• Journal of Acupuncture Research
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• 제34권3호
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• pp.49-58
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• 2017

Objectives : The purpose of this study is to provide data to guide dementia health-care policy in Korea and to establish the position of Korean medical specialists in long-term care hospitals by analyzing the data of dementia inpatients. We analyzed the actual condition of dementia patients in care hospital and the effect of Western-Korean cooperative medicine on the progress of dementia. Methods : From January 1, 2016 to December 31, 2016, inpatients who were diagnosed with dementia at Mungyeong municipal long-term care hospital and admitted for more than 3 months were enrolled. Their medical records and simple tests were analyzed retrospectively. Results : We examined the detailed diagnosis, including both main and sub diagnosis, and Alzheimer disease dementia, at 97%, was the most common. At the time of admission, Korean Version of the Mini-Mental State Exam (K-MMSE) analysis showed that severe dementia affected 52%, and most were rated as Geriatric Depression Scale (GDS) 6. Based on the admission date, the results of a simplified test applied to the dementia patients every 6 months showed an maintain in the K-MMSE and GDS scores in 83%. Conclusion : The results of this study show that the rate of progression of dementia is somewhat lower in inpatients with moderate to severe Alzheimer's who have received Western-Korean cooperative treatment. However, due to institutional limitations, long-term inpatients such as those with dementia do not receive active traditional Korean medical treatment; hence, it is necessary to improve the national institution of traditional Korean medicine in long-term care hospitals.

• 정신신체의학
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• 제22권2호
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• pp.71-78
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• 2014

연구목적 알츠하이머병 환자들의 행동심리증상(BPSD)은 임상적인 문제들을 일으켜 결국 기능의 감퇴, 간병인 스트레스, 입원, 사망률의 증가를 가져온다. 최근의 연구는 성별차이가 BPSD에서 중요한 역할을 한다고 보고하고 있으나, BPSD와 성별 사이 연관에 대한 국내 연구는 시행된 적이 없었다. 이에 본 연구는 알츠하이머병 환자들의 BPSD가 성별 차이에 의해 영향을 받는 것인지를 검증해 보고자 실시하였다. 방 법 면담과 인지기능평가를 통해 DSM-IV 진단기준에 의하여 알츠하이머병으로 진단받은 98명의 환자들이 본 연구에 참가하였다. 간이정신상태검사(MMSE), 임상치매평가척도(CDR), 전반적 퇴화척도(GDS), 한국형 신경정신행동검사(K-NPI)를 사용하여 인지기능 및 BPSD를 평가하였다. 성별 차이를 확인하기 위해서 독립 t 검증을 사용하여 분석하였으며, MMSE, CDR, GDS와 NPI 사이의 관련성을 살펴보기 위해 피어슨 상관분석을 사용하였다. 결 과 알츠하이머병 환자들의 BPSD에서 통계적으로 유의미한 성별 차이는 관찰되지 않았다. MMSE와 NPI 총점, 그리고 NPI 하위영역인 환각과 유의한 상관관계를 보였으며, CDR의 경우 NPI 총점, 무감동/무관심, 과민/불안정과, GDS의 경우 NPI 하위영역인 환각과 유의한 상관관계를 나타내었다. 결 론 본 연구결과 우리나라 알츠하이머병 환자들의 BPSD에서 성별의 차이는 나타나지 않았지만, 추후 알츠하이머형 치매의 BPSD가 성별 차이에 의한 것인지 혹은 개인 차에 의한 것인지를 더 명확하게 밝혀내기 위한 광범위하고 지속적인 연구가 필요할 것으로 생각된다.

• 대한한방내과학회지
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• 제40권5호
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• pp.804-813
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• 2019

The purpose of this study was to evaluate the effect of Korean medicine in a patient with cognitive impairment, emotional disturbance, and sleep disturbance due to a diffuse axonal injury associated with a traumatic brain injury. The patient was treated with herbal medicine and acupuncture. The treatment effects were evaluated using the Korean version of the Mini-Mental State Examination (MMSE-K) and the Global Detraction Scale (GDS), and by observing clinical symptoms. Improvements in the total scores of MMSE-K and GDS were observed after the Korean medicine treatments; the MMSE-K score increased from 13 to 23 and the GDS score decreased from 5 to 4. The emotional and sleep disturbances were also reduced. These case report findings suggest that Korean medicine may be effective for treating symptoms of diffuse axonal injury in patients with traumatic brain injury.

• 정신신체의학
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• 제22권1호
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• pp.23-30
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• 2014

연구목적 호모시스테인은 인지기능의 손상과 다양한 정신과 증상들과 연관되어 있다. 본 연구는 혈중 호모시스테인 농도와 치매의 행동심리증상 사이에 연관성을 검증하기 위해서 시행되었다. 방법 DSM-IV에 의해 알쯔하이머형 치매로 진단된 환자 41명의 혈중 호모시스테인, 엽산, 비타민 $B_{12}$ 농도를 측정하였다. 그리고 병력청취, 신체검사와 간이정신상태기능검사(MMSE), 전반적 퇴화척도(GDS), 임상치매 평가척도(CDR), 한국형 신경정신행동검사(K-NPI)를 수행하였다. 결과 호모시스테인 농도와 NPI 총 점수 사이에 통계적으로 유의한 양의 상관관계가 관찰되었고 망상, 초조/공격성, 우울/불쾌, 들뜸/흥분과 같은 여러 하위항목과도 양의 상관관계가 관찰되었다. 호모시스테인 농도와 MMSE, GDS, CDR 점수 사이에는 유의한 상관관계가 관찰되지 않았다. 결론 본 연구는 혈중 호모시스테인 농도가 치매의 행동심리증상과 연관되어 있음을 보여준다. 추가적인 연구를 통하여 이와 연관된 병태생리학적 기전을 밝히는 것이 필요하다.

• 동의신경정신과학회지
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• 제27권3호
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• pp.185-196
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• 2016

Objectives: This study was undertaken by the department of Korean neuropsychiatry, to evaluate the effects of M&L psychotherapy and Korean Medical Treatments on hospitalized North Korean defectors.Methods: We treated two patients with indigenous Korean medical therapies (acupuncture and herb-medicine) and M&L psychotherapy. Beck's Depression Inventory (BDI), Insomnia Severity Index (ISI), Geriatric Depression Scale (GDS), Mini-mental state examination Korean Version (MMSE-K), and Visual Analogue Scale (VAS) were used to evaluate the patients.Results: Following observations were made after treatments. Case 1: the patient had significant improvement in Beck's Depression Inventory (BDI), Insomnia Severity Index (ISI), and Visual Analogue Scale (VAS). Case 2: similar improvements were observed. Here, the patient had undergone Geriatric Depression Scale (GDS), Mini-mental state examination Korean Version (MMSE-K), and Visual Analogue Scale (VAS). In addition, noticeable improvement was observed in other accompanying symptoms.Conclusions: These results suggest that M&L Psychotherapy and Korean medical treatments might be effective for treating the psychiatric and physical symptoms of hospitalized North Korean Defectors.

• 대한간호학회지
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• 제38권1호
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• pp.1-10
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• 2008

Purpose: The purpose of this study was to examine cognitive functions, depression, and life satisfaction among the elderly receiving visiting nursing services. Methods: The subjects of this study consisted of 221 elderly individuals who were receiving visiting nursing services from a public health center located in Gyeonggi-do. The Mini-mental State Examination Korea version (MMSE-K), Geriatric Depression Scale-short form-Korea version (GDS-K), and Life Satisfaction Scale were utilized to determine cognitive functions, depression, and life satisfaction, Collected data was analyzed by the SPSS PC Win 12,0 program. Results: The prevalence of cognitive impairment (MMSE-K$\leq$24) was 86.4%, and the proportion of severe depression (GDS-K$\leq$10) was 22,6%, Older age, lower education, and low income were associated with cognitive impairment, and low education, no religion, and low income were associated with depression. Cognitive function negatively correlated with depression. Life satisfaction level was fairly low and was not associated with any variables. Conclusion: The high prevalence of cognitive impairment and low life satisfaction status were determined among low-income elderly who were registered at a visiting health care center. Thus, in the future at visiting health care services, efficient and various programs for the elderly should be tried, to improve cognitive functions and reduce depression. Additionally, consistent evaluation studies for those programs will be required.

• 동의신경정신과학회지
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• 제35권3호
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• pp.269-278
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• 2024

Objectives: Vascular dementia (VaD) is a neurodegenerative disorder associated with cognitive impairment resulting from cerebrovascular pathology. This clinical case study aimed to evaluate the efficacy of Korean medicine treatment in treating VaD following an acute cerebral infarction and subarachnoid hemorrhage. Methods: The subject, a female in her 70s, reported cognitive impairment and right-sided hemiparesis following an acute cerebral infarction and subarachnoid hemorrhage. The patient received comprehensive treatment comprising herbal medicine, acupuncture, moxibustion, and cupping therapy for 108 days. We assessed improvements in cognitive impairment and neurological symptoms using the Korean version of the Mini-Mental Status Examination (MMSE-K), Global Deterioration Scale (GDS), and Korean version of Modified Barthel Index (K-MBI). Results: After treatment, both cognitive impairment and right-sided hemiparesis improved. Scores of MMSE-K, GDS, K-MBI, and MMT also increased. Conclusions: Korean medicine treatment could be considered for patients with vascular dementia following acute cerebral infarction and subarachnoid hemorrhage.

• 정신신체의학
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• 제24권1호
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• pp.94-101
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• 2016

연구목적 본빈혈은 노인 환자들에서 흔한 내과적 문제이다. 최근 연구는 빈혈이 인지기능 저하 및 알츠하이머병 치매와 연관성이 있다고 보고되고 있다. 본 연구는 한국 노인들에서 헤모글로빈 농도와 알츠하이머병 치매 및 경도 인지기능 장애와의 연관성에 대해 연구하기 위해 실시되었다. 방 법 116명의 대상자들이 본 연구에 참여하였다(평균 연령 : 74.67세, 여성 : 60.3%). 한국판 간이정신상태검사(MMSE-K), 임상치매평가척도(CDR), 전반적 퇴화척도(GDS)를 사용하여 대상자들을 평가하였고, 혈액학적 검사를 실시하였다. 결 과 알츠하이머병 치매 환자들이 경도인지장애군과 정상군에 비해서 유의미하게 낮은 헤모글로빈 농도와 적혈구 용적율을 가진다는 것이 관찰되었다. 헤모글로빈 농도는 MMSE-K와 양의 상관관계를 나타내었으며, overall CDR 및 GDS와는 음의 상관관계를 보였다. 결 론 한국 노인들에서 낮은 헤모글로빈 농도는 인지기능손상과 연관이 있는 것으로 나타났다. 본 연구 결과 알츠하이머병 치매는 빈혈과 연관이 있었으며, 이를 통해 낮은 헤모글로빈 농도가 알츠하이머병의 유용한 임상적 표지자로서 의미를 가지고 있다고 생각해 볼 수 있겠다. 치매에 대한 위험 요소는 더 광범위한 환자 군에서 전향적 종단 연구에 의해 확인하는 것이 필요하겠다.

• 대한물리의학회지
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• 제15권2호
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• pp.23-30
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• 2020

PURPOSE: The purpose of this study was to examine the effects of dual-task training with cognitive tasks on cognitive functions and β-amyloid levels in the elderly with mild dementia. METHODS: The subjects were 36 elderly inpatients diagnosed with mild dementia at S Hospital located in Gyeongsangbuk-do, South Korea. The patients were randomly divided into a dual-task training group (DTG; n = 18) or a single-task training group (STG; n = 18). DTG performed dual-task training with cognitive tasks while STG performed only exercise tasks. These groups performed their respective exercises during a 30-minute session occurring three times a week over an 8-week period. MMSE-K and GDS were used to measure the subjects' cognitive function. To assess the subjects' dementia-related factors, their β-amyloid levels were measured by blood analysis. RESULTS: The results of the experiment were as follows: DTG showed statistically significant differences between their MMSE-K scores and β-amyloid levels before and after training (p < .05), whereas they exhibited no statistically significant differences in their GDS scores. MMSE-K scores and β-amyloid levels were significantly different between DTG and STG after training. CONCLUSION: The present study's overall results indicate that dual-task training with cognitive tasks is more effective than single-task training in improving cognitive functions and β-amyloid levels in the elderly with mild dementia. In other words, regular dual-task training can be considered as effective in improving cognitive function and dementia-related factors in the elderly with mild dementia and thus may be suggested as an effective exercise method for the treatment and early prevention of dementia.

• 대한물리의학회지
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• 제3권4호
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• pp.285-292
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• 2008

Purpose : To estimate the prevalence of and identity the associates of cognitive function and depression among people over 70 years of age, and to examine the relationship between cognitive impairment and depression, Methods : The elderly in Pusan area were studied on the Korea version Mini Mental Scale Examination instrument(MMSE-K), Short form of Geriatic Depression Scale(SGDS). Results : The prevalence of cognitive impairment($MMSE{\leq}24$) was 64.4% and that of depression($GDS{\geq}8$) was 40.7% Lower education, no religion and no work experience were associated with cognitive impairment. Depression in demented group was 68.2%, in suspect dementia group was 43.7% and in non-demented group was 9.5%. Conclusion : The prevalence of cognitive impairment and depression in elderly was high and depression was in association with cognitive impairment.