• 한국콘텐츠학회:학술대회논문집
• /
• 한국콘텐츠학회 2019년도 춘계종합학술대회
• /
• pp.275-276
• /
• 2019

The purpose of this study was to assess condylar size in volumetric 3D imaging in patients with class I, class II, class III malocclusions. To evaluate the differences among the three experimental groups, the condylar values of men were analyzed. There was a significant difference in the measured values of height. Among the three experimental groups, the condylar measurements in women showed significant differences in height and width. This study is expected to be used for determining the connection between malocclusion and condyle as a base line data.

• Journal of Audiology & Otology
• /
• 제24권2호
• /
• pp.103-106
• /
• 2020

Granular cell tumor (GCT) is a rare, benign neoplasm of Schwann cell origin. GCT is composed of cells with eosinophilic granular cytoplasm. GCT presents as a solitary painless nodule. Because of their subtle clinical presentation, GCTs are often misdiagnosed. This report of a 47-year-old woman with an auricular GCT serves to highlight that complete excision and histopathological evaluation should be attempted even in apparently benign cases, to ensure complete cure.

• 대한청각학회지
• /
• 제24권2호
• /
• pp.103-106
• /
• 2020

Granular cell tumor (GCT) is a rare, benign neoplasm of Schwann cell origin. GCT is composed of cells with eosinophilic granular cytoplasm. GCT presents as a solitary painless nodule. Because of their subtle clinical presentation, GCTs are often misdiagnosed. This report of a 47-year-old woman with an auricular GCT serves to highlight that complete excision and histopathological evaluation should be attempted even in apparently benign cases, to ensure complete cure.

• 천문학회보
• /
• 제45권1호
• /
• pp.49.4-50
• /
• 2020

We introduce a novel method for reconstructing the projected matter distributions of galaxy clusters with weak-lensing (WL) data based on convolutional neural network (CNN). We control the noise level of the galaxy shear catalog such that it mimics the typical properties of the existing Subaru/Suprime-Cam WL observations of galaxy clusters. We find that our mass reconstruction based on multi-layered CNN with architectures of alternating convolution and trans-convolution filters significantly outperforms the traditional mass reconstruction methods.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권6호
• /
• pp.3751-3755
• /
• 2013

Backgroud and Aims: MicroRNA-206 has proven to be down-regulated in many human malignancies in correlation with tumour progression. Our study aimed to characterize miR-206 contributions to initiation and malignant progression of human osteosarcoma. Methods: MiR-206 expression was detected in human osteosarcoma cell 1ine MG63, human normal osteoblastic cell line hFOB 1.19, and paired osteosarcoma and normal adjacent tissues from 65 patients using quantitative RT-PCR. Relationships of miR-206 levels to clinicopathological characteristics were also investigated. Moreover, miR-206 mimics and negative control siRNA were transfected into MG63 cells to observe effects on cell viability, apoptosis, invasion and migration. Results: We found that miR-206 was down-regulated in the osteosarcoma cell line MG63 and primary tumor samples, and decreased miR-206 expression was significantly associated with advanced clinical stage, T classification, metastasis and poor histological differentiation. Additionally, transfection of miR-206 mimics could reduce MG-63 cell viability, promote cell apoptosis, and inhibit cell invasion and migration. Conclusions: These findings indicate that miR-206 may have a key role in osteosarcoma pathogenesis and development. It could serve as a useful biomarker for prediction of osteosarcoma progression, and provide a potential target for gene therapy.

• 대한족부족관절학회지
• /
• 제19권4호
• /
• pp.161-164
• /
• 2015

Purpose: The purpose of this study is to define the geographic patterns of partial avascular necrosis (AVN) of the talar body and to determine whether there were any predictors of both the location and occurrence of partial AVN. Materials and Methods: Nineteen patients with fracture of the talar neck treated by open reduction and internal fixation and followed up for more than 1 year were analyzed. The radiographs were examined 6 to 8 weeks after the operation for Hawkins sign and if it was not observed, magnetic resonance scans were performed. The three-dimensional analysis was performed using Mimics 17.0 (Materialise). The incidence of collapse and time to operative intervention was recorded. Results: Partial AVN of the talar body was observed in six out of 19 patients. The avascular segment of the talar body was located predominantly in the anterolateral portion. The average volume of the avascular segment was $289mm^3$, and it occupied 1% of total volume of the talus, and 10% of the talar dome. Collapse occurred in one patient in the area of the avascular process. There were no observable trends with regard to Hawkins classification, incidence of collapse, or time to operative intervention to the location of the avascular segment. Conclusion: Partial AVN can occur after fracture of the talar neck. The predominant location of the avascular segment was the anterolateral portion of the talar body. This information may be helpful to understanding the process of avascular necrosis of the talar body.

• 대한기계학회논문집 C: 기술과 교육
• /
• 제2권2호
• /
• pp.73-80
• /
• 2014

상기도 내의 약물 전달을 알아보기 위하여 구강 호흡 시 공기유동에 대한 수치해석을 수행하였다. 상기도는 구강과 후두, 기관과 기관지로 구성되어 있다. 정밀 촬영한 CT 데이터로부터 의료영상 소프트웨어(Mimics)를 이용한 구분(segmentation)과 세심한 표면처리를 통하여 해부학적으로 정확한 모델을 만들 수 있었다. 이 3차원 컴퓨터 모델을 이용하여, 구강에서 기관지의 2번째 분지까지 이르는 유로의 수치 모델을 제작하였다. 수치해석은 상용 소프트웨어인 ANSYS/Fluent를 이용하여 계산하였다. 본 연구에 사용된 모델은 노즐이 부착되지 않은 상태에서 초당 250 mL를 흡입하는 정상 구강호흡 모델과 입구에 각각 20 mL/s, 40 mL/s, 60 mL/s의 유량을 갖는 노즐을 장착한 모델을 사용하였다. 전산 유동가시화 결과로부터, 노즐의 유량을 증가시킬수록 선회류의 발생 정도가 증가하여 구강 내 약물의 잔류 량은 증가하지만, 기관/기관지에 약물 도표는 균일하게 나타났다.

• 한국항공우주학회지
• /
• 제43권7호
• /
• pp.635-640
• /
• 2015

본 논문에서는 형상기억합금 구동기를 이용한 소형위성용 비폭발식 분리장치를 소개한다. 앞선 연구결과를 바탕으로 분리장치의 부품의 교체를 통하여 제안된 분리장치의 신뢰성을 향상시킴으로써 고사전하중(preload) 하에서도 구동이 가능하도록 하였다. 또한 충격 실험을 통하여 비폭발식분리장치의 장점인 저충격 발생을 확인하였고, 발사환경 및 우주 환경실험을 통하여 안정적으로 작동하는 것을 검증하였다. 결론적으로 본 연구에서는 충격실험, 진동실험 및 열진공실험 후 고사전하중에서 저충격을 발생시키며 안정적으로 작동 가능한 비폭발식 분리장치를 개발하였다.

• 한국콘텐츠학회논문지
• /
• 제11권10호
• /
• pp.488-493
• /
• 2011

한국과학기술정보연구원과 가톨릭대학교 의과대학 가톨릭응용해부연구소에서는 척추 연구자들이 쉽게 사용할 수 있는 기초 자료를 구축하고 있다. 척추 형상 정보를 제공하기 위해 60-80대 기증시신 20여 표본을 활용하여 고해상도 척추 (whole spine) CT (pixel dimension : 0.4x mm, thickness: 0.6mm)를 촬영하고 이를 3차원 모델링 소프트웨어(Mimics, Ver.14, Materialise, Belgium)를 사용하여 3차원 형상 모델(shell model, STL format)로 구축하고, 목, 등, 허리 척추의 주요 부위를 계측하여 수치화 하였다. 시신기반 자료의 한계를 극복하기 위해 고령자 호발 질환을 중심으로 대상 환자를 선정하여 X-Ray, CT, BMD 자료를 구축하여 보강하고 있다. 물리적 성질 정보 구축은 기증시신 10여 표본을 활용하여 임상적, 물리적 골밀도를 측정하고, 목척추(cervical), 등척추(thoracic), 허리척추(lumbar) 부분의 굽힘-폄(flexion-extension), 가쪽 굽힘(lateral bending), 회전(torsion), 압축(body/disc compression) 시험을 수행하여 작용력과 굽힘량의 관계를 구축하고 있다. 구축된 물성 시험 결과는 형상 모델과 함께 제공되어 자료의 활용도를 높이고 있으며, 이를 이용하여 한국인 특성이 반영된 척추 관련 연구 및 제품 개발에 활용 될 수 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권9호
• /
• pp.5533-5537
• /
• 2013

MicroRNA-10b (miR-10b) has been reported to play an important role in some types of cancer, but the effects and possible mechanisms of action of miR-10b in the metastasis of nasopharyngeal carcinoma cells (NPC) have not been explored. The aim of the present study was to investigate the function of miR-10b in nasopharyngeal carcinoma and to determine the molecular mechanisms underlying its action. The MTT assay was used to assess proliferation of CNE-2Z cells. Wound healing and transwell migration assays were applied to assess cell migration and invasion, while and expression of E-cadherin and MMP-9 were detected using Western blot analysis. Real-time PCR was employed to detect the expression of genes related to migration and invasion and the $2^{-{\Delta}{\Delta}Ct}$ method was used to calculate the degree of expression. MTT assay showed the expression of miR-10b to have no effect on the proliferation of NPC cell lines. The wound healing assay showed that miR-10b mimics promoted the mobility and invasion of NPC cell lines. Inhibitors of miR-10b reduced the ability of NPC cell lines to migrate and invade. In addition, the expression of genes related to migration and invasion, such as E-cadherin, vimentin, and MMP-9, were confirmed to be different in the CNE-2Z NPC cell line transfected with miR-10b mimics and with miR-10b inhibitors. In the present study, miR-10b was found to upregulate the expression of MMP-9 and knockdown of miR-10b was found to significantly downregulate the expression of E-cadherin. On the whole, these results showed that miR-10b plays an important role in the invasion and metastasis of NPC cells.