• Environmental Mutagens and Carcinogens
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• v.21 no.2
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• pp.135-141
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• 2001

Endocrine disruptors have been implicated in carcinogenesis in animal studies, but carcinogenetic effects on human remain controversial. In order to examine the genotoxicity of two common endocrine disruptors, Bisphenol A and Diethylstilbestrol, cytogenetic endpoints including chromosome aberration (CA), sister chromatid exchange (SCE), micronuclei (MN) analyses and DNA damage by single cell gel electrophoresis (SCGE) were assessed. The effects of Bisphenol A and Diethylstilbestrol on the frequencies of CA and MN were increased in a dose-dependent manner and that of Bispheol A was more significant by Kendall'$\tau$test. Bisphenol A and Diethylstilbestrol also increased the frequency of SCE. Bisphenol A and Diethylstilbestrol induced DNA damage in a dose-dependent manner and the DNA damage induced by Diethylstilbestrol in human blood lymphocytes was more significant.

• Journal of Welding and Joining
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• v.33 no.5
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• pp.31-34
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• 2015

Microstructure and tensile property in the weld heat-affected zone (HAZ) of austenitic Fe-Mn-Al-C low density steels were investigated through transmission electron microscopy analysis and tensile tests. The HAZ samples were prepared using Gleeble simulation with high heat input welding condition of 300 kJ/cm, and the HAZ peak temperature of $1200^{\circ}C$ was determined from differential scanning calorimetry (DSC) test. The strain- stress responses of base steels showed that the addition of V improved the tensile and yield strength by grain refinement and precipitation strengthening. Tensile strength and elongation decreased in the weld HAZ as compared to the base steel, due to grain growth, while V-added steel had a higher HAZ strength as compared than V-free steel.

• 한국신재생에너지학회:학술대회논문집
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• 2006.11a
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• pp.364-367
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• 2006

The decrease of polarization resistance in cathode is the key point for intermediate temperature SOFC(Solid Oxide Fuel Cell). In this study, the Influence of Co substitution in B-site at perovskite PSCM (Pr0.3Sr0.7CoxMn(1-x)) was investigated. The PSCM series exhibits excellent MIEC(Mixed ionic Electronic Conductor) properties. The ASR(Area Specific Resistance) of PSCM3773 was $0.174{\Omega}cm^2\;at\;700^{\circ}C$. The activation energy of PSCM3773 was also lower than other compositions of PSCM. The ASR values were increased gradually during the thermal cycling test of PSCM37773 due to the delamination between electrolyte and cathode materials.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.72-77
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• 2003

In order to develop ASTM A302 grade C type steel plate with excellent weldability, several steels with different chemistry have been manufactured and evaluated their mechanical properties and weldability. Trial A302-C steels have revealed tensile strength in the range of $61-67kg/mm^2$ and elongation in the range of $27{\sim}32%$, depending on chemical compositions within the ASTM specification range. In case of impact toughness, trial steels showed in the range of 58-70J at $0^{\circ}C$. From the weldability test, the minimum preheat temperature was found to be about $150^{\circ}C$, and automatic welding condition satisfied the requirements of both ASTM specification and users.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.5
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• pp.881-887
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• 2000

The antimutagenic effects of persimmon leaf tea extract (PLTE) at concentration levels consumed by human were examined in mice using micronuleus induction with MMC(mitomycin C) or 4-NQO (4-nitroquinoline-1-oxide). When mice received oral gavage of 10 equivalent to PLTE 24 hr and 6 hr before, and 5 equivalent to PLTE 6 hr before and 3 hr after intraperitoneal injection of MMC, a significant decrease in the frequency of micronuclei were observed. The induction of micronuclei by 4-NQO was suppressed by oral dosage of PLTE at 5 equivalent to PLTE 6 hr before and 3 hr after, 10 equivalent to PLTE 3 hr before and 3 hr after intraperitoneal injection of MMC. Though the components of PLTE have not been analyzed so far, our present results suggest the existence of several bio-antimutagens and/or desmutagens in PLTE, beside catechin, well-known antimutagen.

• Korean Journal of Metals and Materials
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• v.49 no.6
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• pp.448-453
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• 2011

Pre-aging heat treatment after solution heat treatment (SHT) of Al-0.4 wt%Mg-1.2 wt%Si-0.1 wt%Mn alloy sheets for auto-bodies was carried out to investigate the effect of pre-aging and its conditions on the bake-hardening response. Mechanical properties were evaluated by a tensile and Vickers hardness test. Microstructural observation was also performed using a transmission electron microscope (TEM). It was revealed that pre-aging treatments play a great role in the bake-hardening response. In addition, it was found that the sphere-shaped nanosized clusters that can directly transit to the needle-shaped ${\beta}$" phase during the paint-bake process, not being dissolved into the matrix, are formed at 343 K. The result, reveals that the dominant factor of the bake-hardening response is the pre-aging temperature rather than the pre-aging time.

• Journal of Environmental Health Sciences
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• v.37 no.2
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• pp.102-112
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• 2011

Objectives: The purpose of this study is to analyze the effects of chronic exposure by welders to manganese (Mn) through an analysis of the degree of brain activity in different activities such as cognition and motor activities using the neuroimaging technique of functional magnetic resonance imaging (fMRI). The neurotoxic effect that Mn has on the brain was examined as well as changes in the neuro-network in motor areas, and the usefulness of fMRI was evaluated as a tool to determine changes in brain function from occupational exposure to Mn. Methods: A survey was carried out from July 2010 to October 2010 targeting by means of a questionnaire 160 workers from the shipbuilding and other manufacturing industries. Among them, 14 welders with more than ten years of job-related exposure to Mn were recruited on a voluntary basis as an exposure group, and 13 workers from other manufacturing industries with corresponding gender and age were recruited as a control group. A questionnaire survey, a blood test, and an fMRI test were carried out with the study group as target. Results: Of 27 fMRI targets, blood Mn concentration of the exposure group was significantly higher than that of the control group (p<0.001), and Pallidal Index (PI) of the welder group was also significantly higher than that of the control group (p<0.001). As a result of the survey, the score of the exposure group in self-awareness of abnormal nerve symptoms and abnormal musculoskeletal symptoms was higher than those of the control group, and there was a significant difference between the two groups (p<0.05, respectively). In the correlation between PI and the results of blood tests, the correlation coefficient with blood Mn concentration was 0.893, revealing a significant amount of correlation (p<0.001). As for brain activity area within the control group, the right and the left areas of the superior frontal cortex showed significant activity, and the right area of superior parietal cortex, the left area of occipital cortex and cerebellum showed significant activity. Unlike the control group, the exposure group showed significant activity selectively on the right area of premotor cortex, at the center of supplementary motor area, and on the left side of superior temporal cortex. In the comparison of brain activity areas between the two groups, the exposure group showed a significantly higher activation state than did the control group in such areas as the right and the left superior parietal cortex, superior temporal cortex, and cerebellum including superior frontal cortex and the right area of premotor cortex. However, in nowhere did the control group show a more activated area than did the exposure group. Conclusions: Chronic exposure to Mn increased brain activity during implementation of hand motor tasks. In an identical task, activation increased in the premotor cortex, superior temporal cortex, and supplementary motor area. It was also discovered that brain activity increase in the frontal area and occipital area was more pronounced in the exposure group than in the control group. This result suggests that chronic exposure to Mn in the work environment affects brain activation neuro-networks.

• Journal of radiological science and technology
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• v.34 no.1
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• pp.17-25
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• 2011

In this study, we examined the impact caused by chronic exposure to Mn by investigating the degree of brain activation based on the data of recognition activities using fMRI (functional magnetic resonance imaging). A questionnaire survey, blood tests, and fMRI tests were carried out with respect to two groups. Group 1 was an exposure group consisting of 15 male workers who are 34 years old or older, and who worked for longer than 10 years in a shipbuilding factory as a welder. Group 2 was a control group consisting of 15 workers in manufacturing industries with the same gender and age. The results showed that blood Mn concentration of Group 1($1.3\;{\mu}g/dl$) was significantly higher than that of Group 2($0.8\;{\mu}g/dl$)(p < 0.001), and Pallidal Index (PI) of Group 1 was also significantly higher than that of Group 2 (p < 0.001). PI value of the group whose blood Mn concentration was $0.93\;{\mu}g/dl$ or higher was significantly higher than that of the group whose blood Mn concentration was less than $0.93 \;{\mu}g/dl$ (p < 0.001). As for brain activity area within the control group, the right and the left areas of occipital cortex showed significant activity and the left area of middle temporal cortex, the right area of superior inferior frontal cortex and inferior parietal cortex showed significant activity. Unlike the control group, the exposure group showed significant activity on the right area of superior inferior temporal cortex, the left of insula area. In the comparison of brain activity areas between the two groups, the exposure group showed significantly higher activation than the control group in such areas as the right inferior temporal cortex, the left area of superior parietal cortex and occipital cortex, and cerebellum including middle temporal cortex. However, in nowhere the control group showed more activated area than the exposure group. As the final outcome, chronic exposure to Mn increased brain activity during implementation of arithmetic task. In an identical task, activation increased in superior inferior temporal cortex, and insula area. And it was discovered that brain activity increase in temporal area and occipital area was more pronounced in the exposure group than in the control group. This result suggests that chronic exposure to Mn in the work environment affects brain activation neuro-network.

• Journal of the Korean GEO-environmental Society
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• v.2 no.3
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• pp.37-45
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• 2001

The characteristics of drinking groundwater quality was analyzed by investigating observed data during 1995-1997 in Daejeon city. As the analysis of observed data, the 30.1% of them were over the drinking water quality standards in Daejeon city and the unfit ratios of each region were 36.4% at Dong-Gu, 32.3% Daedeog-Gu, 31.2% Jung-Gu, 30.0% Seo-Gu and 25.2% at Yusoung-Gu. It was found that the items over the drinking water quality standards were 24 items and all of the mean concentration of water quality items were under the drinking water quality standard except Fe and Mn in 1997. The mean concentration of Fe was $1.31mg/{\ell}$ over the water quality at Daedeog-Gu and that of Mn was $0.53mg/{\ell}$ at Jung-Gu. The concentrations of $NH_3$-N, Mn, Fe, Al and F were increased rapidly in 1997, so that the cause of increasing also must be examined closely. It was found that the rainfall and unfit ratio(unfit frequency/test frequency) of E-coli and bacteria had the hydrologic persistance. The coefficient of correlation between them was 0.525. On the rainfall over 100mm, it was 0.673 and on the rainfall over 150mm, it was 0.641. The correlation between E-coli and rainfall was higher than that between bacteria and rainfall.

• The korean journal of orthodontics
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• v.28 no.5 s.70
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• pp.763-774
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• 1998

The purpose of this study was to evaluate the morphology of mandibular symphysis and location of lower incisor under the influence of the craniofacial skeleton in skeletal Class III malocclusion. The sample consisted of 132 adults who have severe Class III malocclusion(prognathism group, 33 males and 33 females), and who have normal occlusion(normal group, 33 males and 33 females). They had not received any orthodontic treatment or orthognathic surgery. The lateral cephalograms were evaluated. The results were as follows : 1. Prognathism group were larger than normal group in comparison of facial skeleton (p<0.05) with the exception of ${\angle}FH-Pal$, ${\angle}SNA$. 2. In the morphology of symphysis, measurements of anteroposterior width(LaABBW, LiABBW, SW) of prognathism group were significantly less than that of normal group(p<0.001). 3. In the correlative analysis between the craniofacial skeleton and symphysis measurements of prognathism group, vertical measurements in relation with cranial base and mandibular plane showed reverse correlationship with anteroposterior width of symphysis(LiACBW, LaACBW, LiABBW, SW)(p<0.05). But, there was not distinct difference between horizontal skeletal measurements and symphysis measurements(p>0.05). 4. The probability by regression test between vertical measurements(${\angle}SN-Mn,\;{\angle}FMA,\;{\angle}Pal-Mn,\;{\angle}LFH$) and symphysis measurements(LiACBW, LiABBW, SW, ${\angle}LISA$) were very high(p<0.001).