• Journal of Wetlands Research
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• v.6 no.4
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• pp.35-43
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• 2004

The non-parametric Mann-Kendall(MK) statistical test has been widely used to assess the significance of trend in hydrologic time series. The test requires sample data should be serially independent. If sample data is serially correlated, the presence of serial correlation in a time series will affect the test ability for trend analysis. So, we would like to use the modified MK test which uses the effective sample size(ESS) to eliminate the effect of serial correlation in a series. This study investigates the ability of ESS to eliminate the influence of serial correlation of MK test by Monte Carlo simulation and by real series. As the results, MK test shows the increase of trend rate as the serial correlation is increased but the modified MK test shows ESS can eliminate the serial correlation for trend analysis. Therefore we confirmed the modified MK test is a very useful tool for trend analysis.

• Animal cells and systems
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• v.15 no.2
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• pp.115-121
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• 2011

Previous studies have demonstrated that N-methyl-D-aspartate (NMDA) receptors and acetylcholine receptors are related to learning and memory in rat and mice. In this study, we examined the effects of MK-801, a non-competitive NMDA receptor antagonist, on learning and memory in zebrafish using a passive avoidance test. We further tested whether or not nicotine, a nicotinic acetylcholine receptor agonist, and physostigmine, an acetylcholinesterase inhibitor, reverse the effects of MK-801. Crossing time was increased significantly in the training and test sessions for the controls. When 20 ${\mu}M$ MK-801 was administered prior to the training session, the crossing time did not increase in either session. The MK-801-induced learning deficit was rescued by pretreatment with 20 ${\mu}M$ physostigmine, and crossing time was increased in the training and test sessions compared to the MK-801-treated zebrafish. Further, the MK-801-induced learning deficit was prevented by pretreatment with 20 ${\mu}M$ nicotine, and crossing time was increased in the training session but not in the test session. These results show that MK-801 induced a learning deficit in zebrafish that was prevented by pretreatment with nicotine and physostigmine.

• Journal of the Korean Ceramic Society
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• v.42 no.11 s.282
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• pp.737-742
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• 2005

Rheological properties of ordinary portland cement (OPC) containing metakaoline (MK), granulated blast furnace slag (GBS) and polycarboxylate type superplasticizer (PCA) were investigated using a mini-slump test, sedimentation test and viscometer. Fluidity of cement pastes containing MK (OPC-MK, OPC-MK-GBS systems) with PCA were higher than those of the cement pastes without MK(OPC, OPC-GBS systems). Colloid suspensions with $0.1\%$ PCA were changed from stable sedimentation behaviors to flocculation behaviors in the OPC-MK, OPC-GBS and OPC-MK-GBS systems. The colloid suspensions showed stable sedimentation behaviors with PCA greater than $0.2\%$. The OPC system showed shear thinning behavior. However, the other systems showed weak shear thinning behaviors with PCA. Rheological properties of cement pastes were improved when MK and GBS were contained together. The rheological properties of OPC-MK, OPC-GBS and OPC-MK-GBS systems were improved by PCA added greater than $0.2\%$.

• Korean Journal of Pharmacognosy
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• v.44 no.2
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• pp.97-103
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• 2013

Schizophrenia is a severe psychiatric disorder and characterized by positive symptom (i.e., delusions, hallucinations), negative symptom (i.e., lack of emotion, social withdrawal), and cognitive impairment. Previously, we reported that the ethanolic extract of Prunella vulgaris var. lilacina attenuated the MK-801-induced schizophrenia-like behaviors such as prepulse inhibition (PPI) deficits and cognitive impairment in mice. The aim of the present study was to investigate whether danshensu isolated from P. vulgaris var. lilacina attenuates MK-801-induced sensorimotor gating dysfunction (PPI deficits), hyperlocomotion, and memory impairment in mice. Acute administration of danshensu (1, 3, or 10 mg/kg) significantly ameliorated the MK-801-induced PPI deficits in the acoustic startle response test. We also observed that the impaired recognition memory induced by MK-801 was attenuated by danshensu (1 mg/kg) in the novel object recognition test. However, danshensu failed to reverse the MK-801-induced hyperlocomotion in the open-field test. Collectively, the present results indicate danshensu would be an active agent for treating neuropsychiatric disorders such as schizophrenia.

• Advances in concrete construction
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• v.5 no.1
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• pp.31-48
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• 2017

Supplementary cementitious materials (SCM) have turned out to be a vital portion of extraordinary strength and performance concrete. Metakaolin (MK) is one of SCM material is acquired by calcinations of kaolinite. Universally utilised as pozzolanic material in concrete to enhance mechanical and durability properties. This study investigates the fresh and hardened properties of conventional concrete (CC) and self compacting concrete (SCC) by partially replacing cement with MK in diverse percentages. In CC and SCC, partial replacement of cement with MK varies from 5-20%. Fresh concrete properties of CC are conducted by slump test and compaction factor tests and for SCC, slump flow, T500, J-Ring, L-Box, V-Funnel and U-Box tests. Hardened concrete characteristics are investigated by compressive, split tensile and flexural strengths at age of 7, 28 and 90 days of curing under water. Carbonation depth, water absorption and density of MK based CC and SCC was also computed. Fresh concrete test results indicated that increase in MK replacement increases workability of concrete in a constant w/b ratio. Also, outcomes reveal that concrete integrating MK had greater compressive, flexural and split tensile strengths. Optimum replacement level of MK for cement was 10%, which increased mechanical properties and robustness properties of concrete.

• Development and Reproduction
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• v.4 no.1
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• pp.101-108
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• 2000

Objectives: The pleiotrophin (PTN) and midkine (MK) are secreted heparin-binding neurokines that share 50％ sequence homology. PTN and MK are expressed in the range of primary human tumors. The association of PTN and MK with carcinogenesis, enhancement of plasminogen activator activity and angiogenic factor are reported. Patients with endometriosis are characterized by the ability of the endometrium to implant; angiogenic and growth factors may play a significant role in the pathogenesis of endometriosis. To test the hypothesis that higher expression of PTN and MK in endometrium from women with endometriosis might be increase angiogenesis and growth ectopic endometriosis implants, we investigated PTN and MK expression by quantitative and competitive polymerase chain reaction (QC-PCR) in endometrium from women with and without endometriosis throughout the menstrual cycle. Design: MK and PTN mRNA expression in endomeoium from women with endometriosis and control patients without endometriosis were determined by QC-PCR throughout the menstrual cycle. Methods: Endometrial tissue was obtained from 25 patients with severe endometriosis and 30 patients without endometriosis undergoing hysterectomy or endometrial biopsy. Stage of endometrial cycle and a diagnosis of endometriosis were confirmed histologically. Total RNA was extracted and reverse transcribed into c-DNA. QC-PCR was performed to evaluate PTN and MK mRNA expression. Results were analysed by Post Hoc test. Results: MK and PTN were expressed throughout the menstrual cycle in both groups. MK expression was higher in follicular phase than luteal phase in endometrium from normal women. endometrium from endometriosis patients showed increased expression of PTN and MK compared to endometrium from normal women in the luteal phase (p<0.05). Conclusion: Our results suggest that uterine endometrium from women with endometriosis expresses higher levels of MK and PTN than endometrium from normal women during luteal phase. Increased MK and PTN expression may be related to the initiation of ectopic endometrial implants and their subsequent peritoneal invasion.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.3
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• pp.476-482
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• 2006

The aim of this work was to perform the screening and identification of the bacterium, MK-15 having the activity of fibrinolytic enzyme for the commercial use. Initially, strain MK-15 was enriched and isolated from naturally fermented soybean. Morphological and various physiological characteristics of the strain MK-15 was examined. The activity of fibrinolytic enzyme derived from supernatants of test culture MK-15 was performed by fibrin plate method for solid fibrinolytic activity. As the result, the fibrinolytic activity of MK-15 grown on the soybean media was about 2.7 times greater than that of plasmin used as stardard. 16S rRNA analyses revealed that strain MK-15 was 99.9% similar to Bacillus subtilis species cluster, and the bacterium was designated as Bacillus sp. MK-15. Strain MK-15 was registered in GenBank as [DQ163021].

• Advances in concrete construction
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• v.5 no.3
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• pp.241-255
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• 2017

Concrete is known to be the most used construction material worldwide. The environmental and economic aspects of Ordinary Portland Cement (OPC) containing concrete have led research studies to investigate the possibility of incorporating supplementary cementitious materials (SCMs) in concrete. Metakaolin (MK) is one SCM with high pozzolanic reactivity generated throughout the thermal activation of high purity kaolinite clay at a temperature ranging from $500^{\circ}C$ to $800^{\circ}C$. Although many studies have evaluated the effect of MK on mechanical properties of concrete and have reported positive effects, limited articles are considering the effect of MK on durability properties of concrete. Considering the lifetime assessment of concrete structures, the durability of concrete has become of particular interest recently. In the present work, the influences of MK on mechanical and durability properties of concrete mixtures are evaluated. Various experiments such as slump flow test, compressive strength, water permeability, freeze and thaw cycles, rapid chloride penetration and surface resistivity tests were carried out to determine mechanical and durability properties of concretes. Concretes made with the incorporation of MK revealed better mechanical and durability properties compared to control concretes due to combined pozzolanic reactivity and the filler effect of MK.

• Nuclear Engineering and Technology
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• v.37 no.6
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• pp.565-574
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• 2005

The CANFLEX Mk-V bundle is designed to improve upon the critical heat flux (CHF) characteristics of the CANFLEX Mk-IV bundle. The main difference between these two bundles is an increase in bearing pad height of about 0.3 mm in the CANFLEX Mk-IV bundle. This change in bearing pad height leads to an increase in gap flow at the bottom of the bundle, primarily eliminating the localized narrow-gap effect that limits the CHF of the CANFLEX Mk-IV bundle. The objective of this paper is to examine the effects of bearing pad height and pressure tube creep on the sheath-temperature distribution, dryout power, and dryout location, as observed ken full-scale bundle tests, between CANFLEX Mk-IV and Mk-V bundles In uncrept and crept channels. A comparison of surface-temperature differences between the top and bottom elements of the bundles showed that increasing the bearing pad height has led to a more homogeneous enthalpy distribution in subchannels of the bundle. Initial dryout locations of the CANFLEX Mk-V bundle were mainly observed at the mid-spacer plane of either the $10^{th}$ (about $80\%$) or $11^{th}$ ($20\%$) bundle in the 12-bundle string, as compared to the mid-spacer and downstream-button planes for the CANFLEX Mk-IV bundle. Dryout power and boiling-length-average (BLA) CHF values exhibit consistent trends and little scatter with varying flow conditions for both types of CANFLEX bundles in uncrept and crept channels. An increase in pressure tube creep has led to a reduction in dryout power (about $20\%$ far the $3.3\%$ crept channel and $27\%$ for the $5.1\%$ crept channel as compared to dryout powers for the uncrept channel). Increasing the bearing pad height of the CANFLEX bundle has led to an increase in the dryout power. Overall, the dryout power of the CANFLEX Mk-V bundle is 7 to $10\%$ higher than that of the CANFLEX Mk-IV bundle at the inlet temperature range of interest (i.e., between 243 and $290^{\circ}C$).

• The Research Journal of the Costume Culture
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• v.11 no.1
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• pp.11-19
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• 2003

This study suggests the new 2D anthropometric method using digital camera. It is used MK2001 program that can convert 2D measurements to 3D measurements. To improve that it is measured 100 college students with direct and indirect anthropometric method. The measurements were processed by the SPSS ver10 Statistical Package. The average, standard deviation, and t-test were calculated for each category. Most measurements by 2D measurements are higher than direct measurements but degree. The difference between direct and indirect measurements is less than 2cm. In the results of t-test, height measurements including other 16 measurements which is easy to measure have no meaningful difference within 1cm. The depth measurements are most high difference. The result of each measurement proves that MK2001 program (2D anthropometry method using digital camera) is available for measuring the human body.