3D) reconstruction and processing. It is powerful, open-source, and users can customize their own needs by self-development of great flexibility. To give the doctors more and detailed information by simulate dissection to the 3-D brain MRI image after reconstruction. A Visualization System (VS) is proposed to achieve 3D brain reconstruction and virtual dissection functions. Based on the free VTK visualization development platform and Visual Studio 2010 IDE development tools, through C++ language, using real people's MRI brain dataset, we realized the images 3D reconstruction and also its applications and extensions correspondingly. The display effect of the reconstructed 3D image is well and intuitive. With the related operations such as measurement, virtual dissection and so on, the good results we desired could be achieved.

• 인터넷정보학회논문지
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• 제24권4호
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• pp.85-92
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• 2023

X-ray, Computed Tomography (CT), Magnetic Resonance Imaging (MRI)과 같은 의료데이터에서 딥러닝을 활용해 질병 유무 판별 태스크와 같은 문제를 해결하려는 시도가 활발하다. 대부분의 데이터 기반 딥러닝 문제들은 높은 정확도 달성과 정답과 비교하는 성능평가의 활용을 위해 지도학습기법을 사용해야 한다. 지도학습에는 다량의 이미지와 레이블 세트가 필요하지만, 학습에 충분한 양의 의료 이미지 데이터를 얻기는 어렵다. 다양한 데이터 증강 기법을 통해 적은 양의 의료이미지와 레이블 세트로 지도학습 기반 모델의 과소적합 문제를 극복할 수 있다. 본 연구는 딥러닝 기반 갈비뼈 골절 세그멘테이션 모델의 성능 향상과 효과적인 좌우 반전, 회전, 스케일링 등의 데이터 증강 기법을 탐색한다. 좌우 반전과 30° 회전, 60° 회전으로 증강한 데이터셋은 모델 성능 향상에 기여하지만, 90° 회전 및 ⨯0.5 스케일링은 모델 성능을 저하한다. 이는 데이터셋 및 태스크에 따라 적절한 데이터 증강 기법의 사용이 필요함을 나타낸다.